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Fycompa\u662f\u7531\u536b\u6750\u7b51\u6ce2\u7814\u7a76\u5b9e\u9a8c\u5ba4\u7814\u53d1\u7684\u4e00\u79cd\u65b0\u578b\u6297\u766b\u75eb\u836f\u7269\uff0c\u6bcf\u65e5\u670d\u7528\u4e00\u6b21\u3002\u8be5\u836f\u7269\u662f\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u3001\u975e\u7ade\u4e89\u6027\u7684AMPA\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u901a\u8fc7\u9776\u5411\u7a81\u89e6\u540e\u819c\u4e0aAMPA\u53d7\u4f53\u5904\u7684\u8c37\u6c28\u9178\u76d0\u6d3b\u6027\uff0c\u51cf\u5c11\u4e0e\u766b\u75eb\u53d1\u4f5c\u76f8\u5173\u7684\u795e\u7ecf\u5143\u7684\u8fc7\u5ea6\u5174\u594b\u3002Fycompa\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4f5c\u4e3a12\u5c81\u53ca\u4ee5\u4e0a\u766b\u75eb\u60a3\u8005\u7684\u90e8\u5206\u6027\u766b\u75eb\u53d1\u4f5c\uff08\u4f34\u6216\u4e0d\u4f34\u7ee7\u53d1\u6027\u5168\u9762\u6027\u766b\u75eb\u53d1\u4f5c\uff09\u7684\u8f85\u52a9\u6cbb\u7597\u3002<\/p>\n

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\u00a0<\/strong>
\n<\/strong>
\n\u5a92\u4f53\u54a8\u8be2\uff1a<\/strong>
\n\u536b\u6750\u682a\u5f0f\u4f1a\u793e
\n\u516c\u5171\u5173\u7cfb\u90e8
\n+81-(0)3-3817-5120<\/p>\n

[<\/strong>\u7f16\u8005\u6ce8]<\/strong><\/p>\n

1.<\/strong>\u5173\u4e8eFycompa\uff08\u901a\u7528\u540d\uff1a\u5421\u4ed1\u5e15\u5948\uff09<\/strong><\/p>\n

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2.<\/strong>\u5173\u4e8e\u5728\u4e2d\u56fd\u63d0\u4ea4\u7684Fycompa\u5355\u836f\u6cbb\u7597\u90e8\u5206\u6027\u766b\u75eb\u53d1\u4f5c\u7684\u8ffd\u52a0\u7533\u62a5\u8d44\u6599\u6240\u4f9d\u636e\u7684III\u671f\u4e34\u5e8a\u7814\u7a76<\/strong><\/p>\n

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1)\u00a0\u00a0\u7814\u7a76335<\/p>\n

\n
4\u30018\u548c12mg Fycompa\/\u5929\u7ec4\u7684\u766b\u75eb\u53d1\u4f5c\u9891\u7387\u53d8\u5316\u767e\u5206\u6bd4\u5206\u522b\u4e3a-17.3%\uff08p=0.223\uff09\u3001-29.0%\uff08p=0.0003\uff09\u3001-38.0%\uff08p<0.00001\uff09\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a-10.8%\u3002<\/li>\n
\u6700\u5e38\u89c1\u76843\u79cd\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u5934\u6655\u3001\u55dc\u7761\u548c\u9f3b\u54bd\u708e\u3002<\/li>\n<\/ul>\n
2)\u00a0\u00a0\u7814\u7a76304<\/p>\n
\n
8mg\u548c12mg Fycompa\/\u5929\u7ec4\u768450%\u7f13\u89e3\u7387\u5206\u522b\u4e3a37.6%\uff08p=0.0760\uff09\u548c36.1%\uff08p=0.0914\uff09\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a26.4%\u3002<\/li>\n
