{"id":3218,"date":"2018-10-17T00:00:00","date_gmt":"2021-03-18T08:15:08","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=3218"},"modified":"2021-03-18T16:15:08","modified_gmt":"2021-03-18T08:15:08","slug":"%e5%8d%ab%e6%9d%90%e5%92%8c%e6%99%ae%e6%9d%9c%e5%88%b6%e8%8d%af%e5%85%ac%e5%b8%83lemborexant%e7%9a%84%e7%ac%ac%e4%ba%8c%e9%a1%b9%e5%85%b3%e9%94%ae%e6%80%a7iii%e6%9c%9f%e7%a0%94%e7%a9%b6sunrise-2","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2018\/10\/17\/%e5%8d%ab%e6%9d%90%e5%92%8c%e6%99%ae%e6%9d%9c%e5%88%b6%e8%8d%af%e5%85%ac%e5%b8%83lemborexant%e7%9a%84%e7%ac%ac%e4%ba%8c%e9%a1%b9%e5%85%b3%e9%94%ae%e6%80%a7iii%e6%9c%9f%e7%a0%94%e7%a9%b6sunrise-2\/","title":{"rendered":"\u536b\u6750\u548c\u666e\u675c\u5236\u836f\u516c\u5e03Lemborexant\u7684\u7b2c\u4e8c\u9879\u5173\u952e\u6027III\u671f\u7814\u7a76SUNRISE 2\u7684\u6700\u65b0\u9633\u6027\u7ed3\u679c"},"content":{"rendered":"<p align=\"center\"><em><i><span lang=\"EN-US\">\u5728\u5931\u7720\u75c7\uff08\u4e00\u79cd\u7761\u7720-\u89c9\u9192\u969c\u788d\uff09\u60a3\u8005\u4e2d\u7684\u957f\u671f\u7597\u6548\u548c\u5b89\u5168\u6027\u8bc4\u4f30\u8fbe\u5230\u4e3b\u8981\u7597\u6548\u76ee\u6807\u548c\u5173\u952e\u6b21\u8981\u7597\u6548\u76ee\u6807<\/span><\/i><\/em><em><i><span lang=\"EN-US\"><br \/>\n<\/span><\/i><\/em><span lang=\"EN-US\"><br \/>\n<\/span><\/p>\n<p><span lang=\"EN-US\">2018<\/span>\u5e74<span lang=\"EN-US\">10<\/span>\u6708<span lang=\"EN-US\">17<\/span>\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u666e\u675c\u5236\u836f\u516c\u53f8\uff08\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\u4e3a<span lang=\"EN-US\">Craig Landau<\/span>\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u666e\u675c\u5236\u836f\u201d\uff09\u516c\u5e03\u4e86\u8bc4\u4f30<span lang=\"EN-US\">Lemborexant<\/span>\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u4e00\u9879\u957f\u671f<span lang=\"EN-US\">III<\/span>\u671f\u7814\u7a76<span lang=\"EN-US\">SUNRISE 2<\/span>\u7684\u6700\u65b0\u9633\u6027\u7ed3\u679c\u3002<span lang=\"EN-US\">Lemborexant<\/span>\u662f\u4e00\u79cd\u5c1a\u5728\u5b9e\u9a8c\u4e2d\u7684\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u8c03\u8282\u5242\uff0c\u76ee\u524d\u6b63\u5728\u7814\u7a76\u5176\u6cbb\u7597\u591a\u79cd\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u969c\u788d\u7684\u6f5c\u80fd\u3002\u62a5\u544a\u7684\u6700\u65b0\u7ed3\u679c\u5305\u62ec\u8be5\u7814\u7a76\u5728\u4e3a\u671f\u516d\u4e2a\u6708\u7684\u5b89\u6170\u5242\u5bf9\u7167\u6cbb\u7597\u4e2d\u7684\u4e3b\u8981\u7ed3\u679c\u548c\u5173\u952e\u6b21\u8981\u7ed3\u679c\uff1b\u8be5\u7814\u7a76\u5c06\u6301\u7eed\u81f3<span lang=\"EN-US\">12<\/span>\u4e2a\u6708\u3002\u536b\u6750\u548c\u666e\u675c\u5236\u836f\u8ba1\u5212\u5728<span lang=\"EN-US\">2019<\/span>\u5e74\u5373\u5c06\u53ec\u5f00\u7684\u533b\u7597\u4f1a\u8bae\u4e0a\u516c\u5e03<span lang=\"EN-US\">SUNRISE 2<\/span>\u7684\u5168\u90e8\u7814\u7a76\u6210\u679c\u3002<\/p>\n<p><span lang=\"EN-US\">SUNRISE 2<\/span>\u62db\u52df\u4e86<span lang=\"EN-US\">900<\/span>\u591a\u540d\u6210\u5e74\u5931\u7720\u75c7\u60a3\u8005\uff08<span lang=\"EN-US\">18<\/span>\u81f3<span lang=\"EN-US\">88<\/span>\u5c81\uff09\uff0c\u5176\u5931\u7720\u7279\u5f81\u662f\u96be\u4ee5\u5165\u7761\u548c<span