{"id":3262,"date":"2018-08-17T00:00:00","date_gmt":"2021-03-18T08:28:32","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=3262"},"modified":"2022-03-11T15:45:05","modified_gmt":"2022-03-11T07:45:05","slug":"%e5%8d%ab%e6%9d%90%e5%92%8c%e9%bb%98%e6%b2%99%e4%b8%9c%e5%ae%a3%e5%b8%83%e7%be%8e%e5%9b%bdfda%e6%89%b9%e5%87%86lenvima%ef%bc%88%e4%bb%91%e4%bc%90%e6%9b%bf%e5%b0%bc%ef%bc%89%e7%94%a8%e4%ba%8e%e4%b8%8d","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2018\/08\/17\/%e5%8d%ab%e6%9d%90%e5%92%8c%e9%bb%98%e6%b2%99%e4%b8%9c%e5%ae%a3%e5%b8%83%e7%be%8e%e5%9b%bdfda%e6%89%b9%e5%87%86lenvima%ef%bc%88%e4%bb%91%e4%bc%90%e6%9b%bf%e5%b0%bc%ef%bc%89%e7%94%a8%e4%ba%8e%e4%b8%8d\/","title":{"rendered":"\u536b\u6750\u548c\u9ed8\u6c99\u4e1c\u5ba3\u5e03\u7f8e\u56fdFDA\u6279\u51c6LENVIMA\uff08\u4ed1\u4f10\u66ff\u5c3c\uff09\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597"},"content":{"rendered":"<p>2018\u5e748\u670817\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u9ed8\u6c99\u4e1c\u516c\u53f8\uff08\u5728\u7f8e\u56fd\u4e0e\u52a0\u62ff\u5927\u88ab\u79f0\u4e3a\u9ed8\u514b\uff09\u5ba3\u5e03\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242LENVIMA\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u6b64\u6b21\u6279\u51c6\u57fa\u4e8eREFLECT\uff08304\u7814\u7a76\uff09\u7684\u7ed3\u679c\uff0c\u5bf9\u4e8e\u6b64\u524d\u672a\u7ecf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u60a3\u8005\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u6b64\u8bd5\u9a8c\u901a\u8fc7\u5bf9\u975e\u52a3\u6548\u6027\u7684\u7edf\u8ba1\u786e\u8ba4\uff0c\u8bc1\u660e\u4e86\u4ed1\u4f10\u66ff\u5c3c\u5728\u603b\u751f\u5b58\u671f\uff08OS\uff09*1\u65b9\u9762\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5e76\u4e14\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09*2\u548c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09*3\u65b9\u9762\u5177\u6709\u663e\u8457\u7edf\u8ba1\u5b66\u4f18\u6548\u6027\u548c\u4e34\u5e8a\u6539\u5584\u3002\u8fd9\u662fLENVIMA\u7ee7\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\u88ab\u65e5\u672c\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u809d\u7ec6\u80de\u764c\u540e\u7b2c\u4e8c\u6b21\u83b7\u6279\uff0c\u4e5f\u662f\u8fd110\u5e74\u6765\u7f8e\u56fd\u7b2c\u4e00\u6b21\u6279\u51c6\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u7cfb\u7edf\u7597\u6cd5\u3002<\/p>\n<p>REFLECT\u663e\u793a\u4ed1\u4f10\u66ff\u5c3c\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u901a\u8fc7\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c\u7684\u975e\u52a3\u6548\u6027\u7edf\u8ba1\u786e\u8ba4\uff0c\u8bc1\u660e\u4e86\u4ed1\u4f10\u66ff\u5c3c\u5728OS\u65b9\u9762\u7684\u6cbb\u7597\u6548\u679c\u3002\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u4f4dOS\u4e3a13.6\u4e2a\u6708\uff0c\u4f7f\u7528\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u4f4dOS\u4e3a12.3\u4e2a\u6708\uff08\u98ce\u9669\u6bd4\uff08HR\uff09\uff1a0.92\uff1b95 %\u7f6e\u4fe1\u533a\u95f4\uff08CI\uff09\uff1a0.79 &#8211; 