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LENVIMA\u7684\u5242\u91cf\u786e\u5b9a\u4f9d\u636e\u60a3\u8005\u7684\u5b9e\u9645\u4f53\u91cd\uff08\u60a3\u8005\u91cd\u4f5360\u516c\u65a4\u6216\u4ee5\u4e0a12 mg\u3001\u60a3\u8005\u4f53\u91cd\u4f4e\u4e8e60\u516c\u65a48 mg\uff09\uff1b\u5efa\u8bae\u5242\u91cf\u548c\u5242\u91cf\u8c03\u6574\u89c1\u5b8c\u6574\u5904\u65b9\u4fe1\u606f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u536b\u6750\u4e0e\u9ed8\u6c99\u4e1c\u7684\u6218\u7565\u5408\u4f5c<\/strong><\/p>\n<p>2018\u5e743\u6708\uff0c\u536b\u6750\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u601d\u5821\u7684\u9ed8\u6c99\u4e1c\u516c\u53f8\u901a\u8fc7\u4e00\u5bb6\u5b50\u516c\u53f8\u5c55\u5f00\u4e86\u4e00\u9879\u5173\u4e8eLENVIMA\uff08\u4ed1\u4f10\u66ff\u5c3c\uff09\u7684\u5168\u7403\u8054\u5408\u5f00\u53d1\u548c\u8054\u5408\u5546\u4e1a\u5316\u7684\u6218\u7565\u5408\u4f5c\u3002\u6839\u636e\u8be5\u534f\u8bae\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u5171\u540c\u5f00\u53d1LENVIMA\u5e76\u5b9e\u73b0\u5546\u4e1a\u5316\uff0c\u5305\u62ec\u5355\u836f\u7597\u6cd5\u4ee5\u53ca\u4e0e\u9ed8\u6c99\u4e1c\u7684\u6297PD-1\u836f\u7269KEYTRUDA\uff08Pembrolizumab\uff09\u7684\u8054\u5408\u7597\u6cd5\u3002\u9664\u4e86\u6b63\u5728\u8fdb\u884c\u7684\u8054\u5408\u4e34\u5e8a\u7814\u7a76\u5916\uff0c\u53cc\u65b9\u8fd8\u5c06\u8054\u5408\u53d1\u8d77\u65b0\u7684\u4e34\u5e8a\u7814\u7a76\u6765\u8bc4\u4f30 LENVIMA\/KEYTRUDA\u8054\u5408\u7597\u6cd5\u57286\u7c7b\u764c\u75c7\u768411\u4e2a\u6f5c\u5728\u9002\u5e94\u75c7\u4e2d\u7684\u7597\u6548\uff0c\u4ee5\u53ca\u9488\u5bf9\u53e6\u59166\u7c7b\u764c\u75c7\u7684\u7bee\u5b50\u8bd5\u9a8c\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8eREFLECT\u8bd5\u9a8c\uff08304\u7814\u7a76\uff09<\/strong><\/p>\n<p>REFLECT\u662f\u536b\u6750\u8fdb\u884c\u7684\u4e00\u9879\u5927\u578b\uff08N = 954\u4f8b\uff09III\u671f\u3001\u968f\u673a\u3001\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u975e\u52a3\u6548\u6027\u7814\u7a76\uff0c\u6bd4\u8f83\u4ed1\u4f10\u66ff\u5c3c\u548c\u7d22\u62c9\u975e\u5c3c\u4f5c\u4e3a\u4e00\u7ebf\u7cfb\u7edf\u7597\u6cd5\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u300220\u4e2a\u56fd\u5bb6154\u4e2a\u7814\u7a76\u4e2d\u5fc3\u7684\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\uff0c\u6839\u636e\u4f53\u91cd\uff08\u226560 kg\u6216&lt; 60 kg\uff09\uff08n = 478\u4f8b\uff09\u6bcf\u5929\u670d\u7528\u4e00\u6b2112 mg\u62168 mg\u4ed1\u4f10\u66ff\u5c3c\uff0c\u6216\u6bcf\u5929\u670d\u7528\u4e24\u6b21400 mg\u7d22\u62c9\u975e\u5c3c\uff08n = 