{"id":3232,"date":"2018-09-05T00:00:00","date_gmt":"2021-03-18T08:19:58","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=3232"},"modified":"2022-03-11T14:47:20","modified_gmt":"2022-03-11T06:47:20","slug":"%e5%8d%ab%e6%9d%90%e5%92%8c%e9%bb%98%e6%b2%99%e4%b8%9c%e5%ae%a3%e5%b8%83%e4%b8%ad%e5%9b%bd%e5%9b%bd%e5%ae%b6%e8%8d%af%e5%93%81%e7%9b%91%e7%9d%a3%e7%ae%a1%e7%90%86%e5%b1%80%e6%89%b9%e5%87%86%e4%b9%90","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2018\/09\/05\/%e5%8d%ab%e6%9d%90%e5%92%8c%e9%bb%98%e6%b2%99%e4%b8%9c%e5%ae%a3%e5%b8%83%e4%b8%ad%e5%9b%bd%e5%9b%bd%e5%ae%b6%e8%8d%af%e5%93%81%e7%9b%91%e7%9d%a3%e7%ae%a1%e7%90%86%e5%b1%80%e6%89%b9%e5%87%86%e4%b9%90\/","title":{"rendered":"\u536b\u6750\u548c\u9ed8\u6c99\u4e1c\u5ba3\u5e03\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u4e50\u536b\u739b\u00ae\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c"},"content":{"rendered":"<p style=\"font-weight: 400\"><strong>\u4e50\u536b\u739b<\/strong><strong><sup>\u00ae<\/sup>\u5728\u534e\u9996\u6b21\u6279\u51c6\u548c\u5341\u5e74\u6765\u4e2d\u56fd\u9996\u6b21\u6279\u51c6\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u809d\u764c\u7684\u65b0\u7597\u6cd5<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400\">2018\u5e7409\u670805\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u601d\u5821\u7684\u9ed8\u6c99\u4e1c\u516c\u53f8\uff08\u5728\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u79f0\u4e3a\u9ed8\u514b\uff09\u5ba3\u5e03\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5df2\u6279\u51c6\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09\u5355\u836f\u5728\u4e2d\u56fd\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u7684\u809d\u764c\u60a3\u8005\u30022017\u5e7410\u6708\uff0c\u536b\u6750\u5728\u4e2d\u56fd\u63d0\u4ea4\u4e86\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u7684\u7533\u8bf7\uff1b\u968f\u540e\uff0c\u9274\u4e8e\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u4e0e\u73b0\u6709\u6cbb\u7597\u836f\u7269\u76f8\u6bd4\u5177\u6709\u663e\u8457\u4e34\u5e8a\u76ca\u5904\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6388\u4e88\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u8d44\u683c\uff0c\u5e76\u4e8e\u7533\u8bf7\u63d0\u4ea4\u540e\u7ea610\u4e2a\u6708\u5feb\u901f\u83b7\u6279\u3002\u4e2d\u56fd\u662f\u5168\u4e16\u754c\u809d\u764c\u60a3\u8005\u6700\u591a\u7684\u56fd\u5bb6\uff0c\u6b64\u6b21\u6279\u51c6\u6807\u5fd7\u7740\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u5c06\u9996\u6b21\u8fdb\u5165\u4e2d\u56fd\uff0c\u662f\u5341\u5e74\u6765\u7b2c\u4e00\u4e2a\u5728\u4e2d\u56fd\u88ab\u6279\u51c6\u4f5c\u4e3a\u809d\u7ec6\u80de\u764c\u4e00\u7ebf\u7cfb\u7edf\u6cbb\u7597\u7684\u65b0\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<p style=\"font-weight: 400\">\u6b64\u6b21\u6279\u51c6\u57fa\u4e8e\u5f00\u653e\u5f0fIII\u671f\u8bd5\u9a8cREFLECT\u7814\u7a76\uff08304\u7814\u7a76\uff09<sup>2<\/sup>\u00a0\u7684\u7ed3\u679c\uff0c\u5176\u4e2d\u4e50\u536b\u739b<strong>\u00ae<\/strong>\u901a\u8fc7\u5bf9954\u4f8b\u6b64\u524d\u672a\u7ecf\u6cbb\u7597\u7684\u4e0d\u80fd\u5207\u9664\u7684\u809d\u764c\u60a3\u8005\u4e0e\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u6807\u51c6\u76f8\u6bd4\uff0c\u8be5\u7814\u7a76\u901a\u8fc7\u975e\u52a3\u6548\u6027\u7684\u7edf\u8ba1\u786e\u8ba4\u8bc1\u660e\u4e86\u4ed1\u4f10\u66ff\u5c3c\u5728\u603b\u751f\u5b58\u671f\uff08OS\uff09*1\u65b9\u9762\u7684\u6cbb\u7597\u6548\u679c\u3002\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\uff08PFS\uff09*2\u3001\u8fdb\u5c55\u65f6\u95f4\uff08TTP\uff09*3\u548c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09*4\u65b9\u9762\uff0c\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u4f18\u52bf\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002\u5728\u6765\u81ea\u5927\u4e2d\u56fd\u5730\u533a\uff08\u4e2d\u56fd\u5927\u9646\u3001\u4e2d\u56fd\u9999\u6e2f\u548c\u4e2d\u56fd\u53f0\u6e7e\uff09\u7684288\u540d\u60a3\u8005\u7684\u4e9a\u7fa4\u5206\u6790\u4e2d\uff0c\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u663e\u8457\u63d0\u9ad8\u60a3\u8005OS\uff0c\u5728PFS\u3001TTP\