{"id":2820,"date":"2019-12-23T00:00:00","date_gmt":"2021-03-18T03:03:09","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=2820"},"modified":"2021-03-18T11:03:09","modified_gmt":"2021-03-18T03:03:09","slug":"%e7%be%8e%e5%9b%bd%e9%a3%9f%e5%93%81%e5%92%8c%e8%8d%af%e7%89%a9%e7%ae%a1%e7%90%86%e5%b1%80%e6%89%b9%e5%87%86-dayvigo%ef%bc%88lemborexant%ef%bc%89%e6%b2%bb%e7%96%97%e6%88%90%e4%ba%ba%e5%a4%b1","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2019\/12\/23\/%e7%be%8e%e5%9b%bd%e9%a3%9f%e5%93%81%e5%92%8c%e8%8d%af%e7%89%a9%e7%ae%a1%e7%90%86%e5%b1%80%e6%89%b9%e5%87%86-dayvigo%ef%bc%88lemborexant%ef%bc%89%e6%b2%bb%e7%96%97%e6%88%90%e4%ba%ba%e5%a4%b1\/","title":{"rendered":"\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6279\u51c6 DAYVIGO\u2122\uff08LEMBOREXANT\uff09\u6cbb\u7597\u6210\u4eba\u5931\u7720\u75c7"},"content":{"rendered":"<h1><em style=\"font-weight: inherit;\"><b><strong style=\"font-style: inherit;\">\u5728\u4e00\u9879\u6d89\u53ca2,000\u591a\u540d\u60a3\u8005\u7684\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212\u4e2d\uff0c\u8bc1\u660e\u98df\u6b32\u7d20\u53d7\u4f53\u62ee\u6297\u5242\u80fd\u591f\u4f7f\u60a3\u8005\u6709\u6548\u5165\u7761\u548c\u7ef4\u6301\u7761\u7720<\/strong><\/b><\/em><\/h1>\n<p>&nbsp;<\/p>\n<p>\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0cCEO\uff1a\u5185\u85e4\u6674\u592b\uff0c\u201c\u536b\u6750\u201d\uff09\u4eca\u5929\u5ba3\u5e03\uff0c\u9488\u5bf9\u5176\u5185\u90e8\u53d1\u73b0\u548c\u5f00\u53d1\u7684\u98df\u6b32\u7d20\u53d7\u4f53\u62ee\u6297\u5242DAYVIGO<sup>TM<\/sup>\uff08lemborexant\uff09\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e86\u65b0\u836f\u7533\u8bf7\u3002DAYVIGO\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u5931\u7720\u75c7\uff0c\u8be5\u75c7\u72b6\u5177\u4f53\u8868\u73b0\u4e3a\u6210\u4eba\u5165\u7761\u548c\/\u6216\u7761\u7720\u7ef4\u6301\u56f0\u96be[1]\u3002\u5728\u7f8e\u56fd\uff0c\u5c06\u6309\u7167\u7f8e\u56fd\u7f09\u6bd2\u5c40\uff08DEA\uff09\u7684\u8ba1\u5212\uff0c\u5728\u5e02\u573a\u4e0a\u4ee55mg\u548c10mg\u7247\u5242\u9500\u552eDAYVIGO\uff0c\u9884\u8ba1\u5c06\u572890\u5929\u5185\u4e0a\u5e02\u3002<\/p>\n<p>\u636e\u63a8\u5b9a\uff0clemborexant\u5728\u6cbb\u7597\u5931\u7720\u75c7\uff08\u5176\u7279\u5f81\u662f\u5165\u7761\u548c\/\u6216\u7761\u7720\u7ef4\u6301\u56f0\u96be\uff09\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u901a\u8fc7\u98df\u6b32\u7d20\u53d7\u4f53\u7684\u62ee\u6297\u4f5c\u7528\u6765\u5b9e\u73b0\u3002\u98df\u6b32\u7d20\u795e\u7ecf\u80bd\u4fe1\u53f7\u7cfb\u7edf\u5728\u89c9\u9192\u4e2d\u8d77\u4f5c\u7528\u3002\u636e\u8ba4\u4e3a\uff0c\u963b\u65ad\u4fc3\u8fdb\u89c9\u9192\u7684\u795e\u7ecf\u80bd\u98df\u6b32\u7d20A\u548c\u98df\u6b32\u7d20B\u4e0e\u98df\u6b32\u7d20\u53d7\u4f53OX1R\u548cOX2R\u7684\u7ed3\u5408\u6291\u5236\u89c9\u9192\u9a71\u52a8\u3002Lemborexant\u4e0e\u98df\u6b32\u7d20\u53d7\u4f53OX1R\u548cOX2R\u7ed3\u5408\uff0c\u4f5c\u4e3a\u7ade\u4e89\u6027\u62ee\u6297\u5242\uff0c\u5bf9OX2R*\u5177\u6709\u8f83\u5f3a\u7684\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<p>\u672c\u6b21\u6279\u51c6\u7684\u4f9d\u636e\u662f\u4e00\u9879\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212\u7684\u7ed3\u679c\uff0c\u8be5\u8ba1\u5212\u5305\u62ec\u4e24\u9879\u5173\u952e\u7684III\u671f\u7814\u7a76\uff08SUNRISE 2\u548cSUNRISE 1\uff09\uff0c\u8fd9\u4e24\u9879\u7814\u7a76\u5bf9\u603b\u5171\u7ea62,000\u540d\u6210\u5e74\u5931\u7720\u75c7\u60a3\u8005\u5206\u522b\u8fdb\u884c\u4e3a\u671f\u4e00\u4e2a\u6708\u7684DAYVIGO\u548c\u6bd4\u8f83\u5242\u4ee5\u53ca\u4e3a\u671f\u516d\u4e2a\u6708\u7684DAYVIGO\u548c\u5b89\u6170\u5242\u7684\u8bc4\u4f30\u3002\u57fa\u4e8e\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\uff0c\u65e0\u8bba\u662f\u4e3b\u89c2\u8bc4\u4ef7\u8fd8\u662f\u5ba2\u89c2\u8bc4\u4ef7\uff0cDAYVIGO\u5728\u5165\u7761\u548c\u7761\u7720\u7ef4\u6301\u65b9\u9762\u5747\u6bd4\u5b89\u6170\u5242\u8868\u73b0\u51fa\u7edf\u8ba1\u5b66\u663e\u8457\u4f18\u52bf\u3002<\/p>\n<p>\u5728SUNRISE 2\u548cSUNRISE 