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2018\u5e7410\u670825\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u6e24\u5065\u516c\u53f8\uff08Biogen Inc.\uff0c\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aBIIB\uff09\uff08\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u5e02\uff0cCEO\u4e3aMichel Vounatsos\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u6e24\u5065\u201d\uff09\u5171\u540c\u5ba3\u5e03\uff0c\u536b\u6750\u5df2\u5728\u7b2c11\u5c4a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e34\u5e8a\u8bd5\u9a8c\uff08CTAD\uff09\u5927\u4f1a\uff08\u4e8e10\u670825\u65e5\u5728\u897f\u73ed\u7259\u5df4\u585e\u7f57\u90a3\u53ec\u5f00\uff09\u7684\u4e13\u9898\u7814\u8ba8\u4f1a\u4e0a\u53d1\u5e03\u4e86\u9898\u4e3a\u300a\u5728\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u4e2d\u8fdb\u884c\u7684BAN2401\u7684201\u7814\u7a76\u7684\u4e34\u5e8a\u548c\u751f\u7269\u6807\u5fd7\u7269\u66f4\u65b0\u300b\uff0c\u4ecb\u7ecd\u6297\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u539f\u7ea4\u7ef4\u6297\u4f53BAN2401\u5728II\u671f\u4e34\u5e8a\u7814\u7a76\uff08201\u7814\u7a76\uff09\u4e2d\u7684\u6700\u65b0\u6570\u636e\u3002<\/p>\n

201\u7814\u7a76\uff08ClinicalTrials.gov\u00a0\u767b\u8bb0\u53f7NCT01767311\uff09\u662f\u4e00\u9879\u5728856\u4f8b\u7531\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u5bfc\u81f4\u7684\u8f7b\u5ea6\u8ba4\u77e5\u529f\u80fd\u969c\u788d\uff08MCI\uff09\u6216\u8f7b\u5ea6AD\u578b\u75f4\u5446\uff08\u7edf\u79f0\u4e3a\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff09\u5e76\u786e\u8ba4\u5b58\u5728\u8111\u6dc0\u7c89\u6837\u75c5\u7406\u6539\u53d8\u7684\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u3001\u5e73\u884c\u3001\u968f\u673a\u4e34\u5e8a\u7814\u7a76\u3002\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u5230\u4e94\u4e2a\u5242\u91cf\u6cbb\u7597\u7ec4\uff0c\u5206\u522b\u662f\uff1a\u6bcf\u4e24\u54682.5mg\/kg\u3001\u6bcf\u67085mg\/kg\u3001\u6bcf\u4e24\u54685mg\/kg\uff0c\u6bcf\u670810mg\/kg\u548c\u6bcf\u4e24\u546810mg\/kg\uff0c\u6216\u8005\u88ab\u5206\u914d\u5230\u5b89\u6170\u5242\u7ec4\u3002\u672c\u7814\u7a76\u91c7\u7528\u8d1d\u53f6\u65af\u81ea\u9002\u5e94\u968f\u673a\u5316\u8bbe\u8ba1\uff0c\u6839\u636e\u4e2d\u671f\u5206\u6790\u7684\u7ed3\u679c\uff0c\u5c06\u65b0\u62db\u52df\u7684\u60a3\u8005\u81ea\u52a8\u5206\u914d\u5230\u663e\u793a\u7597\u6548\u66f4\u597d\u7684\u6cbb\u7597\u7ec4\u3002\u7814\u7a76\u8ba4\u4e3a\u6bcf\u670810mg\/kg\u548c\u6bcf\u4e24\u546810mg\/kg\u5242\u91cf\u7597\u6548\u66f4\u4e3a\u663e\u8457\uff0c\u6240\u4ee5\u5206\u914d\u7ed9\u8fd9\u4e24\u4e2a\u6cbb\u7597\u7ec4\u7684\u60a3\u8005\u5360\u6bd4\u66f4\u5927\u4e9b\u3002<\/p>\n

