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mg\/m2<\/sup>\u901a\u8fc7\u9759\u8109\u7ed9\u836f\uff09\u6cbb\u7597\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u4e3a\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002<\/p>\n \n 1\u00a0<\/sup>Yuan P et al., Eribulin mesilate versus vinorelbine in women with locally recurrent or metastatic breast cancer: A randomized clinical trial\u00a0Eur J Cancer,<\/em>\u00a02019; 112, 57-65 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\n2\u00a0<\/sup>Lei F et al., Breast cancer in China.\u00a0The Lancet Oncology,<\/em>\u00a02014; 15(7), e279\u2013e289
\n3<\/sup>\u00a0Ferlay J, et al., (2018). Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer.\u00a0https:\/\/gco.iarc.fr\/today<\/a>, As of July 17, 2019\u00a0\u00a0<\/sup>
\n4\u00a0<\/sup>Funahashi Y et al., Eribulin mesylate reduces tumor microenvironment abnormality by vascular remodeling in preclinical human breast cancer models.\u00a0Cancer Sci.,\u00a0<\/em>2014; 105, 1334-1342
\n5\u00a0<\/sup>Yoshida T et al., Eribulin mesilate suppresses experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) states. Br J Cancer, 2014; 110, 1497-1505<\/p>\n","protected":false},"excerpt":{"rendered":"