{"id":2996,"date":"2019-07-19T00:00:00","date_gmt":"2021-03-18T06:10:12","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=2996"},"modified":"2021-03-18T14:10:12","modified_gmt":"2021-03-18T06:10:12","slug":"%e5%8d%ab%e6%9d%90%e5%9c%a82019%e5%b9%b4%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e5%8d%8f%e4%bc%9a%e5%9b%bd%e9%99%85%e4%bc%9a%e8%ae%ae%ef%bc%88aaic%ef%bc%89%e4%b8%8a%e5%85%ac%e5%b8%83","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2019\/07\/19\/%e5%8d%ab%e6%9d%90%e5%9c%a82019%e5%b9%b4%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e5%8d%8f%e4%bc%9a%e5%9b%bd%e9%99%85%e4%bc%9a%e8%ae%ae%ef%bc%88aaic%ef%bc%89%e4%b8%8a%e5%85%ac%e5%b8%83\/","title":{"rendered":"\u536b\u6750\u57282019\u5e74\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u534f\u4f1a\u56fd\u9645\u4f1a\u8bae\uff08AAIC\uff09\u4e0a\u516c\u5e03\u6570\u636e\uff0c\u5c55\u793a\u8111\u810a\u6db2\u4e2dTAU\u5fae\u7ba1\u7ed3\u5408\u533a\u7684\u53ef\u5b9a\u91cf\u4ee5\u53ca\u65b0\u7814\u53d1\u7684\u6297-TAU\u6297\u4f53E2814\u7684\u9776\u70b9\u7ed3\u5408\u751f\u7269\u6807\u8bb0\u7269"},"content":{"rendered":"<p><span class=\"a0\">\u536b\u6750\u682a\u5f0f\u4f1a\u793e<span lang=\"EN-US\">(<\/span>\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0<span lang=\"EN-US\">\u201c<\/span>\u536b\u6750<span lang=\"EN-US\">\u201d<\/span>\uff09\u5ba3\u5e03\uff0c\u5176\u65b0\u7814\u53d1\u7684\u6297<span lang=\"EN-US\">-tau<\/span>\u6297\u4f53<span lang=\"EN-US\">E2814<sup>*1<\/sup><\/span>\u76f8\u5173\u6570\u636e\u5df2\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u534f\u4f1a\u56fd\u9645\u4f1a\u8bae\uff08<span lang=\"EN-US\">AAIC<\/span>\uff09\u4e0a\u516c\u5e03\uff08\u6d77\u62a5\u5c55\u793a\u7f16\u53f7\uff1a<span lang=\"EN-US\">P4-696)<\/span>\uff0c\u8be5\u4f1a\u8bae\u4e8e<span lang=\"EN-US\">2019<\/span>\u5e74<span lang=\"EN-US\">7<\/span>\u6708<span lang=\"EN-US\">14<\/span>\u65e5\u81f3<span lang=\"EN-US\">18<\/span>\u65e5\u5728\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u6d1b\u6749\u77f6\u4e3e\u884c\u3002<\/span><\/p>\n<p>\u7531\u805a\u96c6<span lang=\"EN-US\">tau<\/span>\u86cb\u767d\u7ec4\u6210\u7684\u795e\u7ecf\u539f\u7ea4\u7ef4\u7f20\u7ed3\u662f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u75c5\u7406\u7279\u5f81\u4e4b\u4e00\u3002\u5728\u75be\u75c5\u53d1\u5c55\u8fc7\u7a0b\u4e2d\uff0c<span lang=\"EN-US\">tau<\/span>\u88ab\u8ba4\u4e3a\u662f\u901a\u8fc7\u7a81\u89e6\u8fde\u63a5\u8fd9\u4e00\u901a\u8def\u5728\u6574\u4e2a\u5927\u8111\u4e2d\u4f20\u64ad\u7684\u3002\u8fd9\u79cd\u75c5\u7406\u4f20\u64ad\u88ab\u8ba4\u4e3a\u662f\u7531\u542b\u6709<span lang=\"EN-US\">tau<\/span>\u5fae\u7ba1\u7ed3\u5408\u533a\uff08<span lang=\"EN-US\">MTBR<\/span>\uff09\u7684<span lang=\"EN-US\">tau<\/span>\u7247\u6bb5\uff08<span lang=\"EN-US\">\u201c<\/span>\u79cd\u5b50<span lang=\"EN-US\">\u201d<\/span>\uff09\u6765\u4ecb\u5bfc\u7684\u3002<span lang=\"EN-US\">E2814<\/span>\u7684\u8bbe\u8ba1\u901a\u8fc7\u9776\u5411\u542b<span lang=\"EN-US\">MTBR<\/span>\u7684<span lang=\"EN-US\">tau<\/span>\u7247\u6bb5\u6765\u9632\u6b62<span lang=\"EN-US\">tau<\/span>\u79cd\u5b50\u7684\u79ef\u805a\u548c\u4f20\u64ad\uff0c\u4ece\u800c\u51cf\u7f13\u75be\u75c5\u7684\u8fdb\u7a0b\u3002<\/p>\n<p>\u536b\u6750\u6240\u63d0\u4f9b\u7684\u6570\u636e\u63cf\u8ff0\u4e86\u4e00\u79cd\u91cf\u5316<span