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\u6211\u4eec\u8fd8\u5bf9\u9884\u5148\u8bbe\u5b9a\u4e9a\u7ec4\u8fdb\u884c\u4e86\u4e34\u5e8a\u7ed3\u679c\u5206\u6790\u3002\u5206\u6790\u6309\u7167\u4e34\u5e8a\u5206\u671f\u548c\u662f\u5426\u540c\u65f6\u670d\u7528\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u836f\u7269\u4e24\u4e2a\u65b9\u5411\u8fdb\u884c\u3002\u6700\u9ad8\u5242\u91cf\u7ec4\u7684\u53e6\u4e00\u4e2a\u5206\u6790\u7ed3\u679c\u662f\uff1a\u572818\u4e2a\u6708\u65f6\u5404\u4e34\u5e8a\u9636\u6bb5\u4e9a\u7ec4\u540c\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0cADCOMS\u7684\u75be\u75c5\u8fdb\u5c55\u51cf\u7f13\uff08AD\u5bfc\u81f4\u7684MCI\u4e9a\u7ec4\uff1a33\uff05\uff1b\u8f7b\u5ea6AD\u4e9a\u7ec4\uff1a35\uff05\uff09\u3002\u5728\u5408\u5e76\u670d\u7528\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u836f\u7269\u65b9\u9762\uff08\u540c\u65f6\u670d\u7528AD\u836f\u7269\uff1a23\uff05\uff1b\u4e0d\u540c\u65f6\u670d\u7528AD\u836f\u7269\uff1a41\uff05\uff09\u3002\u8be5\u7814\u7a76\u4e2d\u4e9a\u7ec4\u672a\u663e\u793a\u51fa \u7edf\u8ba1\u5b66\u610f\u4e49\u3002<\/p>\n

\u536b\u6750\u8fd8\u63d0\u4f9b\u4e86\u5173\u4e8eAD\u60a3\u8005\u4e2d\u795e\u7ecf\u53d8\u6027\u7684CSF\u751f\u7269\u6807\u5fd7\u7269\u5347\u9ad8\u7684\u63a2\u7d22\u6027\u6570\u636e\u3002\u4e3a\u4e86\u589e\u52a0CSF\u4e9a\u7ec4\u7684\u6837\u672c\u91cf\uff0c\u5408\u5e76\u4e86\u53cc\u546810mg\/kg\u548c\u6bcf\u670810mg\/kg\u7ec4\u7fa4\u6837\u54c1\u8fdb\u884c\u5206\u6790\u3002\u4ece\u7ed3\u679c\u6765\u770b\uff0c\u7a81\u89e6\u635f\u4f24\uff08\u795e\u7ecf\u9897\u7c92\u7d20\uff09\uff0ctau\u75c5\u7406\u5b66\uff08\u78f7\u9178\u5316-tau\uff0cp-Tau\uff09\u548c\u8f74\u7a81\u53d8\u6027\uff08\u795e\u7ecf\u4e1d\u8f7b\u94fe\uff0cNFL\uff09\u7684\u6807\u5fd7\u7269\u663e\u793a\u51fa\u4e00\u79cd\u8d8b\u52bf\uff0c\u5373\u8be5\u836f\u53ef\u80fd\u5bf9\u6f5c\u5728\u75be\u75c5\u7684\u75c5\u7406\u751f\u7406\u5b58\u5728\u5f71\u54cd\u3002<\/p>\n

18\u4e2a\u6708\u7684\u7814\u7a76\u836f\u7269\u670d\u836f\u53f2\u8bc1\u5b9e\uff0cBAN2401\u7684\u8010\u53d7\u6027\u5728\u53ef\u63a5\u53d7\u8303\u56f4\u3002\u6700\u5e38\u89c1\u7684\u6cbb\u7597\u4e2d\u7d27\u6025\u4e0d\u826f\u4e8b\u4ef6\u662f\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u548c\u6dc0\u7c89\u6837\u86cb\u767d\u76f8\u5173\u5f71\u50cf\u5f02\u5e38\uff08ARIA\uff09\uff0c\u4e24\u8005\u90fd\u662f\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u3002APOE4\u643a\u5e26\u8005\u4e2dARIA-E\uff08\u6c34\u80bf\uff09\u7684\u53d1\u751f\u7387\u66f4\u9ad8\u4e9b\u300210\uff05\u7684ARIA-E\u75c5\u4f8b\uff0848\u4f8b\u60a3\u8005\u4e2d\u67095\u4f8b\uff09\u51fa\u73b0\u4e86\u4e0d\u826f\u53cd\u5e94\u75c7\u72b6\uff0c\u5305\u62ec\u5934\u75db\u3001\u89c6\u529b\u969c\u788d\u548c\u610f\u8bc6\u6a21\u7cca\u300260\uff05\u7684ARIA-E\u53d1\u751f\u5728\u6cbb\u7597\u7684\u524d\u4e09\u4e2a\u6708\u5185\uff0c\u7ea689\uff05\u7684\u75c5\u4f8b\u4e0d\u826f\u53cd\u5e94\u7684\u4e25\u91cd\u7a0b\u5ea6\u4e3a\u8f7b\u4e2d\u5ea6\u3002<\/p>\n

