{"id":3406,"date":"2018-07-26T00:00:00","date_gmt":"2021-03-19T01:16:33","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=3406"},"modified":"2021-03-19T09:16:33","modified_gmt":"2021-03-19T01:16:33","slug":"%e5%8d%ab%e6%9d%90%e5%92%8c%e6%b8%a4%e5%81%a5%ef%bc%88biogen%ef%bc%89%e5%9c%a82018%e5%b9%b4%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e5%8d%8f%e4%bc%9a%e5%9b%bd%e9%99%85%e4%bc%9a%e8%ae%ae","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2018\/07\/26\/%e5%8d%ab%e6%9d%90%e5%92%8c%e6%b8%a4%e5%81%a5%ef%bc%88biogen%ef%bc%89%e5%9c%a82018%e5%b9%b4%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e5%8d%8f%e4%bc%9a%e5%9b%bd%e9%99%85%e4%bc%9a%e8%ae%ae\/","title":{"rendered":"\u536b\u6750\u548c\u6e24\u5065\uff08Biogen\uff09\u57282018\u5e74\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u534f\u4f1a\u56fd\u9645\u4f1a\u8bae\u4e0a\u516c\u5e03\u4e86BAN2401\u6cbb\u7597\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u8be6\u7ec6\u7ed3\u679c"},"content":{"rendered":"<p style=\"font-weight: 400;\">7\u670825\u65e5\uff0c\u5728\u7f8e\u56fd\u4f0a\u5229\u8bfa\u4f0a\u5dde\u829d\u52a0\u54e5\u4e3e\u884c\u76842018\u5e74\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u534f\u4f1a\u56fd\u9645\u4f1a\u8bae\uff08AAIC\uff09\u4e0a\uff0c\u4f5c\u4e3a\u4f1a\u8baeDT-01&#8243;\u6cbb\u7597\u7684\u6700\u65b0\u8fdb\u5c55&#8221;\u7684\u4e00\u90e8\u5206\uff08\u6f14\u8bb2\u7f16\u53f7\uff1aDT-01-07\uff09\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u6e24\u5065\uff08Biogen\uff09\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801: BIIB\uff09\uff08\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1aMichel Vounatsos\uff09\u5ba3\u5e03\u4e86BAN2401\uff08\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u03b2\uff08A\u03b2\uff09\u539f\u7ea4\u7ef4\u6297\u4f53\uff09\u5728856\u4f8b\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u4e2d\u7684II\u671f\u7814\u7a76\uff08201\u7814\u7a76\uff09\u7684\u8be6\u7ec6\u7ed3\u679c\u3002\u6b64\u6458\u8981\u5728AAIC\u4e0a\u88ab\u63a5\u53d7\u4e3a\u6700\u65b0\u7a81\u7834\u6027\u53e3\u5934\u62a5\u544a\u3002<\/p>\n<p style=\"font-weight: 400;\">201\u7814\u7a76\uff08ClinicalTrials.gov\u00a0\u767b\u8bb0\u53f7NCT01767311\uff09\u662f\u4e00\u9879\u5728856\u4f8b\u7531\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u5bfc\u81f4\u7684\u8f7b\u5ea6\u8ba4\u77e5\u529f\u80fd\u969c\u788d\uff08MCI\uff09\u6216\u8f7b\u5ea6AD\u578b\u75f4\u5446\uff08\u7edf\u79f0\u4e3a\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff09\u5e76\u786e\u8ba4\u5b58\u5728\u8111\u6dc0\u7c89\u6837\u75c5\u7406\u6539\u53d8\u7684\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u3001\u5e73\u884c\u3001\u968f\u673aII\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u5230\u4e94\u4e2a\u5242\u91cf\u6cbb\u7597\u7ec4\uff0c\u5206\u522b\u662f\uff1a\u6bcf\u4e24\u54682.5 