8mg\u548c12mg Fycompa\/\u5929\u7ec4\u7684\u766b\u75eb\u53d1\u4f5c\u9891\u7387\u53d8\u5316\u767e\u5206\u6bd4\u5206\u522b\u4e3a-26.3%\uff08p=0.0261\uff09\u548c-34.5%\uff08p=0.0158\uff09\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a-21.0%\u3002<\/li>\n
\u6700\u5e38\u89c1\u76846\u79cd\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u5934\u6655\u3001\u55dc\u7761\u3001\u6613\u6fc0\u60f9\u3001\u5934\u75db\u3001\u8dcc\u5012\u548c\u5171\u6d4e\u5931\u8c03\u3002<\/li>\n<\/ul>\n
3)\u00a0\u00a0\u7814\u7a76305<\/p>\n
\n
8mg\u548c12mg Fycompa\/\u5929\u7ec4\u768450%\u7f13\u89e3\u7387\u5206\u522b\u4e3a33.3%\uff08p=0.0018\uff09\u548c33.9%\uff08p=0.0006\uff09\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a14.7%\u3002<\/li>\n
8mg\u548c12mg Fycompa\/\u5929\u7ec4\u7684\u766b\u75eb\u53d1\u4f5c\u9891\u7387\u53d8\u5316\u767e\u5206\u6bd4\u5206\u522b\u4e3a-30.5%\uff08p=0.0008\uff09\u548c-17.6%\uff08p=0.0105\uff09\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a-9.7%\u3002<\/li>\n
\u6700\u5e38\u89c1\u76844\u79cd\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u5934\u6655\u3001\u75b2\u4e4f\u3001\u5934\u75db\u548c\u55dc\u7761\u3002<\/li>\n<\/ul>\n
4)\u00a0\u00a0\u7814\u7a76306<\/p>\n
\n
2\u30014\u548c8mg Fycompa\/\u5929\u7ec4\u768450%\u7f13\u89e3\u7387\u5206\u522b\u4e3a20.6%\uff08p=0.4863\uff09\u300128.5%\uff08p=0.0132\uff09\u548c34.9%\uff08p=0.0003\uff09\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a17.9%\u3002<\/li>\n
2\u30014\u548c8mg Fycompa\/\u5929\u7ec4\u7684\u766b\u75eb\u53d1\u4f5c\u9891\u7387\u53d8\u5316\u767e\u5206\u6bd4\u5206\u522b\u4e3a-13.6%\uff08p=0.4197\uff09\u3001-23.3%\uff08p=0.0026\uff09\u548c-30.8%\uff08p<0.0001\uff09\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a-10.7%\u3002<\/li>\n
\u6700\u5e38\u89c1\u76843\u79cd\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u5934\u6655\u3001\u5934\u75db\u548c\u55dc\u7761\u3002<\/li>\n<\/ul>\n
\u00a0
\n<\/strong><\/p>\n
3.<\/strong>\u5173\u4e8eFREEDOM\uff08\u7814\u7a76342\uff09^{6<\/sup><\/strong><\/p>\n}
FREEDOM\uff08\u7814\u7a76342\uff09\u662f\u4e00\u9879\u5728\u65e5\u672c\u548c\u97e9\u56fd\u5f00\u5c55\u7684\u8bc4\u4ef7Fycompa\u5355\u836f\u6cbb\u7597\u5bf912-74\u5c81\u672a\u7ecf\u6cbb\u7597\u7684\u90e8\u5206\u6027\u766b\u75eb\u53d1\u4f5c\u4f34\u6216\u4e0d\u4f34\u7ee7\u53d1\u6027\u5168\u8eab\u6027\u766b\u75eb\u53d1\u4f5c\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u975e\u5bf9\u7167\u3001\u5f00\u653e\u6027\u3001III\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u7761\u524d\u53e3\u670d\u6700\u591a4 mg