1\u4e2d\uff0cDAYVIGO\u4e0e\u505c\u836f\u540e\u7684\u53cd\u5f39\u6027\u5931\u7720\u75c7\u65e0\u5173\uff0c\u4e14\u65e0\u8bc1\u636e\u8868\u660eDAYVIGO\u5728\u4e24\u79cd\u5242\u91cf\u4e0b\u505c\u836f\u540e\u51fa\u73b0\u505c\u836f\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u5f00\u53d1\u8ba1\u5212\u5305\u62ec\u591a\u9879\u5b89\u5168\u6027\u7814\u7a76\uff0c\u8bc4\u4ef7\u5176\u5bf9\u59ff\u52bf\u7a33\u5b9a\u6027\u3001\u8ba4\u77e5\u3001\u9a7e\u9a76\u8868\u73b0\u548c\u547c\u5438\u5b89\u5168\u7684\u5f71\u54cd\u3002<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>SUNRISE 2\u662f\u4e00\u9879\u957f\u671f\uff086\u4e2a\u6708\uff09\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u8bd5\u9a8c\uff0c\u7814\u7a76\u53d7\u8bd5\u8005\u4e3a18\u5c81\u6216\u4ee5\u4e0a\u7b26\u5408\u5931\u7720\u969c\u788dDSM-5**\u6807\u51c6\u7684\u6210\u5e74\u60a3\u8005\u3002\u5728\u7814\u7a76\u4e2d\uff0c\u5c06\u60a3\u8005\u968f\u673a\u5206\u4e3a\u5b89\u6170\u5242\u7ec4\uff08n=325\uff09\u3001DAYVIGO 5mg\u7ec4\uff08n=323\uff09\u6216DAYVIGO 10mg\u7ec4\uff08n=323\uff09\uff0c\u6bcf\u665a\u7528\u836f\u4e00\u6b21\u3002\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u662f\u60a3\u8005\u62a5\u544a\u7684\uff08\u4e3b\u89c2\uff09\u5165\u7761\u6f5c\u4f0f\u671f\uff08sSOL\uff09\u4ece\u57fa\u7ebf\u5230\u6cbb\u7597\u7ed3\u675f\u7684\u5e73\u5747\u53d8\u5316\uff0c\u5176\u4e2d\uff0c\u201csSOL\u201d\u5b9a\u4e49\u4e3a\u4ece\u53d7\u8bd5\u8005\u5c1d\u8bd5\u5165\u7761\u5230\u771f\u5b9e\u5165\u7761\u7684\u4f30\u8ba1\u5206\u949f\u6570\u3002\u9884\u5148\u6307\u5b9a\u7684\u6b21\u8981\u7597\u6548\u7ec8\u70b9\u5305\u62ec\u5728\u516d\u4e2a\u6708\u65f6\u95f4\u5185\uff0c\u60a3\u8005\u62a5\u544a\u7684\u7761\u7720\u6548\u7387\uff08sSE\uff1b\u5b9a\u4e49\u4e3a\u5728\u5e8a\u4e0a\u7761\u89c9\u6240\u5360\u7684\u65f6\u95f4\u6bd4\u4f8b\uff09\uff0c\u4ee5\u53ca\u4e3b\u89c2\u7684\u5165\u7761\u548c\u7761\u7720\u7ef4\u6301\uff08sWASO\uff1b\u5b9a\u4e49\u4e3a\u4ece\u6301\u7eed\u5165\u7761\u5230\u5f00\u706f\u7684\u89c9\u9192\u5206\u949f\u6570\uff09\u4ece\u57fa\u7ebf\u5230\u6cbb\u7597\u7ed3\u675f\u7684\u5e73\u5747\u53d8\u5316\u3002<\/li>\n<\/ul>\n<p>\u4f7f\u7528\u7761\u7720\u65e5\u8bb0\uff0c\u6d4b\u91cf\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u548c\u9884\u5148\u6307\u5b9a\u7684\u6b21\u8981\u7597\u6548\u7ec8\u70b9\u3002\u5728SUNRISE 2\u4e2d\uff0cDAYVIGO 5mg\u548c10mg\u5728\u4e3b\u8981\u7597\u6548\u6307\u6807sSOL\u65b9\u9762\u663e\u793a\u51fa\u4e0e\u5b89\u6170\u5242\u76f8\u5f53\u7684\u7edf\u8ba1\u5b66\u663e\u8457\u4f18\u52bf\u3002\u53e6\u5916\uff0cDAYVIGO 5mg\u548c10mg\u5728sSE\u548csWASO\u65b9\u9762\u4e5f\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u663e\u8457\u4f18\u52bf[1]\u3002<\/p>\n<ul>\n<li>SUNRISE 1\u662f\u4e00\u9879\u77ed\u671f\uff08\u4e00\u4e2a\u6708\uff09\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u548c\u4e3b\u52a8\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u3001\u5e73\u884c\u7ec4\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7814\u7a76\u53d7\u8bd5\u8005\u4e3a\u5e74\u6ee155\u5c81\u7684\u6210\u5e74\u5973\u6027\u53d7\u8bd5\u8005\u548c\u5e74\u6ee165\u5c81\u7684\u7537\u6027\u53d7\u8bd5\u8005\uff0c\u4e14\u53d7\u8bd5\u8005\u7b26\u5408\u5931\u7720\u969c\u788dDSM-5\u6807\u51c6\u3002\u5c06\u60a3\u8005\u968f\u673a\u5206\u4e3a\u5b89\u6170\u5242\u7ec4\uff08n=208\uff09\u3001DAYVIGO\u7ec4\uff08n=266\uff09\u621610mg\u7ec4\uff08n=269\uff09\u6216\u4e3b\u52a8\u6bd4\u8f83\u5242\u7ec4\uff08n=263\uff09\uff0c\u6bcf\u665a\u7528\u836f\u4e00\u6b21\u3002\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u662f\u6301\u7eed\u7761\u7720\u6f5c\u4f0f\u671f\uff08LPS\uff1b\u5b9a\u4e49\u4e3a\u4ece\u5173\u706f\u5230\u9996\u4e2a\u8fde\u7eed10\u5206\u949f\u4e0d\u9192\u7684\u5206\u949f\u6570\uff09\u4ece\u57fa\u7ebf\u5230\u6cbb\u7597\u7ed3\u675f\uff08\u7b2c29\/30\u5929\uff09\u7684\u5e73\u5747\u53d8\u5316\uff0c\u901a\u8fc7\u591c\u95f4\u591a\u5bfc\u7761\u7720\u63cf\u8bb0\u672f\uff08PSG\uff09\u76d1\u6d4b\u8fdb\u884c\u6d4b\u91cf\u3002\u5728SUNRISE 1\u4e2d\uff0c\u9884\u5148\u6307\u5b9a\u7684\u6b21\u8981\u7597\u6548\u7ec8\u70b9\u662f\u901a\u8fc7PSG\u6d4b\u91cf\u7684\u7761\u7720\u6548\u7387\uff08SE\uff09\u548c\u5165\u7761\u540e\u7684\u89c9\u9192\uff08WASO\uff09\u4ece\u57fa\u7ebf\u5230\u6cbb\u7597\u7ed3\u675f\uff08\u7b2c29\/30\u5929\uff09\u7684\u5e73\u5747\u53d8\u5316\u3002\u5728SUNRISE 