1.06\uff09\u3002OS\u5206\u6790\u6309\u7167\u7edf\u8ba1\u5206\u6790\u8ba1\u5212\u4e2d\u7684\u9884\u5148\u89c4\u5b9a\u8fdb\u884c\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7ec4\u53d1\u751f351\u6b21\u4e8b\u4ef6\uff0c\u7d22\u62c9\u975e\u5c3c\u7ec4\u53d1\u751f350\u6b21\u4e8b\u4ef6\u3002\u5173\u4e8e\u6b21\u8981\u7597\u6548\u7ec8\u70b9\uff0c\u6839\u636e\u57fa\u4e8emRECIST\u6807\u51c6\u7684\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u4e0a\u663e\u8457\u7684\u4f18\u6548\u6027\u548c\u4e34\u5e8a\u6539\u5584\uff0c\u4e2d\u4f4dPFS\uff1a\u4ed1\u4f10\u66ff\u5c3c 7.3\u4e2a\u6708\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c3.6\u4e2a\u6708\uff08HR\uff1a0.64\uff1b95 % CI\uff1a0.55 &#8211; 0.75\uff1bp &lt; 0.0001\uff09\u548cORR\uff1a\u4ed1\u4f10\u66ff\u5c3c 41 %\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c12 %\uff08p &lt; 0.0001\uff09\u3002<\/p>\n<p>\u5728\u7f8e\u56fd\u7684\u836f\u54c1\u8bf4\u660e\u4e66\u4e2d\uff0c\u5728\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u6700\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\uff08\u226520%\uff09\u6709\u9ad8\u8840\u538b\u3001\u75b2\u52b3\u3001\u8179\u6cfb\u3001\u98df\u6b32\u4e0b\u964d\u3001\u5173\u8282\u75db\/\u808c\u75db\u3001\u4f53\u91cd\u4e0b\u964d\u3001\u8179\u75db\u3001\u624b\u8db3\u7efc\u5408\u5f81\u3001\u86cb\u767d\u5c3f\u3001\u53d1\u97f3\u969c\u788d\u3001\u51fa\u8840\u4e8b\u4ef6\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u548c\u6076\u5fc3\u3002\u5728\u63a5\u53d7\u4ed1\u4f10\u66ff\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff08\u22652%\uff09\u6709\u809d\u6027\u8111\u75c5\uff085%\uff09\u3001\u809d\u8870\u7aed\uff083%\uff09\u3001\u8179\u6c34\uff083%\uff09\u548c\u98df\u6b32\u4e0b\u964d\uff082%\uff09\u3002<\/p>\n<p>\u5728\u63a5\u53d7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u6700\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\uff08\u226520%\uff09\u6709\u624b\u8db3\u7efc\u5408\u5f81\u3001\u8179\u6cfb\u3001\u75b2\u52b3\u3001\u9ad8\u8840\u538b\u3001\u8179\u75db\u3001\u98df\u6b32\u4e0b\u964d\u3001\u76ae\u75b9\u3001\u4f53\u91cd\u4e0b\u964d\u548c\u5173\u8282\u75db\/\u808c\u75db\u3002\u5728\u63a5\u53d7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff08\u22652%\uff09\u6709\u8179\u6c34\uff082%\uff09\u548c\u8179\u75db\uff082%\uff09\u3002<\/p>\n<p>\u201c\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u6cbb\u7597\u975e\u5e38\u56f0\u96be\uff0c\u5341\u591a\u5e74\u6765\u6ca1\u6709\u65b0\u7684\u4e00\u7ebf\u7cfb\u7edf\u6cbb\u7597\u65b9\u6848\uff0c\u201d\u7eaa\u5ff5\u65af\u9686-\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u7684\u80bf\u7624\u5185\u79d1\u533b\u751fGhassan Abou-Alfa\u535a\u58eb\u5982\u662f\u8bf4\u3002\u201cREFLECT\u662f\u7b2c\u4e00\u6b21\u9488\u5bf9\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u4e2d\u6d3b\u6027\u836f\u7269\u5bf9\u7167\u7ec4\u7684\u9633\u6027III\u671f\u8bd5\u9a8c\u3002\u6765\u81eaREFLECT\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u6570\u636e\u5bf9\u4e8e\u80bf\u7624\u5b66\u5bb6\u548c\u6cbb\u7597\u809d\u764c\u7684\u591a\u5b66\u79d1\u56e2\u961f\u4e2d\u7684\u5176\u4ed6\u4eba