{"id":2737,"date":"2020-06-02T00:00:00","date_gmt":"2021-03-18T02:31:29","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=2737"},"modified":"2021-03-18T10:31:29","modified_gmt":"2021-03-18T02:31:29","slug":"%e5%8d%ab%e6%9d%90%e5%9c%a8%e7%be%8e%e5%9b%bd%e4%b8%8a%e5%b8%82%e6%96%b0%e8%8d%afdayvigo%ef%bc%88lemborexant%ef%bc%89civ%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97%e6%88%90%e5%b9%b4%e4%ba%ba","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2020\/06\/02\/%e5%8d%ab%e6%9d%90%e5%9c%a8%e7%be%8e%e5%9b%bd%e4%b8%8a%e5%b8%82%e6%96%b0%e8%8d%afdayvigo%ef%bc%88lemborexant%ef%bc%89civ%e7%94%a8%e4%ba%8e%e6%b2%bb%e7%96%97%e6%88%90%e5%b9%b4%e4%ba%ba\/","title":{"rendered":"\u536b\u6750\u5728\u7f8e\u56fd\u4e0a\u5e02\u65b0\u836fDAYVIGO\u2122\uff08LEMBOREXANT\uff09CIV\u7528\u4e8e\u6cbb\u7597\u6210\u5e74\u4eba\u7684\u5931\u7720"},"content":{"rendered":"<p>\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0cCEO\uff1a\u5185\u85e4\u6674\u592b\uff0c\u201c\u536b\u6750\u201d\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5176\u7f8e\u56fd\u5b50\u516c\u53f8Eisai 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\">\u3002\u963b\u65ad\u4fc3\u8fdb\u89c9\u9192\u7684\u795e\u7ecf\u80bd\u98df\u6b32\u7d20A\u548c\u98df\u6b32\u7d20B\u4e0e\u98df\u6b32\u7d20\u53d7\u4f53OX1R\u548cOX2R\u7ed3\u5408\u88ab\u8ba4\u4e3a\u53ef\u6291\u5236\u89c9\u9192\u9a71\u52a8\u56e0\u7d20\u3002*Lemborexant\u4e0e\u98df\u6b32\u7d20\u53d7\u4f53OX1R\u548cOX2R\u7ed3\u5408\uff0c\u5e76\u4f5c\u4e3a\u7ade\u4e89\u6027\u62ee\u6297\u5242\uff08IC50\u503c\u5206\u522b\u4e3a6.1nM\u548c2.6nM\uff09\u800c\u53d1\u6325\u4f5c\u7528\u3002<\/span><\/p>\n<p><span class=\"a0 \">\u57fa\u4e8elemborexant\u5305\u62ec\u5bf9\u8fd12000\u540d\u5931\u7720\u6210\u4eba\u60a3\u8005\u8fdb\u884c\u7684\u4e24\u4e2a\u5173\u952eIII\u671f\uff08SUNRISE 1\u548cSUNRISE 2\uff09<\/span>2<span class=\"a0 \">\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff0cDAYVIGO\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u6279\u51c6\u3002<\/span><\/p>\n<p>SUNRISE 1\u662f\u4e00\u9879\u4e3a\u671f\u4e00\u4e2a\u6708\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u548c\u9633\u6027\u5bf9\u7167\u7684\u591a\u4e2d\u5fc3\u3001\u5e73\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u53d7\u8bd5\u8005\u4e3a\u7b26\u5408DSM-5\uff08\u7cbe\u795e\u75be\u75c5\u8bca\u65ad\u4e0e\u7edf\u8ba1\u624b\u518c-\u7b2c5\u7248\uff09\u5931\u7720\u969c\u788d\u8bca\u65ad\u6807\u51c6\u768455\u5c81\u53ca\u4ee5\u4e0a\u7684\u6210\u5e74\u5973\u6027\u548c65\u5c81\u53ca\u4ee5\u4e0a\u7684\u6210\u5e74\u7537\u6027\u3002\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u662f\u901a\u8fc7\u591c\u95f4\u591a\u5bfc\u7761\u7720\u56fe\uff08PSG\uff09\u76d1\u6d4b\u8fdb\u884c\u6d4b\u91cf\u7684\u6301\u7eed\u7761\u7720\u6f5c\u4f0f\u671f\uff08LPS\uff1b\u5b9a\u4e49\u4e3a\u4ece\u5173\u706f\u5230\u9996\u4e2a\u8fde\u7eed10\u5206\u949f\u672a\u89c9\u9192\u7684\u5206\u949f\u6570\uff09\u4ece\u57fa\u7ebf\u5230\u6cbb\u7597\u7ed3\u675f\uff08\u7b2c29\/30\u65e5\uff09\u7684\u5e73\u5747\u53d8\u5316\u3002SUNRISE 