Fycompa\uff0c\u6bcf\u65e5\u4e00\u6b21\uff08\u5982\u679c\u53d1\u751f\u60ca\u53a5\u53d1\u4f5c\uff0c\u53ef\u4e0a\u8c03\u81f38 mg\uff09\u3002\u672c\u7814\u7a76\u5305\u542b\u4e00\u4e2a\u6cbb\u7597\u671f\u548c\u4e00\u4e2a\u5ef6\u957f\u671f\uff0c\u5176\u4e2d\u6cbb\u7597\u671f\u5305\u62ec6\u5468\u7684\u6ef4\u5b9a\u671f\u548c26\u5468\u7684\u7ef4\u6301\u671f\uff08\u5982\u679c\u4ece4 mg\u5242\u91cf\u4e0a\u8c03\u81f38 mg\uff0c\u5219\u6ef4\u5b9a\u671f\u4e3a4\u5468\uff0c\u7ef4\u6301\u671f\u4e3a26\u5468\uff09\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c89\u4f8b\u60a3\u8005\u63a5\u53d7Fycompa\u5355\u836f\u6cbb\u7597\uff0c\u5176\u4e2d73\u4f8b\u63a5\u53d74 mg\u5242\u91cf\u7684\u60a3\u8005\u5728\u6cbb\u7597\u671f\u95f4\u672a\u51fa\u73b0\u766b\u75eb\u53d1\u4f5c\uff0c\u8be5\u6bd4\u4f8b\u8d85\u8fc7\u4e86\u6709\u6548\u6027\u6807\u51c6*\uff0c\u7b26\u5408\u4e3b\u8981\u7ec8\u70b9\u3002\u6b64\u5916\uff0c\u4e2d\u671f\u7ed3\u679c\u8868\u660e\uff0c\u63a5\u53d74 mg\u548c8 mg\u7684\u60a3\u8005\u7684\u5408\u5e76\u6bd4\u4f8b\u4e5f\u8d85\u8fc7\u4e86\u6709\u6548\u6027\u6807\u51c6\u3002\u672c\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684\u6700\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\uff08\u53d1\u751f\u7387\u226510%\uff09\u4e3a\u5934\u6655\u3001\u55dc\u7761\u3001\u9f3b\u54bd\u708e\u548c\u5934\u75db\uff0c\u8fd9\u4e0eFycompa\u8fc4\u4eca\u4e3a\u6b62\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e00\u81f4\u3002<\/p>\n
*\u672c\u7814\u7a76\u4e2d73\u4f8b\u53ef\u8bc4\u4ef7\u60a3\u8005\u7684\u6709\u6548\u6027\u6807\u51c6\u4e3a52.1%\u6216\u66f4\u9ad8\u6bd4\u4f8b\u7684\u60a3\u8005\u8fbe\u5230\u65e0\u766b\u75eb\u53d1\u4f5c\uff0c\u8be5\u6807\u51c6\u4e3b\u8981\u662f\u6839\u636e\u5176\u4ed6AED\u5355\u836f\u6cbb\u7597\u7814\u7a76\u7684\u7ed3\u679c\u8bbe\u5b9a\u3002<\/p>\n
\n
4.<\/strong>\u5173\u4e8e\u7814\u7a76311^{7<\/sup><\/strong><\/p>\n}
\u7814\u7a76311\u662f\u4e00\u9879\u5168\u7403\u6027\uff08\u7f8e\u56fd\u3001\u6b27\u6d32\u3001\u65e5\u672c\u3001\u97e9\u56fd\uff09\u5f00\u653e\u6027III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u8bc4\u4f30Fycompa\u53e3\u670d\u6df7\u60ac\u6db2\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\u836f\u7269\u7ed9\u836f\u65f6\u7528\u4e8e180\u540d4\u5c81\u81f312\u5c81\u4ee5\u4e0b\u90e8\u5206\u6027\u766b\u75eb\u53d1\u4f5c\u6216\u539f\u53d1\u6027\u5168\u8eab\u5f3a\u76f4\u9635\u631b\u6027\u766b\u75eb\u53d1\u4f5c\u63a7\u5236\u4e0d\u4f73\u7684\u513f\u7ae5\u766b\u75eb\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u66b4\u9732\u7597\u6548\u5173\u7cfb\u3002\u8fd9\u9879\u7814\u7a76\u5305\u542b\u4e00\u4e2a\u6cbb\u7597\u671f\uff08\u5305\u62ec\u957f\u8fbe11\u5468\u7684\u6ef4\u5b9a\u671f\u548c\u957f\u8fbe12\u5468\u7684\u7ef4\u6301\u671f\uff09\u4ee5\u53ca\u4e00\u4e2a\u5ef6\u957f\u671f\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6bcf\u65e5\u7761\u524d\u53e3\u670d\u4e00\u6b212~16mg