lang=\"EN-US\">AD<\/span>\u60a3\u8005\u8111\u810a\u6db2\uff08<span lang=\"EN-US\">CSF<\/span>\uff09\u4e2d\u542b<span lang=\"EN-US\">MTBR<\/span>\u7684<span lang=\"EN-US\">tau<\/span>\u7247\u6bb5\u7684\u65b9\u6cd5\u3002\u6b64\u5916\uff0c\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u536b\u6750\u5c06<span lang=\"EN-US\">E2814<\/span>\u9776\u70b9\u7ed3\u5408\u751f\u7269\u6807\u8bb0\u7269\u5206\u6790\u4e0e\u542b<span lang=\"EN-US\">MTBR<\/span>\u7684<span lang=\"EN-US\">E2814<\/span>\u9776\u5411\u7684\u7247\u6bb5\u7ed3\u5408\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u5176\u7ed3\u679c\u8bc1\u5b9e\uff0c\u4eba\u8111\u810a\u6db2\u4e2d\u542b\u6709<span lang=\"EN-US\">MTBR<\/span>\u7684<span lang=\"EN-US\">tau<\/span>\u7247\u6bb5\u53ef\u4ee5\u88ab\u5b9a\u91cf\u3002\u4e0e\u5065\u5eb7\u6210\u4eba\uff08\u5e74\u9f84\u5728<span lang=\"EN-US\">46-75<\/span>\u5c81\u4e4b\u95f4\u7684\u767d\u79cd\u4eba\uff09\u76f8\u6bd4\uff0c<span lang=\"EN-US\">AD<\/span>\u60a3\u8005\uff08\u5e74\u9f84\u5728<span lang=\"EN-US\">64-84<\/span>\u5c81\u7684\u767d\u79cd\u4eba\uff0c<span lang=\"EN-US\">MMSE:13-26<\/span>\uff09\u8111\u810a\u6db2\u4e2d\u7684<span lang=\"EN-US\">MTBR<\/span>\u663e\u8457\u589e\u52a0\uff08<span lang=\"EN-US\">P&lt;0.0001<\/span>\uff09\u3002\u6b64\u5916\uff0c\u5728<span lang=\"EN-US\">AD<\/span>\u60a3\u8005\u7684\u8111\u810a\u6db2\u4e2d\uff0c\u542b\u6709<span lang=\"EN-US\">MTBR<\/span>\u7684<span lang=\"EN-US\">tau<\/span>\u7247\u6bb5\u4e0e\u78f7\u9178\u5316<span lang=\"EN-US\">tau<\/span>\uff08<span lang=\"EN-US\">R2=0.8849<\/span>\uff09\u6bd4\u4e0e\u603b<span lang=\"EN-US\">tau<\/span>\uff08<span lang=\"EN-US\">R2=0.7811<\/span><span class=\"a0\"><i>\uff09<\/i><\/span>\u66f4\u76f8\u5173\u3002\u8fd9\u53ef\u80fd\u63d0\u6697\u793a\u4e86\u7531<span lang=\"EN-US\">tau<\/span>\u4f20\u64ad\u7684\u75c5\u7406\u79cd\u7c7b\u3002\u7528<span lang=\"EN-US\">AD<\/span>\u60a3\u8005\u7684\u8111\u810a\u6db2\u540c<span lang=\"EN-US\">E2814<\/span>\u6df7\u5408\u8fdb\u884c\u7684\u4f53\u5916\u5b9e\u9a8c\u8868\u660e\uff0c<span lang=\"EN-US\">E2814<\/span>\u80fd\u591f\u540c\u6837\u672c\u4e2d\u5927\u591a\u6570\u542b<span lang=\"EN-US\">MTBR<\/span>\u7684<span lang=\"EN-US\">tau<\/span>\u76f8\u7ed3\u5408\u3002\u6b64\u5916\uff0c\u5728\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\u4e2d\u8fdb\u884c\u7684\u4f53\u5185\u5b9e\u9a8c\u8868\u660e\uff0c\u5728\u8111\u810a\u6db2\u6837\u672c\u4e2d\uff0c<span lang=\"EN-US\">E2814<\/span>\u4e0e\u542b\u6709<span lang=\"EN-US\">MTBR<\/span>\u7684<span lang=\"EN-US\">tau<\/span>\u7247\u6bb5\u8fdb\u884c\u5242\u91cf\u4f9d\u8d56\u6027\u7ed3\u5408\uff0c\u540c\u65f6\u6e38\u79bb\u7684\u542b<span lang=\"EN-US\">MTBR<\/span>\u7684<span lang=\"EN-US\">tau<\/span>\u7247\u6bb5\u51cf\u5c11\u3002<span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p>\u57fa\u4e8e\u5728\u963f\u5c14\u5179\u6d77\u9ed8\u75c5<span lang=\"EN-US\">\/<\/span>\u8001\u5e74\u75f4\u5446\u9886\u57df\u8d85\u8fc7<span lang=\"EN-US\">35<\/span>\u5e74\u7684\u836f\u7269\u7814\u53d1\u7ecf\u9a8c\uff0c\u536b\u6750\u529b\u6c42\u901a\u8fc7\u591a\u7ef4\u5ea6\u5168\u9762\u7684\u9014\u5f84\u6765\u5b9e\u73b0\u75f4\u5446\u7684\u9632\u6cbb\u3002\u536b\u6750\u52aa\u529b\u5c3d\u5feb\u7814\u53d1\u51fa\u521b\u65b0\u836f\u7269\uff0c\u4e3a\u6ee1\u8db3\u73b0\u5b58\u7684\u533b\u7597\u9700\u6c42\u548c\u63d0\u5347\u60a3\u8005\u53ca\u5176\u5bb6\u5c5e\u7684\u798f\u7949\u505a\u51fa\u8d21\u732e\u3002<\/p>\n<p><span