u548cORR3\u4e2d\u4e5f\u6709\u663e\u8457\u6539\u5584\u3002\u6b64\u4e9a\u7ec4\u4eba\u7fa4\u4e2d\uff0c\u7ea680%\u7684\u60a3\u8005\u662f\u7531\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u5f15\u8d77\u7684\u809d\u7ec6\u80de\u764c\uff0c\u5177\u6709\u5f88\u9ad8\u7684\u533b\u7597\u9700\u6c42\u3002\u5bf9\u4e8e\u8fd9\u4e9b\u60a3\u8005\uff0c\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u57fa\u4e8e\u4e0e\u7d22\u62c9\u975e\u5c3cOS\u76f8\u6bd4\u5448\u73b0\u975e\u52a3\u6548\u6027\uff0c\u5176\u663e\u793a\u4e86\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u5728HBV\u5f15\u8d77\u7684\u809d\u764c\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\u3002\uff08\u8be6\u60c5\u8bf7\u53c2\u9605\u4ee5\u4e0b\u201c\u7f16\u8005\u6309\u201d\uff09\u3002<\/p>\n<p style=\"font-weight: 400\">\u5728\u4e2d\u56fd\u8bf4\u660e\u4e66\u4e2d\uff0c\u4f7f\u7528\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u6cbb\u7597\u7684\u60a3\u8005\u6700\u5e38\u89c1\u76845\u79cd\u4e0d\u826f\u53cd\u5e94\u662f\u9ad8\u8840\u538b\uff0845%\uff09\u3001\u75b2\u52b3\uff0844%\uff09\u3001\u8179\u6cfb\uff0839%\uff09\u3001\u98df\u6b32\u4e0b\u964d\uff0834%\uff09\u548c\u4f53\u91cd\u4e0b\u964d\uff0831%\uff09\uff0c\u8fd9\u4e0e\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u5df2\u77e5\u7684\u526f\u4f5c\u7528\u4e00\u81f4\u3002<\/p>\n<p style=\"font-weight: 400\">\u809d\u764c\u662f\u5168\u7403\u7b2c\u4e8c\u5927\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u539f\u56e0\uff0c2012\u5e74\u7edf\u8ba1\u6570\u636e\u663e\u793a\uff0c\u5168\u7403\u6bcf\u5e74\u7ea6\u6709750,0000\u4eba\u6b7b\u4e8e\u8be5\u75c5\uff0c\u4e14\u6bcf\u5e74\u7ea6\u6709780,0000\u4f8b\u65b0\u786e\u8bca\u75c5\u4f8b\uff0c\u5176\u4e2d\u7ea680%\u53d1\u751f\u5728\u4e9a\u6d32\u5730\u533a\u3002\u5728\u4e2d\u56fd\uff0c\u6bcf\u5e74\u7ea6\u6709395,0000\u4f8b\u65b0\u75c5\u4f8b\uff0c\u6b7b\u4ea1380,0000\u4f8b\uff0c\u7ea6\u5360\u5168\u4e16\u754c\u75c5\u4f8b\u768450%\u3002<sup>1<\/sup>\u809d\u7ec6\u80de\u764c\u5360\u809d\u764c\u603b\u4eba\u7fa4\u768485%\u81f390%\u3002\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u65b9\u6848\u6709\u9650\uff0c\u4e14\u6781\u96be\u6cbb\u7597\uff0c\u56e0\u6b64\u9700\u8981\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<p style=\"font-weight: 400\">\u81ea\u9996\u6b21\u4e0a\u5e02\u4ee5\u6765\uff0c\u5df2\u6709\u8d85\u8fc710000\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u6cbb\u7597\u3002\u4eca\u5929\uff0c\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u5df2\u5728\u5305\u62ec\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u6b27\u6d32\u3001\u4e9a\u6d32\u5728\u5185\u768450\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u96be\u6cbb\u6027\u7532\u72b6\u817a\u764c\uff0c\u5e76\u5728\u5305\u62ec\u7f8e\u56fd\u548c\u6b27\u6d32\u5728\u5185\u7684\u8d85\u8fc745\u4e2a\u56fd\u5bb6\u83b7\u6279\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u4e8e\u80be\u7ec6\u80de\u764cRCC\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002\u5bf9\u4e8e\u809d\u7ec6\u80de\u764cHCC\uff0c\u4e50\u536b\u739b<sup><strong>\u00ae<\/strong><\/sup>\u57282018\u5e743\u6708\u5728\u65e5\u672c\u83b7\u6279\u8be5\u9002\u5e94\u75c7\uff0c2018\u5e748\u6708\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u83b7\u6279\u8be5\u9002\u5e94\u75c7\u3002<\/p>\n<p style=\"font-weight: 400\"><sup>*1<\/sup>\u00a0\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff1a\u4ece\u764c\u75c7\u6cbb\u7597\u5f00\u59cb\u5230\u56e0\u4efb\u4f55\u539f\u56e0\u6b7b\u4ea1\u7684\u65f6\u95f4\u3002\u8be5\u53d8\u91cf\u4e0d\u8003\u8651\u6b7b\u56e0\u662f\u5426\u4e3a\u764c\u75c7\u3002<\/p>\n<p style=\"font-weight: 400\"><sup>*2<\/sup>\u00a0\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff1aPFS\u662f\u4ece\u764c\u75c7\u6cbb\u7597\u5f00\u59cb\u5230\u75be\u75c5\u8fdb\u5c55\u7684\u65f6\u95f4\uff0c\u6216\u56e0\u4efb\u4f55\u539f\u56e0\u5bfc\u81f4\u6b7b\u4ea1\u7684\u65f6\u95f4\uff08\u4ee5\u8f83\u65e9\u8005\u4e3a\u51c6\uff09\u7684\u5ba2\u89c2\u786e\u8ba4\u65f6\u95f4\u3002<\/p>\n<p style=\"font-weight: 