1\u4e2d\uff0cDAYVIGO 5mg\u548c10mg\u5728\u4e3b\u8981\u7597\u6548\u6307\u6807LPS\u65b9\u9762\u663e\u793a\u51fa\u4e0e\u5b89\u6170\u5242\u76f8\u5f53\u7684\u7edf\u8ba1\u5b66\u663e\u8457\u4f18\u52bf\u3002\u5728SE\u548cWASO\u65b9\u9762\uff0c\u76f8\u6bd4\u4e8e\u5b89\u6170\u5242\uff0cDAYVIGO 5mg\u548c10mg\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u663e\u8457\u6539\u5584[1]\u3002<\/li>\n<\/ul>\n<p>\u5728SUNRISE 2\uff08\u524d30\u5929\uff09\u548cSUNRISE 1\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u5728\u63a5\u53d7DAYVIGO\u6cbb\u7597\u76845%\u6216\u66f4\u591a\u60a3\u8005\u4e2d\u62a5\u544a\uff0c\u81f3\u5c11\u662f\u5b89\u6170\u5242\u7ec4\u7684\u4e24\u500d\uff09\u662f\u55dc\u7761\uff08DAYVIGO 10mg\uff0c10%\uff1bDAYVIGO 5mg\uff0c7%\uff1b\u5b89\u6170\u5242\uff0c1%\uff09\u3002<\/p>\n<p>\u9664\u8fd9\u4e9b\u5173\u952e\u8bd5\u9a8c\u5916\uff0c\u536b\u6750\u8fd8\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217\u65e8\u5728\u8fdb\u4e00\u6b65\u8bc4\u4ef7DAYVIGO\u5b89\u5168\u6027\u7684\u7814\u7a76\uff0c\u5176\u4e2d\u5305\u62ec\u4e00\u9879\u8bc4\u4f30DAYVIGO\u5bf9\u59ff\u52bf\u7a33\u5b9a\u6027\u548c\u8ba4\u77e5\u80fd\u529b\u7684\u5f71\u54cd\u7684\u7814\u7a76\uff0c\u4ee5\u53ca\u4e00\u9879\u7b2c\u4e8c\u5929\u65e9\u4e0a\u9a7e\u9a76\u7684\u7814\u7a76\u3002<\/p>\n<ul>\n<li>\u5348\u591c\u5b89\u5168\u6027\uff08\u7814\u7a76108\uff09\uff1a\u5728\u4e00\u9879\u968f\u673a\u3001\u5b89\u6170\u5242\u548c\u4e3b\u52a8\u5bf9\u7167\u8bd5\u9a8c\u4e2d\uff0c\u5bf9\u5e74\u9f84\u226555\u5c81\u7684\u5065\u5eb7\u5973\u6027\u53d7\u8bd5\u8005\u6216\u5e74\u9f84\u226565\u5c81\u7684\u7537\u6027\u53d7\u8bd5\u8005\u8fdb\u884cDAYVIGO\u5bf9\u5348\u591c\u5b89\u5168\u6027\u7684\u5f71\u54cd\u8bc4\u4ef7\u3002\u5728\u9884\u5b9a\u7684\u89c9\u9192\uff08\u5728\u5f00\u59cb\u516b\u5c0f\u65f6\u5367\u5e8a\u65f6\u95f4\u4e4b\u540e\u7684\u56db\u5c0f\u65f6\uff09\u4e4b\u540e\u8bc4\u4f30\u59ff\u52bf\u7a33\u5b9a\u6027\u3001\u5bf9\u58f0\u97f3\u523a\u6fc0\u7684\u89c9\u9192\u80fd\u529b\u3001\u6ce8\u610f\u529b\u548c\u8bb0\u5fc6\u529b\u3002\u76f8\u6bd4\u4e8e\u5b89\u6170\u5242\uff0c\u591c\u95f4\u670d\u7528DAYVIGO 5\u548c10mg\u4f1a\u57284\u5c0f\u65f6\u5185\u5bfc\u81f4\u5e73\u8861\u53d7\u635f\uff08\u901a\u8fc7\u8eab\u4f53\u6447\u6446\u9762\u79ef\u8fdb\u884c\u6d4b\u91cf\uff09\u3002\u5728\u58f0\u97f3\u523a\u6fc0\u7684\u89c9\u9192\u80fd\u529b\u65b9\u9762\uff0cDAYVIGO\uff085\u621610mg\uff09\u4e0e\u5b89\u6170\u5242\u4e4b\u95f4\u65e0\u663e\u8457\u5dee\u5f02\u3002\u76f8\u6bd4\u4e8e\u5b89\u6170\u5242\uff0cDAYVIGO\u4e0e\u6ce8\u610f\u529b\u548c\u8bb0\u5fc6\u529b\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u6076\u5316\u6709\u5173[1]\u3002<\/li>\n<li>\u5bf9\u7b2c\u4e8c\u5929\u59ff\u52bf\u7a33\u5b9a\u6027\u3001\u6ce8\u610f\u529b\u548c\u8bb0\u5fc6\u7684\u5f71\u54cd\uff08SUNRISE 1\u548c\u7814\u7a76108\uff09\uff1a\u5728\u4e24\u9879\u968f\u673a\u3001\u5b89\u6170\u5242\u548c\u4e3b\u52a8\u5bf9\u7167\u8bd5\u9a8c\u4e2d\uff0c\u57fa\u4e8e\u5e74\u6ee155\u5c81\u7684\u5065\u5eb7\u53d7\u8bd5\u8005\u548c\u5931\u7720\u75c7\u60a3\u8005\uff0c\u8bc4\u4ef7\u4e86DAYVIGO\u5bf9\u7b2c\u4e8c\u5929\u59ff\u52bf\u7a33\u5b9a\u6027\u3001\u6ce8\u610f\u529b\u548c\u8bb0\u5fc6\u7684\u5f71\u54cd\u3002DAYVIGO\uff085\u621610mg\uff09\u4e0e\u5b89\u6170\u5242\u5728\u7b2c\u4e8c\u5929\u59ff\u52bf\u7a33\u5b9a\u6027\u6216\u8bb0\u5fc6\u65b9\u9762\u65e0\u663e\u8457\u5dee\u5f02\u3002[1]<\/li>\n<li>\u5bf9\u9a7e\u9a76\u7684\u5f71\u54cd\uff08\u7814\u7a76106\uff09\uff1a\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u548c\u4e3b\u52a8\u5bf9\u7167\u7684\u56db\u5468\u671f\u4ea4\u53c9\u7814\u7a76\uff0c24\u540d\u5065\u5eb7\u8001\u5e74\u53d7\u8bd5\u8005\uff08\u226565\u5c81\uff0c\u5e74\u9f84\u4e2d\u503c67\u5c81\uff09\u548c24\u540d\u6210\u5e74\u53d7\u8bd5\u8005\uff08\u5e74\u9f84\u4e2d\u503c49\u5c81\uff09\u670d\u836f\u4e4b\u540e\u5927\u7ea69\u5c0f\u65f6\uff0c\u8bc4\u4f30\u591c\u95f4\u670d\u7528DAYVIGO\u5bf9\u7b2c\u4e8c\u5929\u65e9\u6668\u9a7e\u9a76\u8868\u73b0\u7684\u5f71\u54cd\u3002\u867d\u71365\u548c10mg\u5242\u91cf\u7684DAYVIGO\u5bf9\u6210\u5e74\u6216\u8001\u5e74\u53d7\u8bd5\u8005\u7b2c\u4e8c\u5929\u65e9\u6668\u7684\u9a7e\u9a76\u8868\u73b0\u672a\u9020\u6210\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u635f\u5bb3\uff08\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff09\uff0c\u4f46\u670d\u752810mg