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href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03517449\">clinicaltrials.gov<\/a>\u3002\uff09<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u5b50\u5bab\u5185\u819c\u764c<\/strong><\/p>\n<p>\u5b50\u5bab\u5185\u819c\u764c\u53d1\u751f\u4e8e\u5b50\u5bab\u5185\u819c\uff0c\u51e0\u4e4e\u6240\u6709\u7684\u5b50\u5bab\u764c\u75c7\u90fd\u662f\u5b50\u5bab\u5185\u819c\u764c<sup>3<\/sup>\u3002\u636e\u4f30\u8ba1\uff0c\u57282018\u5e74\u7ea6\u670963,230\u4f8b\u65b0\u589e\u5b50\u5bab\u764c\u75c5\u4f8b\uff0c\u7ea6\u670911,350\u4eba\u6b7b\u4e8e\u5b50\u5bab\u764c\uff08\u5b50\u5bab\u5185\u819c\u764c\u7684\u6570\u636e\u7565\u4f4e\u4e8e\u8fd9\u4e00\u603b\u4f30\u503c\uff09<sup>4<\/sup>\u3002\u5b50\u5bab\u5185\u819c\u764c\u7684\u53d1\u5c55\u5206\u4e3a4\u671f<sup>5<\/sup>\u3002\u8bca\u65ad\u4e3a1A\u671f\u5b50\u5bab\u5185\u819c\u764c\u7684\u5973\u6027\u76845\u5e74\u751f\u5b58\u7387\u4e3a88%\uff0c\u800c\u8bca\u65ad\u4e3a4B\u671f\u7684\u60a3\u80055\u5e74\u751f\u5b58\u7387\u4ec5\u670915%<sup>6<\/sup>\u00a0\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u536b\u6750\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u601d\u5821\u7684\u9ed8\u6c99\u4e1c\u516c\u53f8\u7684\u6218\u7565\u5408\u4f5c<\/strong><\/p>\n<p>2018\u5e743\u6708\uff0c\u536b\u6750\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u601d\u5821\u7684\u9ed8\u6c99\u4e1c\u516c\u53f8\u901a\u8fc7\u4e00\u4e2a\u5206\u516c\u53f8\u5f00\u59cb\u4e86\u4e00\u9879\u6218\u7565\u5408\u4f5c\uff0c\u5728\u5168\u7403\u8303\u56f4\u5185\u5171\u540c\u5f00\u53d1\u5e76\u5171\u540c\u5546\u54c1\u5316LENVIMA\u3002\u6839\u636e\u534f\u8bae\uff0c\u53cc\u65b9\u5c06\u5171\u540c\u5f00\u53d1\u5e76\u5171\u540c\u5546\u54c1\u5316LENVIMA\uff0c\u5305\u62ec\u5355\u836f\u7597\u6cd5\u548c\u540c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u601d\u5821\u7684\u9ed8\u6c99\u4e1c\u516c\u53f8\u7814\u53d1\u7684\u6297PD-1\u836f\u7269KEYTRUDA\u7684\u8054\u5408\u7597\u6cd5\u3002\u9664\u4e86\u6b63\u5728\u8fdb\u884c\u4e2d\u7684\u9488\u5bf9\u8054\u5408\u7597\u6cd5\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u53cc\u65b9\u5c06\u5171\u540c\u8fdb\u884c\u4e00\u9879\u65b0\u7684\u4e34\u5e8a\u7814\u7a76\u6765\u8bc4\u4f30\u8054\u5408\u7597\u6cd5\u57286\u79cd\u764c\u75c7\u7c7b\u578b\uff08\u8180\u80f1\u764c\u3001\u5b50\u5bab\u5185\u819c\u764c\u3001\u5934\u9888\u90e8\u764c\u3001\u809d\u7ec6\u80de\u764c\u3001\u9ed1\u8272\u7d20\u7624\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff09\u768411\u79cd\u53ef\u80fd\u5b58\u5728\u7684\u9002\u5e94\u75c7\u4e2d\u7684\u7597\u6548\uff0c\u4ee5\u53ca\u4e00\u9879\u9488\u5bf9\u53e6\u59166\u79cd\u764c\u75c7\u7684\u201c\u7bee\u5b50\u8bd5\u9a8c\u201d\u3002LENVIMA\u548cKEYTRUDA\u8054\u5408\u7597\u6cd5\u5c1a\u5904\u4e8e\u8c03\u7814\u9636\u6bb5\u3002\u5176\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u5c1a\u672a\u5efa\u7acb\u3002\u76ee\u524dLENVIMA\u548cKEYTRUDA\u8054\u5408\u7597\u6cd5\u5c1a\u672a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u4efb\u4f55\u764c\u75c7\u7c7b\u578b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