{"id":2990,"date":"2019-07-19T00:00:00","date_gmt":"2021-03-18T06:07:38","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=2990"},"modified":"2021-03-18T14:07:38","modified_gmt":"2021-03-18T06:07:38","slug":"2019%e5%b9%b4%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e5%8d%8f%e4%bc%9a%e5%9b%bd%e9%99%85%e4%bc%9a%e8%ae%ae%ef%bc%88aaic%ef%bc%89%e5%90%84%e4%bc%9a%e8%ae%ae%e5%92%8c%e7%a0%94%e8%ae%a8","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2019\/07\/19\/2019%e5%b9%b4%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e5%8d%8f%e4%bc%9a%e5%9b%bd%e9%99%85%e4%bc%9a%e8%ae%ae%ef%bc%88aaic%ef%bc%89%e5%90%84%e4%bc%9a%e8%ae%ae%e5%92%8c%e7%a0%94%e8%ae%a8\/","title":{"rendered":"2019\u5e74\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u534f\u4f1a\u56fd\u9645\u4f1a\u8bae\uff08AAIC\uff09\u5404\u4f1a\u8bae\u548c\u7814\u8ba8\u4f1a\u4e0a\u5173\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6cbb\u7597\u7684\u6700\u65b0\u8d8b\u52bf"},"content":{"rendered":"<p style=\"font-weight: 400;\">\u536b\u6750\u682a\u5f0f\u4f1a\u793e(\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0&#8221;\u536b\u6750&#8221;\uff09\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u534f\u4f1a\u56fd\u9645\u4f1a\u8bae\uff08AAIC\uff0cAlzheimer\u2019s Association International 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AAIC<\/strong><strong>\u7684\u4e13\u9898\u4f1a\u8bae\uff08BACEi\u8bd5\u9a8c\u7ed3\u679c\u8ba8\u8bba\uff1a\u6311\u6218\u548c\u673a\u9047\uff09<\/strong><\/li>\n<\/ol>\n<p>\u5728\u8fd9\u6b21\u4f1a\u8bae\u4e0a\uff0c\u5404\u516c\u53f8\u5206\u522b\u5c55\u793a\u4e86\u81ea\u5df1\u6301\u6709\u7684BACE\u6291\u5236\u5242\u7684\u76f8\u5173\u4fe1\u606f\u3002\u536b\u6750\u5219\u5168\u9762\u4ecb\u7ecd\u4e86\u4ee5\u4e0b\u975e\u4e34\u5e8a\u7814\u7a76\u548c\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u4ee5\u53ca\u5173\u4e8eElenbecestat\u7684\u4e34\u5e8a\u7814\u7a76\u73b0\u72b6\u3002<strong><br \/>\n<\/strong><\/p>\n<ul>\n<li style=\"font-weight: 400;\">\u6839\u636e\u975e\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\uff0cElenbecestat\u5728\u4f7f\u7528\u5230\u53ef\u663e\u8457\u964d\u4f4eCSF\u4e2d\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\uff08A\u03b2\uff09\u6c34\u5e73\u7684\u5242\u91cf\u65f6\uff0c\u672a\u663e\u793a\u5bf9\u6811\u7a81\u68d8\u5bc6\u5ea6\u4e0b\u964d\u548c\u7ebf\u7c92\u4f53\u529f\u80fd\u635f\u5bb3\u6709\u663e\u8457\u5f71\u54cd\uff0c\u4ee5\u4e0a\u4e24\u9879\u7686\u4e0e\u8ba4\u77e5\u529f\u80fd\u8870\u9000\u76f8\u5173\u3002<\/li>\n<li style=\"font-weight: 400;\">\u6570\u636e\u5b89\u5168\u76d1\u6d4b\u59d4\u5458\u4f1a\uff08DSMB\uff09\u5bf9900\u540d\u63a5\u53d7\u8be5\u6cbb\u75976\u4e2a\u6708\u6216\u4ee5\u4e0a\u7684\u60a3\u8005\u7684\u5b89\u5168\u6027\u6570\u636e\u8fdb\u884c\u4e86\u5305\u62ec\u8ba4\u77e5\u529f\u80fd\u53d8\u5316\u7684\u5b9a\u671f\u5ba1\u67e5\u3002\u5728\u6700\u8fd1\u7684\u4e00\u6b21\u5ba1\u67e5\u4e2d\uff0cDSMB\u5efa\u8bae\u7ee7\u7eed\u5bf9Elenbecestat\u7684III\u671f\u00a0Mission