\u536b\u6750\u548c\u6e24\u5065\u76ee\u524d\u6b63\u5728\u4e0e\u76d1\u7ba1\u673a\u6784\u63a2\u8ba8BAN2401\u7684\u4e0b\u4e00\u6b65\u8ba1\u5212\u3002\u76ee\u524d\u6b63\u8ba1\u5212\u5bf9\u4e4b\u524d201\u7814\u7a76\u7684\u53d7\u8bd5\u8005\u8fdb\u884c\u5f00\u653e\u6027\u6269\u5c55\u7814\u7a76\u7684\u62db\u52df\uff0c\u9884\u8ba1\u5c06\u4e8e\u4eca\u5e74\u5f00\u59cb\u62db\u52df\u3002<\/p>\n

\u672c\u65b0\u95fb\u7a3f\u63a2\u8ba8\u4e86\u8fd9\u4e00\u5c1a\u5728\u5f00\u53d1\u7684\u836f\u7269\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u4f5c\u7528\uff0c\u5e76\u975e\u65e8\u5728\u4f20\u8fbe\u5173\u4e8e\u6709\u6548\u6027\u6216\u5b89\u5168\u6027\u7684\u7ed3\u8bba\u3002\u6211\u4eec\u65e0\u6cd5\u4fdd\u8bc1\u8be5\u4ea7\u54c1\u7684\u4efb\u4f55\u7814\u7a76\u4f5c\u7528\u80fd\u591f\u6210\u529f\u5b8c\u6210\u4e34\u5e8a\u5f00\u53d1\u6216\u83b7\u5f97\u536b\u751f\u76d1\u7ba1\u5f53\u5c40\u7684\u6279\u51c6\u3002<\/p>\n

\n\n\n\n\n
\u5a92\u4f53\u54a8\u8be2<\/strong><\/b><\/td>\n<\/tr>\n
\u536b\u6750\u682a\u5f0f\u4f1a\u793e
\n\u516c\u5171\u5173\u7cfb\u90e8
\n\u7535\u8bdd\uff1a+81-(0)3-3817-5120<\/p>\n

\u536b\u6750\uff08\u7f8e\u56fd\uff09
\n\u516c\u5171\u5173\u7cfb\u90e8
\n\u7535\u8bdd: +1-551-262-2686<\/td>\n

\n\u6e24\u5065\uff08Biogen\uff09
\n\u516c\u5171\u4e8b\u52a1\u90e8
\n\u7535\u8bdd\uff1a+1-781-464-3260
\npublic.affairs@biogen.com<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n

<\u7f16\u8005\u6309><\/strong><\/b>
\n1\u3001BAN2401<\/strong><\/b>
\nBAN2401\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u5176\u4e3a\u536b\u6750\u4e0eBioArctic\u4e4b\u95f4\u6218\u7565\u7814\u7a76\u8054\u76df\u7684\u7814\u7a76\u6210\u679c\u3002BAN2401\u901a\u8fc7\u9009\u62e9\u6027\u7ed3\u5408\u6765\u4e2d\u548c\u5e76\u6d88\u9664\u53c2\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u795e\u7ecf\u9000\u884c\u6027\u53d8\u5316\u8fc7\u7a0b\u7684\u53ef\u6eb6\u6027\u6bd2\u6027A\u03b2\u805a\u96c6\u4f53\u3002\u56e0\u6b64\uff0cBAN2401\u53ef\u80fd\u4f1a\u5bf9\u75be\u75c5\u75c5\u7406\u4ea7\u751f\u4f5c\u7528\u5e76\u51cf\u7f13\u75be\u75c5\u8fdb\u5c55\u3002\u6839\u636e2007\u5e7412\u6708\u4e0eBioArctic\u8fbe\u6210\u7684\u534f\u8bae\uff0c\u536b\u6750\u83b7\u5f97\u4e86\u5728\u5168\u7403\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684BAN2401\u7684\u6743\u5229\u30022014\u5e743\u6708\uff0c\u536b\u6750\u4e0e\u6e24\u5065\uff08Biogen\uff09\u5c31BAN2401\u7b7e\u8ba2\u4e86\u4e00\u4efd\u8054\u5408\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u534f\u8bae\uff0c\u53cc\u65b9\u4e8e2017\u5e7410\u6708\u5bf9\u8be5\u534f\u8bae\u8fdb\u884c\u4e86\u4fee\u8ba2\u3002<\/p>\n