lang=\"EN-US\">\/<\/span>\u6216\u96be\u4ee5\u6301\u7eed\u7761\u7720\u3002\u901a\u8fc7\u8bc4\u4f30\u60a3\u8005\u7684\u81ea\u6211\u62a5\u544a\uff08\u7761\u7720\u65e5\u8bb0\uff09\uff0c\u8be5\u7814\u7a76\u8fbe\u5230\u4e86\u9884\u5148\u8bbe\u5b9a\u7684\u4e3b\u8981\u7597\u6548\u76ee\u6807\u548c\u5173\u952e\u6b21\u8981\u7597\u6548\u76ee\u6807\u3002\u5728\u4e3a\u671f<span lang=\"EN-US\">6<\/span>\u4e2a\u6708\u7684\u5b89\u6170\u5242\u5bf9\u7167\u6cbb\u7597\u7ed3\u675f\u65f6\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c<span lang=\"EN-US\">5mg<\/span>\u548c<span lang=\"EN-US\">10mg<\/span>\u7684<span lang=\"EN-US\">Lemborexant<\/span>\u6cbb\u7597\u7ec4\u5728\u4e3b\u89c2\u7761\u7720\u6f5c\u4f0f\u671f\uff08\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\uff09\u6709\u663e\u8457\u6539\u5584\u3002\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c<span lang=\"EN-US\">5mg<\/span>\u548c<span lang=\"EN-US\">10mg<\/span>\u7684<span lang=\"EN-US\">Lemborexant<\/span>\u6cbb\u7597\u7ec4\u8fd8\u5728\u4e3b\u89c2\u7761\u7720\u6548\u7387\u548c\u5165\u7761\u540e\u4e3b\u89c2\u89c9\u9192\u7b49\u7761\u7720\u7ef4\u6301\u53d8\u91cf\u65b9\u9762\uff08\u8be5\u7814\u7a76\u7684\u5173\u952e\u6b21\u8981\u7ec8\u70b9\uff09\u6709\u663e\u8457\u6539\u5584\u3002\u5931\u7720\u75c7\u4e25\u91cd\u7a0b\u5ea6\u6307\u6570\u6d4b\u91cf\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c<span lang=\"EN-US\">5mg<\/span>\u548c<span lang=\"EN-US\">10mg<\/span>\u7684<span lang=\"EN-US\">Lemborexant<\/span>\u6cbb\u7597\u7ec4\u8fd8\u6539\u5584\u4e86\u65e5\u5e38\u751f\u6d3b\u529f\u80fd\u3002\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u55dc\u7761\uff0c\u5934\u75db\u548c\u6d41\u611f\u3002\u4e24\u4e2a<span lang=\"EN-US\">Lemborexant<\/span>\u6cbb\u7597\u7ec4\u7684\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u90fd\u8d85\u8fc7\u4e86<span lang=\"EN-US\">5<\/span>\uff05\uff0c\u9ad8\u51fa\u5b89\u6170\u5242\u7ec4\u3002\u7531\u4e0d\u826f\u53cd\u5e94\u5f15\u8d77\u7684\u603b\u505c\u836f\u7387\u5728\u5b89\u6170\u5242\u7ec4\u548c<span lang=\"EN-US\">Lemborexant 5mg<\/span>\u7ec4\u76f8\u5f53\uff0c\u5728<span lang=\"EN-US\">Lemborexant 10mg<\/span>\u7ec4\u66f4\u9ad8\u3002<\/p>\n<p>\u201c\u4f5c\u4e3a\u4e34\u5e8a\u533b\u751f\u548c\u7814\u7a76\u4eba\u5458\uff0c\u6211\u5df2\u7ecf\u6cbb\u7597\u5931\u7720\u548c\u5176\u4ed6\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u969c\u788d\u60a3\u8005<span lang=\"EN-US\">30<\/span>\u5e74\u3002\u5bf9\u6211\u800c\u8a00\uff0c\u6210\u529f\u7684\u6cbb\u7597\u610f\u5473\u7740\u60a3\u8005\u80fd\u591f\u5feb\u901f\u5165\u7761\uff0c\u7761\u7720\u826f\u597d\uff0c\u89c9\u9192\u826f\u597d\uff0c\u6ca1\u6709\u529f\u80fd\u969c\u788d\uff0c\u4e5f\u4e0d\u4f1a\u968f\u65f6\u95f4\u63a8\u79fb\u5931\u53bb\u7597\u6548\uff0c\u201d<span lang=\"EN-US\">Lemborexant<\/span>\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u7f8e\u56fd\u7761\u7720\u533b\u5b66\u59d4\u5458\u4f1a\u4e13\u79d1\u533b\u751f\u3001\u7f8e\u56fd\u56fd\u5bb6\u7761\u7720\u57fa\u91d1\u4f1a\u524d\u8463\u4e8b\u957f<span lang=\"EN-US\">Russell Rosenberg<\/span>\u535a\u58eb\u5982\u662f\u8bf4\u3002\u201c\u5bf9\u4e8e\u8bb8\u591a\u906d\u53d7\u6162\u6027\u5931\u7720\u75c7\u7684\u60a3\u8005\u6765\u8bf4\uff0c<span