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\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u201c\u536b\u6750\u201d\uff09\u548cMSD K.K.\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u603b\u88c1\uff1aJannie Oothuizen\uff0c\u201cMSD\u201d\uff09\u8fd1\u65e5\u5ba3\u5e03\u536b\u6750\u5728\u65e5\u672c\u63d0\u4ea4\u4e86\u4e00\u4efd\u5173\u4e8e\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u6291\u5236\u5242Lenvima\uff08\u4e50\u536b\u739b\uff09\u00ae<\/sup>\uff08\u901a\u7528\u540d\uff1a\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u80f8\u817a\u764c\u9002\u5e94\u75c7\u7684\u7533\u8bf7\u30022020\u5e746\u6708\uff0cLenvima\uff08\u4e50\u536b\u739b\uff09\u5728\u65e5\u672c\u56e0\u4e0d\u53ef\u5207\u9664\u80f8\u817a\u764c\u5df2\u83b7\u5f97\u5b64\u513f\u836f\u79f0\u53f7\u3002<\/p>\n

\u8be5\u7533\u8bf7\u57fa\u4e8e\u5728\u65e5\u672c\u8fdb\u884c\u7684\u4e00\u9879\u5f00\u653e\u6027\u3001\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u7814\u7a76\u8005\u53d1\u8d77\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff08NCCH1508\uff09\u7684\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u5c06Lenvima\uff08\u4e50\u536b\u739b\uff09\u5355\u836f\u5e94\u7528\u4e8e42\u540d\u66fe\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u94c2\u7c7b\u65b9\u6848\u6cbb\u7597\u7684\u80f8\u817a\u764c\u60a3\u8005\u3002<\/p>\n

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\u81ea2018\u5e7410\u6708\u4ee5\u6765\uff0c\u536b\u6750\u548cMSD\u5728\u65e5\u672c\u4e00\u76f4\u901a\u8fc7Lenvima\uff08\u4e50\u536b\u739b\uff09\u8fdb\u884c\u5408\u4f5c\uff0c\u5e76\u5171\u540c\u52aa\u529b\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8Lenvima\uff08\u4e50\u536b\u739b\uff09\u5bf9\u764c\u75c7\u60a3\u8005\u7684\u8d21\u732e\u3002<\/p>\n

\n\n\n\n\n
\u5a92\u4f53\u54a8\u8be2\uff1a<\/td>\n<\/tr>\n
\u516c\u5171\u5173\u7cfb\u90e8<\/p>\n

\u536b\u6750\u682a\u5f0f\u4f1a\u793e<\/p>\n

\u7535\u8bdd\uff1a+81-(0)3-3817-5120<\/td>\n

\u5bf9\u5916\u8054\u7edc\u90e8<\/p>\n

MSD K.K.<\/p>\n

\u7535\u8bdd\uff1a+81-(0)3-6272-1001<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/span><\/p>\n

<\u7f16\u8f91\u6ce8\u610f\u4e8b\u9879><\/strong><\/b><\/p>\n

    \n
  1. \u5173\u4e8eLenvima\uff08\u4e50\u536b\u739b\uff09\u00ae<\/sup>\uff08\u901a\u7528\u540d\uff1a\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09<\/strong><\/li>\n<\/ol>\n