\u4ee5\u53ca\u53d7\u5176\u5f71\u54cd\u7684\u60a3\u8005\u6765\u8bf4\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u201d<\/p>\n<p>\u809d\u764c\u662f\u5168\u7403\u7b2c\u4e8c\u5927\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u539f\u56e0\uff0c2012\u5e74\u7edf\u8ba1\u6570\u636e\u663e\u793a\uff0c\u5168\u7403\u6bcf\u5e74\u7ea6\u670975,0000\u4eba\u6b7b\u4e8e\u8be5\u75c5\uff0c\u4e14\u6bcf\u5e74\u670978,0000\u4f8b\u65b0\u786e\u8bca\u75c5\u4f8b\u30021\u809d\u7ec6\u80de\u764c\u5360\u809d\u764c\u603b\u4eba\u7fa4\u768485%\u81f390%\u3002\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u65b9\u6848\u6709\u9650\uff0c\u9884\u540e\u8f83\u5dee\uff0c\u533b\u7597\u9700\u6c42\u4e25\u91cd\u672a\u88ab\u6ee1\u8db3\u3002<\/p>\n<p>\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242LENVIMA\u4e8e2015\u5e742\u6708\u9996\u6b21\u5728\u7f8e\u56fd\u88ab\u6279\u51c6\u7528\u4e8e\u60a3\u6709\u5c40\u90e8\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u3001\u8fdb\u884c\u6027\u3001\u653e\u5c04\u6027\u7898\u96be\u6cbb\u5206\u5316\u578b\u7532\u72b6\u817a\u764c\uff08DTC\uff09\u7684\u60a3\u8005\u30022016\u5e745\u6708\uff0cLENVIMA\u5728\u7f8e\u56fd\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u4e8e\u665a\u671f\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7597\u4e4b\u540e\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u60a3\u8005\u3002\u536b\u6750\u548c\u9ed8\u6c99\u4e1c\u516c\u53f8\u4e8e2018\u5e746\u6708\u5728\u7f8e\u56fd\u8054\u5408\u542f\u52a8\u4e86LENVIMA\u7684\u5546\u4e1a\u5316\u6d3b\u52a8\u3002\u81ea\u6700\u521d\u4e0a\u5e02\u4ee5\u6765\uff0cLENVIMA\u5df2\u5728\u5168\u740350\u591a\u4e2a\u56fd\u5bb6\u83b7\u5f97\u6279\u51c6\uff0c1\u4e07\u591a\u540d\u60a3\u8005\u63a5\u53d7\u4e86 LENVIMA\u6cbb\u7597\u3002\u81ea2018\u5e743\u6708\u5728\u65e5\u672c\u88ab\u6279\u51c6\u809d\u7ec6\u80de\u764c\u9002\u5e94\u75c7\u4ee5\u6765\uff0c\u7ea6\u67093000\u540d\u809d\u7ec6\u80de\u764c\u60a3\u8005\u5df2\u63a5\u53d7LENVIMA\u6cbb\u7597\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"a0 \">*1<\/span> \u603b\u751f\u5b58\u671f\uff08OS\uff09\uff1a\u4ece\u764c\u75c7\u6cbb\u7597\u5f00\u59cb\u5230\u56e0\u4efb\u4f55\u539f\u56e0\u6b7b\u4ea1\u7684\u65f6\u95f4\u3002\u8be5\u53d8\u91cf\u4e0d\u8003\u8651\u6b7b\u56e0\u662f\u5426\u4e3a\u764c\u75c7\u3002<\/p>\n<p><span class=\"a0 \">*2<\/span> \u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff1aPFS\u662f\u4ece\u764c\u75c7\u6cbb\u7597\u5f00\u59cb\u5230\u75be\u75c5\u8fdb\u5c55\u7684\u65f6\u95f4\uff0c\u6216\u56e0\u4efb\u4f55\u539f\u56e0\u5bfc\u81f4\u6b7b\u4ea1\u7684\u65f6\u95f4\uff08\u4ee5\u8f83\u65e9\u8005\u4e3a\u51c6\uff09\u7684\u5ba2\u89c2\u786e\u8ba4\u65f6\u95f4\u3002<\/p>\n<p><span class=\"a0 \">*<\/span><span class=\"a0 \">3<\/span> \u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\uff1aORR\u662f\u6307\u7ecf\u5f71\u50cf\u5b66\u8bca\u65ad\uff0c\u80bf\u7624\u5b8c\u5168\u7f13\u89e3\uff08\u80bf\u7624\u6d88\u5931\uff09\u6bd4\u4f8b\u4e0e\u80bf\u7624\u90e8\u5206\u7f13\u89e3\uff08\u80bf\u7624\u4f53\u79ef\u51cf\u5c11\u8d85\u8fc730%\uff09\u6bd4\u4f8b\u4e4b\u548c\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5a92\u4f53\u54a8\u8be2\uff1a<\/strong><\/p>\n<p>\u536b\u6750\u682a\u5f0f\u4f1a\u793e<\/p>\n<p>\u516c\u5171\u5173\u7cfb\u90e8<\/p>\n<p>+81-(0)3-3817-5120<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8eLENVIMA\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09<\/strong><\/p>\n<p>LENVIMA\u7531\u536b\u6750\u72ec\u7acb\u7814\u53d1\uff0c\u662f\u4e00\u79cd\u53e3\u670d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5177\u6709\u65b0\u7684\u53d7\u4f53\u7ed3\u5408\u6a21\u5f0f\uff0c\u9664\u4e86\u5176\u4ed6\u4e0e\u901a\u8def\u76f8\u5173\u7684RTKs\uff08\u5305\u62ec\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\uff08PDGF\uff09\u53d7\u4f53PDGFR\u03b1\uff1bKIT\u548c RET\uff09\u53c2\u4e0e\u80bf\u7624\u8840\u7ba1\u751f\u6210\u3001\u80bf\u7624\u8fdb\u5c55\u548c\u80bf\u7624\u514d\u75ab\u7684\u6539\u826f\u4e4b\u5916\uff0c\u8fd8\u9009\u62e9\u6027\u5730\u6291\u5236\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u53d7\u4f53\uff08VEGFR1\u3001VEGFR2\u548cVEGFR3\uff09\u548c\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGF\uff09\u53d7\u4f53\uff08FGFR1\u3001FGFR2\u3001FGFR3\u548cFGFR4\uff09\u7684\u591a\u9879\u6d3b\u52a8\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u536b\u6750\u5df2\u5728\u5305\u62ec\u7f8e\u56fd\u3001\u65e5\u672c\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u5728\u5185\u768450\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u5c06LENVIMA\u7528\u4e8e\u6cbb\u7597\u96be\u6cbb\u6027\u7532\u72b6\u817a\u764c\u3002\u6b64\u5916\uff0c\u536b\u6750\u8fd8\u5728\u5305\u62ec\u7f8e\u56fd\u548c\u6b27\u6d32\u5728\u5185\u7684\u8d85\u8fc745\u4e2a\u56fd\u5bb6\u83b7\u6279\u5c06\u8be5\u836f\u4e0e\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u4e8e\u80be\u7ec6\u80de\u764c\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002\u5728\u6b27\u6d32\uff0c\u8be5\u836f\u4ee5Kisplyx\u4e3a\u5546\u54c1\u540d\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u3002<\/p>\n<p>\u9664\u7f8e\u56fd\u5916\uff0cLENVIMA\u5df2\u5728\u65e5\u672c\u88ab\u6279\u51c6\u4f5c\u4e3a\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u536b\u6750\u5df2\u4e8e2017\u5e747\u6708\u5728\u6b27\u6d32\u30012017\u5e7410\u6708\u5728\u4e2d\u56fd\u5927\u9646\u30012017\u5e7412\u6708\u5728\u4e2d\u56fd\u53f0\u6e7e\u4ee5\u53ca\u5176\u4ed6\u56fd\u5bb6\uff0c\u63d0\u4ea4\u4e86\u5c06\u8be5\u836f\u9002\u5e94\u75c7\u6269\u5c55\u81f3\u5305\u62ec\u809d\u7ec6\u80de\u764c\u7684\u7533\u8bf7\u3002<\/p>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5bf9\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff0c LENVIMA\u7684\u5242\u91cf\u786e\u5b9a\u4f9d\u636e\u60a3\u8005\u7684\u5b9e\u9645\u4f53\u91cd\uff08\u60a3\u8005\u91cd\u4f5360\u516c\u65a4\u6216\u4ee5\u4e0a12 mg\u3001\u60a3\u8005\u4f53\u91cd\u4f4e\u4e8e60\u516c\u65a48 