1\u6b21\u8981\u7597\u6548\u7ec8\u70b9\u662f\u901a\u8fc7PSG\u8fdb\u884c\u6d4b\u91cf\u7684\u4ece\u57fa\u7ebf\u5230\u6cbb\u7597\u7ed3\u675f\uff08\u7b2c29\/30\u65e5\uff09\u7684\u7761\u7720\u6548\u7387\uff08SEF\uff09\u548c\u5165\u7761\u540e\u89c9\u9192\u65f6\u95f4\uff08WASO\uff09\u7684\u5e73\u5747\u53d8\u5316\u3002\u5728SUNRISE 1\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u6bd4\u8f83\uff0cDAYVIGO 5mg\u548c10mg\u5728\u4e3b\u8981\u7597\u6548\u6307\u6807LPS\u65b9\u9762\u663e\u793a\u51fa\u663e\u8457\u7684\u7edf\u8ba1\u5b66\u4f18\u52bf\u3002\u4e0e\u5b89\u6170\u5242\u548c\u9633\u6027\u5bf9\u7167\u836f\u7269\u76f8\u6bd4\uff0c5mg\u548c10mg DAYVIGO\u5728SE\u548cWASO\u65b9\u9762\u5177\u6709\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u6539\u5584\u3002<\/p>\n<p><span class=\"a0 \">SUNRISE 2\u662f\u4e00\u9879\u957f\u671f\uff086\u4e2a\u6708\uff09\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u8bd5\u9a8c\uff0c\u7814\u7a76\u53d7\u8bd5\u8005\u4e3a18\u5c81\u6216\u4ee5\u4e0a\u7b26\u5408DSM-5\u5931\u7720\u969c\u788d\u8bca\u65ad\u6807\u51c6\u7684\u60a3\u8005\u3002\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u662f\u60a3\u8005\u62a5\u544a\u7684\u4e3b\u89c2\u5165\u7761\u6f5c\u4f0f\u671f\uff08sSOL\uff1b\u5b9a\u4e49\u4e3a\u4ece\u53d7\u8bd5\u8005\u5c1d\u8bd5\u5165\u7761\u5230\u5165\u7761\u7684\u4f30\u8ba1\u5206\u949f\u6570\uff09\u4ece\u57fa\u7ebf\u52306\u4e2a\u6708\u6cbb\u7597\u7ed3\u675f\u65f6\u7684\u5e73\u5747\u53d8\u5316\u3002\u9884\u5148\u8bbe\u5b9a\u7684\u6b21\u8981\u7597\u6548\u7ec8\u70b9\u662f\u7761\u7720\u7ef4\u6301\u6307\u6807\u60a3\u8005\u62a5\u544a\u7684\u7761\u7720\u6548\u7387\uff08sSEF\u5b9a\u4e49\u4e3a\u6bcf\u6b21\u5728\u5e8a\u4e0a\u7761\u7720\u7684\u65f6\u95f4\u6bd4\u4f8b\uff09\u548c\u5165\u7761\u540e\u89c9\u9192\u65f6\u95f4\uff08sWASO\u5b9a\u4e49\u4e3a\u4ece\u5165\u7761\u5230\u89c9\u9192\u7684\u5206\u949f\u6570\uff09\u4ece\u57fa\u7ebf\u52306\u4e2a\u6708\u6cbb\u7597\u7ed3\u675f\u65f6\u7684\u5e73\u5747\u53d8\u5316\u3002\u9884\u5148\u8bbe\u5b9a\u7684\u4e3b\u8981\u548c\u6b21\u8981\u7597\u6548\u7ec8\u70b9\u901a\u8fc7\u7761\u7720\u65e5\u8bb0\u6765\u8bc4\u4f30\u3002\u5728SUNRISE 2\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u6bd4\u8f83\uff0cDAYVIGO 5mg\u548c10mg\u5728\u4e3b\u8981\u7597\u6548\u6307\u6807sSOL\u65b9\u9762\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u4e0a\u663e\u8457\u7684\u4f18\u52bf\u3002\u5728sSEF\u548csWASO\u65b9\u9762\u4e5f\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u4f18\u52bf\u3002<\/span>1<\/p>\n<p><span class=\"a0 \">\u00a0\u00a0\u00a0 \u4e24\u9879\u7814\u7a76\u7684\u5206\u6790\u5747\u8868\u660e\uff0cDAYVIGO\u4e0d\u4f1a\u5bfc\u81f4\u53cd\u8df3\u6027\u5931\u7720\uff0c\u4ea6\u6ca1\u6709\u8bc1\u636e\u663e\u793a\u505c\u836f\u540e\u4f1a\u4ea7\u751f\u6212\u65ad\u6548\u5e94\uff0c\u8fd9\u8868\u660e\u670d\u836f\u8fbe\u4e00\u5e74\u4e0d\u4f1a\u4ea7\u751f\u8eaf\u4f53\u4f9d\u8d56\u3002DAYVIGO<\/span>\u662f\u9996\u4e2a\u83b7\u5f97FDA\u6279\u51c6\u7684\u5728\u5173\u952e\u7814\u7a76\u4e2d\u670912\u4e2a\u6708\u6cbb\u7597\u5b89\u5168\u6027\u6570\u636e\u548c6\u4e2a\u6708\u5165\u7761\u548c\u7761\u7720\u7ef4\u6301\u7597\u6548\u6570\u636e\u7684\u5931\u7720\u836f\u7269\u3002<\/p>\n<p><span class=\"a0 \">\u5728SUNRISE 1\u548cSUNRISE 