Fycompa\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u7597\u6548\u4e0e\u5bf912\u5c81\u53ca\u4ee5\u4e0a\u60a3\u8005\u89c2\u5bdf\u5230\u7684\u76f8\u4f3c\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08\u53d1\u751f\u7387\u4e3a10%\u6216\u66f4\u9ad8\uff09\u662f\u55dc\u7761\u3001\u9f3b\u54bd\u708e\u3001\u53d1\u70ed\u3001\u5455\u5410\u3001\u5934\u6655\u3001\u6d41\u884c\u6027\u611f\u5192\u3001\u4ee5\u53ca\u6613\u6012\uff0c\u8fd9\u4e0e\u8fc4\u4eca\u4e3a\u6b62Fycompa\u7684\u5b89\u5168\u7279\u6027\u4e00\u81f4\u3002<\/p>\n
\n
5.<\/strong>\u5173\u4e8e\u766b\u75eb<\/strong><\/p>\n
\u766b\u75eb\u5728\u4e2d\u56fd\u5f71\u54cd\u4e86\u5927\u7ea6900\u4e07\u4eba\uff0c\u5728\u65e5\u672c\u5f71\u54cd\u4e86\u5927\u7ea6100\u4e07\u4eba\uff0c\u5728\u7f8e\u56fd\u5f71\u54cd\u4e86\u5927\u7ea6340\u4e07\u4eba\uff0c\u5728\u6b27\u6d32\u5f71\u54cd\u4e86\u5927\u7ea6600\u4e07\u4eba\uff0c\u5728\u5168\u4e16\u754c\u5f71\u54cd\u4e86\u5927\u7ea66000\u4e07\u4eba\u3002\u7531\u4e8e\u7ea630%\u7684\u766b\u75eb\u60a3\u8005\u65e0\u6cd5\u7528\u76ee\u524d\u7684AEDs^{1<\/sup>\u6765\u63a7\u5236\u5176\u766b\u75eb\u53d1\u4f5c\uff0c\u8fd9\u662f\u4e00\u79cd\u533b\u7597\u9700\u6c42\u663e\u8457\u672a\u5f97\u5230\u6ee1\u8db3\u7684\u75be\u75c5\u3002<\/p>\n}
\u766b\u75eb\u5927\u81f4\u6309\u53d1\u4f5c\u7c7b\u578b\u5206\u7c7b\uff0c\u90e8\u5206\u6027\u766b\u75eb\u53d1\u4f5c\u7ea6\u5360\u766b\u75eb\u75c5\u4f8b\u768460%\uff0c\u5168\u8eab\u6027\u766b\u75eb\u53d1\u4f5c\u7ea6\u536040%\u3002\u5728\u90e8\u5206\u6027\u766b\u75eb\u53d1\u4f5c\u4e2d\uff0c\u5f02\u5e38\u653e\u7535\u5e72\u6270\u53d1\u751f\u5728\u5927\u8111\u7684\u6709\u9650\u533a\u57df\uff0c\u5e76\u53ef\u80fd\u968f\u540e\u6269\u6563\u5230\u6574\u4e2a\u5927\u8111\uff0c\u6210\u4e3a\u5168\u8eab\u6027\u766b\u75eb\u53d1\u4f5c(\u79f0\u4e3a\u7ee7\u53d1\u6027\u5168\u8eab\u6027\u766b\u75eb\u53d1\u4f5c)\u3002\u5728\u5168\u8eab\u6027\u766b\u75eb\u53d1\u4f5c\u4e2d\uff0c\u5f02\u5e38\u653e\u7535\u5e72\u6270\u53d1\u751f\u5728\u6574\u4e2a\u5927\u8111\uff0c\u968f\u540e\u53ef\u80fd\u51fa\u73b0\u610f\u8bc6\u4e27\u5931\u6216\u5168\u8eab\u51fa\u73b0\u8eaf\u4f53\u75c7\u72b6\u3002<\/p>\n