476\u4f8b\uff09\u3002\u6cbb\u7597\u6301\u7eed\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u3002\u8fd9\u9879\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u603b\u751f\u5b58\u671f\uff0c\u9996\u5148\u6d4b\u8bd5\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c\u7684\u975e\u52a3\u6548\u6027\uff0c\u7136\u540e\u662f\u4f18\u6548\u6027\u3002\u4e0e\u7d22\u62c9\u975e\u5c3c\u7ec4\u76f8\u6bd4\uff0c\u968f\u673a\u7eb3\u5165\u4ed1\u4f10\u66ff\u5c3c\u7ec4\u7684\u60a3\u8005\u7684OS\u8fbe\u5230\u975e\u52a3\u6548\u76ee\u6807\u3002\u6b64\u5916\uff0c\u4ed1\u4f10\u66ff\u5c3c\u5728PFS\u548cORR\u7684\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u65b9\u9762\u663e\u793a\u51fa\u663e\u8457\u7edf\u8ba1\u5b66\u4f18\u6548\u6027\u548c\u4e34\u5e8a\u6539\u5584\uff0c\u8fd9\u4e00\u70b9\u5df2\u88ab\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\uff08IIR\uff09\u6240\u8bc1\u5b9e\u3002<\/p>\n<p>\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7684\u4e2d\u4f4dPFS\u589e\u52a0\u4e86\u4e00\u500d\uff1a\u4f9d\u636e\u57fa\u4e8emRECIST\u6807\u51c6\u7684\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\uff0c7.3\u4e2a\u6708\u5bf9\u6bd43.6\u4e2a\u6708\uff08HR\uff1a0.64\uff1b95%CI\uff1a0.55 &#8211; 0.75\uff1bp &lt; 0.0001\uff09\uff0c\u4f9d\u636eRECIST 1.1\u6807\u51c6\uff0c\u4ed1\u4f10\u66ff\u5c3c 7.3\u4e2a\u6708\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c3.6\u4e2a\u6708\uff08HR\uff1a0.65\uff1b95% CI\uff1a0.56 &#8211; 0.77\uff09\u3002\u4ed1\u4f10\u66ff\u5c3c\u7684ORR\u663e\u793a\u662f\u7d22\u62c9\u975e\u5c3c\u7684\u8fd13.5\u500d\uff1a\u4f9d\u636e\u57fa\u4e8emRECIST\u6807\u51c6\u7684\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\u5206\u522b\u4e3a41%\uff0895% CI\uff1a36 &#8211; 45%\uff09\uff08\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09= 2.1%\uff08n = 10\u4f8b\uff09\u3001\u90e8\u5206\u7f13\u89e3\uff08PR\uff09= 38.5%\uff08n = 184\u4f8b\uff09\u5bf9\u6bd412%\uff0895% CI\uff1a10 &#8211; 16%\uff09\uff08CR = 0.8%\uff08n = 4\u4f8b\uff09\u3001PR = 11.6%\uff08n = 55\uff09\uff0c\uff08p &lt; 0.0001\uff09\uff0c\u4f9d\u636eRECIST 1.1\u6807\u51c6\uff0c\u4ed1\u4f10\u66ff\u5c3c\u00a019%\uff0895% CI\uff1a15-22\uff09\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c7%\uff0895% CI\uff1a4-9\uff09\u3002\u6b64\u5916\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7684\u4e2d\u4f4d\u8fdb\u5c55\u65f6\u95f4\uff08TTP\uff09\u662f\u7d22\u62c9\u975e\u5c3c\u7684\u4e24\u500d\uff1a\u4f9d\u636e\u57fa\u4e8emRECIST\u6807\u51c6\u7684\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\uff0c7.4\u4e2a\u6708\u5bf9\u6bd43.7\u4e2a\u6708\uff08HR\uff1a0.60\uff1b95% CI\uff1a0.51 &#8211; 0.71\uff1bp &lt; 0.0001\uff09\uff0c\u4f9d\u636eRECIST 1.1\u6807\u51c6\uff0c\u4ed1\u4f10\u66ff\u5c3c7.4\u4e2a\u6708\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c3.7\u4e2a\u6708\uff08HR\uff1a0.61\uff1b95% CI\uff1a0.51 &#8211; 0.72\uff1bp &lt; 0.0001\uff09\u3002<\/p>\n<p>REFLECT\u8bd5\u9a8c\u7684\u7ed3\u679c\u53d1\u8868\u5728\u300a\u67f3\u53f6\u5200\u300b2018\u5e74\u7b2c391\u671f\uff0810126\u671f\uff09\u3001\u7b2c1163-1173\u671f\uff082018\u5e742\u67089\u65e5\u5728\u7ebf\u53d1\u5e03\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c<\/strong><\/p>\n<p>\u809d\u764c\u662f\u5168\u7403\u7b2c\u4e8c\u5927\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u539f\u56e0\uff0c2012\u5e74\u7edf\u8ba1\u6570\u636e\u663e\u793a\uff0c\u5168\u7403\u6bcf\u5e74\u7ea6\u670975,0000\u4eba\u6b7b\u4e8e\u8be5\u75c5\u3002\u6b64\u5916\uff0c\u6bcf\u5e74\u670978,0000\u4f8b\u65b0\u786e\u8bca\u75c5\u4f8b\u3002<span