2\u3001201\u7814\u7a76<\/strong><\/b>
\n201\u7814\u7a76\u662f\u4e00\u9879\u5728856\u4f8b\u7531\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u5bfc\u81f4\u7684\u8f7b\u5ea6\u8ba4\u77e5\u529f\u80fd\u969c\u788d\uff08MCI\uff09\u6216\u8f7b\u5ea6AD\u578b\u75f4\u5446\uff08\u7edf\u79f0\u4e3a\u201c\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u201d\uff09\u5e76\u786e\u8ba4\u5b58\u5728\u8111\u6dc0\u7c89\u6837\u75c5\u7406\u6539\u53d8\u7684\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u3001\u5e73\u884c\u3001\u968f\u673aII\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u672c\u7814\u7a76\u91c7\u7528\u8d1d\u53f6\u65af\u81ea\u9002\u5e94\u968f\u673a\u5316\u8bbe\u8ba1\uff0c\u6839\u636e\u4e2d\u671f\u5206\u6790\u7684\u7ed3\u679c\uff0c\u5c06\u65b0\u62db\u52df\u7684\u60a3\u8005\u81ea\u52a8\u5206\u914d\u5230\u663e\u793a\u7597\u6548\u66f4\u597d\u7684\u6cbb\u7597\u7ec4\u3002\u7814\u7a76\u8bbe\u8ba1\u5305\u62ec\u4e94\u4e2a\u5242\u91cf\u6cbb\u7597\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\uff0c\u5e76\u901a\u8fc716\u9879\u8bc4\u4f30\u65e9\u671f\u6210\u529f\u53ef\u80fd\u6027\u7684\u4e2d\u671f\u5206\u6790\u30011\u9879\u57fa\u4e8e12\u4e2a\u6708\u65f6ADCOMS\u7684\u5206\u6790\u4ee5\u53ca1\u987918\u4e2a\u6708\u65f6\u7684\u5168\u9762\u6700\u7ec8\u5206\u6790\uff0c\u8003\u8651\u5c06BAN2401\u7684\u7597\u6548\u4ee5\u53ca\u5242\u91cf\u6548\u5e94\u4f5c\u4e3a\u63a2\u7d22\u6027\u7ec8\u70b9\u3002\u63a5\u53d7BAN2401\u6cbb\u7597\u7684\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u81f35\u4e2a\u5242\u91cf\u65b9\u6848\u7ec4\uff0c\u6bcf\u4e24\u54682.5 mg\/kg\uff0852\u4f8b\u60a3\u8005\uff09\u3001\u6bcf\u67085 mg\/kg\uff0851\u4f8b\u60a3\u8005\uff09\u3001\u6bcf\u4e24\u54685 mg\/kg\uff0892\u4f8b\u60a3\u8005\uff09\u3001\u6bcf\u670810 mg\/kg\uff08253\u4f8b\u60a3\u8005\uff09\u4ee5\u53ca\u6bcf\u4e24\u546810 mg\/kg\uff08161\u4f8b\u60a3\u8005\uff09\u3002\u751f\u7269\u6807\u5fd7\u7269\u7ec8\u70b9\u5305\u62ec\u901a\u8fc7\u6dc0\u7c89\u6837\u86cb\u767dPET\uff08\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff09\u6d4b\u91cf\u53d1\u73b0\u8111\u4e2d\u4ee5\u53ca\u8111\u810a\u6db2\uff08CSF\uff09\u4e2d\u7684A\u03b2\u79ef\u805a\u53d8\u5316\uff0c\u800cADCOMS\uff08\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7efc\u5408\u8bc4\u5206\uff09\u3001\u4e34\u5e8a\u75f4\u5446\u7efc\u5408\u6c47\u603b\u8bc4\u5b9a\u91cf\u8868\uff08CDR-SB\uff09\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8bc4\u4f30\u91cf\u8868\u00a0–\u00a0\u8ba4\u77e5\u5206\u91cf\u8868\uff08ADAS-Cog\uff09\u5219\u4f5c\u4e3a\u7597\u6548\u7ec8\u70b9\uff08\u4e34\u5e8a\uff09\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n