DAYVIGO\u7684\u4e00\u4e9b\u53d7\u8bd5\u8005\u7684\u9a7e\u9a76\u80fd\u529b\u53d7\u5230\u635f\u5bb3\u3002<\/li>\n<\/ul>\n<p>DAYVIGO\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u56fd\u5bb6\u7761\u7720\u57fa\u91d1\u4f1a\u7684\u524d\u4e3b\u5e2dRussell Rosenberg\uff0cPhD\uff0cD.ABSM\u8868\u793a\u201c\u5931\u7720\u969c\u788d\u662f\u4e00\u79cd\u6162\u6027\u75be\u75c5\uff0c\u4f1a\u5bf9\u5065\u5eb7\u548c\u5e78\u798f\u4ea7\u751f\u5404\u79cd\u6f5c\u5728\u7684\u8d1f\u9762\u5f71\u54cd\u548c\u957f\u671f\u540e\u679c\u201d[2]\uff0c\u201c\u4e34\u5e8a\u8bd5\u9a8c\u63d0\u4f9b\u7684\u8bc1\u636e\u8868\u660e\uff0cDAYVIGO\u53ef\u4ee5\u63d0\u9ad8\u60a3\u8005\u5165\u7761\u548c\u7ef4\u6301\u7761\u7720\u7684\u80fd\u529b\u3002\u201d<\/p>\n<p>\u536b\u6750\u795e\u7ecf\u75c5\u5b66\u4e1a\u52a1\u7ec4\u9996\u5e2d\u4e34\u5e8a\u5b98Lynn Kramer\uff0cMD\u8868\u793a\u201c\u6211\u4eec\u8ba4\u4e3aDAYVIGO\u7684\u6279\u51c6\u7279\u522b\u4ee4\u4eba\u5174\u594b\uff0c\u56e0\u4e3a\u5b83\u662f\u7b2c\u4e00\u6b3e\u7ecf\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u5165\u7761\u548c\u7761\u7720\u7ef4\u6301\u836f\u7269\uff0c\u4e14\u4e00\u9879\u5173\u952e\u4e34\u5e8a\u7814\u7a76\u62a5\u544a\u4e86\u8be5\u836f\u7269\u768412\u4e2a\u6708\u5b89\u5168\u6027\u6570\u636e\u4ee5\u53ca6\u4e2a\u6708\u5165\u7761\u548c\u7761\u7720\u7ef4\u6301\u529f\u6548\u6570\u636e\u201d\u3002\u201c\u6211\u4eec\u671f\u5f85\u7740\u4e3a\u6570\u767e\u4e07\u5931\u7720\u75c7\u60a3\u8005\u63d0\u4f9b\u8fd9\u79cd\u5168\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n<p>\u536b\u6750\u5df2\u7ecf\u63d0\u4ea4\u65b0\u7684\u836f\u7269\u7533\u8bf7\uff0c\u8bf7\u6c42\u6279\u51c6\u8be5\u836f\u7269\u7528\u4e8e\u65e5\u672c\uff082019\u5e7403\u6708\uff09\u548c\u52a0\u62ff\u5927\uff082019\u5e7408\u6708\uff09\u7684\u5931\u7720\u75c7\u6cbb\u7597\u3002<\/p>\n<p>\u5931\u7720\u7684\u7279\u5f81\u662f\u5c3d\u7ba1\u6709\u5145\u8db3\u7684\u7761\u7720\u673a\u4f1a\uff0c\u4f46\u4f9d\u7136\u96be\u4ee5\u5165\u7761\u3001\u7ef4\u6301\u7761\u7720\u72b6\u6001\u6216\u8005\u4e24\u79cd\u60c5\u51b5\u5747\u5b58\u5728\uff0c\u8fd9\u53ef\u80fd\u5f71\u54cd\u767d\u5929\u7684\u72b6\u6001\uff0c\u4f8b\u5982\uff0c\u75b2\u52b3\u3001\u6ce8\u610f\u529b\u96be\u4ee5\u96c6\u4e2d\u548c\u6613\u6012[2\uff0c9]\u3002\u5931\u7720\u75c7\u662f\u6700\u5e38\u89c1\u7684\u7761\u7720-\u89c9\u9192\u969c\u788d\u4e4b\u4e00\uff0c\u53d1\u75c5\u7387\u5f88\u9ad8\u3002\u5168\u7403\u7ea6\u670930%\u7684\u6210\u5e74\u4eba\u6709\u5931\u7720\u75c7\u72b6[7\uff0c8]\uff0c\u5176\u4e2d\u8bb8\u591a\u4eba\u6301\u7eed\u6570\u6708\u81f3\u6570\u5e74\u3002\u56e0\u6b64\uff0c\u5931\u7720\u75c7\u4f1a\u5bfc\u81f4\u5404\u79cd\u793e\u4f1a\u635f\u5931\uff0c\u4f8b\u5982\uff0c\u957f\u671f\u7f3a\u5e2d\u548c\u751f\u4ea7\u529b\u4e0b\u964d\u3002<\/p>\n<p>\u51ed\u501fDAYVIGO\u548c\u4e13\u6ce8\u4e8e\u98df\u6b32\u7d20\u751f\u7269\u5b66\u7684\u7814\u53d1\u52aa\u529b\uff0c\u536b\u6750\u6e34\u671b\u6539\u5584\u7761\u7720\u969c\u788d\u60a3\u8005\u7684\u751f\u6d3b\u3002<\/p>\n<p>*Lemborexant\u4e0e\u98df\u6b32\u7d20\u53d7\u4f53OX1R\u548cOX2R\u7ed3\u5408\uff0c\u5e76\u4f5c\u4e3a\u7ade\u4e89\u6027\u62ee\u6297\u5242\uff08IC50\u503c\u5206\u522b\u4e3a6.1nM\u548c2.6nM\uff09\u3002\u6fc0\u6d3b\u540e\uff0cOX1R\u7684\u4f5c\u7528\u662f\u6291\u5236REM\u7761\u7720\uff0cOX2R\u7684\u4f5c\u7528\u662f\u6291\u5236\u975eREM\u7761\u7720\u548cREM\u7761\u7720\u3002Lemborexant\u901a\u8fc7\u963b\u6b62OX1R\u548cOX2R\u7684\u6fc0\u6d3b\uff0c\u5b9e\u73b0\u7761\u7720\u3002<\/p>\n<p>**DSM-5\uff1a\u7cbe\u795e\u75be\u75c5\u8bca\u65ad\u548c\u7edf\u8ba1\u624b\u518c\uff0c\u7b2c\u4e94\u7248\uff08\u7f8e\u56fd\u7cbe\u795e\u75c5\u5b66\u534f\u4f1a\uff09<\/p>\n<p>&nbsp;<\/p>\n<p><b><strong style=\"font-style: inherit;\">\u5a92\u4f53\u54a8\u8be2\uff1a<\/strong><\/b><br \/>\n\u516c\u5171\u5173\u7cfb\u90e8<br \/>\n\u536b\u6750\u682a\u5f0f\u4f1a\u793e<br \/>\n+81-(0)3-3817-5120<\/p>\n<p>&nbsp;<\/p>\n<p><b><strong style=\"font-style: inherit;\">[\u7f16\u8f91\u987b\u77e5]<\/strong><\/b><br \/>\n<strong>1.