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Lemborexant\u4f5c\u7528\u4e8e\u98df\u6b32\u7d20\u795e\u7ecf\u9012\u8d28\u7cfb\u7edf\uff0c\u88ab\u8ba4\u4e3a\u80fd\u591f\u6291\u5236\u89c9\u9192\u800c\u4e0d\u59a8\u788d\u5916\u90e8\u5524\u9192\u523a\u6fc0\uff0c\u4ee5\u6b64\u6765\u8c03\u8282\u7761\u7720\u548c\u89c9\u9192\u8282\u5f8b\uff0c\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u5931\u7720\u75c7\u5728\u5185\u7684\u591a\u79cd\u7761\u7720\u00a0–\u00a0\u89c9\u9192\u969c\u788d\u3002\u7f8e\u56fd\u548c\u65e5\u672c\u5206\u522b\u57282018\u5e7412\u6708\u548c2019\u5e743\u6708\u63d0\u4ea4\u4e86Lemborexant\u65b0\u836f\u7533\u8bf7\uff0c\u5e0c\u671b\u83b7\u51c6\u5c06\u5176\u7528\u4e8e\u6cbb\u7597\u5931\u7720\u75c7\u3002\u6b32\u4e86\u89e3\u8fdb\u884c\u4e2d\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u8bf7\u8bbf\u95eeclinicaltrials.gov\u3002<\/p>\n
\u536b\u6750\u901a\u8fc7\u7814\u53d1Lemborexant\u6765\u4e3a\u9971\u53d7\u7761\u7720-\u89c9\u9192\u969c\u788d\u6298\u78e8\u7684\u60a3\u8005\u63d0\u4f9b\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u4ee5\u6539\u5584\u5176\u5165\u7761\u3001\u4fdd\u6301\u7761\u7720\u548c\u5728\u7b2c\u4e8c\u5929\u65e9\u6668\u5b8c\u597d\u9192\u6765\u7684\u80fd\u529b\uff0c\u5e76\u4e3a\u8fdb\u4e00\u6b65\u6ee1\u8db3\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u7684\u5404\u79cd\u9700\u6c42\u3001\u63d0\u9ad8\u5176\u798f\u7949\u505a\u51fa\u8d21\u732e\u3002<\/p>\n
\u25a0\u00a0Lemborexant\u6d77\u62a5\u5c55\u793a\uff1a<\/strong> <\/p>\n \u9664\u6d77\u62a5\u5c55\u793a\u5916\uff0c\u536b\u6750\u8fd8\u5c06\u4e3e\u529e\u4e00\u4e2a\u4e13\u9898\u7814\u8ba8\u4f1a\uff0c\u9488\u5bf9\u5173\u4e8e\u5931\u7720\u8bca\u65ad\u548c\u6cbb\u7597\u51b3\u7b56\u8fdb\u884c\u4e92\u52a8\u5bf9\u8bdd\u3002\u7814\u8ba8\u4f1a\u5c06\u4e8e\u5f53\u5730\u65f6\u95f46\u67089\u65e5\uff08\u661f\u671f\u65e5\uff09\u4e0b\u53486:15-8:30\u4e3e\u884c\u3002<\/p>\n <\/p>\n \u5a92\u4f53\u54a8\u8be2\uff1a<\/strong> Lemborexant\u662f\u4e00\u79cd\u65b0\u578b\u7684\u4e34\u5e8a\u8bd5\u7528\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u7531\u536b\u6750\u53d1\u73b0\u5e76\u8fdb\u884c\u5f00\u53d1\u3002\u8be5\u836f\u901a\u8fc7\u4e0e\u4e24\u79cd\u98df\u6b32\u7d20\u53d7\u4f53\u4e9a\u578b\uff08\u98df\u6b32\u7d20\u53d7\u4f531\u548c2\uff09\u8fdb\u884c\u7ade\u4e89\u6027\u7ed3\u5408\u6765\u6291\u5236\u98df\u6b32\u7d20\u7684\u4fe1\u53f7\u4f20\u5bfc\u3002\u5728\u5177\u6709\u6b63\u5e38\u7684\u6bcf\u65e5\u7761\u7720\u00a0–\u00a0\u89c9\u9192\u8282\u5f8b\u7684\u4e2a\u4f53\u4e2d\uff0c\u98df\u6b32\u7d20\u4fe1\u53f7\u4f20\u5bfc\u88ab\u8ba4\u4e3a\u53ef\u4fc3\u8fdb\u6e05\u9192\u3002\u5728\u60a3\u6709\u7761\u7720\u00a0–\u00a0\u89c9\u9192\u969c\u788d\u7684\u4e2a\u4f53\u4e2d\uff0c\u8c03\u8282\u89c9\u9192\u7684\u98df\u6b32\u7d20\u4fe1\u53f7\u4f20\u5bfc\u53ef\u80fd\u4e0d\u6b63\u5e38\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u6291\u5236\u4e0d\u6b63\u5e38\u7684\u98df\u6b32\u7d20\u4fe1\u53f7\u4f20\u5bfc\u53ef\u4ee5\u4fc3\u8fdb\u5165\u7761\u548c\u7ef4\u6301\u7761\u7720\u3002\u536b\u6750\u6b63\u5728\u5c06lemborexant\u4f5c\u4e3a\u591a\u79cd\u7761\u7720\u00a0–\u00a0\u89c9\u9192\u969c\u788d\uff08\u5982\u5931\u7720\u75c7\uff09\u7684\u4e00\u79cd\u53ef\u80fd\u7684\u6cbb\u7597\u9009\u62e9\u8fdb\u884c\u8c03\u7814\u3002<\/p>\n \u6b64\u5916\uff0c\u4e00\u9879\u5173\u4e8eLemborexant\u00a0\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u4e0d\u89c4\u5219\u7684\u7761\u7720-\u89c9\u9192\u8282\u5f8b\u969c\u788d\uff08ISWRD\uff09\u548c\u8f7b\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u75f4\u5446\u60a3\u8005\u4e2d\u8fdb\u884c\u3002<\/p>\n \n 2.<\/strong>\u5173\u4e8e\u7761\u7720\u969c\u788d<\/strong><\/p>\n \u591a\u4e2a\u4eba\u53e3\u7814\u7a76\u663e\u793a\uff0c\u5168\u4e16\u754c\u53d7\u7761\u7720\u969c\u788d\u5f71\u54cd\u7684\u4eba\u6570\u6bd4\u5148\u524d\u8ba4\u4e3a\u7684\u8981\u591a\u30021<\/sup>\u5931\u7720\u75c7\u662f\u6700\u5e38\u89c1\u7684\u7761\u7720\u969c\u788d\uff0c\u5168\u4e16\u754c\u7ea6\u670930\uff05\u7684\u6210\u5e74\u4eba\u6709\u6301\u7eed\u5931\u7720\u7684\u75c7\u72b6\u30021,2<\/sup>\u5931\u7720\u75c7\u7684\u7279\u70b9\u662f\u62e5\u6709\u8db3\u591f\u7684\u7761\u7720\u673a\u4f1a\u5374\u5165\u7761\u56f0\u96be\uff0c\u4e0d\u80fd\u5165\u7761\u6216\u4e24\u8005\u517c\u800c\u6709\u4e4b\u3002\u8fd9\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4e00\u4e9b\u767d\u5929\u75c7\u72b6\uff0c\u5982\u75b2\u52b3\uff0c\u6ce8\u610f\u529b\u4e0d\u96c6\u4e2d\u548c\u70e6\u8e81\u4e0d\u5b89\u7b49\u30023,4<\/sup><\/p>\n \u597d\u7684\u7761\u7720\u5bf9\u5305\u62ec\u5927\u8111\u5065\u5eb7\u5728\u5185\u7684\u8eab\u4f53\u5065\u5eb7\u81f3\u5173\u91cd\u8981\u3002\u7761\u7720\u4e0d\u4f73\u53ef\u5bfc\u81f4\u591a\u79cd\u5065\u5eb7\u95ee\u9898\uff0c\u5982\u9ad8\u8840\u538b\u3001\u610f\u5916\u4f24\u5bb3\u3001\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\u3001\u6291\u90c1\u3001\u5fc3\u810f\u75c5\u3001\u4e2d\u98ce\u548c\u75f4\u5446\u75c7\u98ce\u9669\u589e\u52a0\u7b49\uff0c\u5e76\u53ef\u80fd\u5bf9\u60c5\u7eea\u548c\u884c\u4e3a\u4ea7\u751f\u4e0d\u826f\u5f71\u54cd\u30023,5<\/sup><\/p>\n \u5bf9\u52a8\u7269\u548c\u4eba\u7c7b\u7684\u5b9e\u9a8c\u7814\u7a76\u63d0\u4f9b\u4e86\u7761\u7720\u548c\u75be\u75c5\u98ce\u9669\u56e0\u7d20\u3001\u75be\u75c5\u548c\u6b7b\u4ea1\u7387\u76f8\u5173\u7684\u8bc1\u636e\u30026<\/sup>\u7814\u7a76\u8868\u660e\uff0c\u6700\u4f73\u7761\u7720\u65f6\u957f\u4e3a7\u81f38\u4e2a\u5c0f\u65f6\u30027<\/sup>\u5973\u6027\u7f79\u60a3\u5931\u7720\u75c7\u7684\u53ef\u80fd\u6027\u662f\u7537\u6027\u76841.4\u500d\u30028<\/sup>\u8001\u5e74\u4eba\u5931\u7720\u7684\u60a3\u75c5\u7387\u4e5f\u8f83\u9ad8;\u00a0\u4eba\u7c7b\u8001\u53bb\u7684\u8fc7\u7a0b\u5f80\u5f80\u4f34\u968f\u7740\u7761\u7720\u6a21\u5f0f\u7684\u53d8\u5316\uff0c\u5305\u62ec\u7761\u7720\u4e2d\u65ad\u3001\u9891\u7e41\u9192\u6765\u548c\u65e9\u9192\u7b49\uff0c\u8fd9\u4e9b\u90fd\u4f1a\u4f7f\u7761\u7720\u65f6\u95f4\u51cf\u5c11\u30029<\/sup><\/p>\n \n \u53c2\u8003\u8d44\u6599<\/strong><\/b><\/p>\n 1<\/sup>\u00a0Ferrie JE, et al. Sleep epidemiology \u2013 a rapidly growing field.\u00a0Int J Epidemiol<\/em>. 