3\u3001ADCOMS<\/strong><\/b>
\nADCOMS\uff08AD\u7efc\u5408\u8bc4\u5206\uff09\u7531\u536b\u6750\u5f00\u53d1\uff0c\u7ed3\u5408\u4e86ADAS-Cog\uff08\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8bc4\u4f30\u91cf\u8868\u00a0–\u00a0\u8ba4\u77e5\u5206\u91cf\u8868\uff09\u3001CDR-SB\uff08\u4e34\u5e8a\u75f4\u5446\u7efc\u5408\u6c47\u603b\u8bc4\u5b9a\u91cf\u8868\uff09\u548cMMSE\uff08\u7b80\u6613\u667a\u529b\u72b6\u6001\u68c0\u67e5\u91cf\u8868\uff09\u4e2d\u7684\u9879\u76ee\uff0c\u80fd\u591f\u7075\u654f\u5730\u68c0\u6d4b\u51fa\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u75c7\u72b6\u7684\u4e34\u5e8a\u529f\u80fd\u53d8\u5316\u548c\u8bb0\u5fc6\u53d8\u5316\u3002\u672c\u7814\u7a76201\u5229\u7528ADCOMS\u4f5c\u4e3a\u8bc4\u4f30\u4e34\u5e8a\u75c7\u72b6\u7684\u4e3b\u8981\u7ec8\u70b9\u3002<\/p>\n

4<\/strong>\u3001\u6dc0\u7c89\u6837\u86cb\u767dPET\u6210\u50cf<\/strong>
\n\u6dc0\u7c89\u6837\u86cb\u767dPET\uff08\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff09\u6210\u50cf\u662f\u4e00\u79cd\u8bca\u65ad\u65b9\u6cd5\uff0c\u80fd\u591f\u663e\u793a\u8111\u4e2d\u5b58\u5728\u7684\u6dc0\u7c89\u6837\u6591\u5757\uff0c\u5e76\u901a\u8fc7\u7ed9\u4e88\u5fae\u91cf\u53ef\u7279\u5f02\u6027\u7ed3\u5408\u6dc0\u7c89\u6837\u6591\u5757\u5e76\u7528\u6b63\u7535\u5b50\u8fdb\u884c\u6807\u8bb0\u7684PET\u793a\u8e2a\u5242\u5b9a\u91cf\u8bc4\u4f30\u8111\u5185\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u7684\u5206\u5e03\u548c\u805a\u96c6\u60c5\u51b5\u3002\u6dc0\u7c89\u6837\u86cb\u767dPET\u6210\u50cf\u80fd\u591f\u8bc4\u4f30\u75c5\u7406\u6539\u53d8\u5e76\u8f85\u52a9\u8bca\u65ad\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08\u5305\u62ecMCI\uff09\u60a3\u8005\uff0c\u5e76\u6839\u636e\u6dc0\u7c89\u6837\u86cb\u767d\u5047\u8bbe\u4f30\u8ba1\u75be\u75c5\u4fee\u9970\u6cbb\u7597\u836f\u7269\u5242\u7684\u4e34\u5e8a\u7597\u6548\u3002<\/p>\n