8eLENVIMA\uff08\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09<\/strong><\/p>\n<p>LENVIMA\u662f\u4e00\u79cd\u53e3\u670d\u7684\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff08RTK\uff09\u6291\u5236\u5242\uff0c\u7531\u536b\u6750\u53d1\u73b0\u5e76\u8fdb\u884c\u5f00\u53d1\u3002\u9664\u540c\u80bf\u7624\u6269\u6563\u76f8\u5173\u7684\u4fc3\u4f7f\u8840\u7ba1\u751f\u6210\u7684\u5404\u79cd\u81f4\u764cRTKs\uff08\u5305\u62ec\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\uff08PDGF\uff09\u53d7\u4f53\u00a0PDGFR\u03b1\u3001KIT\u548cRET\uff09\u4e4b\u5916\uff0c\u8be5\u6291\u5236\u5242\u7528\u4e00\u79cd\u65b0\u7684\u7ed3\u5408\u65b9\u5f0f\u6765\u9009\u62e9\u6027\u5730\u6291\u5236\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u53d7\u4f53\uff08VEGFR1\u3001VEGFR2\u548cVEGFR3\uff09\u548c\u7ea4\u7ef4\u6bcd\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGF\uff09\u53d7\u4f53\uff08FGFR1\/\u3001FGFR2\u3001\u00a0FGFR3\u00a0\u548c\u00a0FGFR4)\uff09\u7684\u6fc0\u9176\u6d3b\u6027\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u536b\u6750\u5df2\u5728\u5305\u62ec\u7f8e\u56fd\u3001\u65e5\u672c\u548c\u6b27\u6d32\u5728\u5185\u768450\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u5c06LENVIMA\u7528\u4e8e\u6cbb\u7597\u987d\u56fa\u6027\u7532\u72b6\u817a\u764c\u3002\u6b64\u5916\uff0c\u536b\u6750\u8fd8\u5728\u5305\u62ec\u7f8e\u56fd\u548c\u6b27\u6d32\u5728\u5185\u768440\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u5c06\u8be5\u836f\u540c\u4f9d\u7ef4\u83ab\u53f8\uff08Everolimus\uff09\u8054\u5408\u4f7f\u7528\u6765\u6cbb\u7597\u80be\u7ec6\u80de\u764c\uff08\u4e8c\u7ebf\u836f\u7269\uff09\u3002\u5728\u6b27\u6d32\uff0c\u8be5\u836f\u4ee5Kisplyx\u4e3a\u5546\u54c1\u540d\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u3002<\/p>\n<p>\u6b64\u5916\uff0cLENVIMA\u5df2\u5728\u65e5\u672c\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u809d\u7ec6\u80de\u764c\u3002\u536b\u6750\u5df2\u4e8e2017\u5e747\u6708\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u63d0\u4ea4\u4e86\u5c06\u8be5\u836f\u9002\u5e94\u75c7\u626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style=\"font-weight: 400\">\u516c\u53f8\u6ca1\u6709\u4e49\u52a1\u5bf9\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u8fdb\u884c\u516c\u5f00\u66f4\u65b0\uff0c\u65e0\u8bba\u662f\u4f5c\u4e3a\u65b0\u4fe1\u606f\u3001\u672a\u6765\u4e8b\u4ef6\u7684\u7ed3\u679c\u6216\u5176\u4ed6\u5f62\u5f0f\u3002\u53ef\u80fd\u5bfc\u81f4\u4e0e\u524d\u77bb\u6027\u9648\u8ff0\u4e2d\u6240\u63cf\u8ff0\u7684\u7ed3\u679c\u5927\u4e0d\u76f8\u540c\u7684\u5176\u4ed6\u56e0\u7d20\u89c1\u516c\u53f8\u76842017\u5e7410-K\u8868\u683c\u5e74\u5ea6\u62a5\u544a\u4ee5\u53ca\u516c\u53f8\u63d0\u4ea4\u7ed9\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u7684\u6587\u4ef6\uff08\u89c1\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u7f51\u7ad9<a href=\"https:\/\/www.sec.gov\/\">www.sec.gov<\/a>\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<ol>\n<li>Makker V, et al. Lenvatinib + pembrolizumab in patients with advanced endometrial cancer: Update results. ASCO MeetingAbstract, 2018; #5596<\/li>\n<li>Makker V, et al. Biomarker results and preclinical rationale for combination lenvatinib and pembrolizumab in advancedendometrial carcinoma. ASCO Meeting Abstract, 2018; #5597<\/li>\n<li>American Cancer Society. What Is Endometrial Cancer.