400\"><sup>*3<\/sup>\u00a0\u8fdb\u5c55\u65f6\u95f4\uff08TTP\uff09\uff1aTTP\u662f\u4ece\u764c\u75c7\u6cbb\u7597\u5f00\u59cb\u5230\u75be\u75c5\u8fdb\u5c55\u65e5\u671f\u7684\u5ba2\u89c2\u786e\u8ba4\u65f6\u95f4\u3002\u4e0ePFS\u4e0d\u540c\uff0cTTP\u4e0d\u8003\u8651\u4efb\u4f55\u539f\u56e0\u5bfc\u81f4\u7684\u6b7b\u4ea1\u3002<\/p>\n<p style=\"font-weight: 400\"><sup>*4<\/sup>\u00a0\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff1aORR\u662f\u6307\u7ecf\u5f71\u50cf\u5b66\u8bca\u65ad\uff0c\u80bf\u7624\u5b8c\u5168\u7f13\u89e3\uff08\u80bf\u7624\u6d88\u5931\uff09\u6bd4\u4f8b\u4e0e\u80bf\u7624\u90e8\u5206\u7f13\u89e3\uff08\u80bf\u7624\u4f53\u79ef\u51cf\u5c11\u8d85\u8fc730%\uff09\u6bd4\u4f8b\u4e4b\u548c\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.eisai.com.cn\/userfiles\/%E6%97%A0%E6%A0%871111%E9%A2%98(7).jpg\" alt=\"\" width=\"500\" height=\"136\" \/><\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400\"><strong>\u7f16\u8005\u6309\uff1a<\/strong><\/p>\n<p style=\"font-weight: 400\"><strong>\u5173\u4e8eREFLECT\u8bd5\u9a8c\uff08304\u7814\u7a76\uff09<sup>2<\/sup><\/strong><\/p>\n<p style=\"font-weight: 400\">REFLECT\u662f\u536b\u6750\u8fdb\u884c\u7684\u4e00\u9879\u5927\u578b\uff08N = 954\u4f8b\uff09III\u671f\u3001\u968f\u673a\u3001\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u975e\u52a3\u6548\u6027\u7814\u7a76\uff0c\u6bd4\u8f83\u4ed1\u4f10\u66ff\u5c3c\u548c\u7d22\u62c9\u975e\u5c3c\u4f5c\u4e3a\u4e00\u7ebf\u7cfb\u7edf\u7597\u6cd5\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u300220\u4e2a\u56fd\u5bb6154\u4e2a\u7814\u7a76\u4e2d\u5fc3\u7684\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\uff0c\u6839\u636e\u4f53\u91cd\uff08\u226560 kg\u6216&lt; 60 kg\uff09\uff08n = 478\u4f8b\uff09\u6bcf\u5929\u670d\u7528\u4e00\u6b2112 mg\u62168 mg\u4ed1\u4f10\u66ff\u5c3c\uff0c\u6216\u6bcf\u5929\u670d\u7528\u4e24\u6b21400 mg\u7d22\u62c9\u975e\u5c3c\uff08n = 476\u4f8b\uff09\u3002\u6cbb\u7597\u6301\u7eed\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u3002\u8fd9\u9879\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u603b\u751f\u5b58\u671f\uff0c\u9996\u5148\u6d4b\u8bd5\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c\u7684\u975e\u52a3\u6548\u6027\uff0c\u7136\u540e\u662f\u4f18\u6548\u6027\u3002\u672c\u7814\u7a76\u7684\u4e3b\u8981\u6b21\u8981\u7597\u6548\u7ec8\u70b9\u5305\u62ecPFS\u3001TTP\u548cORR\uff0c\u6d4b\u8bd5\u4e0e\u7d22\u62c9\u975e\u5c3c\u5bf9\u6bd4\u7684\u4f18\u6548\u6027\u3002<\/p>\n<p style=\"font-weight: 400\">\u5728\u4e2d\u56fd\u8bf4\u660e\u4e66\u4e2d\uff0cREFLECT\u663e\u793a\u4e50\u536b\u739b\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u901a\u8fc7\u4e0e\u7d22\u62c9\u83f2\u5c3c\u975e\u52a3\u6548\u6027\u7684\u7edf\u8ba1\u786e\u8ba4\uff0c\u8bc1\u660e\u4e86\u4ed1\u4f10\u66ff\u5c3c\u5728\u603b\u751f\u5b58\u671f\uff08OS\uff09<sup>*1<\/sup>\u65b9\u9762\u7684\u6cbb\u7597\u6548\u679c\u3002REFLECT\u663e\u793a\u4ed1\u4f10\u66ff\u5c3c\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u901a\u8fc7\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c\u7684\u975e\u52a3\u6548\u6027\u7edf\u8ba1\u786e\u8ba4\uff0c\u8bc1\u660e\u4e86\u4ed1\u4f10\u66ff\u5c3c\u5728OS\u65b9\u9762\u7684\u6cbb\u7597\u6548\u679c\u3002\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u4f4dOS\u4e3a13.6\u4e2a\u6708\uff0c\u4f7f\u7528\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u4f4dOS\u4e3a12.3\u4e2a\u6708\uff08\u98ce\u9669\u6bd4\uff08HR\uff09\uff1a0.92\uff1b95 %\u7f6e\u4fe1\u533a\u95f4\uff08CI\uff09\uff1a0.79 &#8211; 1.06\uff09\u3002\u6b64\u5916\uff0c\u4ed1\u4f10\u66ff\u5c3c\u5728PFS\u548cORR\u7684\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u65b9\u9762\u663e\u793a\u51fa\u663e\u8457\u7edf\u8ba1\u5b66\u4f18\u6548\u6027\u548c\u4e34\u5e8a\u6539\u5584\uff0c\u8fd9\u4e00\u70b9\u5df2\u88ab\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\uff08IIR\uff09\u6240\u8bc1\u5b9e\u3002<\/p>\n<ul>\n<li style=\"font-weight: 400\">\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7684\u4e2d\u4f4dPFS\u589e\u52a0\u4e86\u4e00\u500d\uff1a\u4f9d\u636e\u57fa\u4e8emRECIST\u6807\u51c6\u7684\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\uff0c7.3\u4e2a\u6708\u5bf9\u6bd43.6\u4e2a\u6708\uff08HR\uff1a0.64\uff1b95 % CI\uff1a0.55 &#8211; 0.75\uff1bp &lt; 0.0001\uff09\uff0c\u4f9d\u636eRECIST 1.1\u6807\u51c6<\/li>\n<li style=\"font-weight: 400\">\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7684\u4e2d\u4f4d\u8fdb\u5c55\u65f6\u95f4\uff08TTP\uff09\u662f\u7d22\u62c9\u975e\u5c3c\u7684\u4e24\u500d\uff1a\u4f9d\u636e\u57fa\u4e8emRECIST\u6807\u51c6\u7684\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\uff0c7.4\u4e2a\u6708\u5bf9\u6bd43.7\u4e2a\u6708\uff08HR\uff1a0.60\uff1b95 % CI\uff1a0.51 &#8211; 0.71\uff1bp &lt; 0.0001\uff09<\/li>\n<li style=\"font-weight: 400\">\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7684ORR\u663e\u793a\u662f\u7d22\u62c9\u975e\u5c3c\u7684\u8fd13.5\u500d\uff1a\u4f9d\u636e\u57fa\u4e8emRECIST\u6807\u51c6\u7684\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e540.6\uff05\uff0895\uff05CI\uff1a36.2-45.0\uff09\uff0c\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u6bcf\u76f2\u72ec\u7acb\u6210\u50cf\u68c0\u67e512.4\uff05\uff0895\uff05CI\uff1a9.4-15.4\uff09\uff08\u4f18\u52bf\u6bd45.01\uff0c95\uff05CI\uff1a3.59-7.01\uff1bp&lt;0.00001\uff09<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400\"><strong>\u5927\u4e2d\u534e\u533a\u4eba\u7fa4\u4e9a\u7fa4\u5206\u6790<sup>3<\/sup><\/strong><\/p>\n<p style=\"font-weight: 400\">\u5bf9\u4e8e\u5927\u4e2d\u534e\u5730\u533a\u60a3\u8005\u7684\u4e9a\u7ec4\u4eba\u7fa4\u5206\u6790\u7ed3\u679c\u57fa\u4e8e\u53c2\u4e0eREFLECT\u7814\u7a76\u7684\u6240\u6709954\u540d\u809d\u7ec6\u80de\u764c\u60a3\u8005\u4e2d\u7684288\u540d\u3002\u5728\u8fd9\u4e2a\u4e9a\u7fa4\u4f53\u5206\u6790\u4e2d\uff0cLENVIMA\u60a3\u8005\u7684\u4e2d\u4f4dOS\u4e3a15.0\u4e2a\u6708\uff0c\u7d22\u62c9\u975e\u5c3c\u4e3a10.2\u4e2a\u6708\uff08HR\uff1a0.73\uff1b95%CI\uff1a0.55-0.96\uff1bnominal p=0.02620\uff09\u3002\u57fa\u4e8eMcReCIST\u6807\u51c6\u7684\u72ec\u7acb\u6210\u50cf\u68c0\u67e5\u63ed\u793a\u4e86\u4ee5\u4e0b\u7ed3\u679c\uff1aPFS\uff08\u4e50\u536b\u739b8.4\u6708\u5bf9\u6bd4\u7d22\u62c9\u83f2\u5c3c3.6\u6708\u4e2d\u4f4d\u6570\u00a0[HR: 0.47; 95% CI: 0.35-0.64; nominal p&lt;0.00001]), TTP (\u4e50\u536b\u739b9.2\u4e2a\u6708\u5bf9\u6bd4\u7d22\u62c9\u83f2\u5c3c3.6\u4e2a\u6708\u4e2d\u4f4d\u6570\u00a0[HR: 0.45; 95% CI: 0.33-0.62; nominal p&lt;0.00001]) and ORR (\u4e50\u536b\u739b43.8%\u00a0\u5bf9\u6bd4\u7d22\u62c9\u83f2\u5c3c13.2% [odds ratio 5.14; 95% CI: 2.84-9.31; nominal p&lt;0.00001])\u3002<\/p>\n<p style=\"font-weight: 400\">\u53e6\u5916\uff0c\u5728\u6b64\u4e9a\u7ec4\u4eba\u7fa4\u7684288\u540d\u60a3\u8005\u4e2d\uff0c\u7ea680%\uff08n=242\uff09\u7684\u60a3\u8005\u662f\u7531\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u5f15\u8d77\u7684\u809d\u7ec6\u80de\u764c\u3002\u5bf9\u8fd9\u4e9b\u60a3\u8005\u7684\u5206\u6790\u663e\u793a\u4ee5\u4e0b\u7ed3\u679c\uff1a\u5bf9\u8fd9\u4e9b\u60a3\u8005\u7684\u5206\u6790\u663e\u793aOS\u7684\u4e0b\u5217\u7ed3\u679c\uff1a\u4e50\u536b\u739b\uff08n=123\uff0914.9\u4e2a\u6708\uff0c\u7d22\u62c9\u975e\u5c3c\uff08n=119\uff099.9\u4e2a\u6708\uff0c\u4e2d\u4f4d\u6570\uff08HR\uff1a0.72\uff1b95%CI\uff1a0.53-0.97\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400\"><strong>\u5173\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c<\/strong><\/p>\n<p style=\"font-weight: 400\">\u809d\u764c\u662f\u5168\u7403\u7b2c\u4e8c\u5927\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u539f\u56e0\uff0c2012\u5e74\u7edf\u8ba1\u6570\u636e\u663e\u793a\uff0c\u5168\u7403\u6bcf\u5e74\u7ea6\u670975,0000\u4eba\u6b7b\u4e8e\u8be5\u75c5\u3002\u6b64\u5916\uff0c\u6bcf\u5e74\u670978,0000\u4f8b\u65b0\u786e\u8bca\u75c5\u4f8b\u30021\u533a\u57df\u5dee\u5f02\u5f88\u5927\uff0c\u5927\u7ea680%\u7684\u65b0\u75c5\u4f8b\u53d1\u751f\u5728\u4e9a\u6d32\u5730\u533a\uff0c\u5305\u62ec\u4e2d\u56fd\u548c\u65e5\u672c\u3002\u809d\u7ec6\u80de\u764c\u5360\u809d\u764c\u603b\u4eba\u7fa4\u768485% &#8211; 