5<\/strong>\u3001\u5173\u4e8e\u76f8\u5173\u7cfb\u6570<\/strong>
\n\u76f8\u5173\u7cfb\u6570\u8868\u793a\u6765\u81ea\u4e24\u4e2a\u5b9a\u91cf\u6570\u636e\u5206\u5e03\u7684\u4e24\u4e2a\u53d8\u91cf\u4e4b\u95f4\u7684\u5173\u7cfb\u5f3a\u5ea6\u3002\u76f8\u5173\u7cfb\u6570\u7684\u53d6\u503c\u8303\u56f4\u4e3a-1\u81f31\uff0c\u5f53\u63a5\u8fd1\u7edd\u5bf9\u503c1\u65f6\uff0c\u8868\u793a\u603b\u7684\u6b63\u7ebf\u6027\u76f8\u5173\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u5982\u679c\u76f8\u5173\u7cfb\u6570\u662f0.6\u6216\u66f4\u5927\uff0c\u8868\u660e\u53d8\u91cf\u95f4\u5b58\u5728\u4e00\u79cd\u5173\u7cfb\u3002<\/p>\n

6\u3001\u536b\u6750\u548c\u6e24\u5065\uff08Biogen\uff09\u5173\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u8054\u5408\u5f00\u53d1\u534f\u8bae<\/strong>
\n\u536b\u6750\u548c\u6e24\u5065\uff08Biogen\uff09\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6cbb\u7597\u7684\u8054\u5408\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u65b9\u9762\u8fdb\u884c\u4e86\u5927\u91cf\u5408\u4f5c\u3002\u536b\u6750\u662f\u8054\u5408\u5f00\u53d1Elenbecestat\uff08\u4e00\u79cdBACE\u6291\u5236\u5242\uff09\u548cBAN2401\uff08\u4e00\u79cd\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u03b2\uff08A\u03b2\uff09\u539f\u7ea4\u7ef4\u6297\u4f53\uff09\u7684\u4e3b\u5bfc\u8005\uff0c\u800c\u6e24\u5065\uff08Biogen\uff09\u662f\u8054\u5408\u5f00\u53d1Aducanumab\uff08\u6e24\u5065\uff08Biogen\uff09\u7528\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u8bd5\u9a8c\u7528\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u03b2\uff08A\u03b2\uff09\u6297\u4f53\uff09\u7684\u4e3b\u5bfc\u8005\uff0c\u4e24\u5bb6\u516c\u53f8\u8ba1\u5212\u5bfb\u6c42\u8fd9\u4e09\u79cd\u5316\u5408\u7269\u5728\u5168\u7403\u8303\u56f4\u5185\u7684\u4e0a\u5e02\u8bb8\u53ef\u3002\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u53cc\u65b9\u516c\u53f8\u8fd8\u5c06\u5728\u4e3b\u8981\u5e02\u573a\uff08\u5982\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u65e5\u672c\uff09\u5171\u540c\u63a8\u5e7f\u4ea7\u54c1\u3002<\/p>\n

\u5bf9\u4e8eBAN2401\u548cElenbecestat\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u5e73\u5747\u5206\u644a\u603b\u4f53\u6210\u672c\uff0c\u5305\u62ec\u7814\u53d1\u8d39\u7528\u3002\u536b\u6750\u5c06\u5728\u83b7\u5f97\u4e0a\u5e02\u8bb8\u53ef\u540e\u63a5\u53d7Elenbecestat\u548cBAN2401\u7684\u6240\u6709\u9500\u552e\u9884\u8ba2\u5e76\u8fdb\u884c\u53d1\u5e03\uff0c\u5e76\u4e14\u4e24\u5bb6\u516c\u53f8\u5c06\u5747\u4eab\u5229\u6da6\u3002<\/p>\n