    Lenvima\uff08\u4e50\u536b\u739b\uff09\u4e3a\u536b\u6750\u53d1\u73b0\u5e76\u7814\u53d1\u7684\u4e00\u79cd\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u6291\u5236\u5242\uff0c\u53ef\u6291\u5236\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08vegf\uff09\u53d7\u4f53VEGFR1\uff08FLT1\uff09\u3001VEGFR2\uff08KDR\uff09\u548cVEGFR3\uff08FLT4\uff09\u7684\u6fc0\u9176\u6d3b\u6027\u3002Lenvima\uff08\u4e50\u536b\u739b\uff09\u9664\u4e86\u6291\u5236\u6b63\u5e38\u7684\u7ec6\u80de\u529f\u80fd\u5916\uff0c\u8fd8\u80fd\u6291\u5236\u4e0e\u81f4\u75c5\u6027\u8840\u7ba1\u751f\u6210\u3001\u80bf\u7624\u751f\u957f\u548c\u764c\u75c7\u8fdb\u5c55\u6709\u5173\u7684\u5176\u4ed6\u4f9d\u8d56\u6027\u6fc0\u9176\uff0c\u5176\u4e2d\u5305\u62ec\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGF\uff09\u53d7\u4f53FGFR1-4\uff1b\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u03b1\uff08PDGFR\u03b1\uff09\u3001KIT\u548cRET\u3002\u5728\u540c\u7cfb\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\uff0cLenvima\uff08\u4e50\u536b\u739b\uff09\u51cf\u5c11\u4e86\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff0c\u589e\u52a0\u4e86\u6d3b\u5316\u7684\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u3002\u76ee\u524d\uff0c\u65e5\u672c\u3001\u7f8e\u56fd\u7b4965\u4e2a\u4ee5\u4e0a\u56fd\u5bb6\u3001\u4ee5\u53ca\u6b27\u6d32\u548c\u4e9a\u6d32\uff0c\u5df2\u5c06Lenvima\uff08\u4e50\u536b\u739b\uff09\u6279\u51c6\u4f5c\u4e3a\u7532\u72b6\u817a\u764c\u7684\u5355\u4e00\u7597\u6cd5\uff0c\u4e14\u5728\u65e5\u672c\u3001\u7f8e\u56fd\u7b4965\u591a\u4e2a\u56fd\u5bb6\u3001\u4ee5\u53ca\u6b27\u6d32\u3001\u4e2d\u56fd\u548c\u4e9a\u6d32\uff0c\u5176\u5df2\u6279\u51c6\u4f5c\u4e3a\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u5355\u4e00\u7597\u6cd5\u3002\u6b64\u5916\uff0cLENVIMA\u8fd8\u5728\u8d85\u8fc755\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u6d32\uff08\u5728\u6b27\u6d32\u4ee5Kisplyx\u00ae<\/sup>\u54c1\u724c\u540d\u79f0\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c\uff09\u548c\u4e9a\u6d32\uff09\u83b7\u6279\u5e76\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u4e8e\u65e2\u5f80\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7597\u540e\u7684\u80be\u7ec6\u80de\u764c\u6cbb\u7597\u3002\u6b64\u5916\uff0c\u5b83\u4e0eKEYTRUDA\uff08\u53ef\u745e\u8fbe\uff09\u00ae<\/sup>\uff08\u901a\u7528\u540d\uff1a\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u5df2\u83b7\u6279\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u975e\u9ad8\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08dMMR\uff09\u7684\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u65e2\u5f80\u7cfb\u7edf\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\uff0c\u5e76\u4e14\u5728\u7f8e\u56fd\u3001\u6fb3\u5927\u5229\u4e9a\u548c\u52a0\u62ff\u5927\u7b49\u56fd\u5bb6\u4e0d\u9002\u5408\u8fdb\u884c\u6cbb\u7597\u6027\u624b\u672f\u6216\u653e\u7597\u3002\u6b64\u9002\u5e94\u75c7\u7684\u6301\u7eed\u6279\u51c6\u53ef\u80fd\u53d6\u51b3\u4e8e\u9a8c\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u7684\u4e34\u5e8a\u83b7\u76ca\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002<\/p>\n

    2.\u00a0<\/strong>\u5173\u4e8eNCCH1508\uff08REMORA\u7814\u7a76\uff09*<\/strong><\/p>\n

    \u8be5\u7814\u7a76\u662f\u4e00\u9879\u5f00\u653e\u6027\u3001\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u7814\u7a76\u8005\u53d1\u8d77\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff08\u5168\u56fd8\u4e2a\u7814\u7a76\u4e2d\u5fc3\uff0c\u5305\u62ec\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u533b\u9662\uff09\u300242\u540d\u80f8\u817a\u764c\u60a3\u8005\u53c2\u4e0e\u4e86\u7814\u7a76\uff0c\u5979\u4eec\u5728\u8fdb\u884c\u81f3\u5c11\u4e00\u6b21\u94c2\u7c7b\u836f\u7269\u6cbb\u7597\u540e\u75be\u75c5\u51fa\u73b0\u8fdb\u5c55\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u57fa\u4e8eRECIST1.1\u6807\u51c6\u8fdb\u884c\u7684\u72ec\u7acb\u5f71\u50cf\u8bc4\u4f30\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u4ee524 mg\u7684\u8d77\u59cb\u5242\u91cf\u670d\u7528Lenvatinib\uff0c\u5e76\u6839\u636e\u60a3\u8005\u7684\u75c5\u60c5\u9002\u5f53\u964d\u4f4e\u5242\u91cf\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u89c2\u5bdf\u5230\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n