90%\u3002\u809d\u7ec6\u80de\u764c\u4e0e\u6162\u6027\u809d\u75c5\u76f8\u5173\uff0c\u5c24\u5176\u662f\u809d\u786c\u5316\u3002\u809d\u786c\u5316\u7684\u4e3b\u8981\u539f\u56e0\u5305\u62ec\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u548c\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u3002\u7136\u800c\uff0c\u6839\u636e\u6700\u8fd1\u7684\u8c03\u67e5\uff0c\u975e\u4e59\u578b\/\u975e\u4e19\u578b\u809d\u7ec6\u80de\u764c\u5448\u4e0a\u5347\u8d8b\u52bf\u3002\u624b\u672f\u662f\u6cbb\u7597\u7684\u9996\u9009\u65b9\u6848\uff0c\u4f46\u5bf9\u4e8e\u60a3\u6709\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u60a3\u8005\uff0c\u4e0d\u9002\u5408\u8fdb\u884c\u6f5c\u5728\u6cbb\u6108\u6027\u6cbb\u7597\u5e72\u9884\uff0c\u5305\u62ec\u809d\u79fb\u690d\uff0c\u624b\u672f\u5207\u9664\u548c\u80bf\u7624\u6d88\u878d\uff08\u901a\u5e38\u4e3a\u5c04\u9891\u6d88\u878d\u6216\u51b7\u51bb\u6cbb\u7597\uff09\uff0c\u6216\u4e0d\u9002\u5408\u809d\u52a8\u8109\u5316\u7597\u6813\u585e\u672f\uff08TACE\uff09\u7684\u60a3\u8005\uff0c\u6cbb\u7597\u65b9\u6848\u6709\u9650\uff0c\u9884\u540e\u8f83\u5dee\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400\"><strong>\u5173\u4e8e\u4e50\u536b\u739b<sup>\u00ae<\/sup>\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09<\/strong><\/p>\n<p style=\"font-weight: 400\">\u4e50\u536b\u739b<sup>\u00ae<\/sup>\u7531\u536b\u6750\u72ec\u7acb\u7814\u53d1\uff0c\u662f\u4e00\u79cd\u53e3\u670d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5177\u6709\u65b0\u7684\u53d7\u4f53\u7ed3\u5408\u6a21\u5f0f\uff0c\u9664\u4e86\u5176\u4ed6\u4e0e\u901a\u8def\u76f8\u5173\u7684RTKs\uff08\u5305\u62ec\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\uff08PDGF\uff09\u53d7\u4f53PDGFR\u03b1\uff1bKIT\u548c\u00a0RET\uff09\u53c2\u4e0e\u80bf\u7624\u8840\u7ba1\u751f\u6210\u3001\u80bf\u7624\u8fdb\u5c55\u548c\u80bf\u7624\u514d\u75ab\u7684\u6539\u826f\u4e4b\u5916\uff0c\u8fd8\u9009\u62e9\u6027\u5730\u6291\u5236\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u53d7\u4f53\uff08VEGFR1\u3001VEGFR2\u548cVEGFR3\uff09\u548c\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGF\uff09\u53d7\u4f53\uff08FGFR1\u3001FGFR2\u3001FGFR3\u548cFGFR4\uff09\u7684\u591a\u9879\u6d3b\u52a8\u3002<\/p>\n<p style=\"font-weight: 400\">\u76ee\u524d\uff0c\u536b\u6750\u5df2\u5728\u5305\u62ec\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u5728\u5185\u768450\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u5c06\u4e50\u536b\u739b<sup>\u00ae<\/sup>\u7528\u4e8e\u6cbb\u7597\u96be\u6cbb\u6027\u7532\u72b6\u817a\u764c\u3002\u6b64\u5916\uff0c\u536b\u6750\u8fd8\u5728\u5305\u62ec\u7f8e\u56fd\u548c\u6b27\u6d32\u5728\u5185\u7684\u8d85\u8fc745\u4e2a\u56fd\u5bb6\u83b7\u6279\u5c06\u8be5\u836f\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u4e8e\u80be\u7ec6\u80de\u764c\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002\u5728\u6b27\u6d32\uff0c\u8be5\u836f\u4ee5Kisplyx\u4e3a\u5546\u54c1\u540d\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u3002<\/p>\n<p style=\"font-weight: 400\">\u9664\u6b27\u6d32\u5916\uff0c\u4e50\u536b\u739b<sup>\u00ae<\/sup>\u5df2\u5728\u65e5\u672c\u3001\u7f8e\u56fd\u548c\u6b27\u6d32\u88ab\u6279\u51c6\u4f5c\u4e3a\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u536b\u6750\u5df2\u5728\u4e2d\u56fd\u53f0\u6e7e\uff082017\u5e7412\u6708\uff09\u548c\u97e9\u56fd\uff082018\u5e743\u6708\uff09\u4ee5\u53ca\u5176\u4ed6\u56fd\u5bb6\u63d0\u4ea4\u4e86\u5c06\u8be5\u836f\u9002\u5e94\u75c7\u6269\u5c55\u81f3\u5305\u62ec\u809d\u7ec6\u80de\u764c\u7684\u7533\u8bf7\u3002<\/p>\n<p style=\"font-weight: 400\">\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5bf9\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff0c \u4e50\u536b\u739b<sup>\u00ae<\/sup>\u7684\u5242\u91cf\u786e\u5b9a\u4f9d\u636e\u60a3\u8005\u7684\u4f53\u91cd\uff08\u60a3\u8005\u91cd\u4f5360\u516c\u65a4\u6216\u4ee5\u4e0a12 mg\u3001\u60a3\u8005\u4f53\u91cd\u4f4e\u4e8e60\u516c\u65a48 mg\uff09\uff1b\u5efa\u8bae\u5242\u91cf\u548c\u5242\u91cf\u8c03\u6574\u89c1\u5b8c\u6574\u5904\u65b9\u4fe1\u606f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400\"><strong>\u5173\u4e8e\u536b\u6750\u4e0e\u9ed8\u6c99\u4e1c\u7684\u6218\u7565\u5408\u4f5c<\/strong><\/p>\n<p style=\"font-weight: 