7\u3001\u5173\u4e8e\u536b\u6750\u682a\u5f0f\u4f1a\u793e<\/strong><\/b>
\n\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u662f\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u7684\u5168\u7403\u9886\u5148\u7684\u533b\u836f\u7814\u53d1\u516c\u53f8\u3002\u6211\u4eec\u516c\u53f8\u7684\u4f7f\u547d\u662f\u201c\u6211\u4eec\u5c06\u60a3\u8005\u53ca\u5bb6\u5c5e\u7684\u5229\u76ca\u653e\u5728\u9996\u4f4d\uff0c\u4e3a\u63d0\u5347\u5176\u798f\u7949\u505a\u51fa\u8d21\u732e\u3002\u201d\uff0c\u6211\u4eec\u79f0\u4e4b\u4e3a\u201c\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\uff08hhc<\/em>\uff09\u201d\u7406\u5ff5\u3002\u5168\u7403\u7ea6\u670910000\u540d\u5458\u5de5\u5206\u522b\u5de5\u4f5c\u5728\u7814\u53d1\u4e2d\u5fc3\u3001\u751f\u4ea7\u57fa\u5730\u53ca\u9500\u552e\u5b50\u516c\u53f8\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u901a\u8fc7\u63d0\u4f9b\u521b\u65b0\u4ea7\u54c1\u4ee5\u89e3\u51b3\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u6765\u5b9e\u73b0\u6211\u4eec\u7684hhc<\/em><\/em>\u7406\u5ff5\uff0c\u7279\u522b\u5173\u6ce8\u795e\u7ecf\u79d1\u5b66\u548c\u80bf\u7624\u5b66\u4e24\u5927\u6218\u7565\u9886\u57df\u3002
\n\u901a\u8fc7\u7814\u53d1\u548c\u9500\u552e\u5b89\u7406\u7533\uff08\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u53ca\u8def\u6613\u4f53\u75f4\u5446\u7684\u836f\u7269\uff09\u7684\u7ecf\u9a8c\uff0c\uff0c\u536b\u6750\u5df2\u5efa\u7acb\u4e86\u6db5\u76d6\u6bcf\u4e2a\u793e\u533a\u7684\u60a3\u8005\uff0c\u5e76\u534f\u8c03\u5404\u4e2a\u5229\u76ca\u76f8\u5173\u8005\uff08\u5305\u62ec\uff1a\u653f\u5e9c\u3001\u533b\u7597\u4e13\u4e1a\u4eba\u58eb\u53ca\u7167\u62a4\u8005\uff09\u7684\u793e\u4f1a\u73af\u5883\uff0c\u4e14\u5728\u5168\u7403\u4e3e\u529e\u4e86\u8d85\u4e00\u4e07\u6b21\u6709\u5173\u75f4\u5446\u8ba4\u77e5\u7684\u6d3b\u52a8\u3002\u4f5c\u4e3a\u5728\u75f4\u5446\u6cbb\u7597\u9886\u57df\u7684\u5148\u9a71\uff0c\u536b\u6750\u4e0d\u4ec5\u7814\u53d1\u4e0b\u4e00\u4ee3\u6cbb\u7597\u836f\u7269\uff0c\u540c\u65f6\u4e5f\u7814\u53d1\u8bca\u65ad\u65b9\u6cd5\u5e76\u63d0\u4f9b\u89e3\u51b3\u65b9\u6848\u3002
\n\u5173\u4e8e\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.eisai.com<\/a>\u3002<\/p>\n

8<\/strong>\u3001<\/strong>\u5173\u4e8e\u6e24\u5065\uff08Biogen\uff09<\/strong>
\n\u5728\u6e24\u5065\uff08Biogen\uff09\uff0c\u6211\u4eec\u7684\u4f7f\u547d\u6e05\u6670\u660e\u786e\uff1a\u6211\u4eec\u662f\u795e\u7ecf\u79d1\u5b66\u9886\u57df\u7684\u5148\u950b\u3002\u6e24\u5065\uff08Biogen\uff09\u4e3a\u5168\u7403\u7f79\u60a3\u4e25\u91cd\u795e\u7ecf\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4eba\u7fa4\u63a2\u5bfb\u3001\u7814\u53d1\u548c\u63d0\u4f9b\u521b\u65b0\u7597\u6cd5\u3002\u6e24\u5065\uff08Biogen\uff09\u662fCharles Weissmann\uff0cHeinz Schaller\uff0cKenneth Murray\u4e0e\u8bfa\u8d1d\u5c14\u5956\u83b7\u5f97\u8005Walter Gilbert\u548cPhillip Sharp\u643a\u624b\u57281978\u5e74\u6210\u7acb\u7684\u5168\u7403\u9996\u6279\u751f\u7269\u6280\u672f\u516c\u53f8\u4e4b\u4e00\uff0c\u4eca\u5929\u6e24\u5065\uff08Biogen\uff09\u62e5\u6709\u6cbb\u7597\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u9886\u5148\u836f\u7269\u7ec4\u5408;\u00a0\u63a8\u51fa\u7b2c\u4e00\u4e2a\u4e5f\u662f\u552f\u4e00\u4e00\u4e2a\u6279\u51c6\u7528\u4e8e\u810a\u9ad3\u6027\u808c\u840e\u7f29\u7684\u6cbb\u7597\u836f\u7269\uff1b\u5e76\u4e13\u6ce8\u4e8e\u63a8\u8fdb\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u548c\u75f4\u5446\u3001\u795e\u7ecf\u514d\u75ab\u5b66\u3001\u8fd0\u52a8\u969c\u788d\u3001\u795e\u7ecf\u808c\u8089\u75be\u75c5\u3001\u75bc\u75db\u3001\u773c\u79d1\u3001\u795e\u7ecf\u7cbe\u795e\u75c5\u5b66\u548c\u6025\u6027\u795e\u7ecf\u75c5\u5b66\u9886\u57df\u7684\u79d1\u5b66\u7814\u7a76\u9879\u76ee\u3002\u6e24\u5065\uff08Biogen\uff09\u8fd8\u751f\u4ea7\u548c\u63a8\u5e7f\u5148\u8fdb\u751f\u7269\u5236\u5242\u7684\u751f\u7269\u4eff\u5236\u836f\u3002
\n\u6211\u4eec\u5b9a\u671f\u5728\u5b98\u7f51www.biogen.com<\/a>\u53d1\u5e03\u5bf9\u4e8e\u6295\u8d44\u8005\u6765\u8bf4\u53ef\u80fd\u91cd\u8981\u7684\u4fe1\u606f\u3002\u9884\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.biogen.com<\/a>\u5e76\u5728Twitter<\/a>,\u00a0LinkedIn<\/a><\/u>,\u00a0Facebook<\/a>,\u00a0YouTube<\/a><\/u>\u7b49\u793e\u4ea4\u5a92\u4f53\u5e73\u53f0\u5173\u6ce8\u6211\u4eec\u3002<\/p>\n