    \u5bf9\u4e8e\u7597\u6548\u5206\u6790\uff0cORR\u4e3a38.1%\uff0890%\u7f6e\u4fe1\u533a\u95f4\uff08CI\uff09\uff1a25.6-52.0\uff09\uff0c\u6700\u4f73\u603b\u4f53\u7f13\u89e3\u7387\u4e3a\u90e8\u5206\u7f13\u89e338.1%\uff0c\u75be\u75c5\u7a33\u5b9a57.1%\uff0c\u75be\u75c5\u8fdb\u5c554.8%\u3002PFS\uff08\u4e2d\u4f4d\u6570\uff09\u4e3a9.3\u4e2a\u6708\uff0895% CI\uff1a7.7-13.9\uff09\uff0cDCR\u4e3a95.2%\uff0895% CI\uff1a83.8-99.4\uff09\uff0cOS\u4e2d\u4f4d\u6570\u672a\u8fbe\u5230\uff0895% CI\uff1a16.1-NR\uff08\u672a\u8fbe\u5230\uff09\uff09\u3002\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e3b\u8981\u4e0d\u826f\u4e8b\u4ef6**\uff08\u8d85\u8fc730%\uff09\u5305\u62ec\u9ad8\u8840\u538b\uff0888.1%\uff09\u3001\u86cb\u767d\u5c3f\uff0871.4%\uff09\u3001\u638c\u8dd6\u611f\u89c9\u4e27\u5931\u6027\u7ea2\u6591\u7efc\u5408\u5f81\uff0869.0%\uff09\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\uff0864.3%\uff09\u3001\u8179\u6cfb\uff0857.1%\uff09\u3001\u8840\u5c0f\u677f\u51cf\u5c11\uff0854.8%\uff09\u3001\u98df\u6b32\u4e0b\u964d\uff0842.9%\uff09\u3001\u4f53\u91cd\u51cf\u8f7b\uff0840.5%\uff09\u3001\u541e\u54bd\u56f0\u96be\uff0840.5%\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\u5347\u9ad8\uff0833.3%\uff09\u3001\u4e0d\u9002\uff0833.3%\uff09\u548c\u53e3\u8154\u708e\uff0833.3%\uff09\u3002<\/p>\n

    * Jun Sato, Miyako Satouchi, Shoichi Itoh, Yusuke Okuma, Seiji Niho, Hidenori Mizugaki, Haruyasu Murakami, Yasuhito Fujisaka, Toshiyuki Kozuki, Kenichi Nakamura, Yukari Nagasaka, Mamiko Kawasaki, Tomoaki Yamada, Ryunosuke Machida, Aya Kuchiba, Yuichiro Ohe, Noboru Yamamoto\uff1bLenvatinib\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80f8\u817a\u764c\uff08REMORA\uff09\u60a3\u8005\uff1a\u4e00\u9879\u591a\u4e2d\u5fc32\u671f\u8bd5\u9a8c\u3002\u300a\u67f3\u53f6\u5200\u80bf\u7624\u5b66\u300b\uff0c2020\u5e74\uff0c\u537721\uff0c\u7b2c6\u671f\uff0c\u7b2c843-850\u9875<\/p>\n

    **\u7533\u8bf7\u4e2d\u4f7f\u7528\u7684\u4e0d\u826f\u4e8b\u4ef6\u6570\u636e\u5df2\u6839\u636e\u672c\u6587\u4e2d\u7684\u6570\u636e\u8fdb\u884c\u66f4\u65b0\u3002<\/p>\n


    \n3.\u00a0<\/strong>\u5173\u4e8e\u536b\u6750\u548c\u9ed8\u6c99\u4e1c\u6218\u7565\u5408\u4f5c<\/strong><\/span><\/p>\n

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