lang=\"EN-US\"><\/p>\n<p><\/span><\/p>\n<p><span class=\"a0\"><sup><span lang=\"EN-US\">*1<\/span><\/sup><\/span><span class=\"a0\"><span lang=\"EN-US\"> E2814<\/span><\/span><span class=\"a0\">\u662f\u536b\u6750\u4e0e\u82f1\u56fd\u4f26\u6566\u5927\u5b66\u5b66\u9662\u5408\u4f5c\u7814\u7a76\u4e2d\u53d1\u73b0\u7684\u7b2c\u4e00\u4e2a\u4e34\u5e8a\u5019\u9009\u836f\u7269\uff0c\u662f\u8be5\u5408\u4f5c\u7814\u7a76\u7684\u4e00\u90e8\u5206\u3002<\/span><\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><b>\u5a92\u4f53\u54a8\u8be2\uff1a<\/b><\/p>\n<p>\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff0c\u516c\u5173\u90e8<\/p>\n<p><span lang=\"EN-US\">+81-(0)3-3817-5120<\/span><\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><b>\u3010\u7f16\u8005\u6309\u3011<\/b><\/p>\n<p><span class=\"a0\"><b><span lang=\"EN-US\">1. <\/span><\/b><\/span><span class=\"a0\"><b>\u5173\u4e8e<span lang=\"EN-US\">E2814<\/span><\/b><\/span><\/p>\n<p>\u4e00\u79cd\u6297<span lang=\"EN-US\">tau<\/span>\u5355\u514b\u9686\u6297\u4f53\u8bd5\u9a8c\u836f\u7269\u3002<span lang=\"EN-US\">E2814<\/span>\u662f\u4e00\u79cd\u5c1a\u5728\u5f00\u53d1\u4e2d\u7684\u9488\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5176\u4ed6<span lang=\"EN-US\">tau<\/span>\u86cb\u767d\u75c5\u7684\u75be\u75c5\u4fee\u9970\u836f\u7269\u3002\u76f8\u5173<span lang=\"EN-US\">I<\/span>\u671f\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u51c6\u5907\u4e2d\u3002\u8be5\u4e34\u5e8a\u5019\u9009\u836f\u7269\u662f\u5728\u536b\u6750\u548c\u82f1\u56fd\u4f26\u6566\u5927\u5b66\u5b66\u9662\u7684\u7814\u7a76\u5408\u4f5c\u4e2d\u7814\u53d1\u51fa\u6765\u7684\uff0c\u662f\u8be5\u5408\u4f5c\u7814\u7a76\u7684\u4e00\u90e8\u5206\u3002<span lang=\"EN-US\">E2814<\/span>\u7684\u8bbe\u8ba1\u4e3b\u65e8\u662f\u9632\u6b62<span lang=\"EN-US\">tau<\/span>\u86cb\u767d\u79cd\u5b50\u5728\u60a3\u8005\u7684\u5927\u8111\u4e2d\u4f20\u64ad\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u536b\u6750\u682a\u5f0f\u4f1a\u793e(\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u5ba3\u5e03\uff0c\u5176\u65b0\u7814\u53d1\u7684\u6297-tau\u6297\u4f53E2814*1\u76f8\u5173\u6570\u636e\u5df2\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u534f\u4f1a\u56fd\u9645\u4f1a\u8bae\uff08AAIC\uff09\u4e0a\u516c\u5e03\uff08\u6d77\u62a5\u5c55\u793a\u7f16\u53f7\uff1aP4-696)\uff0c\u8be5\u4f1a\u8bae\u4e8e2019\u5e747\u670814\u65e5\u81f318\u65e5\u5728\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u6d1b\u6749\u77f6\u4e3e\u884c\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-2996","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/2996"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=2996"}],"version-history":[{"count":2,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/2996\/revisions"}],"predecessor-version":[{"id":3000,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/2996\/revisions\/3000"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=2996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=2996"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=2996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}