\u5173\u4e8eLemborexant<\/strong><br \/>\nLemborexant\u662f\u536b\u6750\u5185\u90e8\u53d1\u73b0\u548c\u5f00\u53d1\u7684\u5c0f\u5206\u5b50\uff0c\u53ef\u4e0e\u98df\u6b32\u7d20\u53d7\u4f53OX1R\u548cOX2R\u7ed3\u5408\uff0c\u5e76\u4f5c\u4e3a\u7ade\u4e89\u6027\u62ee\u6297\u5242\uff08IC50\u503c\u5206\u522b\u4e3a6.1nM\u548c2.6nM\uff09\u3002\u636e\u63a8\u5b9a\uff0clemborexant\u6cbb\u7597\u5931\u7720\u75c7\u7684\u4f5c\u7528\u673a\u5236\u901a\u8fc7\u98df\u6b32\u7d20\u53d7\u4f53\u7684\u62ee\u6297\u4f5c\u7528\u6765\u5b9e\u73b0\u3002\u98df\u6b32\u7d20\u795e\u7ecf\u80bd\u4fe1\u53f7\u7cfb\u7edf\u5728\u89c9\u9192\u4e2d\u8d77\u4f5c\u7528\u3002\u636e\u8ba4\u4e3a\uff0c\u963b\u65ad\u4fc3\u8fdb\u89c9\u9192\u7684\u795e\u7ecf\u80bd\u98df\u6b32\u7d20A\u548c\u98df\u6b32\u7d20B\u4e0e\u53d7\u4f53OX1R\u548cOX2R\u7684\u7ed3\u5408\u6291\u5236\u89c9\u9192\u9a71\u52a8\u3002<\/p>\n<p>\u4f5c\u4e3a\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\uff0clemborexant\u7684\u4f5c\u7528\u4e0d\u4ec5\u9002\u7528\u4e8e\u539f\u53d1\u6027\u5931\u7720\uff0c\u800c\u4e14\u9002\u7528\u4e8e\u4e0e\u6291\u90c1\u75c7\u7b49\u75be\u75c5\u76f8\u5173\u7684\u5931\u7720\uff08SUNRISE-1\u548cSUNRISE-2\uff09\u3002<\/p>\n<p>\u9664\u5931\u7720\u9002\u7528\u75c7\u5916\uff0c\u8fd8\u5bf9\u60a3\u6709\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75f4\u5446\u75c7\u76f8\u5173\u7684ISWRD\u60a3\u8005\u8fdb\u884clemborexant\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u3002<b><strong style=\"font-style: inherit;\"><\/p>\n<p>2.\u5173\u4e8e\u7761\u7720-\u89c9\u9192\u969c\u788d\u548c\u5931\u7720\u75c7<\/strong><\/b><\/p>\n<p><span style=\"font-weight: 400;\">\u7761\u7720-\u89c9\u9192\u969c\u788d\u5305\u62ec\u5931\u7720\u75c7\u3001ISWRD\u3001\u55dc\u7761\u548c\u547c\u5438\u76f8\u5173\u7761\u7720\u969c\u788d\u7b49\u75be\u75c5\u7c7b\u522b\u3002\u5728\u7761\u7720-\u89c9\u9192\u969c\u788d\u4e2d\uff0c\u5931\u7720\u75c7\u662f\u5168\u7403\u7ea630%\u6210\u5e74\u4eba\u7ecf\u5386\u7684\u6700\u5e38\u89c1\u7684\u6301\u7eed\u6027\u5931\u7720\u75c7\u72b6[7\uff0c8]\u3002\u5931\u7720\u969c\u788d\u5177\u4f53\u8868\u73b0\u4e3a\u5c3d\u7ba1\u6709\u5145\u8db3\u7684\u7761\u7720\u673a\u4f1a\uff0c\u4f46\u4f9d\u7136\u96be\u4ee5\u5165\u7761\u3001\u7ef4\u6301\u7761\u7720\u72b6\u6001\u6216\u8005\u4e24\u79cd\u60c5\u51b5\u5747\u5b58\u5728\uff0c\u8fd9\u53ef\u80fd\u5f71\u54cd\u767d\u5929\u7684\u72b6\u6001\uff0c\u4f8b\u5982\uff0c\u75b2\u52b3\u3001\u6ce8\u610f\u529b\u96be\u4ee5\u96c6\u4e2d\u548c\u6613\u6012[2\uff0c9]\u3002<\/span><span style=\"font-weight: 400;\"><br \/>\n\u826f\u597d\u7684\u7761\u7720\u8d28\u91cf\u5bf9\u4e8e\u8eab\u4f53\u5065\u5eb7\uff08\u5305\u62ec\u5927\u8111\u5065\u5eb7\uff09\u81f3\u5173\u91cd\u8981[11]\uff0c\u4e14\u7814\u7a76\u8868\u660e\uff0c\u6700\u4f73\u7761\u7720\u65f6\u95f4\u4e3a7-8\u5c0f\u65f6[12]\u3002\u7761\u7720\u4e0d\u826f\u4f1a\u5bfc\u81f4\u591a\u79cd\u5065\u5eb7\u540e\u679c\uff0c\u5305\u62ec\u9ad8\u8840\u538b\u3001\u610f\u5916\u4f24\u5bb3\u3001\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\u75c7\u3001\u6291\u90c1\u75c7\u3001\u5fc3\u810f\u75c5\u53d1\u4f5c\u3001\u4e2d\u98ce\u3001\u75f4\u5446\u75c7\u4ee5\u53ca\u5bf9\u60c5\u7eea\u548c\u884c\u4e3a\u7684\u4e0d\u5229\u5f71\u54cd[2\uff0c10]\u3002<\/span><span style=\"font-weight: 400;\"><br \/>\n\u5973\u6027\u5931\u7720\u7684\u53ef\u80fd\u6027\u662f\u7537\u6027\u76841.4\u500d[13]\u3002\u8001\u5e74\u4eba\u5931\u7720\u7684\u60a3\u75c5\u7387\u4e5f\u5f88\u9ad8\uff1b\u8870\u8001\u901a\u5e38\u4f34\u968f\u7740\u7761\u7720\u6a21\u5f0f\u7684\u6539\u53d8\uff0c\u5305\u62ec\u7761\u7720\u4e2d\u65ad\u3001\u9891\u7e41\u9192\u6765\u548c\u65e9\u9192\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4\u7761\u7720\u65f6\u95f4\u51cf\u5c11[14]\u3002<\/span><span style=\"font-weight: 400;\"><b><strong style=\"font-style: inherit;\"><\/p>\n<p>3.SUNRISE 2\uff08\u7814\u7a76303\uff09[4]<\/strong><\/b><\/span><\/p>\n<p>SUNRISE 