lang=\"EN-US\">SUNRISE 2<\/span>\u7684\u7ed3\u679c\u683c\u5916\u9f13\u821e\u4eba\u5fc3\u3002\u201d<\/p>\n<p><span lang=\"EN-US\">SUNRISE 2<\/span>\u7684\u7814\u7a76\u7ed3\u679c\u5efa\u7acb\u5728\u652f\u6301<span lang=\"EN-US\">Lemborexant<\/span>\u7814\u53d1\u8fc7\u7a0b\u4e2d\u4e0d\u65ad\u4e30\u5bcc\u7684\u77e5\u8bc6\u4f53\u7cfb\u4e0a\uff0c\u5176\u4e2d\u5305\u62ec\u4e00\u9879\u6700\u8fd1\u5b8c\u6210\u7684<span lang=\"EN-US\">III<\/span>\u671f\u4e34\u5e8a\u7814\u7a76<span lang=\"EN-US\">\u00a0SUNRISE 1<\/span>\u3002\u8be5\u7814\u7a76\u5c06<span lang=\"EN-US\">5mg<\/span>\u548c<span lang=\"EN-US\">10mg Lemborexant<\/span>\u4e0e\u5b89\u6170\u5242\u8fdb\u884c\u5bf9\u7167\u3002\u5176\u6b21\u8981\u7ec8\u70b9\u662f\u4e0e\u9152\u77f3\u9178\u5511\u5421\u5766\u7f13\u91ca\u7247\uff08<span lang=\"EN-US\">zolpidem ER<\/span>\uff09\u8fdb\u884c\u4f18\u6548\u5bf9\u6bd4\uff0c\u4ee5\u53ca\u4e00\u9879\u8bc4\u4f30\u635f\u4f24\u7684\u5173\u952e\u5b89\u5168\u6027\u7814\u7a76\u3002\u5176\u65b9\u6cd5\u662f\u8bc4\u4f30\u534a\u591c\u548c\u6b21\u65e5\u65e9\u4e0a\u9192\u6765\u540e\u4fdd\u6301\u59ff\u52bf\u7a33\u5b9a\u7684\u80fd\u529b<span lang=\"EN-US\">&#8212;<\/span>\u8fd9\u4e00\u80fd\u529b\u53ef\u9884\u6d4b\u8dcc\u5012\u98ce\u9669\uff0c\u4ee5\u53ca\u6b21\u65e5\u65e9\u4e0a\u9a7e\u9a6d\u8eab\u4f53\u7684\u80fd\u529b\u3002<\/p>\n<p>\u201c\u6211\u4eec\u5bf9<span lang=\"EN-US\">Lemborexant<\/span>\u7684\u671f\u671b\u662f\uff0c\u4e3a\u6570\u767e\u4e07\u9971\u53d7\u5931\u7720\u75c7\u548c\u5176\u4ed6\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u75c7\u6298\u78e8\u7684\u60a3\u8005\u63d0\u4f9b\u4e00\u79cd\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u8c03\u8282\u5242\uff0c\u63d0\u9ad8\u4ed6\u4eec\u5165\u7761\u548c\u4fdd\u6301\u7761\u7720\u7684\u80fd\u529b\uff0c\u5e76\u80fd\u591f\u957f\u671f\u6709\u6548\uff0c\u201d\u536b\u6750\u795e\u7ecf\u79d1\u5b66\u4e8b\u4e1a\u90e8\u9996\u5e2d\u4e34\u5e8a\u5b98\u53ca\u9996\u5e2d\u533b\u7597\u5b98\u3001\u533b\u5b66\u535a\u58eb<span lang=\"EN-US\">Lynn Kramer<\/span>\u6307\u51fa\u3002\u201c\u5728<span lang=\"EN-US\">SUNRISE 2<\/span>\u4e2d\uff0c<span lang=\"EN-US\">Lemborexant<\/span>\u5728\u516d\u4e2a\u6708\u7684\u65f6\u95f4\u5185\u5bf9\u5165\u7761\u65f6\u95f4\u548c\u7761\u7720\u7ef4\u6301\u65f6\u95f4\u90fd\u6709\u6539\u5584\u3002\u6536\u83b7\u8fd9\u4e9b\u7ed3\u679c\u540e\uff0c\u73b0\u5728\u6211\u4eec\u671f\u5f85\u8fdb\u884c\u9488\u5bf9<span lang=\"EN-US\">Lemborexant<\/span>\u7684\u76d1\u7ba1\u7533\u8bf7\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u4e00\u4e2a\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u969c\u788d\u548c\u5931\u7720\u75c7\u7684\u957f\u671f\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n<p><span lang=\"EN-US\">Lemborexant<\/span>\u53ef\u4f5c\u7528\u4e8e\u5f71\u54cd\u60a3\u8005\u7761\u7720\u7684\u6839\u672c\u56e0\u7d20\uff0c\u5373\u98df\u6b32\u7d20\u795e\u7ecf\u9012\u8d28\u7cfb\u7edf\u3002\u8be5\u5236\u5242\u88ab\u8ba4\u4e3a\u53ef\u901a\u8fc7\u6291\u5236\u89c9\u9192\u800c\u4e0d\u59a8\u788d\u5916\u90e8\u523a\u6fc0\u5524\u9192\u80fd\u529b\u6765\u8c03\u8282\u7761\u7720\u548c\u89c9\u9192\u3002<\/p>\n<p>\u201c\u5bf9\u9971\u53d7\u5931\u7720\u75c7\u6298\u78e8\u7684\u60a3\u8005\u6765\u8bf4\uff0c<span