^{1<\/sup>\u00a0\u201c\u766b\u75eb\u548c\u766b\u75eb\u53d1\u4f5c\uff1a\u7814\u7a76\u671f\u671b\u3002\u4ec0\u4e48\u662f\u766b\u75eb?\u201d\u56fd\u7acb\u795e\u7ecf\u75c5\u5b66\u4e0e\u4e2d\u98ce\u7814\u7a76\u6240\uff0c2016\u5e745\u670824\u65e5\u8bbf\u95ee\uff0chttp:\/\/www.ninds.nih.gov\/disorders\/epilepsy\/detail epilepsy.htm#230253109<\/u><\/p>\n}
^{2<\/sup>\u00a0Nishida T, et al.\u00a0\u5421\u4ed1\u5e15\u5948\u8f85\u52a9\u6cbb\u7597\u90e8\u5206\u6027\u766b\u75eb\u53d1\u4f5c\uff1a\u4e9a\u592a\u5730\u533a\u968f\u673a\u5316III\u671f\u7814\u7a76\u3002\u00a0Acta Neurol Scand.\u00a0<\/em>2018\u5e74\uff1b\u7b2c137\u671f\uff0c\u7b2c392-399\u9875\u3002<\/p>\n}
^{3<\/sup>\u00a0French JA, et al. \u5421\u4ed1\u5e15\u5948\u8f85\u52a9\u6cbb\u7597\u96be\u6cbb\u6027\u90e8\u5206\u6027\u766b\u75eb\u53d1\u4f5c\uff1a\u968f\u673a\u5316III\u671f\u7814\u7a76304\u3002Neurology<\/em>.\u00a0<\/em>2012\u5e74\uff1b\u7b2c79\u671f\uff0c\u7b2c589-596\u9875\u3002<\/p>\n}
^{4<\/sup>\u00a0French JA, et al.\u00a0\u8bc4\u4f30\u5421\u4ed1\u5e15\u5948\u8f85\u52a9\u6cbb\u7597\u96be\u6cbb\u6027\u90e8\u5206\u6027\u766b\u75eb\u53d1\u4f5c\u60a3\u8005\uff1a\u5168\u7403\u968f\u673a\u5316III\u671f\u7814\u7a76305\u7684\u7ed3\u679c\u3002Epilepsia.\u00a0<\/em>2013\u5e74\uff1b\u7b2c54\u671f\uff0c\u7b2c117-125\u9875\u3002<\/p>\n}
^{5<\/sup>\u00a0Krauss GL, et al.\u00a0\u968f\u673a\u5316III\u671f\u7814\u7a76306\uff1a\u5421\u4ed1\u5e15\u5948\u8f85\u52a9\u6cbb\u7597\u96be\u6cbb\u6027\u90e8\u5206\u6027\u766b\u75eb\u53d1\u4f5c\u3002Neurology.\u00a0<\/em>2012\u5e74\uff1b\u7b2c78\u671f\uff0c\u7b2c1408-1415\u9875\u3002<\/p>\n}
^{6<\/sup>\u00a0Yamamoto, Takamichi et al.\u00a0\u5421\u4ed1\u5e15\u5948\u5355\u836f\u6cbb\u7597\u65b0\u8bca\u65ad\u7684\u5c40\u7076\u6027\u766b\u75eb\u53d1\u4f5c\u6216\u7f13\u89e3\u671f\u540e\u7684\u766b\u75eb\u590d\u53d1\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff1a\u5f00\u653e\u6027\u7814\u7a76342\uff08FREEDOM\u7814\u7a76\uff09\u3002Epilepsia<\/em>. 2020\u5e74\uff1b\u7b2c5\u671f\uff0c\u7b2c274-284\u9875\u3002.<\/p>\n}
^{7<\/sup>\u00a0Fogarasi, Andras et al.\u00a0\u5f00\u653e\u6027\u7814\u7a76-\u65e8\u5728\u7814\u7a76\u8f85\u52a9\u6cbb\u7597\u836f\u7269\u5421\u4ed1\u5e15\u5948\u7528\u4e8e\u513f\u7ae5\uff084\u5c81\u81f3<12\u5c81\uff09\u5c40\u7076\u6027\u766b\u75eb\u53d1\u4f5c\u6216\u5168\u8eab\u5f3a\u76f4\u9635\u631b\u6027\u766b\u75eb\u53d1\u4f5c\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002Epilepsia.\u00a0<\/em>2020\u5e74\uff1b\u7b2c61\u671f\uff0c\u7b2c125-137\u9875\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"}
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