mg\/kg\u3001\u6bcf\u67085 mg\/kg\u3001\u6bcf\u4e24\u54685 mg\/kg\uff0c\u6bcf\u670810 mg\/kg\u548c\u6bcf\u4e24\u546810 mg\/kg\uff0c\u6216\u8005\u88ab\u5206\u914d\u5230\u5b89\u6170\u5242\u7ec4\u3002\u672c\u7814\u7a76\u91c7\u7528\u8d1d\u53f6\u65af\u81ea\u9002\u5e94\u968f\u673a\u5316\u8bbe\u8ba1\uff0c\u6839\u636e\u4e2d\u671f\u5206\u6790\u7684\u7ed3\u679c\uff0c\u5c06\u65b0\u62db\u52df\u7684\u60a3\u8005\u81ea\u52a8\u5206\u914d\u5230\u663e\u793a\u7597\u6548\u66f4\u597d\u7684\u6cbb\u7597\u7ec4\u3002<\/p>\n<p style=\"font-weight: 400;\">\u672c\u7814\u7a76\u8bc4\u4f30\u4e86\u8861\u91cf\u6f5c\u5728\u75be\u75c5\u75c5\u7406\u751f\u7406\u5b66\u7684\u751f\u7269\u6807\u5fd7\u7269\u4ece\u57fa\u7ebf\u523018\u4e2a\u6708\u7684\u53d8\u5316\uff0c\u5305\u62ec\u7528\u6dc0\u7c89\u6837\u86cb\u767dPET\uff08\u6b63\u7535\u5b50\u5c42\u6790\u6210\u50cf\uff09\u6d4b\u91cf\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u5728\u8111\u5185\u79ef\u805a\u7684\u53d8\u5316\u3002\u4ece\u57fa\u7ebf\u5230\u6cbb\u759718\u4e2a\u6708\uff0c\u4e5f\u5bf9\u7814\u7a76\u7ec8\u70b9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7efc\u5408\u8bc4\u5206\uff08ADCOMs\uff09\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8bc4\u5b9a\u91cf\u8868-\u8ba4\u77e5\u91cf\u8868\uff08ADAS-COG\uff09\u548c\u4e34\u5e8a\u75f4\u5446\u7efc\u5408\u6c47\u603b\u8bc4\u5b9a\u91cf\u8868\uff08CDR-SB\uff09\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002<\/p>\n<p style=\"font-weight: 400;\">\u901a\u8fc7\u8d1d\u53f6\u65af\u4e2d\u671f\u5206\u6790\uff0c\u6700\u9ad8\u5242\u91cf\u6bcf\u670810 mg\/kg\u548c\u6bcf\u4e24\u546810 mg\/kg\u88ab\u786e\u5b9a\u4e3a\u7684\u662f\u5728\u8bd5\u9a8c\u65e9\u671f\u5177\u6709\u8f83\u9ad8\u7597\u6548\u7684\u6cbb\u7597\u5242\u91cf\uff0c\u56e0\u6b64\uff0c\u5206\u914d\u7ed9\u8fd9\u4e9b\u6cbb\u7597\u7ec4\u7684\u60a3\u8005\u6bd4\u4f8b\u66f4\u5927\uff08\u5b89\u6170\u5242\uff1a247\u4f8b\u60a3\u8005\uff0c\u6bcf\u4e24\u54682.5 mg\/kg\uff1a52\u4f8b\u60a3\u8005\uff0c\u6bcf\u67085 mg\/kg\uff1a51\u4f8b\u60a3\u8005\uff0c\u6bcf\u4e24\u54685 mg\/kg\uff1a92\u4f8b\u60a3\u8005\uff0c\u6bcf\u670810 mg\/kg\uff1a253\u4f8b\u60a3\u8005\uff0c\u6bcf\u4e24\u546810 mg\/kg\uff1a161\u4f8b\u60a3\u8005\uff09\u3002\u6309\u71672014\u5e747\u6708\u7684\u6cd5\u89c4\u8981\u6c42\uff08\u7f8e\u56fd\u4ee5\u5916\uff09\uff0c\u5206\u914d\u5230\u6bcf\u4e24\u546810 mg\/kg\u7ec4\u7684APOE4\u643a\u5e26\u8005\u53d7\u5230\u9650\u5236\uff0c\u5bfc\u81f4\u8be5\u7ec4\u4e2dAPOE4\u00a0\u643a\u5e26\u8005\u66f4\u5c11\uff0c\u66f4\u591a\u7684\u60a3\u8005\u88ab\u5206\u914d\u5230\u6bcf\u670810 mg\/kg\u6cbb\u7597\u7ec4\u3002<\/p>\n<p style=\"font-weight: 