2\u7814\u7a76\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94<\/span>\uff08DAYVIGO\u6cbb\u7597\u60a3\u8005\u4e2d\u62a5\u544a\u7387\u22655%\uff0c\u548c\u5b89\u6170\u5242\u7ec4\u4e24\u500d\u4ee5\u4e0a\uff09\u662f\u660f\u7761\uff08DAYVIGO 10mg\uff0c10%\uff1bDAYVIGO 5mg\uff0c7%\uff1b\u5b89\u6170\u5242\uff0c1%\uff09\u3002<\/p>\n<p>\u5728\u4e00\u9879\u4e13\u95e8\u7684\u5b89\u5168\u6027\u7814\u7a76\u4e2d\uff08\u7814\u7a76106\uff093\uff0c\u867d\u71365\u548c10mg\u5242\u91cf\u7684DAYVIGO\u5bf9\u6210\u5e74\u6216\u8001\u5e74\u53d7\u8bd5\u8005\u7b2c\u4e8c\u5929\u65e9\u6668\u7684\u9a7e\u9a76\u8868\u73b0\u672a\u9020\u6210\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u635f\u5bb3\uff08\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff09\uff0c\u4f46\u6709\u4e9b\u670d\u752810mg DAYVIGO\u7684\u53d7\u8bd5\u8005\u7684\u9a7e\u9a76\u80fd\u529b\u53d7\u5230\u635f\u5bb3\u3002\u56e0\u5bf9DAYVIGO\u7684\u654f\u611f\u6027\u5b58\u5728\u4e2a\u4f53\u5dee\u5f02\uff0c\u4ecd\u5e94\u8b66\u793a\u670d\u752810mg\u5242\u91cf\u7684\u60a3\u8005\u6b21\u6668\u6f5c\u5728\u7684\u9a7e\u9a76\u969c\u788d\u98ce\u9669\u3002\u53e6\u4e00\u9879\u4e13\u95e8\u7684\u5b89\u5168\u6027\u7814\u7a76\u4e2d\uff08\u7814\u7a76108\uff094\uff0c\u8bc4\u4f30\u4e86\u5348\u591c\u5b89\u5168\u6027\u548c\u5bf9\u6b21\u6668\u59ff\u52bf\u7a33\u5b9a\u6027\u548c\u8bb0\u5fc6\u529b\u7684\u5f71\u54cd\u3002\u5728\u4e24\u9879\u968f\u673a\u3001\u5b89\u6170\u5242\u548c\u9633\u6027\u5bf9\u7167\u8bd5\u9a8c\u4e2d\uff0c\u5bf9\u4e8e55\u5c81\u53ca\u4ee5\u4e0a\u7684\u5065\u5eb7\u53d7\u8bd5\u8005\u548c\u5931\u7720\u60a3\u8005\uff0c\u8bc4\u4ef7\u4e86DAYVIGO\u5bf9\u6b21\u65e5\u59ff\u52bf\u7a33\u5b9a\u6027\u548c\u8bb0\u5fc6\u7684\u5f71\u54cd\u3002DAYVIGO\uff085\u621610mg\uff09\u4e0e\u5b89\u6170\u5242\u5728\u7b2c\u4e8c\u5929\u59ff\u52bf\u7a33\u5b9a\u6027\u6216\u8bb0\u5fc6\u65b9\u9762\u65e0\u663e\u8457\u5dee\u5f02\u3002\u5e94\u63d0\u9192\u60a3\u8005\u5348\u591c\u59ff\u52bf\u4e0d\u7a33\u4ee5\u53ca\u6ce8\u610f\u529b\u548c\u8bb0\u5fc6\u529b\u53d7\u635f\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<p><span class=\"a0 \">DAYVIGO\uff085mg\u300110mg\u7247\u5242\uff09\u4e8e2019\u5e7412\u6708\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\uff0c\u5e76\u4e8e2020\u5e744\u6708\u88ab\u7f8e\u56fd\u836f\u54c1\u5f3a\u5236\u7ba1\u7406\u5c40\uff08DEA\uff09\u6307\u5b9a\u4e3a\u9644\u8868IV\u7c7b\u7ba1\u5236\u836f\u3002<\/span>\u6709\u9152\u7cbe\u6216\u836f\u7269\u6ee5\u7528\u6216\u6210\u763e\u75c5\u53f2\u7684\u4eba\uff0c\u53ef\u80fd\u4f1a\u589e\u52a0DAYVIGO\u7684\u6ee5\u7528\u548c\u6210\u763e\u7684\u98ce\u9669\uff0c\u56e0\u6b64\u5e94\u8c28\u614e\u968f\u8bbf\u3002\u536b\u6750\u4e8e2020\u5e741\u6708\u5728\u65e5\u672c\u83b7\u5f97\u4e86DAYVIGO\u4f5c\u4e3a\u5931\u7720\u6cbb\u7597\u836f\u7684\u751f\u4ea7\u548c\u9500\u552e\u8bb8\u53ef\uff0c\u5e76\u4e8e2020\u5e744\u6708\u88ab\u5217\u5165\u65e5\u672c\u7684\u300a\u56fd\u6c11\u5065\u5eb7\u4fdd\u9669\u836f\u7269\u4ef7\u683c\u8868\u300b\uff0c\u8be5\u836f\u6b63\u51c6\u5907\u5728\u65e5\u672c\u4e0a\u5e02\u3002\u536b\u6750\u4e8e2019\u5e748\u6708\u5728\u52a0\u62ff\u5927\u63d0\u4ea4\u4e86\u7528\u4e8e\u5931\u7720\u6cbb\u7597\u7684\u65b0\u836f\u7533\u8bf7\u3002<\/p>\n<p><span class=\"a0 \">\u5931\u7720\u7684\u7279\u70b9\u662f\u5c3d\u7ba1\u6709\u5145\u8db3\u7684\u7761\u7720\u65f6\u95f4\uff0c\u4f46\u4f9d\u7136\u5165\u7761\u3001\u7761\u7720\u7ef4\u6301\u56f0\u96be\u6216\u4e24\u8005\u517c\u6709<\/span>5, 