2011;40(6):1431\u20131437. \u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5c06\u5728\u8054\u5408\u4e13\u4e1a\u7761\u7720\u5b66\u4f1a(Associated Professional Sleep Societies)\u7b2c33\u5c4a\u5e74\u4f1a\uff08SLEEP 2019\uff09\u4e0a\u53d1\u5e03\u6709\u5173Lemborexant\u7684\u6700\u65b0\u6d88\u606f\u3002Lemborexant\u662f\u4e00\u79cd\u6b63\u5728\u5f00\u53d1\u4e2d\u7684\u7761\u7720-\u89c9\u9192\u8c03\u8282\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u7761\u7720-\u89c9\u9192\u969c\u788d\uff0c\u5305\u62ec\u5931\u7720\u75c7\u548c\u4e0d\u89c4\u5219\u7761\u7720-\u89c9\u9192\u8282\u5f8b\u969c\u788d\uff08Irregular Sleep-Wake Rhythm Disorder\uff0cISWRD\uff09\u3002\u5927\u4f1a\u5c06\u4e8e6\u67088\u65e5\u81f312\u65e5\u5728\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u5dde\u7684\u5723\u5b89\u4e1c\u5c3c\u5965\u5e02\u4e3e\u884c\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-3055","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3055"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=3055"}],"version-history":[{"count":2,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3055\/revisions"}],"predecessor-version":[{"id":3057,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3055\/revisions\/3057"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=3055"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=3055"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=3055"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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\n\u516c\u5171\u5173\u7cfb\u90e8
\n+81-(0)3-3817-5120<\/p>\n
\n\u3010\u7f16\u8005\u6309\u3011<\/strong>
\n1.<\/strong>\u5173\u4e8eLemborexant<\/strong><\/span><\/p>\n
\n2<\/sup>\u00a0Roth T. Insomnia: definition, prevalence, etiology and consequences.\u00a0J Clin Sleep Med<\/em>. 2007;3(5 Suppl):S7\u2013S10.
\n3<\/sup>\u00a0Institute of Medicine. Sleep disorders and sleep deprivation: An unmet public health problem. Washington, DC: National Academies Press. 2006.
\n4<\/sup>\u00a0Ohayon MM, et al. Epidemiology of insomnia: what we know and what we still need to learn.\u00a0Sleep Med Rev<\/em>. 2002;6(2):97-111.
\n5<\/sup>\u00a0Pase MP, Himali JJ, Grima NA, et al. Sleep architecture and the risk of incident dementia in the community.\u00a0Neurology<\/em>. 2017;89(12):1244-1250.
\n6<\/sup>\u00a0Cappuccio FP et al. Sleep and cardio-metabolic disease.\u00a0Curr Cardiol Rep<\/em>. 2017;19:110.
\n7<\/sup>\u00a0Cappuccio FP et al. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies.\u00a0Sleep<\/em>. 2010;33(5):585-592.
\n8<\/sup>\u00a0Roth T, et al. Prevalence and perceived health associated with insomnia based on DSM-IV-TR; International Statistical Classification of Diseases and Related Health Problems, tenth revision; and Research Diagnostic Criteria\/International Classification of Sleep Disorders, second edition criteria: results from the America Insomnia Survey.\u00a0Biol Psychiatry<\/em>. 2011;69:592\u2013 600.
\n9<\/sup>\u00a0Crowley, K. Sleep and sleep disorders in older adults.\u00a0Neuropsychol Rev<\/em>. 2011;21(1):41-53.<\/p>\n","protected":false},"excerpt":{"rendered":"