400;\">\u7ecf\u6dc0\u7c89\u6837\u86cb\u767dPET\u6d4b\u5b9a\uff0cBAN2401\u00a0\u663e\u793a\u51fa\u6dc0\u7c89\u6837\u6591\u5757\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u51cf\u5c11\uff0c\u4e14\u6240\u6709\u5242\u91cf\u6cbb\u7597\u7ec4\u5747\u5b58\u5728\u663e\u8457\u7edf\u8ba1\u5b66\u5dee\u5f02\u7684\u51cf\u5c11\u3002BAN2401\u6700\u9ad8\u5242\u91cf\uff08\u6bcf\u4e24\u546810 mg\/kg\uff09\u65f6\uff0c\u4f7f\u7528\u6807\u51c6\u5316PET\uff0c\u6309Centiloid\u00a0\u91cf\u8868\u6d4b\u91cf\uff0c\u5206\u6790\u8111\u4e2d\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u79ef\u805a\uff0c\u663e\u793a\u51fa\u6d4b\u5b9a\u7684\u5e73\u5747\u503c\u5728\u57fa\u7ebf\u4e3a74.5\uff0c18\u4e2a\u6708\u4e3a5.5\u3002\u4f7f\u7528\u6df7\u5408\u6a21\u578b\u91cd\u590d\u6d4b\u91cf\uff08MMRM\uff09\uff0c\u6dc0\u7c89\u6837\u86cb\u767d\u8d1f\u8377\u5e73\u5747\u51cf\u5c1170\u4e2a\u5355\u4f4d\uff0c\u5dee\u5f02\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08p\uff1c0.0001\uff09\u3002\u5728\u6dc0\u7c89\u6837\u86cb\u767dPET\u56fe\u50cf\u89c6\u89c9\u8bfb\u53d6\u4e2d\uff0cBAN2401\u663e\u793a\u51fa\u6dc0\u7c89\u6837\u86cb\u767d\u9633\u6027\u81f3\u9634\u6027\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u8f6c\u6362\uff0c\u5728\u6700\u9ad8\u5242\u91cf\u65f6\uff0c81%\u7684\u60a3\u8005\u572818\u4e2a\u6708\u5185\u4ece\u6dc0\u7c89\u6837\u86cb\u767d\u9633\u6027\u8f6c\u4e3a\u9634\u6027\uff08p\uff1c0.0001\uff09\u3002<\/p>\n<p style=\"font-weight: 400;\">\u572818\u4e2a\u6708\u6700\u7ec8\u7597\u6548\u65f6\u95f4\u70b9\u4e0a\u9884\u5b9a\u4e49\u7684\u4e34\u5e8a\u7ec8\u70b9\u7684\u5e38\u89c4\u7edf\u8ba1\u65b9\u6cd5\u8bc1\u5b9e\u4e86ADCOMS\u4ece\u57fa\u7ebf\u7684\u8ba4\u77e5\u529f\u80fd\u8870\u9000\u5b58\u5728\u5242\u91cf\u4f9d\u8d56\u6027\u51cf\u7f13\u3002\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u6bcf\u4e24\u546810 mg\/kg\u00a0\u7684\u6700\u9ad8\u5242\u91cf\u7ec4\u663e\u793a\u51fa18\u4e2a\u6708\u65f6\u4e34\u5e8a\u8870\u9000\u5b58\u5728\u5728\u7edf\u8ba1\u5b66\u4e0a\u663e\u8457\u51cf\u7f1330% (p=0.034)\u3002\u65e9\u57286\u4e2a\u6708\uff08p&lt;0.05\uff09\u4ee5\u53ca12\u6708\u65f6\uff08p&lt;0.05\uff09\uff0c\u89c2\u5bdf\u5230ADCOMS\u00a0\u8870\u9000\u5b58\u5728\u7edf\u8ba1\u5b66\u4e0a\u663e\u8457\u51cf\u6162\u3002\u5bf9\u4e8eBAN2401\uff0c\u4e5f\u89c2\u5bdf\u5230\u4e86\u4ece\u57fa\u7ebfADAS-Cog\u7684\u8ba4\u77e5\u4e0b\u964d\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u51cf\u7f13\uff1b\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u4f7f\u7528\u6700\u9ad8\u6cbb\u7597\u5242\u91cf\u7684BAN2401\uff0c\u663e\u793a\u51fa18\u4e2a\u6708\u65f6\u4e34\u5e8a\u8870\u9000\u7684\u663e\u8457\u51cf\u7f13\uff08\u51cf\u7f13\u4e0b\u964d47%\uff0cp=0.017\uff09\u3002\u6b64\u5916\uff0c\u89c2\u5bdf\u5230\u4ece\u57fa\u7ebfCDR-SB\u8ba4\u77e5\u8870\u9000\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u51cf\u7f13\uff0c\u5728\u7814\u7a76\u671f\u95f4\u8d85\u8fc7\u9884\u5148\u89c4\u5b9a\u768425