AD1\u548c2\u7814\u7a76\uff0c\u4e14\u4e0d\u505a\u4efb\u4f55\u4fee\u6539\u3002<\/li>\n<li style=\"font-weight: 400;\">\u5728II\u671f\u4e34\u5e8a\u7814\u7a76\uff08\u7814\u7a76202\uff09\u4e2d\uff0c\u60a3\u7531AD\u5bfc\u81f4\u7684\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\uff08MCI\uff09\u6216\u7531AD\u5bfc\u81f4\u7684\u8f7b\u81f3\u4e2d\u5ea6\u75f4\u5446\uff08\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u7406\u7ecf\u6b63\u7535\u5b50\u53d1\u5c04\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\uff08PET\uff09\u8bc1\u5b9e\uff09\u7684\u60a3\u8005\u5728\u63a5\u53d750mg Elenbecestat\u7ed9\u836f\u540e\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c18\u4e2a\u6708\u65f6\u6dc0\u7c89\u6837PET\u663e\u793a\u5927\u8111\u4e2d\u6dc0\u7c89\u6837\u86cb\u767d\u91cf\u663e\u8457\u51cf\u5c11\u3002<\/li>\n<li style=\"font-weight: 400;\">\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u572818\u4e2a\u6708\u65f6\uff0c\u4f7f\u7528\u4e34\u5e8a\u75f4\u5446\u8bc4\u5206\u603b\u548c\u91cf\u8868\uff08CDR-SB\uff09\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7efc\u5408\u8bc4\u5206\uff08ADCOMS\uff09\u7684\u4e34\u5e8a\u8bc4\u4f30\u7ed3\u679c\u663e\u793a\uff0cElenbecestat 50mg\u5242\u91cf\u7ec4\u7684\u6574\u4f53\u6076\u5316\u7a0b\u5ea6\u8f83\u5c0f\u3002\u7814\u7a76202\u4e2d\uff0cElenbecestat\u7684\u8010\u53d7\u6027\u53ef\u63a5\u53d7\u3002<\/li>\n<li style=\"font-weight: 400;\">Elenbecestat\u5df2\u88ab\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u8054\u5408\u4f1a\uff08ACTC, Alzheimer\u2019s Clinical Trials Consortium\uff09\u9009\u5b9a\u4e3a\u5f85\u8bc4\u4ef7\u6cbb\u7597\u65b9\u6848\uff0c\u5e76\u5c06\u5728\u5373\u5c06\u8fdb\u884c\u7684\u9488\u5bf9AD\u4e00\u7ea7\u9884\u9632\uff08A3\u7814\u7a76\uff09\u548c\u4e8c\u7ea7\u9884\u9632\uff08A45\u7814\u7a76\uff09\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fdb\u884c\u8bc4\u4ef7\uff1b\u7814\u7a76\u7b5b\u9009\u5c06\u4e8e2020\u5e74\u5f00\u59cb\u3002<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\u00a0<sup><br \/>\n<\/sup><\/p>\n<ol start=\"2\">\n<li><strong>\u536b\u6750\u53d1\u8d77\u7684\u7814\u8ba8\u4f1a\uff08\u4e34\u5e8a\u524d\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u9776\u5411\u6cbb\u7597\uff09<\/strong><\/li>\n<\/ol>\n<p style=\"font-weight: 400;\">\u5728\u672c\u6b21\u7814\u8ba8\u4f1a\u4e0a\uff0c\u5b66\u672f\u5148\u9a71\u4eec\u4f5c\u4e86\u4e00\u4e2a\u4e13\u9898\u4ecb\u7ecd\uff0c\u5305\u62ecAD\u7684\u751f\u7269\u5b66\u5b9a\u4e49\u3001\u5206\u5b50\u9014\u5f84\u548c\u65e9\u671f\u6cbb\u7597\u76f8\u5173\u7684\u95ee\u9898\u548c\u5c55\u671b\uff0c\u968f\u4e4b\u5c55\u5f00\u4e86\u4e00\u573a\u70ed\u70c8\u7684\u8ba8\u8bba\u3002<\/p>\n<p style=\"font-weight: 