lang=\"EN-US\">Lemborexant<\/span>\u5728\u5165\u7761\u548c\u7761\u7720\u7ef4\u6301\u65b9\u9762\u7684\u7814\u7a76\u7ed3\u679c\u662f\u7406\u60f3\u7684\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u6a21\u5f0f\u7684\u5173\u952e\u90e8\u5206\uff0c\u201d\u666e\u675c\u5236\u836f\u9996\u5e2d\u533b\u7597\u5b98\u3001\u533b\u5b66\u535a\u58eb<span lang=\"EN-US\">Marcelo Bigal<\/span>\u6307\u51fa\u3002\u201c\u6211\u4eec\u660e\u767d\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u8c03\u8282\u5bf9\u60a3\u8005\u6574\u4f53\u5065\u5eb7\u548c\u75be\u75c5\u9884\u540e\u7684\u91cd\u8981\u6027\uff0c\u800c\u4e14\uff0c\u6211\u4eec\u671f\u5f85\u7740\u540c\u5408\u4f5c\u4f19\u4f34\u536b\u6750\u5171\u540c\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u8fd9\u662f\u6211\u4eec\u5bf9\u60a3\u6709\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u969c\u788d\u7684\u5404\u79cd\u60a3\u8005\u7fa4\u4f53\u7684\u627f\u8bfa\u7684\u4e00\u90e8\u5206\u3002\u201d<\/p>\n<p><span lang=\"EN-US\">Lemborexant<\/span>\u7531\u536b\u6750\u53d1\u73b0\uff0c\u5c06\u88ab\u536b\u6750\u548c\u666e\u675c\u5236\u836f\u8054\u5408\u5f00\u53d1\u3002\u4e86\u89e3\u6709\u5173\u8fdb\u884c\u4e2d\u7684\u4e34\u5e8a\u7814\u7a76\u7684\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<span lang=\"EN-US\">clinicaltrials.gov<\/span>\u3002<\/p>\n<p>\u672c\u65b0\u95fb\u7a3f\u63a2\u8ba8\u4e86\u8fd9\u4e00\u5c1a\u5728\u5f00\u53d1\u7684\u836f\u7269\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u7528\u9014\uff0c\u5e76\u975e\u65e8\u5728\u4f20\u9012\u5173\u4e8e\u6709\u6548\u6027\u6216\u5b89\u5168\u6027\u7684\u7ed3\u8bba\u3002\u6211\u4eec\u65e0\u6cd5\u4fdd\u8bc1\u6b64\u8bd5\u9a8c\u836f\u7269\u80fd\u591f\u6210\u529f\u5b8c\u6210\u4e34\u5e8a\u5f00\u53d1\u6216\u83b7\u5f97\u536b\u751f\u76d1\u7ba1\u5f53\u5c40\u7684\u6279\u51c6\u3002<span lang=\"EN-US\"><br \/>\n<\/span><\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><strong><br \/>\n\u8054\u7cfb\u65b9\u5f0f\uff1a<\/strong><br \/>\n\u536b\u6750\u682a\u5f0f\u4f1a\u793e<span lang=\"EN-US\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span>\u666e\u675c\u5236\u836f\u516c\u53f8<\/p>\n<p>\u516c\u5171\u5173\u7cfb\u90e8<span lang=\"EN-US\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Danielle Lewis<\/span><\/p>\n<p><span lang=\"EN-US\">+81-(0)3-3817-5120\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0+1-203-588-7653<\/span><\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><strong><span lang=\"EN-US\">&lt;<\/span><\/strong><strong>\u7f16\u8005\u6309<span lang=\"EN-US\">&gt;<\/span><\/strong><\/p>\n<p><strong><span lang=\"EN-US\">1<\/span><\/strong><strong>\u3001\u5173\u4e8e<span lang=\"EN-US\">Lemborexant<\/span><\/strong><\/p>\n<p><span lang=\"EN-US\">Lemborexant<\/span>\u662f\u4e00\u79cd\u5c1a\u5728\u8bd5\u9a8c\u9636\u6bb5\u7684\u53cc\u98df\u6b32\u7d20\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u7531\u536b\u6750\u7387\u5148\u53d1\u73b0\u5e76\u8fdb\u884c\u7814\u53d1\u3002\u8fd9\u4e00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u901a\u8fc7\u7ade\u4e89\u6027\u5730\u7ed3\u5408\u4e24\u79cd\u4e9a\u578b\u7684\u98df\u6b32\u7d20\u53d7\u4f53\uff08\u98df\u6b32\u7d20\u53d7\u4f53<span