class=\"a0 \">1<\/span>\u533a\u57df\u5dee\u5f02\u5f88\u5927\uff0c\u5927\u7ea680%\u7684\u65b0\u75c5\u4f8b\u53d1\u751f\u5728\u4e9a\u6d32\u5730\u533a\uff0c\u5305\u62ec\u4e2d\u56fd\u548c\u65e5\u672c\u3002\u809d\u7ec6\u80de\u764c\u5360\u809d\u764c\u603b\u4eba\u7fa4\u768485% &#8211; 90%\u3002\u809d\u7ec6\u80de\u764c\u4e0e\u6162\u6027\u809d\u75c5\u76f8\u5173\uff0c\u5c24\u5176\u662f\u809d\u786c\u5316\u3002\u809d\u786c\u5316\u7684\u4e3b\u8981\u539f\u56e0\u5305\u62ec\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u548c\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u3002\u7136\u800c\uff0c\u6839\u636e\u6700\u8fd1\u7684\u8c03\u67e5\uff0c\u975e\u4e59\u578b\/\u975e\u4e19\u578b\u809d\u7ec6\u80de\u764c\u5448\u4e0a\u5347\u8d8b\u52bf\u3002\u65e9\u671f\u809d\u7ec6\u80de\u764c\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u65b9\u6cd5\u6cbb\u7597\uff0c\u5305\u62ec\u624b\u672f\u3001\u5c04\u9891\u6d88\u878d\u3001\u4e59\u9187\u6ce8\u5c04\u548c\u5316\u7597\u6813\u585e\u6cbb\u7597\uff0c\u4f46\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u65b9\u6848\u6709\u9650\uff0c\u9884\u540e\u8f83\u5dee\uff0c\u533b\u7597\u9700\u6c42\u4e25\u91cd\u672a\u88ab\u6ee1\u8db3\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>1 GLOBOCAN2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012.\u00a0<a href=\"http:\/\/globocan.iarc.fr\/\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/globocan.iarc.fr\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2018\u5e748\u670823\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u9ed8\u6c99\u4e1c\u516c\u53f8\uff08\u5728\u7f8e\u56fd\u4e0e\u52a0\u62ff\u5927\u88ab\u79f0\u4e3a\u9ed8\u514b\uff09\u5ba3\u5e03\u6b27\u6d32\u59d4\u5458\u4f1a\uff08EC\uff09\u6279\u51c6\u53e3\u670d\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242LENVIMA\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09\u5355\u836f\u7528\u4e8e\u60a3\u6709\u665a\u671f\u6216\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u4e14\u6b64\u524d\u672a\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u8fd9\u662f\u8fd110\u5e74\u6765\u7b2c\u4e00\u4e2a\u5728\u6b27\u6d32\u83b7\u6279\u7528\u4e8e\u665a\u671f\u6216\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u65b0\u4e00\u7ebf\u7597\u6cd5\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-3250","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3250"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=3250"}],"version-history":[{"count":4,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3250\/revisions"}],"predecessor-version":[{"id":6045,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3250\/revisions\/6045"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=3250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=3250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=3250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}