400;\">\u5927\u8111\u4e2d\u7684A\u03b2\u79ef\u7d2f\uff08A\u03b2\u662fAD\u7684\u81f4\u56e0\u7269\u8d28\uff09\u5728AD\u8bb0\u5fc6\u75c7\u72b6\u51fa\u73b0\u524d\u7684\u5341\u5230\u4e8c\u5341\u5e74\u4fbf\u5df2\u5f00\u59cb\uff0c\u56e0\u6b64\uff0c\u9700\u8981\u6839\u636e\u75c5\u7406\u800c\u4e0d\u662f\u4e34\u5e8a\u75c7\u72b6\u6765\u8fdb\u884c\u8bca\u65ad\u548c\u5206\u7c7b\u3002\u5728\u6700\u65b0\u7684AD\u5206\u7c7bATN\uff08\u6dc0\u7c89\u6837\u86cb\u767d\u3001Tau\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\/\u795e\u7ecf\u5143\u635f\u4f24\uff09\u4e2d\uff0c&#8221;AD\u662f\u4e00\u79cd\u968f\u7740\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4e00\u7cfb\u5217\u4e8b\u4ef6\u8fde\u7eed\u4f53\u800c\u53d1\u5c55\u53d8\u5316\u7684\u75be\u75c5&#8221;\u8fd9\u4e00\u6982\u5ff5\u5f97\u5230\u4e86\u8be0\u91ca\u3002\u968f\u7740\u751f\u7269\u6807\u5fd7\u7269\uff08\u8840\u6db2\u3001CSF\u3001\u5f71\u50cf\u5b66\uff09\u7814\u7a76\u7684\u8fdb\u5c55\uff0c\u5f15\u5165\u4e86AD\u73b0\u72b6\uff08\u80fd\u591f\u786e\u5b9aAD\u5206\u671f\uff0c\u5305\u62ec\u4e34\u5e8a\u524dAD\uff09\u8fd9\u4e00\u6982\u5ff5\u3002\u968f\u7740\u6b64\u7c7b\u8bca\u65ad\u6280\u672f\u7684\u53d1\u5c55\uff0c\u5bf9AD\u8fdb\u884c\u4e34\u5e8a\u524d\u6cbb\u7597\u6027\u5e72\u9884\u6210\u4e3a\u53ef\u80fd\u3002\u901a\u8fc7\u57fa\u4e8e\u901a\u8def\u7684\u9776\u5411\u7597\u6cd5\u6765\u51cf\u5c11\u6bd2\u6027A\u03b2\u79cd\u7c7b\u7684\u4ea7\u751f\uff0c\u662f\u6291\u5236AD\u53d1\u75c5\u7684\u7814\u7a76\u65b9\u6cd5\u4e2d\u7684\u4e00\u79cd\u5408\u7406\u9014\u5f84\u3002\u6b64\u5916\uff0c\u8fd8\u8ba8\u8bba\u4e86\u9488\u5bf9\u4eca\u540e\u7684\u7814\u7a76\u8bbe\u8ba1\u521b\u65b0\u3001\u8054\u5408\u7597\u6cd5\u7684\u5e94\u7528\u548c\u5efa\u7acb\u7cbe\u7b80\u5316\u8840\u57fa\u8bca\u65ad\u6cd5\u7684\u5c55\u671b\u3002<\/p>\n<p style=\"font-weight: 400;\">\u57fa\u4e8e\u5728\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u548c\u75f4\u5446\u9886\u57df\u8d85\u8fc735\u5e74\u7684\u836f\u7269\u7814\u53d1\u7ecf\u9a8c\uff0c\u536b\u6750\u529b\u6c42\u901a\u8fc7\u591a\u7ef4\u5ea6\u548c\u5168\u9762\u65b9\u6cd5\u6765\u5b9e\u73b0\u75f4\u5446\u7684\u9632\u6cbb\u3002\u536b\u6750\u81f4\u529b\u4e8e\u5c3d\u5feb\u7814\u53d1\u51fa\u521b\u65b0\u836f\u7269\uff0c\u4e3a\u6ee1\u8db3\u73b0\u5b58\u7684\u533b\u7597\u9700\u6c42\u548c\u63d0\u5347\u60a3\u8005\u53ca\u5176\u5bb6\u5c5e\u7684\u798f\u7949\u505a\u51fa\u8d21\u732e\u3002<\/p>\n<p><sup>*<\/sup>\u00a0\u00a0Elenbecestat\u00a0\u7531\u536b\u6750\u548c\u6e24\u5065\u516c\u53f8\uff08\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u7684\u5251\u6865\u5e02\uff0c\u4ee5\u4e0b\u7b80\u79f0&#8221;\u6e24\u5065&#8221;\uff09\u5171\u540c\u7814\u53d1\u3002<\/p>\n<p style=\"font-weight: 400;\">\n<p style=\"font-weight: 400;\"><strong>\u5a92\u4f53\u54a8\u8be2\uff1a<\/strong><br \/>\n\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff0c\u516c\u5173\u90e8<br \/>\n+81-(0)3-3817-5120<\/p>\n<p style=\"font-weight: 400;\">\n<p style=\"font-weight: 400;\"><strong>\u3010\u7f16\u8005\u6309\u3011<\/strong><br \/>\n<strong>1.<\/strong><strong>\u5173\u4e8e\u00a0Elenbecestat\u00a0\uff08\u901a\u7528\u540d\uff0c\u5f00\u53d1\u4ee3\u7801\uff1aE2609\uff09<\/strong><br \/>\nElenbecestat\u662f\u7531\u536b\u6750\u7387\u5148\u7814\u53d1\u7684\u4e00\u79cd\u4e0b\u4e00\u4ee3\u5019\u9009\u53e3\u670d\u836f\uff0c\u53ef\u901a\u8fc7\u6291\u5236\u00a0BACE 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