9<\/strong>\u3001\u5173\u4e8eBioArctic AB<\/strong>
\nBioArctic AB\uff08publ\uff09\u662f\u4e00\u5bb6\u745e\u5178\u7684\u7814\u53d1\u578b\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u75be\u75c5\u4fee\u9970\u6cbb\u7597\u548c\u53ef\u9760\u7684\u751f\u7269\u6807\u5fd7\u7269\u53ca\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u8bca\u65ad\uff0c\u5982\uff1a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\u3002\u516c\u53f8\u4e5f\u5728\u7814\u53d1\u5b8c\u5168\u6027\u810a\u9ad3\u635f\u4f24\u7684\u6f5c\u5728\u7597\u6cd5\u3002BioArctic\u5173\u6ce8\u9ad8\u5ea6\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u9886\u57df\u7684\u521b\u65b0\u6cbb\u7597\u3002\u57fa\u4e8e\u745e\u5178\u4e4c\u666e\u8428\u62c9\u5927\u5b66\u7684\u521b\u65b0\u7814\u7a76\uff0c\u516c\u53f8\u521b\u7acb\u4e8e2003\u5e74\u3002\u4e0e\u5404\u5927\u5b66\u4ee5\u53ca\u6211\u4eec\u5168\u7403\u91cd\u8981\u6218\u7565\u4f19\u4f34\uff08\u5305\u62ec\uff1a\u536b\u6750\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u9879\u76ee\u4ee5\u53ca\u827e\u4f2f\u7ef4\u7684\u5e15\u91d1\u68ee\u75c5\u9879\u76ee\uff09\u7684\u5408\u4f5c\u5bf9\u516c\u53f8\u81f3\u5173\u91cd\u8981\u3002\u9879\u76ee\u662f\u5bf9\u4e0e\u5168\u7403\u533b\u836f\u516c\u53f8\u5408\u4f5c\u7684\u5168\u8d44\u91d1\u9879\u76ee\u4ee5\u53ca\u5177\u6709\u663e\u8457\u5e02\u573a\u6f5c\u529b\u548c\u5bf9\u5916\u8bb8\u53ef\u6f5c\u529b\u7684\u521b\u65b0\u81ea\u7814\u9879\u76ee\u7684\u6574\u5408\u3002BioArctic\u7684B\u80a1\u5df2\u5728\u7eb3\u65af\u8fbe\u514b\u65af\u5fb7\u54e5\u5c14\u6469\u8bc1\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\u3002www.bioarctic.com<\/a>\u3002<\/p>\n

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