6<span class=\"a0 \">\u3002\u5931\u7720\u662f\u6700\u5e38\u89c1\u7684\u7761\u7720-\u89c9\u9192\u969c\u788d\u4e4b\u4e00\uff0c\u60a3\u75c5\u7387\u5f88\u9ad8\u3002\u5168\u4e16\u754c\u7ea630%\u7684\u6210\u4eba\u6709\u5931\u7720\u75c7\u72b6<\/span>7, 8<span class=\"a0 \">\uff0c\u5176\u4e2d\u8bb8\u591a\u75c7\u72b6\u6301\u7eed\u6570\u6708\u751a\u81f3\u6570\u5e74\u4e4b\u4e45\u3002<\/span><\/p>\n<p>\u968f\u7740DAYVIGO\u7684\u4e0a\u5e02\uff0c\u536b\u6750\u81f4\u529b\u4e8e\u901a\u8fc7\u5176\u5bf9\u98df\u6b32\u7d20\u751f\u7269\u5b66\u7684\u6301\u7eed\u7814\u53d1\uff0c\u53bb\u6539\u5584\u7761\u7720\u969c\u788d\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5a92\u4f53\u54a8\u8be2\uff1a<\/strong><br \/>\n\u536b\u6750\u682a\u5f0f\u4f1a\u793e<br \/>\n\u516c\u5171\u5173\u7cfb\u90e8<br \/>\n+81-(0)3-3817-5120<\/p>\n<p>&nbsp;<\/p>\n<p>[\u7f16\u8005\u6ce8]<br \/>\n<span class=\"a0 \">1. <\/span><span class=\"a0 \">\u5173\u4e8e\uff08lemborexant\uff09<\/span><\/p>\n<p>Lemborexant\u662f\u536b\u6750\u5185\u90e8\u7814\u53d1\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u53ef\u4e0e\u98df\u6b32\u7d20\u53d7\u4f53OX1R\u548cOX2R\uff08IC50\u503c\u5206\u522b\u4e3a6.1nM\u548c2.6nM\uff09\u7ed3\u5408\uff0c\u662f\u4e00\u79cd\u7ade\u4e89\u6027\u62ee\u6297\u5242\uff0c\u5bf9OX2R\u6709\u8f83\u5f3a\u7684\u6291\u5236\u4f5c\u7528\u3002\u5728\u5931\u7720\u60a3\u8005\u4e2d\uff0c\u8c03\u8282\u89c9\u9192\u7684\u98df\u6b32\u7d20\u4fe1\u53f7\u7cfb\u7edf\u53ef\u80fd\u65e0\u6cd5\u6b63\u5e38\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n<p><span class=\"a0 \">\u98df\u6b32\u7d20\u795e\u7ecf\u80bd\u4fe1\u53f7\u7cfb\u7edf\u5728\u89c9\u9192\u4e2d\u53d1\u6325\u4f5c\u7528\u3002<\/span>2<span class=\"a0 \">\u963b\u65ad\u4fc3\u8fdb\u89c9\u9192\u7684\u795e\u7ecf\u80bd\u98df\u6b32\u7d20A\u548c\u98df\u6b32\u7d20B\u4e0e\u53d7\u4f53OX1R\u548cOX2R\u7ed3\u5408\u88ab\u8ba4\u4e3a\u53ef\u6291\u5236\u89c9\u9192\u9a71\u52a8\u56e0\u7d20\u3002\u536b\u6750\u6b63\u51c6\u5907\u5728\u65e5\u672c\u4e0a\u5e02DAYVIGO\u3002\u536b\u6750\u4e5f\u4e8e2019\u5e748\u6708\u63d0\u4ea4\u4e86\u65b0\u836f\u7533\u8bf7\uff0c\u5bfb\u6c42\u6279\u51c6\u8be5\u836f\u53ef\u5728\u52a0\u62ff\u5927\u7528\u4e8e\u6cbb\u7597\u5931\u7720\u3002<\/span><\/p>\n<p><span class=\"a0 \">\u5982\u6b32\u4e86\u89e3\u66f4\u591aDAYVIGO\u5728\u7f8e\u56fd\u7684\u4fe1\u606f\uff0c\u5305\u62ec\u91cd\u8981\u5b89\u5168\u6027\u4fe1\u606f\uff08ISI\uff09\uff0c\u8bf7\u8bbf\u95eeDAYVIGO\u7f51\u7ad9\uff08<\/span><span class=\"a0 \">DAYVIGO.com<\/span><span class=\"a0 \">\uff09\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"a0 \">2. <\/span><span class=\"a0 \">\u5173\u4e8e\u7761\u7720\u89c9\u9192\u969c\u788d\u548c\u5931\u7720<\/span><\/p>\n<p><span class=\"a0 \">\u7761\u7720-\u89c9\u9192\u969c\u788d\u5305\u62ec\u5931\u7720\u3001\u4e0d\u89c4\u5219\u7761\u7720-\u89c9\u9192\u8282\u5f8b\u969c\u788d\uff08ISWRD\uff09\u3001\u55dc\u7761\u4ee5\u53ca\u4e0e\u547c\u5438\u76f8\u5173\u7684\u7761\u7720\u969c\u788d\u7b49\u75be\u75c5\u7c7b\u522b\u3002\u5728\u7761\u7720-\u89c9\u9192\u969c\u788d\u4e2d\uff0c\u5931\u7720\u662f\u6700\u5e38\u89c1\u7684\uff0c\u5168\u4e16\u754c\u7ea630%\u7684\u6210\u4eba\u6709\u6301\u7eed\u5931\u7720\u75c7\u72b6\u3002<\/span>7,8<span