mg\uff09\uff1b\u5efa\u8bae\u5242\u91cf\u548c\u5242\u91cf\u8c03\u6574\u89c1\u5b8c\u6574\u5904\u65b9\u4fe1\u606f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u536b\u6750\u4e0e\u9ed8\u6c99\u4e1c\u7684\u6218\u7565\u5408\u4f5c<\/strong><\/p>\n<p>2018\u5e743\u6708\uff0c\u536b\u6750\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u601d\u5821\u7684\u9ed8\u6c99\u4e1c\u516c\u53f8\u901a\u8fc7\u4e00\u5bb6\u5b50\u516c\u53f8\u5c55\u5f00\u4e86\u4e00\u9879\u5173\u4e8eLENVIMA\uff08\u4ed1\u4f10\u66ff\u5c3c\uff09\u7684\u5168\u7403\u8054\u5408\u5f00\u53d1\u548c\u8054\u5408\u5546\u4e1a\u5316\u7684\u6218\u7565\u5408\u4f5c\u3002\u6839\u636e\u8be5\u534f\u8bae\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u5171\u540c\u5f00\u53d1LENVIMA\u5e76\u5b9e\u73b0\u5546\u4e1a\u5316\uff0c\u5305\u62ec\u5355\u836f\u7597\u6cd5\u4ee5\u53ca\u4e0e\u9ed8\u6c99\u4e1c\u7684\u6297PD-1\u836f\u7269KEYTRUDA\uff08Pembrolizumab\uff09\u7684\u8054\u5408\u7597\u6cd5\u3002\u9664\u4e86\u6b63\u5728\u8fdb\u884c\u7684\u8054\u5408\u4e34\u5e8a\u7814\u7a76\u5916\uff0c\u53cc\u65b9\u8fd8\u5c06\u8054\u5408\u53d1\u8d77\u65b0\u7684\u4e34\u5e8a\u7814\u7a76\u6765\u8bc4\u4f30 LENVIMA\/KEYTRUDA\u8054\u5408\u7597\u6cd5\u57286\u7c7b\u764c\u75c7\u768411\u4e2a\u6f5c\u5728\u9002\u5e94\u75c7\u4e2d\u7684\u7597\u6548\uff0c\u4ee5\u53ca\u9488\u5bf9\u53e6\u59166\u7c7b\u764c\u75c7\u7684\u7bee\u5b50\u8bd5\u9a8c\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8eREFLECT\u8bd5\u9a8c\uff08304\u7814\u7a76\uff09<\/strong><\/p>\n<p>REFLECT\u662f\u536b\u6750\u8fdb\u884c\u7684\u4e00\u9879\u5927\u578b\uff08N = 954\u4f8b\uff09III\u671f\u3001\u968f\u673a\u3001\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u975e\u52a3\u6548\u6027\u7814\u7a76\uff0c\u6bd4\u8f83\u4ed1\u4f10\u66ff\u5c3c\u548c\u7d22\u62c9\u975e\u5c3c\u4f5c\u4e3a\u4e00\u7ebf\u7cfb\u7edf\u7597\u6cd5\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u300220\u4e2a\u56fd\u5bb6154\u4e2a\u7814\u7a76\u4e2d\u5fc3\u7684\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\uff0c\u6839\u636e\u4f53\u91cd\uff08\u226560 kg\u6216&lt; 60 kg\uff09\uff08n = 478\u4f8b\uff09\u6bcf\u5929\u670d\u7528\u4e00\u6b2112 mg\u62168 mg\u4ed1\u4f10\u66ff\u5c3c\uff0c\u6216\u6bcf\u5929\u670d\u7528\u4e24\u6b21400 mg\u7d22\u62c9\u975e\u5c3c\uff08n = 476\u4f8b\uff09\u3002\u6cbb\u7597\u6301\u7eed\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u3002\u8fd9\u9879\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u603b\u751f\u5b58\u671f\uff0c\u9996\u5148\u6d4b\u8bd5\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c\u7684\u975e\u52a3\u6548\u6027\uff0c\u7136\u540e\u662f\u4f18\u6548\u6027\u3002\u4e0e\u7d22\u62c9\u975e\u5c3c\u7ec4\u76f8\u6bd4\uff0c\u968f\u673a\u7eb3\u5165\u4ed1\u4f10\u66ff\u5c3c\u7ec4\u7684\u60a3\u8005\u7684OS\u8fbe\u5230\u975e\u52a3\u6548\u76ee\u6807\u3002\u6b64\u5916\uff0c\u4ed1\u4f10\u66ff\u5c3c\u5728PFS\u548cORR\u7684\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u65b9\u9762\u663e\u793a\u51fa\u663e\u8457\u7edf\u8ba1\u5b66\u4f18\u6548\u6027\u548c\u4e34\u5e8a\u6539\u5584\uff0c\u8fd9\u4e00\u70b9\u5df2\u88ab\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\uff08IIR\uff09\u6240\u8bc1\u5b9e\u3002<\/p>\n<p>\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7684\u4e2d\u4f4dPFS\u589e\u52a0\u4e86\u4e00\u500d\uff1a\u4f9d\u636e\u57fa\u4e8emRECIST\u6807\u51c6\u7684\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\uff0c7.3\u4e2a\u6708\u5bf9\u6bd43.6\u4e2a\u6708\uff08HR\uff1a0.64\uff1b95 % CI\uff1a0.55 &#8211; 0.75\uff1bp &lt; 0.0001\uff09\uff0c\u4f9d\u636eRECIST 1.1\u6807\u51c6\uff0c\u4ed1\u4f10\u66ff\u5c3c 7.3\u4e2a\u6708\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c3.6\u4e2a\u6708\uff08HR\uff1a0.65\uff1b95 % CI\uff1a0.56 &#8211; 0.77\uff09\u3002\u4ed1\u4f10\u66ff\u5c3c\u7684ORR\u663e\u793a\u662f\u7d22\u62c9\u975e\u5c3c\u7684\u8fd13.5\u500d\uff1a\u4f9d\u636e\u57fa\u4e8emRECIST\u6807\u51c6\u7684\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\u5206\u522b\u4e3a41 %\uff0895 % CI\uff1a36 &#8211; 45 %\uff09\uff08\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09= 2.1 %\uff08n = 10\u4f8b\uff09\u3001\u90e8\u5206\u7f13\u89e3\uff08PR\uff09= 38.5 %\uff08n = 184\u4f8b\uff09\u5bf9\u6bd412 %\uff0895 % CI\uff1a10 &#8211; 16 %\uff09\uff08CR = 0.8 %\uff08n = 4\u4f8b\uff09\u3001PR = 11.6 %\uff08n = 55\uff09\uff0c\uff08p &lt; 0.0001\uff09\uff0c\u4f9d\u636eRECIST 1.1\u6807\u51c6\uff0c\u4ed1\u4f10\u66ff\u5c3c\u00a019%\uff0895% CI\uff1a15-22\uff09\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c7%\uff0895% CI\uff1a4-9\uff09\u3002\u6b64\u5916\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u7684\u4e2d\u4f4d\u8fdb\u5c55\u65f6\u95f4\uff08TTP\uff09\u662f\u7d22\u62c9\u975e\u5c3c\u7684\u4e24\u500d\uff1a\u4f9d\u636e\u57fa\u4e8emRECIST\u6807\u51c6\u7684\u76f2\u6cd5\u72ec\u7acb\u5f71\u50cf\u5ba1\u67e5\uff0c7.4\u4e2a\u6708\u5bf9\u6bd43.7\u4e2a\u6708\uff08HR\uff1a0.60\uff1b95 % CI\uff1a0.51 &#8211; 0.71\uff1bp &lt; 0.0001\uff09\uff0c\u4f9d\u636eRECIST 1.1\u6807\u51c6\uff0c\u4ed1\u4f10\u66ff\u5c3c7.4\u4e2a\u6708\u5bf9\u6bd4\u7d22\u62c9\u975e\u5c3c3.7\u4e2a\u6708\uff08HR\uff1a0.61\uff1b95 % CI\uff1a0.51 &#8211; 0.72\uff1bp &lt; 0.0001\uff09\u3002REFLECT\u8bd5\u9a8c\u7684\u7ed3\u679c\u53d1\u8868\u5728\u300a\u67f3\u53f6\u5200\u300b2018\u5e74\u7b2c391\u671f\uff0810126\u671f\uff09\u3001\u7b2c1163-1173\u671f\uff082018\u5e742\u67089\u65e5\u5728\u7ebf\u53d1\u5e03\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c<\/strong><\/p>\n<p>\u809d\u764c\u662f\u5168\u7403\u7b2c\u4e8c\u5927\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u539f\u56e0\uff0c2012\u5e74\u7edf\u8ba1\u6570\u636e\u663e\u793a\uff0c\u5168\u7403\u6bcf\u5e74\u7ea6\u670975,0000\u4eba\u6b7b\u4e8e\u8be5\u75c5\u3002\u6b64\u5916\uff0c\u6bcf\u5e74\u670978,0000\u4f8b\u65b0\u786e\u8bca\u75c5\u4f8b\u3002<span class=\"a0 \">1<\/span>\u533a\u57df\u5dee\u5f02\u5f88\u5927\uff0c\u5927\u7ea680%\u7684\u65b0\u75c5\u4f8b\u53d1\u751f\u5728\u4e9a\u6d32\u5730\u533a\uff0c\u5305\u62ec\u4e2d\u56fd\u548c\u65e5\u672c\u3002\u809d\u7ec6\u80de\u764c\u5360\u809d\u764c\u603b\u4eba\u7fa4\u768485% &#8211; 