400\">2018\u5e743\u6708\uff0c\u536b\u6750\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u601d\u5821\u7684\u9ed8\u6c99\u4e1c\u516c\u53f8\u901a\u8fc7\u4e00\u5bb6\u5b50\u516c\u53f8\u5c55\u5f00\u4e86\u5173\u4e8e\u4e50\u536b\u739b<sup>\u00ae<\/sup>\uff08\u4ed1\u4f10\u66ff\u5c3c\uff09\u7684\u5168\u7403\u8054\u5408\u5f00\u53d1\u548c\u8054\u5408\u5546\u4e1a\u5316\u7684\u6218\u7565\u5408\u4f5c\u3002\u6839\u636e\u8be5\u534f\u8bae\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u5171\u540c\u5f00\u53d1\u4e50\u536b\u739b<sup>\u00ae<\/sup>\u5e76\u5b9e\u73b0\u5546\u4e1a\u5316\uff0c\u5305\u62ec\u5355\u836f\u7597\u6cd5\u4ee5\u53ca\u4e0e\u9ed8\u6c99\u4e1c\u7684\u6297PD-1\u836f\u7269KEYTRUDA\uff08Pembrolizumab\uff09\u7684\u8054\u5408\u7597\u6cd5\u3002\u9664\u4e86\u6b63\u5728\u8fdb\u884c\u7684\u8054\u5408\u4e34\u5e8a\u7814\u7a76\u5916\uff0c\u53cc\u65b9\u8fd8\u5c06\u8054\u5408\u53d1\u8d77\u65b0\u7684\u4e34\u5e8a\u7814\u7a76\u6765\u8bc4\u4f30\u4e50\u536b\u739b<sup>\u00ae<\/sup>\u548cKEYTRUDA\u8054\u5408\u7597\u6cd5\u57286\u7c7b\u764c\u75c7\u768411\u4e2a\u6f5c\u5728\u9002\u5e94\u75c7\u4e2d\u7684\u7597\u6548\uff0c\u4ee5\u53ca\u9488\u5bf9\u53e6\u59166\u7c7b\u764c\u75c7\u7684\u8bd5\u9a8c\u3002\u4eca\u5929\uff0c\u4e50\u536b\u739b\u548cKEYTRUDA\u7684\u7ec4\u5408\u5c1a\u672a\u88ab\u6279\u51c6\u7528\u4e8e\u4efb\u4f55\u7c7b\u578b\u7684\u764c\u75c7\u6cbb\u7597\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400\"><strong>\u5173\u4e8e\u536b\u6750\u682a\u5f0f\u4f1a\u793e<\/strong><\/p>\n<p style=\"font-weight: 400\">\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u662f\u5168\u7403\u9886\u5148\u7684\u7814\u53d1\u578b\u5236\u836f\u4f01\u4e1a\uff0c\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u3002\u6211\u4eec\u628a\u516c\u53f8\u7684\u4f7f\u547d\u5b9a\u4e49\u4e3a\u201c\u5c06\u60a3\u8005\u53ca\u5bb6\u5c5e\u7684\u5229\u76ca\u653e\u5728\u9996\u4f4d\uff0c\u5e76\u63d0\u5347\u5176\u533b\u7597\u5065\u5eb7\u798f\u7949\u201d\uff0c\u5373\u201c\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\uff08<em>hhc<\/em>\uff09\u201d\u7684\u7406\u5ff5\u3002\u516c\u53f8\u62e5\u6709\u8fd110000\u540d\u5458\u5de5\u548c\u904d\u5e03\u5168\u7403\u7814\u53d1\u3001\u751f\u4ea7\u57fa\u5730\u548c\u8425\u9500\u5b50\u516c\u53f8\u7f51\u7edc\uff0c\u6211\u4eec\u901a\u8fc7\u5728\u5404\u79cd\u6cbb\u7597\u9886\u57df\u63d0\u4f9b\u521b\u65b0\u4ea7\u54c1\uff0c\u586b\u8865\u9ad8\u5ea6\u672a\u88ab\u6ee1\u8db3\u533b\u7597\u9700\u6c42\uff0c\u5305\u62ec\u80bf\u7624\u6cbb\u7597\u9886\u57df\u548c\u795e\u7ecf\u79d1\u5b66\u9886\u57df\uff0c\u81f4\u529b\u4e8e\u5b9e\u73b0\u6211\u4eec\u7684\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\u7684\u4f01\u4e1a\u7406\u5ff5\u3002<\/p>\n<p style=\"font-weight: 400\">\u4f5c\u4e3a\u4e00\u5bb6\u5168\u7403\u6027\u7684\u5236\u836f\u516c\u53f8\uff0c\u6211\u4eec\u7684\u4f7f\u547d\u901a\u8fc7\u6295\u8d44\u548c\u53c2\u4e0e\u57fa\u4e8e\u4f19\u4f34\u5173\u7cfb\u7684\u884c\u52a8\uff0c\u6269\u5927\u5230\u4e16\u754c\u5404\u5730\u7684\u60a3\u8005\uff0c\u4ee5\u6539\u5584\u53d1\u5c55\u4e2d\u56fd\u5bb6\u548c\u65b0\u5174\u56fd\u5bb6\u7684\u836f\u7269\u53ef\u53ca\u6027\u3002<\/p>\n<p style=\"font-weight: 400\">\u6709\u5173\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u00a0<a href=\"https:\/\/www.eisai.com\/index.html\">www.eisai.com<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400\"><strong>\u5173\u4e8e\u9ed8\u6c99\u4e1c\u80bf\u7624<\/strong><\/p>\n<p style=\"font-weight: 400\">\u9ed8\u6c99\u4e1c\u80bf\u7624\u81f4\u529b\u4e8e\u5c06\u79d1\u7814\u7a81\u7834\u8f6c\u5316\u4e3a\u521b\u65b0\u6cbb\u7597\u6210\u679c\u4ee5\u9020\u798f\u5168\u7403\u60a3\u8005\u3002\u5728\u9ed8\u6c99\u4e1c\uff0c\u4e3a\u764c\u75c7\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\uff0c\u79ef\u6781\u6539\u5584\u836f\u7269\u53ef\u53ca\u6027\u662f\u6211\u4eec\u4e0d\u53d8\u7684\u627f\u8bfa\u3002<\/p>\n<p style=\"font-weight: 