class=\"a0 \"> \u5931\u7720\u969c\u788d\u7684\u7279\u70b9\u662f\u5c3d\u7ba1\u6709\u5145\u8db3\u7684\u7761\u7720\u65f6\u95f4\uff0c\u4f46\u4ecd\u7136\u5165\u7761\u3001\u7ef4\u6301\u7761\u7720\u969c\u788d\u6216\u4e24\u8005\u517c\u6709\u3002<\/span>5,6<\/p>\n<p>\u5728\u7f8e\u56fd\uff0c\u5931\u7720\u969c\u788d\u7684\u8bca\u65ad\u6807\u51c6\u5305\u62ec\u7761\u7720\u969c\u788d\u662f\u5426\u4f1a\u5728\u793e\u4f1a\u3001\u804c\u4e1a\u3001\u6559\u80b2\u3001\u5b66\u672f\u3001\u884c\u4e3a\u6216\u5176\u4ed6\u91cd\u8981\u529f\u80fd\u65b9\u9762\u9020\u6210\u4e34\u5e8a\u4e0a\u663e\u8457\u7684\u82e6\u607c\u6216\u635f\u5bb3\uff0c\u662f\u5426\u6bcf\u5468\u81f3\u5c11\u6709\u4e09\u665a\u51fa\u73b0\uff0c\u4ee5\u53ca\u662f\u5426\u6301\u7eed\u81f3\u5c11\u4e09\u4e2a\u6708\u3002<\/p>\n<p><span class=\"a0 \">\u826f\u597d\u7761\u7720\u5bf9\u8eab\u4f53\u5065\u5eb7\u81f3\u5173\u91cd\u8981<\/span><span class=\"a0 \">9<\/span><span class=\"a0 \">\uff0c\u7814\u7a76\u8868\u660e\u6700\u4f73\u7761\u7720\u65f6\u95f4\u57287\u52308\u4e2a\u5c0f\u65f6\u4e4b\u95f4\u3002<\/span><span class=\"a0 \">10<\/span><span class=\"a0 \">\u7761\u7720\u4e0d\u4f73\u4f1a\u5f15\u8d77\u4e00\u7cfb\u5217\u5065\u5eb7\u95ee\u9898\u3002<\/span>5,12<\/p>\n<p><span class=\"a0 \">\u5973\u6027\u60a3\u5931\u7720\u7684\u51e0\u7387\u662f\u7537\u6027\u76841.4\u500d\u3002<\/span>11<span class=\"a0 \">\u8001\u5e74\u4eba\u7684\u5931\u7720\u60a3\u75c5\u7387\u4e5f\u8f83\u9ad8\uff1b\u8870\u8001\u5f80\u5f80\u4f34\u968f\u7740\u7761\u7720\u6a21\u5f0f\u7684\u6539\u53d8\uff0c\u5305\u62ec\u7761\u7720\u4e2d\u65ad\u3001\u9891\u7e41\u9192\u6765\u548c\u65e9\u9192\uff0c\u8fd9\u4f1a\u5bfc\u81f4\u7761\u7720\u65f6\u95f4\u51cf\u5c11\u3002<\/span>12<\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"a0 \">3. <\/span><span class=\"a0 \">\u5173\u4e8eSUNRISE 1\uff08304\u7814\u7a76\uff09<\/span>2<\/p>\n<p>SUNRISE 1\u662f\u4e00\u9879\u4e3a\u671f\u4e00\u4e2a\u6708\u7684\u8bd5\u9a8c\uff0c\u53d7\u8bd5\u8005\u4e3a\u7b26\u5408DSM-5\u5931\u7720\u969c\u788d\u8bca\u65ad\u6807\u51c6\u768455\u5c81\u53ca\u4ee5\u4e0a\u7684\u6210\u5e74\u5973\u6027\u60a3\u8005\u548c65\u5c81\u53ca\u4ee5\u4e0a\u7684\u6210\u5e74\u7537\u6027\u60a3\u8005\u3002\u5c06\u60a3\u8005\u968f\u673a\u5206\u4e3a\u5b89\u6170\u5242\u7ec4\uff08n=208\uff09\u3001DAYVIGO 5mg\u7ec4\uff08n=266\uff09\u621610mg\u7ec4\uff08n=269\uff09\u6216\u9633\u6027\u5bf9\u7167\u7ec4\uff08n=263\uff09\uff0c\u6bcf\u665a\u670d\u836f\u4e00\u6b21\u3002\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u662f\u6301\u7eed\u7761\u7720\u6f5c\u4f0f\u671f\uff08LPS\uff1a\u5b9a\u4e49\u4e3a\u4ece\u5173\u706f\u5230\u9996\u4e2a\u8fde\u7eed10\u5206\u949f\u672a\u89c9\u9192\u7684\u5206\u949f\u6570\uff09\u4ece\u57fa\u7ebf\u5230\u6cbb\u7597\u7ed3\u675f\uff08\u7b2c29\/30\u65e5\uff09\u7684\u5e73\u5747\u53d8\u5316\u3002\u6b21\u8981\u7597\u6548\u7ec8\u70b9\u662f\u7761\u7720\u6548\u7387\uff08SEF\uff09\u548c\u5165\u7761\u540e\u89c9\u9192\u65f6\u95f4\uff08WASO\uff09\u4ece\u57fa\u7ebf\u5230\u6cbb\u7597\u7ed3\u675f\uff08\u7b2c29\/30\u65e5\uff09\u7684\u5e73\u5747\u53d8\u5316\u3002\u8fd9\u4e9b\u7ec8\u70b9\u901a\u8fc7\u6574\u591c\u591a\u5bfc\u7761\u7720\u56fe\u76d1\u6d4b\u6765\u6d4b\u91cf\u3002<\/p>\n<p><span