2\u662f\u4e00\u9879\u4e3a\u671f12\u4e2a\u6708\u7684\u591a\u4e2d\u5fc3\u3001\u5168\u7403\u6027\uff08\u65e5\u672c\u3001\u5317\u7f8e\u3001\u5357\u7f8e\u3001\u6b27\u6d32\u3001\u4e9a\u6d32\u548c\u5927\u6d0b\u6d32\uff09\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u3001\u5e73\u884c\u7ec4III\u671f\u7814\u7a76\uff0c\u7814\u7a76\u53d7\u8bd5\u8005\u4e3a949\u540d\u60a3\u6709\u5931\u7720\u969c\u788d\u7684\u7537\u6027\u6216\u5973\u6027\u6210\u5e74\u53c2\u4e0e\u8005\uff0818-88\u5c81\uff09\u3002SUNRISE 2\u5305\u62ec\u6700\u591a35\u5929\u7684\u9884\u968f\u673a\u5316\u9636\u6bb5\uff08\u5305\u62ec\u4e3a\u671f\u4e24\u5468\u7684\u5b89\u6170\u5242\u5bfc\u5165\u671f\uff09\u548c\u968f\u673a\u5316\u9636\u6bb5\uff0c\u968f\u673a\u5316\u9636\u6bb5\u5305\u62ec\u4e3a\u671f6\u4e2a\u6708\u7684\u5b89\u6170\u5242\u5bf9\u7167\u6cbb\u7597\u671f\u3001\u4e3a\u671f6\u4e2a\u6708\u7684\u4ec5\u79ef\u6781\u6cbb\u7597\u671f\u548c\u7814\u7a76\u7ed3\u675f\u8bbf\u89c6\u4e4b\u524d\u4e3a\u671f\u4e24\u5468\u7684\u65e0\u6cbb\u7597\u671f\u3002\u5728\u7814\u7a76\u7684\u524d\u516d\u4e2a\u6708\uff0c\u60a3\u8005\u6bcf\u665a\u5728\u5bb6\u6253\u7b97\u7761\u89c9\u524d\uff0c\u53e3\u670d5mg\u300110mg lemborexant\u6216\u76f8\u5e94\u7684\u5b89\u6170\u5242\u3002\u5728\u7b2c\u4e00\u4e2a\u516d\u4e2a\u6708\u671f\u95f4\u63a5\u53d7\u5b89\u6170\u5242\u7684\u60a3\u8005\u5728\u7b2c\u4e8c\u4e2a\u516d\u4e2a\u6708\u671f\u95f4\u670d\u75285mg\u621610mg lemborexant\u3002\u5728\u7b2c\u4e00\u9636\u6bb5\u63a5\u53d7\u79ef\u6781\u6cbb\u7597\u7684\u60a3\u8005\u7ee7\u7eed\u4ed6\u4eec\u6700\u521d\u968f\u673a\u63a5\u53d7\u7684\u6cbb\u7597\u3002<\/p>\n<p>\u4e3b\u8981\u7ed3\u679c\u6307\u6807\u662f\u7ecf\u8fc76\u4e2a\u6708\u5b89\u6170\u5242\u5bf9\u7167\u6cbb\u7597\u4e4b\u540e\u4e3b\u89c2\u5165\u7761\u6f5c\u4f0f\u671f\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u7684\u5e73\u5747\u53d8\u5316\u3002\u5173\u952e\u7684\u6b21\u8981\u7ed3\u679c\u6307\u6807\u5305\u62ec\u7ecf\u8fc76\u4e2a\u6708\u5b89\u6170\u5242\u5bf9\u7167\u6cbb\u7597\u4e4b\u540e\u7684\u4e3b\u89c2\u7761\u7720\u6548\u7387\u548c\u4e3b\u89c2\u5165\u7761\u540e\u89c9\u9192\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u7684\u5e73\u5747\u53d8\u5316\u3002<\/p>\n<p>\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0clemborexant\u7ec4\u7684\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u548c\u6240\u6709\u6b21\u8981\u7597\u6548\u7ec8\u70b9\u5747\u5df2\u8fbe\u5230\uff0c\u5e76\u4e14\u8bc1\u5b9e\uff0c\u5728\u516d\u4e2a\u6708\u7684\u6cbb\u7597\u671f\u5185\uff0c\u76f8\u6bd4\u4e8e\u5b89\u6170\u5242\u7ec4\uff0clemborexant\u7ec4\u5728\u5165\u7761\u548c\u7761\u7720\u7ef4\u6301\u65b9\u9762\u5b9e\u73b0\u7edf\u8ba1\u5b66\u663e\u8457\u6539\u5584\u3002lemborexant\u7ec4\u4e2d\u5e38\u89c1\u7684AE\u5305\u62ec\u55dc\u7761\u3001\u9f3b\u54bd\u708e\u3001\u5934\u75db\u548c\u6d41\u884c\u6027\u611f\u5192\u3002<\/p>\n<p><b><strong style=\"font-style: inherit;\">4.SUNRISE 1\uff08\u7814\u7a76304\uff09[3]<\/strong><\/b><\/p>\n<p>SUNRISE 1\u662f\u5173\u4e8elemborexant\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u4e3b\u52a8\u6bd4\u8f83\u5242\u3001\u5e73\u884c\u7ec4\u7684III\u671f\u7814\u7a76\uff0c\u7814\u7a76\u53d7\u8bd5\u8005\u4e3a1,006\u540d\u5e74\u6ee155\u5c81\u7684\u5931\u7720\u969c\u788d\u60a3\u8005\uff0845%\u7684\u60a3\u8005\u5e74\u6ee165\u5c81\uff09\uff0c\u7814\u7a76\u5730\u70b9\u4e3a\u5317\u7f8e\u548c\u6b27\u6d32\u3002SUNRISE 1\u5305\u62ec\u6700\u591a35\u5929\u7684\u9884\u968f\u673a\u5316\u9636\u6bb5\uff08\u5305\u62ec\u4e3a\u671f\u4e24\u5468\u7684\u5b89\u6170\u5242\u5bfc\u5165\u671f\uff09\u548c\u968f\u673a\u5316\u9636\u6bb5\uff08\u5305\u62ec\u4e3a\u671f30\u5929\u7684\u6cbb\u7597\u671f\u548c\u7814\u7a76\u7ed3\u675f\u968f\u8bbf\u4e4b\u524d\u4e3a\u671f\u4e24\u5468\u7684\u65e0\u6cbb\u7597\u671f\uff09\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u670d\u7528\u5b89\u6170\u5242\u6216\u4e09\u79cd\u6cbb\u7597\u65b9\u6848\u4e4b\u4e00\uff08lemborexant 5mg\u3001lemborexant 10mg\u3001\u5511\u5421\u5766ER 6.25mg\uff09\u3002<\/p>\n<p>SUNRISE 