90%\u3002\u809d\u7ec6\u80de\u764c\u4e0e\u6162\u6027\u809d\u75c5\u76f8\u5173\uff0c\u5c24\u5176\u662f\u809d\u786c\u5316\u3002\u809d\u786c\u5316\u7684\u4e3b\u8981\u539f\u56e0\u5305\u62ec\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u548c\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u3002\u7136\u800c\uff0c\u6839\u636e\u6700\u8fd1\u7684\u8c03\u67e5\uff0c\u975e\u4e59\u578b\/\u975e\u4e19\u578b\u809d\u7ec6\u80de\u764c\u5448\u4e0a\u5347\u8d8b\u52bf\u3002\u65e9\u671f\u809d\u7ec6\u80de\u764c\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u65b9\u6cd5\u6cbb\u7597\uff0c\u5305\u62ec\u624b\u672f\u3001\u5c04\u9891\u6d88\u878d\u3001\u4e59\u9187\u6ce8\u5c04\u548c\u5316\u7597\u6813\u585e\u6cbb\u7597\uff0c\u4f46\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u65b9\u6848\u6709\u9650\uff0c\u9884\u540e\u8f83\u5dee\uff0c\u533b\u7597\u9700\u6c42\u4e25\u91cd\u672a\u88ab\u6ee1\u8db3\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>1 GLOBOCAN2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012.\u00a0<a href=\"http:\/\/globocan.iarc.fr\/\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/globocan.iarc.fr\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2018\u5e748\u670817\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u9ed8\u6c99\u4e1c\u516c\u53f8\uff08\u5728\u7f8e\u56fd\u4e0e\u52a0\u62ff\u5927\u88ab\u79f0\u4e3a\u9ed8\u514b\uff09\u5ba3\u5e03\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242LENVIMA\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u6b64\u6b21\u6279\u51c6\u57fa\u4e8eREFLECT\uff08304\u7814\u7a76\uff09\u7684\u7ed3\u679c\uff0c\u5bf9\u4e8e\u6b64\u524d\u672a\u7ecf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u60a3\u8005\uff0c\u4e0e\u7d22\u62c9\u975e\u5c3c\u76f8\u6bd4\uff0c\u6b64\u8bd5\u9a8c\u901a\u8fc7\u5bf9\u975e\u52a3\u6548\u6027\u7684\u7edf\u8ba1\u786e\u8ba4\uff0c\u8bc1\u660e\u4e86\u4ed1\u4f10\u66ff\u5c3c\u5728\u603b\u751f\u5b58\u671f\uff08OS\uff09*1\u65b9\u9762\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5e76\u4e14\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09*2\u548c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09*3\u65b9\u9762\u5177\u6709\u663e\u8457\u7edf\u8ba1\u5b66\u4f18\u6548\u6027\u548c\u4e34\u5e8a\u6539\u5584\u3002\u8fd9\u662fLENVIMA\u7ee7\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\u88ab\u65e5\u672c\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u809d\u7ec6\u80de\u764c\u540e\u7b2c\u4e8c\u6b21\u83b7\u6279\uff0c\u4e5f\u662f\u8fd110\u5e74\u6765\u7f8e\u56fd\u7b2c\u4e00\u6b21\u6279\u51c6\u4e0d\u53ef\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u7cfb\u7edf\u7597\u6cd5\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-3262","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3262"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=3262"}],"version-history":[{"count":5,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3262\/revisions"}],"predecessor-version":[{"id":6049,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3262\/revisions\/6049"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=3262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=3262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=3262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}