400\">\u4f5c\u4e3a\u9ed8\u6c99\u4e1c\u5728\u80bf\u7624\u9886\u57df\u7684\u91cd\u70b9\u4e4b\u4e00\uff0c\u6211\u4eec\u627f\u8bfa\u5c06\u4e0d\u65ad\u5bf9\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u8fdb\u884c\u63a2\u7d22\u3002\u5982\u4eca\uff0c\u9ed8\u6c99\u4e1c\u5df2\u5728\u80bf\u7624\u9886\u57df\u542f\u52a8\u884c\u4e1a\u5185\u6700\u5927\u7684\u7814\u53d1\u9879\u76ee\u4e4b\u4e00\uff0c\u8986\u76d6\u8d85\u8fc730\u4e2a\u764c\u79cd\u3002\u6b64\u5916\uff0c\u6211\u4eec\u8fd8\u5c06\u901a\u8fc7\u6218\u7565\u5e03\u5c40\u4ee5\u62d3\u5c55\u4ea7\u54c1\u7ec4\u5408\uff0c\u5e76\u4f18\u5316\u4ea7\u54c1\u7814\u53d1\u7ba1\u7ebf\uff0c\u5f00\u53d1\u6709\u6f5c\u529b\u7684\u4ea7\u54c1\u4ee5\u6cbb\u7597\u6076\u6027\u80bf\u7624\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400\"><strong>\u5173\u4e8e\u9ed8\u6c99\u4e1c<\/strong><\/p>\n<p style=\"font-weight: 400\">\u4e00\u4e2a\u591a\u4e16\u7eaa\u4ee5\u6765\uff0c\u9ed8\u6c99\u4e1c\u5df2\u7ecf\u6210\u4e3a\u5168\u7403\u533b\u7597\u884c\u4e1a\u7684\u9886\u5148\u8005\uff0c\u5e26\u6765\u836f\u54c1\u548c\u75ab\u82d7\uff0c\u653b\u514b\u5168\u7403\u6700\u4e3a\u68d8\u624b\u7684\u75be\u75c5\u3002\u5728\u7f8e\u56fd\u4e0e\u52a0\u62ff\u5927\uff0c\u9ed8\u6c99\u4e1c\u79f0\u4e3a\u9ed8\u514b\u3002\u51ed\u501f\u5904\u65b9\u836f\u3001\u75ab\u82d7\u4e0e\u751f\u7269\u5236\u54c1\u548c\u52a8\u7269\u4fdd\u5065\u4ea7\u54c1\uff0c\u6211\u4eec\u4e0e\u5404\u65b9\u7d27\u5bc6\u5408\u4f5c\uff0c\u4e3a140\u591a\u4e2a\u5e02\u573a\u63d0\u4f9b\u521b\u65b0\u7684\u533b\u7597\u89e3\u51b3\u65b9\u6848\u3002\u901a\u8fc7\u5f71\u54cd\u6df1\u8fdc\u7684\u653f\u7b56\u3001\u9879\u76ee\u548c\u5408\u4f5c\u5173\u7cfb\uff0c\u6211\u4eec\u5c65\u884c\u7740\u5bf9\u63d0\u9ad8\u533b\u7597\u670d\u52a1\u53ef\u53ca\u6027\u7684\u627f\u8bfa\u3002<\/p>\n<p style=\"font-weight: 400\">\u5982\u4eca\uff0c\u9ed8\u6c99\u4e1c\u7ee7\u7eed\u8d70\u5728\u7814\u53d1\u7684\u524d\u6cbf\uff0c\u9488\u5bf9\u5a01\u80c1\u5168\u7403\u4eba\u7c7b\u53ca\u793e\u533a\u7684\u75be\u75c5\u2014\u2014\u5305\u62ec\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u4ee3\u8c22\u75be\u75c5\u3001\u65b0\u5174\u52a8\u7269\u75be\u75c5\u3001\u963f\u5179\u6d77\u9ed8\u75c7\u3001\u4f20\u67d3\u75c5\u5982\u827e\u6ecb\u75c5\u75c5\u6bd2\u548c\u57c3\u535a\u62c9\u75c5\u6bd2\u2014\u2014\u63a8\u52a8\u5176\u9884\u9632\u53ca\u6cbb\u7597\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400\"><strong>\u9ed8\u6c99\u4e1c\u524d\u77bb\u6027\u58f0\u660e<\/strong><\/p>\n<p style=\"font-weight: 400\">\u9ed8\u6c99\u4e1c\u516c\u53f8\u5168\u7403\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u5c3c\u6c83\u65af\u5e02\uff08\u4e0b\u79f0\u201c\u516c\u53f8\u201d\uff09\u3002\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u6839\u636e\u300a1995\u00a0\u5e74\u7f8e\u56fd\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\u4e4b\u5b89\u5168\u6761\u6b3e\u800c\u505a\u51fa\u7684\u201c\u524d\u77bb\u6027\u58f0\u660e\u201d\u3002\u672c\u6587\u5185\u5bb9\u57fa\u4e8e\u516c\u53f8\u7ba1\u7406\u5c42\u5f53\u524d\u7684\u770b\u6cd5\u548c\u9884\u671f\uff0c\u5e76\u4e14\u53d7\u5236\u4e8e\u53ef\u80fd\u51fa\u73b0\u7684\u91cd\u5927\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u56e0\u7d20\u3002\u9ed8\u6c99\u4e1c\u4e0d\u4fdd\u8bc1\u5728\u7814\u4ea7\u54c1\u80fd\u83b7\u5f97\u6240\u9700\u7684\u76d1\u7ba1\u90e8\u95e8\u6279\u51c6\u6216\u53d6\u5f97\u5546\u4e1a\u6210\u529f\u3002\u5982\u679c\u76f8\u5173\u5047\u8bbe\u4e0e\u73b0\u5b9e\u6709\u6240\u51fa\u5165\u3001\u51fa\u73b0\u98ce\u9669\uff0c\u6216\u53d1\u751f\u4e0d\u786e\u5b9a\u60c5\u51b5\uff0c\u5b9e\u9645\u7ed3\u679c\u53ef\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u4e2d\u7684\u9884\u671f\u6709\u5b9e\u8d28\u4e0a\u7684\u5dee\u5f02\u3002<\/p>\n<p style=\"font-weight: 400\">\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u56e0\u7d20\u5305\u62ec\u4f46\u4e0d\u4ec5\u9650\u4e8e\u4e00\u822c\u884c\u4e1a\u60c5\u51b5\u4e0e\u7ade\u4e89\u3001\u4e00\u822c\u7ecf\u6d4e\u56e0\u7d20\uff08\u5305\u62ec\u5229\u7387\u4e0e\u6c47\u7387\u6d6e\u52a8\uff09\u3001\u7f8e\u56fd\u53ca\u5176\u4ed6\u56fd\u5bb6\u5236\u836f\u884c\u4e1a\u76d1\u7ba1\u4ee5\u53ca\u533b\u7597\u653f\u7b56\u7684\u5f71\u54cd\u3001\u5168\u7403\u8303\u56f4\u5185\u63a7\u5236\u533b\u7597\u6210\u672c\u7684\u8d8b\u52bf\u3001\u6280\u672f\u53d1\u5c55\u3001\u7ade\u4e89\u5bf9\u624b\u83b7\u5f97\u7684\u65b0\u4ea7\u54c1\u4e0e\u4e13\u5229\u3001\u65b0\u4ea7\u54c1\u5f00\u53d1\u56fa\u6709\u7684\u6311\u6218\uff08\u5305\u62ec\u83b7\u5f