class=\"a0 \">4. <\/span><span class=\"a0 \">\u5173\u4e8eSUNRISE 2\uff08303\u7814\u7a76\uff09<\/span>2<\/p>\n<p>SUNRISE 2\u662f\u4e00\u9879\u4e3a\u671f6\u4e2a\u6708\u7684\u5b89\u6170\u5242\u5bf9\u7167\u6cbb\u7597\u8bd5\u9a8c\uff0c\u5177\u67096\u4e2a\u6708\u7684\u5e73\u884c\u5206\u7ec4\u5ef6\u957f\u671f\uff0c\u53d7\u8bd5\u8005\u5305\u62ec\u7b26\u5408DSM-5\u5931\u7720\u969c\u788d\u6807\u51c6\u768418\u5c81\u6216\u4ee5\u4e0a\u7684\u6210\u5e74\u60a3\u8005\u3002\u5728\u7814\u7a76\u4e2d\uff0c\u5c06\u60a3\u8005\u968f\u673a\u5206\u4e3a\u5b89\u6170\u5242\u7ec4\uff08n=325\uff09\u3001DAYVIGO 5mg\u7ec4\uff08n=323\uff09\u6216DAYVIGO 10mg\u7ec4\uff08n=323\uff09\uff0c\u6bcf\u665a\u670d\u836f\u4e00\u6b21\u3002\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u662f\u4ece\u57fa\u7ebf\u52306\u4e2a\u6708\u6cbb\u7597\u7ed3\u675f\u65f6\u4e3b\u89c2\u5165\u7761\u6f5c\u4f0f\u671f\uff08sSOL\uff1b\u4ece\u60a3\u8005\u8bd5\u56fe\u5165\u7761\u5230\u5165\u7761\u7684\u4f30\u8ba1\u5206\u949f\u6570\uff09\u7684\u5e73\u5747\u53d8\u5316\u503c\u3002\u6b21\u8981\u7597\u6548\u7ec8\u70b9\u662f\u4ece\u57fa\u7ebf\u52306\u4e2a\u6708\u6cbb\u7597\u7ed3\u675f\u65f6\u4e3b\u89c2\u7761\u7720\u6548\u7387\uff08sSEF\uff1a\u6bcf\u6b21\u5728\u5e8a\u4e0a\u5165\u7761\u7684\u65f6\u95f4\u6bd4\u4f8b\uff09\u548c\u5165\u7761\u540e\u89c9\u9192\u65f6\u95f4\uff08sWASO\uff1a\u4ece\u5165\u7761\u5230\u89c9\u9192\u7684\u5206\u949f\u6570\uff09\u7684\u5e73\u5747\u53d8\u5316\u503c\u3002\u8fd9\u4e9b\u7ec8\u70b9\u901a\u8fc7\u7761\u7720\u65e5\u8bb0\u6765\u8bc4\u4f30\u3002<\/p>\n<p><span class=\"a0 \">5. <\/span><span class=\"a0 \">\u5173\u4e8e106\u7814\u7a76<\/span>3<\/p>\n<p>\u7814\u7a76106\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u548c\u9633\u6027\u5bf9\u7167\u3001\u56db\u5468\u671f\u3001\u4ea4\u53c9\u7684I\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30lemborexant\u5bf948\u540d\u5065\u5eb7\u6210\u4eba\u548c\u8001\u5e74\u5fd7\u613f\u8005\uff0823-58\u5c81\uff0c\u5e73\u5747\u5e74\u9f84\uff1a58.5\u5c81\uff09\u7684\u5f71\u54cd\uff0c\u4ee5\u8bc4\u4ef7\u9053\u8def\u9a7e\u9a76\u8868\u73b0\u3002\u5fd7\u613f\u8005\uff0865\u5c81\u53ca\u4ee5\u4e0a\uff1a24\u4eba\uff0c23-64\u5c81\uff1a24\u4eba\uff09\u8fde\u7eed\u516b\u5929\u5728\u7761\u89c9\u65f6\u63a5\u53d7lemborexant\u4e09\u4e2a\u5242\u91cf\uff082.5\u30015\u621610mg\uff09\u4e2d\u7684\u4e24\u4e2a\u5242\u91cf\u548c\u5b89\u6170\u5242\u7684\u6cbb\u7597\u3002\u4f50\u5339\u514b\u96867.5mg\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\uff0c\u4ec5\u5728\u7b2c\u4e00\u5929\u548c\u7b2c\u516b\u5929\u7ed9\u836f\uff0c\u5176\u95f4\u7684\u516d\u5929\u8fdb\u884c\u5b89\u6170\u5242\u7ed9\u836f\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u8bc4\u4f30\u7b2c\u4e00\u6b21\u6cbb\u7597\u7ed9\u836f\u4e4b\u540e9\u5c0f\u65f6\uff08\u7b2c2\u5929\u4e0a\u5348\uff09\u548c\u6700\u540e\u4e00\u5929\u6cbb\u7597\u7ed9\u836f\u4e4b\u540e9\u5c0f\u65f6\uff08\u7b2c9\u5929\u4e0a\u5348\uff09\u8fdb\u884c\u7684\u9053\u8def\u9a7e\u9a76\u8bd5\u9a8c\u671f\u95f4\u6a2a\u5411\u4f4d\u7f6e\u6807\u51c6\u5dee\u7684\u53d8\u5316\u3002<\/p>\n<p>\u5728\u516c\u8def\u6d4b\u8bd5\u4e2d\uff0c\u5fd7\u613f\u8005\u5728\u4e00\u540d\u6301\