lang=\"EN-US\">1<\/span>\u548c\u98df\u6b32\u7d20\u53d7\u4f53<span lang=\"EN-US\">2<\/span>\uff09\u6765\u6291\u5236\u98df\u6b32\u7d20\u795e\u7ecf\u4f20\u9012\u6216\u53d1\u51fa\u795e\u7ecf\u4fe1\u53f7\u3002\u60a3\u6709\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u969c\u788d\u7684\u4eba\u7fa4\u4f53\u5185\u8c03\u8282\u89c9\u9192\u7684\u98df\u6b32\u7d20\u7cfb\u7edf\u53ef\u80fd\u65e0\u6cd5\u6b63\u5e38\u8fd0\u8f6c\u3002\u5728\u6b63\u5e38\u7761\u7720\u671f\u95f4\uff0c\u98df\u6b32\u7d20\u7cfb\u7edf\u7684\u6d3b\u8dc3\u5ea6\u88ab\u6291\u5236\uff0c\u6709\u53ef\u80fd\u4f1a\u81ea\u89c9\u963b\u6b62\u4e0d\u6b63\u5e38\u89c9\u9192\uff0c\u5e76\u4fc3\u8fdb\u5165\u7761\u548c\u7ef4\u6301\u7761\u7720\u8fc7\u7a0b\u3002<\/p>\n<p>\u536b\u6750\u548c\u666e\u675c\u5236\u836f\u6b63\u5728\u5bf9<span lang=\"EN-US\">Lemborexant<\/span>\u8fdb\u884c\u4e34\u5e8a\u7814\u7a76\u3002\u8be5\u836f\u6709\u53ef\u80fd\u4f1a\u6210\u4e3a\u5931\u7720\u75c7\u548c\u5176\u4ed6\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u969c\u788d\u7684\u4e00\u79cd\u6cbb\u7597\u9009\u62e9\u3002\u4e00\u9879\u5173\u4e8e<span lang=\"EN-US\">Lemborexant<\/span>\u7684<span lang=\"EN-US\">II<\/span>\u671f\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u4e0d\u89c4\u5219\u7761\u7720<span lang=\"EN-US\">&#8211;<\/span>\u89c9\u9192\u8282\u5f8b\u969c\u788d\u548c\u8f7b\u3001\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u6027\u75f4\u5446\u60a3\u8005\u4e2d\u8fdb\u884c\u3002<\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><strong><span lang=\"EN-US\">2<\/span><\/strong><strong>\u3001\u5173\u4e8e<span lang=\"EN-US\">SUNRISE 2 \/\u00a0<\/span>303<sup>1<\/sup>\u7814\u7a76<\/strong><\/p>\n<p><span lang=\"EN-US\">SUNRISE 2 \/ 303<sup>1<\/sup><\/span>\u7814\u7a76\u662f\u4e00\u9879\u4e3a\u671f<span lang=\"EN-US\">12<\/span>\u4e2a\u6708\u7684\u591a\u4e2d\u5fc3\u3001\u5168\u7403\u6027\u3001\u968f\u673a\u3001\u5bf9\u7167\u3001\u53cc\u76f2\u3001\u5e73\u884c\u7ec4\u7814\u7a76\uff0c\u5728<span lang=\"EN-US\">971<\/span>\u540d\u7537\u6027\u6216\u5973\u6027\u6210\u5e74\u5931\u7720\u75c7\u60a3\u8005\uff08<span lang=\"EN-US\">18<\/span>\u81f3<span lang=\"EN-US\">88<\/span>\u5c81\uff09\u4e2d\u8fdb\u884c\uff0c\u5305\u62ec\u7b5b\u67e5\u3001\u4e3a\u671f\u4e24\u5468\u7684\u5b89\u6170\u5242\u78e8\u5408\u671f\u3001<span lang=\"EN-US\">52<\/span>\u5468\u7684\u6cbb\u7597\u671f\u548c\u4e24\u5468\u7684\u968f\u8bbf\u671f\u3002\u6240\u6709\u60a3\u8005\u5728\u7814\u7a76\u671f\u95f4\u90fd\u63a5\u53d7\u4e86\u81f3\u5c11\u516d\u4e2a\u6708\u7684<span lang=\"EN-US\">Lemborexant<\/span>\u6cbb\u7597\u3002\u5728\u7814\u7a76\u7684\u524d\u516d\u4e2a\u6708\uff0c\u60a3\u8005\u9700\u5728\u5bb6\u6bcf\u665a\u5165\u7761\u524d\u53e3\u670d<span lang=\"EN-US\">5mg<\/span>\u6216<span lang=\"EN-US\">10mg<\/span>\u7684<span lang=\"EN-US\">Lemborexant<\/span>\u7247\u5242\uff0c\u6216\u5bf9\u5e94\u7684\u5b89\u6170\u5242\u7247\u5242\u3002\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ed3\u679c\u6d4b\u91cf\u6307\u6807\u662f\u5728\u8fdb\u884c<span lang=\"EN-US\">6<\/span>\u4e2a\u6708\u7684\u5b89\u6170\u5242\u5bf9\u7167\u6cbb\u7597\u540e\uff0c\u53d7\u8bd5\u8005\u7684\u5165\u7761\u65f6\u95f4\u8f83\u57fa\u7ebf\u7684\u5e73\u5747\u53d8\u5316\u3002\u5173\u952e\u6b21\u8981\u7ed3\u679c\u6d4b\u91cf\u6307\u6807\u662f\u5728\u8fdb\u884c<span