1\u7684\u4e3b\u8981\u76ee\u7684\u662f\u4f7f\u7528\u591a\u5bfc\u7761\u7720\u63cf\u8bb0\u672f\u8bc1\u660e5mg\u621610mg\u5242\u91cf\u7684lemborexant\u5728\u5ba2\u89c2\u5165\u7761\u65b9\u9762\u4f18\u4e8e\u5b89\u6170\u5242\uff0c\u901a\u8fc7\u6cbb\u7597\u4e4b\u540e\u4e00\u4e2a\u6708\u7684\u6700\u540e\u4e24\u4e2a\u665a\u4e0a\u6301\u7eed\u7761\u7720\u7684\u6f5c\u4f0f\u671f\u8fdb\u884c\u8861\u91cf\u3002\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u6cbb\u7597\u4e00\u4e2a\u6708\u540e\uff0clemborexant\u4e24\u4e2a\u5242\u91cf\u76f8\u6bd4\u4e8e\u5b89\u6170\u5242\u7684\u7761\u7720\u6548\u7387\uff0clemborexant\u4e24\u4e2a\u5242\u91cf\u76f8\u6bd4\u4e8e\u5b89\u6170\u5242\u7684\u7761\u7720\u540e\u89c9\u9192\uff08WASO\uff09\uff0c\u4ee5\u53ca\u76f8\u6bd4\u4e8e\u5511\u5421\u5766ER\uff0clemborexant\u4e24\u4e2a\u5242\u91cf\u5728\u4e0b\u534a\u591c\u7684WASO\uff08WASO2H\uff09\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u7684\u5e73\u5747\u53d8\u5316\uff0c\u5176\u901a\u8fc7\u591a\u5bfc\u7761\u7720\u63cf\u8bb0\u672f\u4e88\u4ee5\u5ba2\u89c2\u6d4b\u91cf\u3002<\/p>\n<p>\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5728\u4e3b\u8981\u7ec8\u70b9\u548c\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u8bc4\u4f30\u7684\u7761\u7720\u53c2\u6570\u65b9\u9762\uff0c\u76f8\u6bd4\u4e8e\u5511\u5421\u5766ER 6.25mg\u548c\u5b89\u6170\u5242\uff0clemborexant\u5b9e\u73b0\u7edf\u8ba1\u5b66\u663e\u8457\u6539\u5584\u3002DAYVIGO\u7ec4\u7684\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5305\u62ec\u5934\u75db\u548c\u55dc\u7761\u3002<\/p>\n<p><b><strong style=\"font-style: inherit;\">5.\u5173\u4e8e\u7814\u7a76106[5]<\/strong><\/b><\/p>\n<p>\u7814\u7a76106\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u548c\u4e3b\u52a8\u5bf9\u7167\u3001\u56db\u5468\u671f\u3001\u4ea4\u53c9\u7684I\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30lemborexant\u5bf948\u540d\u5065\u5eb7\u6210\u4eba\u548c\u8001\u5e74\u5fd7\u613f\u8005\uff0823-58\u5c81\uff0c\u5e73\u5747\u5e74\u9f84\uff1a58.5\u5c81\uff09\u7684\u5f71\u54cd\uff0c\u4ee5\u8bc4\u4ef7\u9053\u8def\u9a7e\u9a76\u8868\u73b0\u3002\u5fd7\u613f\u8005\uff0865\u5c81\u53ca\u4ee5\u4e0a\uff1a24\uff0c23-64\u5c81\uff1a24\uff09\u8fde\u7eed\u516b\u5929\u5728\u7761\u89c9\u65f6\u63a5\u53d7lemborexant\u4e09\u4e2a\u5242\u91cf\u6c34\u5e73\uff082.5\u30015\u621610mg\uff09\u4e2d\u7684\u4e24\u4e2a\u5242\u91cf\u6c34\u5e73\u548c\u5b89\u6170\u5242\u7684\u6cbb\u7597\u3002\u4f50\u5339\u514b\u96867.5mg\u4f5c\u4e3a\u4e3b\u52a8\u5bf9\u7167\uff0c\u4ec5\u5728\u7b2c\u4e00\u5929\u548c\u7b2c\u516b\u5929\u7ed9\u836f\uff0c\u5176\u95f4\u7684\u516d\u5929\u8fdb\u884c\u5b89\u6170\u5242\u7ed9\u836f\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u8bc4\u4f30\u7b2c\u4e00\u6b21\u6cbb\u7597\u7ed9\u836f\u4e4b\u540e9\u5c0f\u65f6\uff08\u7b2c2\u5929\u4e0a\u5348\uff09\u548c\u6700\u540e\u4e00\u5929\u6cbb\u7597\u7ed9\u836f\u4e4b\u540e9\u5c0f\u65f6\uff08\u7b2c9\u5929\u4e0a\u5348\uff09\u8fdb\u884c\u7684\u9053\u8def\u9a7e\u9a76\u8bd5\u9a8c\u671f\u95f4\u6a2a\u5411\u4f4d\u7f6e\u6807\u51c6\u504f\u5dee\u7684\u53d8\u5316\u3002<\/p>\n<p>\u5728\u516c\u8def\u6d4b\u8bd5\u4e2d\uff0c\u5fd7\u613f\u8005\u5728\u4e00\u540d\u6301\u8bc1\u9a7e\u9a76\u6559\u5458\u7684\u966a\u540c\u4e0b\uff0c\u9a7e\u9a76\u4e00\u8f86\u88c5\u6709\u7279\u6b8a\u4eea\u5668\u7684\u8f66\u8f86\uff0c\u5728100 km\uff08\u7ea660\u82f1\u91cc\uff09\u7684\u4e3b\u8981\u516c\u8def\u4e0a\u9a7e\u9a76\u7ea6\u4e00\u5c0f\u65f6\u3002\u5177\u4f53\u4efb\u52a1\u662f\u5728\u6162\u8f66\u9053\u7684\u5212\u5b9a\u8fb9\u754c\u4e4b\u95f4\uff0c\u4ee5\u7a33\u5b9a\u7684\u6a2a\u5411\u4f4d\u7f6e\u884c\u9a76\uff0c\u540c\u65f6\u4fdd\u630195 km\/h\u6052\u5b9a\u901f\u5ea6\u3002<\/p>\n<p>\u867d\u71365\u548c10mg\u5242\u91cf\u7684lemborexant\u5bf9\u6210\u5e74\u6216\u8001\u5e74\u53d7\u8bd5\u8005\u7b2c\u4e8c\u5929\u65e9\u6668\u7684\u9a7e\u9a76\u8868\u73b0\u672a\u9020\u6210\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u635f\u5bb3\uff08\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff09\uff0c\u4f46\u670d\u752810mg lemborexant\u7684\u4e00\u4e9b\u53d7\u8bd5\u8005\u7684\u9a7e\u9a76\u80fd\u529b\u53d7\u5230\u635f\u5bb3\u3002<\/p>\n<p><b><strong style=\"font-style: inherit;\">6.