u8bc1\u9a7e\u9a76\u6559\u5458\u7684\u966a\u540c\u4e0b\uff0c\u9a7e\u9a76\u4e00\u8f86\u88c5\u6709\u7279\u6b8a\u4eea\u5668\u7684\u8f66\u8f86\uff0c\u5728100km\uff08\u7ea660\u82f1\u91cc\uff09\u7684\u4e3b\u8981\u516c\u8def\u4e0a\u9a7e\u9a76\u7ea6\u4e00\u5c0f\u65f6\u3002\u5177\u4f53\u4efb\u52a1\u662f\u5728\u6162\u8f66\u9053\u7684\u5212\u5b9a\u8fb9\u754c\u4e4b\u95f4\uff0c\u4ee5\u7a33\u5b9a\u7684\u6a2a\u5411\u4f4d\u7f6e\u884c\u9a76\uff0c\u540c\u65f6\u4fdd\u630195km\/h\u6052\u5b9a\u901f\u5ea6\u3002<\/p>\n<p>\u867d\u71365\u548c10mg\u5242\u91cf\u7684 lemborexant\u5bf9\u6210\u5e74\u6216\u8001\u5e74\u53d7\u8bd5\u8005\u6b21\u65e5\u65e9\u6668\u7684\u9a7e\u9a76\u8868\u73b0\u672a\u9020\u6210\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u635f\u5bb3\uff08\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff09\uff0c\u4f46\u4e00\u4e9b\u670d\u752810mg lemborexant\u7684\u53d7\u8bd5\u8005\u7684\u9a7e\u9a76\u80fd\u529b\u53d7\u5230\u635f\u5bb3\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"a0 \">6. <\/span><span class=\"a0 \">\u5173\u4e8e108\u7814\u7a76<\/span>4<\/p>\n<p>\u7814\u7a76108\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u56db\u5468\u671f\u3001\u4ea4\u53c9I\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30lemborexant\u5bf956\u540d55\u5c81\u53ca\u4ee5\u4e0a\u5065\u5eb7\u5fd7\u613f\u8005\u7684\u59ff\u52bf\u7a33\u5b9a\u6027\u3001\u542c\u89c9\u89c9\u9192\u9608\u503c\u548c\u8ba4\u77e5\u80fd\u529b\u7684\u5f71\u54cd\u3002\u53d7\u8bd5\u8005\u5728\u7761\u524d\u63a5\u53d7\u5355\u5242\u91cf\u5b89\u6170\u5242\u30015mg lemborexant\u300110mg lemborexant\u6216\u9633\u6027\u5bf9\u7167\u836f\u7269\u6cbb\u7597\u3002\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u4e24\u79cd\u5242\u91cf\u7684lemborexant\u7ec4\u7684\u8eab\u4f53\u6446\u52a8\u6bd4\u7387\u90fd\u6709\u7edf\u8ba1\u4e0a\u7684\u663e\u8457\u589e\u52a0\u3002\u6b21\u65e5\uff0c\u5728\u5e8a\u4e0a\u8eba\u4e86\u516b\u4e2a\u5c0f\u65f6\u4e4b\u540e\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u4e24\u79cd\u5242\u91cf\u7684lemborexant\u5bf9\u59ff\u52bf\u7a33\u5b9a\u6027\u6307\u6807\u7684\u6b8b\u7559\u6548\u5e94\u5747\u65e0\u7edf\u8ba1\u5b66\u663e\u8457\u5dee\u5f02\u3002<\/p>\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<p>1 <span class=\"a0 \">Scammell TE, Winrow CJ. Orexin receptors: pharmacology and therapeutic opportunities. <\/span><span class=\"a0 \">Annu Rev Pharmacol Toxicol<\/span><span class=\"a0 \">. 2011;51:243-266.<\/span><\/p>\n<p>2 <span class=\"a0 \">Eisai Inc. DAYVIGO Full Prescribing Information. 2020.<\/span><\/p>\n<p>3<span class=\"a0 \"> Vermeeren A, et al. On-the-road driving performance the morning after bedtime administration of lemborexant in healthy adult and elderly volunteers. <\/span><span class=\"a0 \">Sleep. <\/span><span class=\"a0 \">2019 42 (4): zsy260.<\/span><\/p>\n<p>4<span class=\"a0 \"> Murphy P, et al. Safety of lemborexant versus placebo and zolpidem: effects on auditory awakening threshold, postural stability, and cognitive performance in healthy older participants in the middle of the night and upon morning awakening, <\/span><span class=\"a0 \">J. Clinical Sleep Medicine. <\/span><span class=\"a0 \">2020: 16(5):765-773.