%\u7684\u5dee\u5f02\u300218\u4e2a\u6708\u65f6\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u6700\u9ad8\u6cbb\u7597\u5242\u91cf\u7684BAN2401\u7684CDR-SB\u4e34\u5e8a\u4e0b\u964d\u51cf\u7f1326%\u3002\u5b89\u6170\u5242\u7ec4\u7684\u4e34\u5e8a\u8870\u9000\u7387\u4e0e\u7f8e\u56fd\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u795e\u7ecf\u5f71\u50cf\u5b66\u8ba1\u5212\uff08ADNI\uff09\u7684\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\u3002<\/p>\n<p style=\"font-weight: 400;\">\u572812\u4e2a\u6708\u7684ADCOMS\u7684\u8d1d\u53f6\u65af\u5206\u6790\u4e2d\uff0c\u6700\u9ad8\u5242\u91cf\u7684BAN2401\u6bd4\u5b89\u6170\u5242\u4e34\u5e8a\u8870\u9000\u66f4\u6162\u7684\u6982\u7387\u4e3a98%\u3002\u867d\u7136\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u4e34\u5e8a\u4e0a\u663e\u8457\u7684\u5dee\u5f02\uff08\u4e34\u5e8a\u8870\u9000\u51cf\u7f1325%\u6216\u66f4\u591a\uff09\uff0c12\u4e2a\u6708\u65f6\u65e9\u671f\u6210\u529f\u7684\u6807\u51c6\u88ab\u9884\u5148\u8bbe\u5b9a\u4e3a80%\u6216\u66f4\u9ad8\u7684\u4f30\u8ba1\u6982\u7387\uff0c\u6839\u636e\u8d1d\u53f6\u65af\u5206\u6790\uff0c\u8be5\u6807\u51c6\u7684\u5b9e\u9645\u6982\u7387\u4e3a64%\u3002<\/p>\n<p style=\"font-weight: 400;\">\u89c2\u5bdf\u5230BA2401\u6cbb\u7597\u60a3\u8005\u8111\u810a\u6db2\uff08CSF\uff09\u4e2dA\u03b2\u6c34\u5e73\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u589e\u52a0\uff0818\u4e2a\u6708\u6700\u9ad8\u5242\u91cf\uff1ap\uff1c0.0001\uff09\u3002\u63a5\u53d710 mg\/kg BAN2401\uff08\u6bcf\u6708\u6216\u6bcf\u4e24\u5468\uff09\u7684\u60a3\u8005\u7efc\u5408\u5206\u6790\u8bc1\u5b9e\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u603btau\u968f\u65f6\u95f4\u4ece\u5934\u5230\u5c3e\u663e\u8457\u964d\u4f4e\uff08p&lt;0.05\uff09\u3002<\/p>\n<p style=\"font-weight: 400;\">\u7ecf\u8fc718\u4e2a\u6708\u7684\u670d\u836f\u7814\u7a76\uff0cBAN2401\u663e\u793a\u51fa\u53ef\u63a5\u53d7\u7684\u8010\u53d7\u6027\u3002\u5b89\u6170\u5242\u7ec4\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a26.5%\uff0c\u6bcf\u670810 mg\/kg\u6cbb\u7597\u7ec4\u4e3a53.4%\uff0c\u6bcf\u4e24\u546810 mg\/kg\u6cbb\u7597\u7ec4\u4e3a47.2%\u3002\u6700\u5e38\u89c1\u7684\u6cbb\u7597\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\u662f\u6dc0\u7c89\u6837\u86cb\u767d\u76f8\u5173\u7684\u5f71\u50cf\u5b66\u5f02\u5e38\uff08ARIA\uff09\u548c\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\u3002\u5728\u6700\u9ad8\u6cbb\u7597\u5242\u91cf\u4e0b\uff0cARIA-E\uff08\u6c34\u80bf\uff09\u53d1\u751f\u7387\u4e3a9.9%\uff1b\u5176\u4ed6\u6cbb\u7597\u7ec4\u4e0d\u8d85\u8fc710%\u3002\u5728\u6700\u9ad8\u5242\u91cf\uff0cAPOE4\u643a\u5e26\u8005\u4e2dARIA-E\u53d1\u751f\u7387\u4e3a14.6%\u3002\u6309\u7167\u65b9\u6848\uff0c\u6240\u6709\u5728MRI\u4e0a\u51fa\u73b0ARIA-E\u7684\u60a3\u8005\u5747\u5e94\u505c\u6b62\u672c\u7814\u7a76\u3002\u5b89\u6170\u5242\u7ec4\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a17.6%\uff0c\u6bcf\u670810 