\u5173\u4e8e\u7814\u7a76108[6]<\/strong><\/b><\/p>\n<p>\u7814\u7a76108\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u56db\u5468\u671f\u3001\u4ea4\u53c9I\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30lemborexant\u5bf956\u540d55\u5c81\u53ca\u4ee5\u4e0a\u5065\u5eb7\u5fd7\u613f\u8005\u7684\u59ff\u52bf\u7a33\u5b9a\u6027\u3001\u542c\u89c9\u89c9\u9192\u9608\u503c\u548c\u8ba4\u77e5\u80fd\u529b\u7684\u5f71\u54cd\u3002\u53c2\u4e0e\u8005\u5728\u7761\u89c9\u65f6\u63a5\u53d7\u5355\u5242\u91cf\u5b89\u6170\u5242\u3001lemborexant 5mg\u3001lemborexant 10mg\u6216\u5511\u5421\u5766ER 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\u536b\u6750\uff0c\u4e00\u9879\u65e8\u5728\u7814\u7a76\u5bf9\u5931\u7720\u969c\u788d\u60a3\u8005\u4f7f\u7528lemborexant\u65f6\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u7684\u957f\u671f\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5bf9\u7167\u3001\u5e73\u884c\u7ec4\u7814\u7a76\uff08E2006-G000-303\uff09\u3002\uff08Clinicaltrials.gov\u6807\u8bc6\u7b26NCT02952820\uff09\u30022018\u3002\u5b58\u6863\u7684\u672a\u53d1\u5e03\u6570\u636e\u3002<br \/>\n5. \u536b\u6750\uff0c\u4e00\u9879\u65e8\u5728\u8bc4\u4ef7\u76f8\u6bd4\u4e8e\u5b89\u6170\u5242\uff0cDAYVIGO\u5bf9\u5065\u5eb7\u6210\u4eba\u548c\u8001\u5e74\u4eba\u9a7e\u9a76\u8868\u73b0\u7684\u5f71\u54cd\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u548c\u4e3b\u52a8\u63a7\u5236\u76844\u671f\u4ea4\u53c9\u7814\u7a76\uff08E2006-E044-106\uff09\u3002\uff08Clinicaltrials.gov\u6807\u8bc6\u7b26NCT02583451\uff09\u30022017\u3002\u5b58\u6863\u7684\u672a\u53d1\u5e03\u6570\u636e\u3002<br \/>\n6. \u536b\u6750\uff0c\u4e00\u9879\u65e8\u5728\u8bc4\u4ef7\u76f8\u6bd4\u4e8e\u5b89\u6170\u5242\u548c\u5511\u5421\u5766\uff0cDAYVIGO\u5bf9\u59ff\u52bf\u7a33\u5b9a\u6027\u3001\u542c\u89c9\u89c9\u9192\u7684\u5f71\u54cd\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u548c\u4e3b\u52a8\u6bd4\u8f83\u5242\u30014\u671f\u4ea4\u53c9\u7814\u7a76\uff08E2006-A001-108\uff09\u3002\uff08Clinicaltrials.gov\u6807\u8bc6\u7b26NCT03008447\uff09\u30022017\u3002\u5b58\u6863\u7684\u672a\u53d1\u5e03\u6570\u636e\u3002<br \/>\n7. Ferrie JE\u7b49\u4eba\uff0c\u7761\u7720\u6d41\u884c\u75c5\u5b66-\u4e00\u4e2a\u5feb\u901f\u53d1\u5c55\u7684\u9886\u57df\u3002\u300a\u56fd\u9645\u6d41\u884c\u75c5\u5b66\u671f\u520a\u300b2011\uff1b40(6):1431-1437.<br \/>\n8. Roth T.\uff0c\u5931\u7720\uff1a\u5b9a\u4e49\u3001\u60a3\u75c5\u7387\u3001\u75c5\u56e0\u548c\u540e\u679c\u3002\u300a\u4e34\u5e8a\u7761\u7720\u533b\u5b66\u6742\u5fd7\u300b2007\uff1b3\uff085\u8865\u7f16\uff09\uff1aS7-S10\u3002<br \/>\n9. Ohayon MM\u7b49\u4eba\uff0c\u5931\u7720\u75c7\u7684\u6d41\u884c\u75c5\u5b66\uff1a\u6211\u4eec\u5df2\u7ecf\u4e86\u89e3\u548c\u6211\u4eec\u4ecd\u7136\u9700\u8981\u4e86\u89e3\u7684\u77e5\u8bc6\u3002\u300a\u7761\u7720\u533b\u5b66\u8bc4\u8bba\u6742\u5fd7\u300b2002\uff1b6\uff082\uff09\uff1a97-111\u3002<br \/>\n10. Pase MP\u3001Himali JJ\u548cGrima NA\u7b49\u4eba\uff0c\u7761\u7720\u7ed3\u6784\u4e0e\u793e\u533a\u4e2d\u5076\u53d1\u75f4\u5446\u7684\u98ce\u9669\u3002\u300a\u795e\u7ecf\u75c5\u5b66\u300b2017\uff1b89(12):1244-1250.<br \/>\n11. Cappuccio FP\u7b49\u4eba\uff0c\u7761\u7720\u548c\u5fc3\u810f\u4ee3\u8c22\u75be\u75c5\u3002\u300a\u6700\u65b0\u5fc3\u810f\u5b66\u62a5\u544a\u300b2017\uff1b19:110\u3002<br \/>\n12. Cappuccio FP\u7b49\u4eba\uff0c\u7761\u7720\u6301\u7eed\u65f6\u95f4\u548c\u5168\u56e0\u6b7b\u4ea1\u7387\uff1a\u524d\u77bb\u6027\u7814\u7a76\u7684\u7cfb\u7edf\u56de\u987e\u548c\u835f\u8403\u5206\u6790\u3002\u300a\u7761\u7720\u300b2010\uff1b33(5):585-592.<br \/>\n13. Roth T\u7b49\u4eba\uff0c\u5931\u7720\u75c7\u60a3\u75c5\u7387\u548c\u57fa\u4e8eDSM-IV-TR\uff0c\u611f\u77e5\u7684\u5931\u7720\u75c7\u76f8\u5173\u5065\u5eb7\u95ee\u9898\uff1b\u300a\u75be\u75c5\u53ca\u76f8\u5173\u5065\u5eb7\u95ee\u9898\u7684\u56fd\u9645\u7edf\u8ba1\u5b66\u5206\u7c7b\u300b\uff0c\u7b2c\u5341\u4fee\u8ba2\u7248\uff1b\u548c\u7814\u7a76\u8bca\u65ad\u6807\u51c6\/\u56fd\u9645\u7761\u7720\u969c\u788d\u5206\u7c7b\uff0c\u7b2c\u4e8c\u7248\u6807\u51c6\uff1a\u7f8e\u56fd\u5931\u7720\u75c7\u8c03\u67e5\u7ed3\u679c\u3002\u300a\u751f\u7269\u7cbe\u795e\u75c5\u5b66\u300b2011\uff1b69:592\u2013600\u3002<br \/>\n14. 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