<a href=\"https:\/\/www.cancer.org\/cancer\/endometrial-cancer\/about\/what-isendometrial-cancer.html\">https:\/\/www.cancer.org\/cancer\/endometrial-cancer\/about\/what-isendometrial-cancer.html<\/a>.<\/li>\n<li>American Cancer Society. Key Statistics for Endometrial Cancer.<a href=\"https:\/\/www.cancer.org\/cancer\/endometrialcancer\/about\/key-statistics.html\">https:\/\/www.cancer.org\/cancer\/endometrialcancer\/about\/key-statistics.html<\/a>.<\/li>\n<li>American Cancer Society. Endometrial Cancer Stages.<a href=\"https:\/\/www.cancer.org\/cancer\/endometrial-cancer\/detectiondiagnosis-staging\/staging.html\">https:\/\/www.cancer.org\/cancer\/endometrial-cancer\/detectiondiagnosis-staging\/staging.html<\/a>.<\/li>\n<li>American Cancer Society. Endometrial Cancer Survival Rates, by Stage.<a href=\"https:\/\/www.cancer.org\/cancer\/endometrialcancer\/detection-diagnosis-staging\/survival-rates.html\">https:\/\/www.cancer.org\/cancer\/endometrialcancer\/detection-diagnosis-staging\/survival-rates.html<\/a>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>2018\u5e747\u670831\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u601d\u5821\u7684\u9ed8\u6c99\u4e1c\u516c\u53f8\u5ba3\u5e03\uff0cLENVIMA\uff08\u901a\u7528\u540d\uff1a\u7532\u78fa\u9178\u4ed1\u4f10\u66ff\u5c3c\uff09\u548cKEYTRUDA\uff08\u901a\u7528\u540d\uff1a\u5e15\u59c6\u5355\u6297\uff09\u8054\u5408\u7597\u6cd5\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002\u8fd9\u4e00\u836f\u7269\u7ec4\u5408\u6709\u6f5c\u529b\u6cbb\u7597\u6b64\u524d\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u6b21\u7cfb\u7edf\u6027\u6cbb\u7597\u7684\u665a\u671f\u548c\/\u6216\u8f6c\u79fb\u6027\u975e\u9ad8\u9891\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\uff08MSI-H\uff09\/\u719f\u7ec3\u9519\u914d\u4fee\u590d\uff08pMMR\uff09\u7684\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u3002LENVIMA\u662f\u7531\u536b\u6750\u7814\u53d1\u7684\u4e00\u79cd\u53e3\u670d\u6fc0\u9176\u6291\u5236\u5242\uff0cKEYTRUDA\u5219\u662f\u7531\u4f4d\u4e8e\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u601d\u5821\u7684\u9ed8\u6c99\u4e1c\u516c\u53f8\u7814\u53d1\u7684\u4e00\u79cd\u6297PD-1\u7597\u6cd5\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-3396","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3396"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=3396"}],"version-history":[{"count":4,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3396\/revisions"}],"predecessor-version":[{"id":6046,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3396\/revisions\/6046"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=3396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=3396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=3396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}