lang=\"EN-US\">6<\/span>\u4e2a\u6708\u7684\u5b89\u6170\u5242\u5bf9\u7167\u6cbb\u7597\u540e\uff0c\u53d7\u8bd5\u8005\u7684\u7761\u7720\u6548\u7387\u548c\u5165\u7761\u540e\u89c9\u9192\u60c5\u51b5\u8f83\u57fa\u7ebf\u7684\u5e73\u5747\u53d8\u5316\u3002<\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><strong><span lang=\"EN-US\">3<\/span><\/strong><strong>\u3001\u5173\u4e8e\u7761\u7720\u969c\u788d<\/strong><\/p>\n<p>\u4eba\u53e3\u7814\u7a76\u8868\u660e\uff0c\u5168\u7403\u53d7\u7761\u7720\u969c\u788d\u5f71\u54cd\u7684\u4eba\u6570\u6bd4\u5148\u524d\u8ba4\u5b9a\u7684\u8fd8\u8981\u591a\u3002<sup>1<\/sup>\u5931\u7720\u75c7\u7684\u7279\u5f81\u662f\u5c3d\u7ba1\u6709\u8db3\u591f\u7684\u7761\u7720\u673a\u4f1a\uff0c\u5374\u56e0\u5165\u7761\u56f0\u96be\uff0c\u7ef4\u6301\u7761\u7720\u56f0\u96be\u6216\u4e24\u8005\u517c\u800c\u6709\u4e4b\u800c\u5bfc\u81f4\u5728\u767d\u5929\u51fa\u73b0\u75b2\u52b3\u3001\u6ce8\u610f\u529b\u4e0d\u96c6\u4e2d\u548c\u70e6\u8e81\u4e0d\u5b89\u7b49\u3002<sup><span lang=\"EN-US\">3,4<\/span><\/sup>\u5931\u7720\u75c7\u662f\u6700\u5e38\u89c1\u7684\u7761\u7720\u969c\u788d\uff0c\u7ea6<span lang=\"EN-US\">10<\/span>\uff05\u7684\u6210\u5e74\u4eba\u6709\u6301\u7eed\u6027\u5931\u7720\u75c7\u72b6\u3002<sup><span lang=\"EN-US\">2,3<\/span><\/sup>\u826f\u597d\u7684\u7761\u7720\u5bf9\u8eab\u4f53\u5065\u5eb7\uff08\u5305\u62ec\u5927\u8111\u5065\u5eb7\uff09\u81f3\u5173\u91cd\u8981\u3002\u7761\u7720\u4e0d\u4f73\u53ef\u5bfc\u81f4\u591a\u79cd\u5065\u5eb7\u95ee\u9898\uff0c\u5982\uff1a\u9ad8\u8840\u538b\u3001\u610f\u5916\u4f24\u5bb3\u3001\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\u3001\u6291\u90c1\u3001\u5fc3\u810f\u75c5\u3001\u4e2d\u98ce\u548c\u75f4\u5446\u75c7\u98ce\u9669\u589e\u52a0\u7b49\uff0c\u5e76\u53ef\u80fd\u5bf9\u60c5\u7eea\u548c\u884c\u4e3a\u4ea7\u751f\u4e0d\u826f\u5f71\u54cd\u3002<sup><span lang=\"EN-US\">4,5<\/span><\/sup><\/p>\n<p>\u5bf9\u52a8\u7269\u548c\u4eba\u7c7b\u7684\u5b9e\u9a8c\u7814\u7a76\u63d0\u4f9b\u4e86\u7761\u7720\u548c\u75be\u75c5\u98ce\u9669\u56e0\u7d20\u3001\u75be\u75c5\u548c\u6b7b\u4ea1\u7387\u76f8\u5173\u7684\u8bc1\u636e\u3002<sup><span lang=\"EN-US\">2,6<\/span><\/sup>\u7814\u7a76\u8868\u660e\uff0c\u6700\u4f73\u7761\u7720\u65f6\u957f\u4e3a<span lang=\"EN-US\">7<\/span>\u81f3<span lang=\"EN-US\">8<\/span>\u5c0f\u65f6\u3002<sup><span lang=\"EN-US\">2,6<\/span><\/sup>\u5973\u6027\u7f79\u60a3\u5931\u7720\u75c7\u7684\u53ef\u80fd\u6027\u662f\u7537\u6027\u7684<span lang=\"EN-US\">1.4<\/span>\u500d\u3002<sup><span lang=\"EN-US\">7<\/span><\/sup>\u8001\u5e74\u4eba\u5931\u7720\u7684\u60a3\u75c5\u7387\u4e5f\u8f83\u9ad8\uff1b\u4eba\u7c7b\u8001\u53bb\u7684\u8fc7\u7a0b\u5f80\u5f80\u4f34\u968f\u7740\u7761\u7720\u6a21\u5f0f\u7684\u53d8\u5316\uff0c\u5305\u62ec\uff1a\u7761\u7720\u4e2d\u65ad\u3001\u9891\u7e41\u9192\u6765\u548c\u65e9\u9192\u7b49\uff0c\u8fd9\u4e9b\u90fd\u4f1a\u51cf\u5c11\u7761\u7720\u65f6\u95f4\u3002<sup><span lang=\"EN-US\">8<\/span><\/sup><\/p>\n<p><strong><span lang=\"EN-US\">\u00a0<\/span><\/strong><\/p>\n<p><strong><span