97\u76d1\u7ba1\u90e8\u95e8\u6279\u51c6\uff09\u3001\u9ed8\u6c99\u4e1c\u5bf9\u672a\u6765\u5e02\u573a\u5f62\u52bf\u505a\u51fa\u51c6\u786e\u9884\u6d4b\u7684\u80fd\u529b\u3001\u751f\u4ea7\u4e0a\u7684\u56f0\u96be\u6216\u8fdf\u5ef6\u3001\u56fd\u9645\u7ecf\u6d4e\u91d1\u878d\u72b6\u51b5\u4e0d\u7a33\u5b9a\u4e0e\u4e3b\u6743\u98ce\u9669\u3001\u5bf9\u9ed8\u6c99\u4e1c\u4e13\u5229\u548c\u5176\u5b83\u521b\u65b0\u4ea7\u54c1\u4fdd\u62a4\u7684\u6709\u6548\u6027\u7684\u4f9d\u8d56\u7a0b\u5ea6\uff0c\u4ee5\u53ca\u516c\u53f8\u9762\u4e34\u4e13\u5229\u8bc9\u8bbc\u548c\/\u6216\u76d1\u7ba1\u884c\u52a8\u7684\u98ce\u9669\u3002<\/p>\n<p style=\"font-weight: 400\">\u9ed8\u6c99\u4e1c\u6ca1\u6709\u4e49\u52a1\u5c31\u65b0\u4fe1\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u6216\u5176\u5b83\u539f\u56e0\u5bf9\u4efb\u4f55\u524d\u77bb\u6027\u58f0\u660e\u8fdb\u884c\u516c\u5f00\u7684\u66f4\u65b0\u3002\u5c1a\u6709\u5176\u5b83\u56e0\u7d20\u53ef\u80fd\u5bfc\u81f4\u5b9e\u9645\u7ed3\u679c\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u5b58\u5728\u5b9e\u8d28\u6027\u5dee\u5f02\uff0c\u8bf7\u53c2\u89c1\u9ed8\u6c99\u4e1c2017\u5e74\u5e74\u62a510-K\u62a5\u8868\u4ee5\u53ca\u516c\u53f8\u5728\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u6240\u5907\u6848\u7684\u5176\u5b83\u6587\u4ef6\uff08\u53ef\u5728\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u6240\u7f51\u7ad9<a href=\"https:\/\/www.sec.gov\/\">www.sec.gov<\/a>\u4e0a\u67e5\u9605\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"font-weight: 400\"><sup>1<\/sup>\u00a0GLOBOCAN2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012.\u00a0<a href=\"http:\/\/globocan.iarc.fr\/Default.aspx\">http:\/\/globocan.iarc.fr\/<\/a>.<br \/>\n<sup>2<\/sup>\u00a0Kudo M et al., \u201cLenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial\u201d\u00a0<em>The Lancet<\/em>\u00a02018, 391 (10126), 1163-1173<br \/>\n<sup>3<\/sup>\u00a0The Package Insert of Lenvatinib Mesilate Capsules in China<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2018\u5e7409\u670805\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u601d\u5821\u7684\u9ed8\u6c99\u4e1c\u516c\u53f8\uff08\u5728\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u79f0\u4e3a\u9ed8\u514b\uff09\u5ba3\u5e03\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5df2\u6279\u51c6\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u4e50\u536b\u739b\u00ae\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09\u5355\u836f\u5728\u4e2d\u56fd\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u7684\u809d\u764c\u60a3\u8005\u30022017\u5e7410\u6708\uff0c\u536b\u6750\u5728\u4e2d\u56fd\u63d0\u4ea4\u4e86\u4e50\u536b\u739b\u00ae\u7684\u7533\u8bf7\uff1b\u968f\u540e\uff0c\u9274\u4e8e\u4e50\u536b\u739b\u00ae\u4e0e\u73b0\u6709\u6cbb\u7597\u836f\u7269\u76f8\u6bd4\u5177\u6709\u663e\u8457\u4e34\u5e8a\u76ca\u5904\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6388\u4e88\u4e50\u536b\u739b\u00ae\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u8d44\u683c\uff0c\u5e76\u4e8e\u7533\u8bf7\u63d0\u4ea4\u540e\u7ea610\u4e2a\u6708\u5feb\u901f\u83b7\u6279\u3002\u4e2d\u56fd\u662f\u5168\u4e16\u754c\u809d\u764c\u60a3\u8005\u6700\u591a\u7684\u56fd\u5bb6\uff0c\u6b64\u6b21\u6279\u51c6\u6807\u5fd7\u7740\u4e50\u536b\u739b\u00ae\u5c06\u9996\u6b21\u8fdb\u5165\u4e2d\u56fd\uff0c\u662f\u5341\u5e74\u6765\u7b2c\u4e00\u4e2a\u5728\u4e2d\u56fd\u88ab\u6279\u51c6\u4f5c\u4e3a\u809d\u7ec6\u80de\u764c\u4e00\u7ebf\u7cfb\u7edf\u6cbb\u7597\u7684\u65b0\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-3232","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3232"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=3232"}],"version-history":[{"count":4,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3232\/revisions"}],"predecessor-version":[{"id":6001,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3232\/revisions\/6001"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=3232"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=3232"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=3232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}