<\/span><\/p>\n<p>5<span class=\"a0 \"> Institute of Medicine. Sleep disorders and sleep deprivation: An unmet public health problem. Washington<\/span><span class=\"a0 \">, <\/span><span class=\"a0 \">DC: National Academies Press. 2006.<\/span><\/p>\n<p>6 <span class=\"a0 \">Ohayon MM, et al. Epidemiology of insomnia: what we know and what we still need to learn. <\/span><span class=\"a0 \">Sleep Med Rev. <\/span><span class=\"a0 \">2002;6(2):97-111.<\/span><\/p>\n<p>7<span class=\"a0 \"> Ferrie JE, et al. Sleep epidemiology \u2013 a rapidly growing field<\/span><span class=\"a0 \">. Int J Epidemiol. <\/span><span class=\"a0 \">2011;40(6):1431\u20131437.<\/span><\/p>\n<p>8 <span class=\"a0 \">Roth T. Insomnia: definition, prevalence, etiology and consequences. <\/span><span class=\"a0 \">J Clin Sleep Med<\/span><span class=\"a0 \">. 2007;3(5 Suppl):S7\u2013S10.<\/span><\/p>\n<p>9<span class=\"a0 \"> Cappuccio FP, et al. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. <\/span><span class=\"a0 \">Sleep. <\/span><span class=\"a0 \">2010;33(5):585-592.<\/span><span class=\"a0 \"><br \/>\n<\/span><\/p>\n<p><span class=\"a0 \">10<\/span> <span class=\"a0 \">Pase MP, Himali JJ, Grima NA, et al. Sleep architecture and the risk of incident dementia in the community. <\/span><span class=\"a0 \">Neurology. <\/span><span class=\"a0 \">2017;89(12):1244-1250.<\/span><\/p>\n<p>11<span class=\"a0 \"> Roth T, et al. Prevalence and perceived health associated with insomnia based on DSM-IV-TR; International Statistical Classification of Diseases and Related Health Problems, tenth revision; and Research Diagnostic Criteria\/International Classification of Sleep Disorders, second edition criteria: results from the America Insomnia Survey<\/span><span class=\"a0 \">. Biol Psychiatry. <\/span><span class=\"a0 \">2011;69:592\u2013 600.<\/span><\/p>\n<p>12 <span class=\"a0 \">Crowley K. Sleep and sleep disorders in older adults. <\/span><span class=\"a0 \">Neuropsychol Rev<\/span><span class=\"a0 \">. 2011;21(1):41-53.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0cCEO\uff1a\u5185\u85e4\u6674\u592b\uff0c\u201c\u536b\u6750\u201d\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5176\u7f8e\u56fd\u5b50\u516c\u53f8Eisai Inc.\u5df2\u4e8e\u7f8e\u56fd\u4e0a\u5e02\u5176\u5185\u90e8\u7814\u53d1\u7684\u98df\u6b32\u7d20\u53d7\u4f53\u62ee\u6297\u5242DAYVIGO\u2122\uff08LEMBOREXANT\uff09CIV\u7528\u4e8e\u6cbb\u7597\u6210\u5e74\u4eba\u7684\u5931\u7720\uff0c\u8be5\u75c5\u5177\u4f53\u8868\u73b0\u4e3a\u5165\u7761\u548c\/\u6216\u7ef4\u6301\u7761\u7720\u969c\u788d\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-2737","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/2737"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=2737"}],"version-history":[{"count":2,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/2737\/revisions"}],"predecessor-version":[{"id":2739,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/2737\/revisions\/2739"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=2737"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=2737"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=2737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}