lang=\"EN-US\">4<\/span><\/strong><strong>\u3001\u5173\u4e8e\u536b\u6750\u682a\u5f0f\u4f1a\u793e<\/strong><\/p>\n<p>\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u662f\u4e00\u5bb6\u9886\u5148\u7684\u4ee5\u7814\u7a76\u5f00\u53d1\u533b\u836f\u4ea7\u54c1\u4e3a\u4e3b\u7684\u8de8\u56fd\u516c\u53f8\uff0c\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u3002\u6211\u4eec\u7684\u516c\u53f8\u4f7f\u547d\u4e3a\u201c\u5c06\u60a3\u8005\u53ca\u5bb6\u5c5e\u7684\u5229\u76ca\u653e\u5728\u9996\u4f4d\uff0c\u4e3a\u63d0\u5347\u5176\u798f\u7949\u505a\u51fa\u8d21\u732e\u201d\uff0c\u5373\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\uff08<em><span lang=\"EN-US\">hhc<\/span><\/em>\uff09\u7684\u7406\u5ff5\u3002\u536b\u6750\u62e5\u6709\u7ea6<span lang=\"EN-US\">10,000<\/span>\u540d\u5458\u5de5\uff0c\u5de5\u4f5c\u5728\u516c\u53f8\u904d\u5e03\u5168\u7403\u7684\u7814\u53d1\u4e2d\u5fc3\u3001\u751f\u4ea7\u57fa\u5730\u548c\u8425\u9500\u5b50\u516c\u53f8\u4e2d\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u901a\u8fc7\u7814\u53d1\u521b\u65b0\u4ea7\u54c1\u6765\u7f13\u89e3\u533b\u7597\u9700\u6c42\u7f3a\u53e3\uff0c\u7279\u522b\u662f\u80bf\u7624\u5b66\u548c\u795e\u7ecf\u79d1\u5b66\u8fd9\u4e24\u4e2a\u6218\u7565\u9886\u57df\uff0c\u4ee5\u6b64\u6765\u5b9e\u73b0\u6211\u4eec\u7684<span lang=\"EN-US\">hhc<\/span>\u7406\u5ff5\u3002<\/p>\n<p>\u4f5c\u4e3a\u4e00\u5bb6\u5168\u7403\u533b\u836f\u516c\u53f8\uff0c\u6211\u4eec\u7684\u4f7f\u547d\u662f\u901a\u8fc7\u6295\u8d44\u548c\u5408\u4f5c\u7684\u5f62\u5f0f\u6765\u63a5\u89e6\u4e16\u754c\u5404\u5730\u7684\u60a3\u8005\uff0c\u4f7f\u6211\u4eec\u7684\u836f\u54c1\u80fd\u591f\u60e0\u53ca\u53d1\u5c55\u4e2d\u56fd\u5bb6\u548c\u65b0\u5174\u56fd\u5bb6\u3002<\/p>\n<p>\u6709\u5173\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<span lang=\"EN-US\"><a href=\"http:\/\/www.eisai.com\/\">www.eisai.com\/<\/a><\/span>\u3002<\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><strong><span lang=\"EN-US\">5<\/span><\/strong><strong>\u3001\u5173\u4e8e\u666e\u675c\u5236\u836f\u516c\u53f8<\/strong><\/p>\n<p>\u666e\u675c\u5236\u836f\u516c\u53f8\u81f4\u529b\u4e8e\u5f00\u53d1\u5e76\u63d0\u4f9b\u5904\u65b9\u836f\uff0c\u6765\u6ee1\u8db3\u533b\u7597\u4e13\u4e1a\u4eba\u58eb\u3001\u60a3\u8005\u548c\u533b\u62a4\u4eba\u5458\u4e0d\u65ad\u53d8\u5316\u7684\u9700\u6c42\u3002\u516c\u53f8\u7531\u533b\u751f\u521b\u5efa\uff0c\u76ee\u524d\u4ecd\u7531\u533b\u751f\u6765\u9886\u5bfc\u3002\u9664\u4e86\u52aa\u529b\u63d0\u4f9b\u4f18\u8d28\u836f\u7269\u4e4b\u5916\uff0c\u666e\u675c\u8fd8\u81f4\u529b\u4e8e\u652f\u6301\u540c\u56fd\u5bb6\u3001\u5730\u533a\u548c\u5f53\u5730\u8fdb\u884c\u5408\u4f5c\u6765\u63a8\u52a8\u60a3\u8005\u62a4\u7406\u65b9\u9762\u7684\u521b\u65b0\u3002\u666e\u675c\u662f\u4e00\u5bb6\u79c1\u6709\u4f01\u4e1a\uff0c\u52aa\u529b\u901a\u8fc7\u5185\u90e8\u7814\u53d1\u548c\u5efa\u7acb\u6218\u7565\u4ea7\u4e1a\u4f19\u4f34\u5173\u7cfb\u6765\u5f00\u53d1\u51fa\u4e00\u7cfb\u5217\u65b0\u836f\u548c\u65b0\u6280\u672f\u3002\u6b32\u4e86\u89e3\u8be5\u516c\u53f8\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.purduepharma.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">www.purduepharma.com<\/a>\u3002<\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><span lang=\"EN-US\">\u00a0<\/span><\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<p><sup>1<\/sup>\u00a0Eisai Inc. Long-term study of lemborexant in insomnia disorder (E2006-G000-303). Available from\u00a0<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02952820.\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02952820.<\/a>\u00a0NLM identifier: NCT02952820.<sup><br \/>\n2<\/sup>\u00a0Ferrie JE, et al. Sleep epidemiology \u2013 a rapidly growing field.\u00a0<i>Int J Epidemiol<\/i>. 2011;40(6):1431\u20131437.<sup><br \/>\n3<\/sup>\u00a0Ohayon MM, et al. Epidemiology of insomnia: what we know and what we still need to learn.\u00a0<i>Sleep Med Rev.<\/i>\u00a02002;6(2):97-111.<br \/>\n<sup>4<\/sup>\u00a0Institute of Medicine. Sleep disorders and sleep deprivation: An unmet public health problem. Washington, DC: National Academies Press. 2006.<sup><br \/>\n5<\/sup>\u00a0Pase MP, Himali JJ, Grima NA, et al. Sleep architecture and the risk of incident dementia in the community.\u00a0<i>Neurology<\/i>. 2017;89(12):1244-1250.<sup><br \/>\n6<\/sup>\u00a0Trenell MI, et al. Sleep and metabolic control: waking to a problem?\u00a0<i>Clin Exp Pharmacol Physiol.<\/i>\u00a02007;34:1-9.<br \/>\n<sup>7<\/sup>\u00a0Zhang B, Wing, YK. Sex differences in insomnia: a meta-analysis.\u00a0<i>Sleep.\u00a0<\/i>2006;29(1):85-93.<br \/>\n<sup>8<\/sup>\u00a0Ohayon MM, et al. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan.\u00a0<i>Sleep<\/i>. 2004;27:1255-1273.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2018\u5e7410\u670817\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u666e\u675c\u5236\u836f\u516c\u53f8\uff08\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\u4e3aCraig Landau\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u666e\u675c\u5236\u836f\u201d\uff09\u516c\u5e03\u4e86\u8bc4\u4f30Lemborexant\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u4e00\u9879\u957f\u671fIII\u671f\u7814\u7a76SUNRISE 2\u7684\u6700\u65b0\u9633\u6027\u7ed3\u679c\u3002Lemborexant\u662f\u4e00\u79cd\u5c1a\u5728\u5b9e\u9a8c\u4e2d\u7684\u7761\u7720-\u89c9\u9192\u8c03\u8282\u5242\uff0c\u76ee\u524d\u6b63\u5728\u7814\u7a76\u5176\u6cbb\u7597\u591a\u79cd\u7761\u7720-\u89c9\u9192\u969c\u788d\u7684\u6f5c\u80fd\u3002\u62a5\u544a\u7684\u6700\u65b0\u7ed3\u679c\u5305\u62ec\u8be5\u7814\u7a76\u5728\u4e3a\u671f\u516d\u4e2a\u6708\u7684\u5b89\u6170\u5242\u5bf9\u7167\u6cbb\u7597\u4e2d\u7684\u4e3b\u8981\u7ed3\u679c\u548c\u5173\u952e\u6b21\u8981\u7ed3\u679c\uff1b\u8be5\u7814\u7a76\u5c06\u6301\u7eed\u81f312\u4e2a\u6708\u3002\u536b\u6750\u548c\u666e\u675c\u5236\u836f\u8ba1\u5212\u57282019\u5e74\u5373\u5c06\u53ec\u5f00\u7684\u533b\u7597\u4f1a\u8bae\u4e0a\u516c\u5e03SUNRISE 2\u7684\u5168\u90e8\u7814\u7a76\u6210\u679c\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-3218","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3218"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=3218"}],"version-history":[{"count":2,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3218\/revisions"}],"predecessor-version":[{"id":3220,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3218\/revisions\/3220"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=3218"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=3218"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=3218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}