mg\/kg\u6cbb\u7597\u7ec4\u4e3a12.3%\uff0c\u6bcf\u4e24\u546810 mg\/kg\u6cbb\u7597\u7ec4\u4e3a15.5%\u3002<\/p>\n<p style=\"font-weight: 400;\">\u672c\u65b0\u95fb\u7a3f\u8ba8\u8bba\u4e86\u836f\u7269\u5728\u7814\u53d1\u4e2d\u7684\u7814\u7a76\u6027\u7528\u9014\uff0c\u5e76\u975e\u65e8\u5728\u4f20\u9012\u5173\u4e8e\u6709\u6548\u6027\u6216\u5b89\u5168\u6027\u7684\u7ed3\u8bba\u3002\u5728\u6b64\u65e0\u6cd5\u4fdd\u8bc1\u8be5\u836f\u7269\u7814\u7a76\u80fd\u591f\u6210\u529f\u5b8c\u6210\u4e34\u5e8a\u5f00\u53d1\u6216\u83b7\u5f97\u76d1\u7ba1\u5f53\u5c40\u7684\u6279\u51c6\u3002<\/p>\n<table>\n<tbody>\n<tr>\n<td colspan=\"2\" width=\"568\">\u5a92\u4f53\u54a8\u8be2<\/td>\n<\/tr>\n<tr>\n<td width=\"284\">\u536b\u6750\u682a\u5f0f\u4f1a\u793e<br \/>\n\u516c\u5171\u5173\u7cfb\u90e8<br \/>\n\u7535\u8bdd\uff1a+81-(0)3-3817-5120<\/p>\n<p>\u536b\u6750\uff08\u7f8e\u56fd\uff09<br \/>\nPatricia_Councill@eisai.com<br \/>\n\u7535\u8bdd\uff1a+1-201-746-2139<\/td>\n<td width=\"284\">\n<p>\u6e24\u5065\uff08Biogen\uff09<br \/>\n\u516c\u5171\u4e8b\u52a1\u90e8<br \/>\n\u7535\u8bdd\uff1a+1-781-464-3260<br \/>\npublic.affairs@biogen.com<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><br style=\"font-weight: 400;\" \/><br style=\"font-weight: 400;\" \/><\/p>\n<p style=\"font-weight: 400;\"><strong>&lt;<\/strong><strong>\u7f16\u8005\u6309&gt;<\/strong><\/p>\n<p style=\"font-weight: 400;\"><b><strong style=\"font-style: inherit;\">1\u3001BAN2401<\/strong><\/b><\/p>\n<p>BAN2401\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u5176\u4e3a\u536b\u6750\u4e0eBioArctic\u4e4b\u95f4\u6218\u7565\u7814\u7a76\u8054\u76df\u7684\u7814\u7a76\u6210\u679c\u3002BAN2401\u901a\u8fc7\u9009\u62e9\u6027\u7ed3\u5408\u6765\u4e2d\u548c\u5e76\u6d88\u9664\u53c2\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u795e\u7ecf\u9000\u884c\u6027\u53d8\u5316\u8fc7\u7a0b\u7684\u53ef\u6eb6\u6027\u6bd2\u6027A\u03b2\u805a\u96c6\u4f53\u3002\u56e0\u6b64\uff0cBAN2401\u53ef\u80fd\u4f1a\u5bf9\u75be\u75c5\u75c5\u7406\u4ea7\u751f\u4f5c\u7528\u5e76\u51cf\u7f13\u75be\u75c5\u8fdb\u5c55\u3002\u6839\u636e2007\u5e7412\u6708\u4e0eBioArctic\u8fbe\u6210\u7684\u534f\u8bae\uff0c\u536b\u6750\u83b7\u5f97\u4e86\u5728\u5168\u7403\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684BAN2401\u7684\u6743\u5229\u30022014\u5e743\u6708\uff0c\u536b\u6750\u4e0e\u6e24\u5065\uff08Biogen\uff09\u5c31BAN2401\u7b7e\u8ba2\u4e86\u4e00\u4efd\u8054\u5408\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u534f\u8bae\uff0c\u53cc\u65b9\u4e8e2017\u5e7410\u6708\u5bf9\u8be5\u534f\u8bae\u8fdb\u884c\u4e86\u4fee\u8ba2\u3002<\/p>\n<p style=\"font-weight: 400;\">\n<p><b><strong style=\"font-style: inherit;\">2\u3001201\u7814\u7a76<\/strong><\/b><\/p>\n<p>201\u7814\u7a76\u662f\u4e00\u9879\u5728856\u4f8b\u7531\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u5bfc\u81f4\u7684\u8f7b\u5ea6\u8ba4\u77e5\u529f\u80fd\u969c\u788d\uff08MCI\uff09\u6216\u8f7b\u5ea6AD\u578b\u75f4\u5446\uff08\u7edf\u79f0\u4e3a\u201c\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u201d\uff09\u5e76\u786e\u8ba4\u5b58\u5728\u8111\u6dc0\u7c89\u6837\u75c5\u7406\u6539\u53d8\u7684\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u3001\u5e73\u884c\u3001\u968f\u673aII\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u672c\u7814\u7a76\u91c7\u7528\u8d1d\u53f6\u65af\u81ea\u9002\u5e94\u968f\u673a\u5316\u8bbe\u8ba1\uff0c\u6839\u636e\u4e2d\u671f\u5206\u6790\u7684\u7ed3\u679c\uff0c\u5c06\u65b0\u62db\u52df\u7684\u60a3\u8005\u81ea\u52a8\u5206\u914d\u5230\u663e\u793a\u7597\u6548\u66f4\u597d\u7684\u6cbb\u7597\u7ec4\u3002\u7814\u7a76\u8bbe\u8ba1\u5305\u62ec\u4e94\u4e2a\u5242\u91cf\u6cbb\u7597\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\uff0c\u5e76\u901a\u8fc716\u9879\u8bc4\u4f30\u65e9\u671f\u6210\u529f\u53ef\u80fd\u6027\u7684\u4e2d\u671f\u5206\u6790\u30011\u9879\u57fa\u4e8e12\u4e2a\u6708\u65f6ADCOMS\u7684\u5206\u6790\u4ee5\u53ca1\u987918\u4e2a\u6708\u65f6\u7684\u5168\u9762\u6700\u7ec8\u5206\u6790\uff0c\u8003\u8651\u5c06BAN2401\u7684\u7597\u6548\u4ee5\u53ca\u5242\u91cf\u6548\u5e94\u4f5c\u4e3a\u63a2\u7d22\u6027\u7ec8\u70b9\u3002\u63a5\u53d7BAN2401\u6cbb\u7597\u7684\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u81f35\u4e2a\u5242\u91cf\u65b9\u6848\u7ec4\uff0c\u6bcf\u4e24\u54682.5 mg\/kg\uff0852\u4f8b\u60a3\u8005\uff09\u3001\u6bcf\u67085 mg\/kg\uff0851\u4f8b\u60a3\u8005\uff09\u3001\u6bcf\u4e24\u54685 mg\/kg\uff0892\u4f8b\u60a3\u8005\uff09\u3001\u6bcf\u670810 mg\/kg\uff08253\u4f8b\u60a3\u8005\uff09\u4ee5\u53ca\u6bcf\u4e24\u546810 mg\/kg\uff08161\u4f8b\u60a3\u8005\uff09\u3002\u751f\u7269\u6807\u5fd7\u7269\u7ec8\u70b9\u5305\u62ec\u901a\u8fc7\u6dc0\u7c89\u6837\u86cb\u767dPET\uff08\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff09\u6d4b\u91cf\u53d1\u73b0\u8111\u4e2d\u4ee5\u53ca\u8111\u810a\u6db2\uff08CSF\uff09\u4e2d\u7684A\u03b2\u79ef\u805a\u53d8\u5316\uff0c\u800cADCOMS\uff08\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7efc\u5408\u8bc4\u5206\uff09\u3001\u4e34\u5e8a\u75f4\u5446\u7efc\u5408\u6c47\u603b\u8bc4\u5b9a\u91cf\u8868\uff08CDR-SB\uff09\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8bc4\u4f30\u91cf\u8868\u00a0&#8211;\u00a0\u8ba4\u77e5\u5206\u91cf\u8868\uff08ADAS-Cog\uff09\u5219\u4f5c\u4e3a\u7597\u6548\u7ec8\u70b9\uff08\u4e34\u5e8a\uff09\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n<p style=\"font-weight: 400;\">\n<p style=\"font-weight: 400;\"><b><strong style=\"font-style: inherit;\">3\u3001ADCOMS<\/strong><\/b><\/p>\n<p>ADCOMS\uff08AD\u7efc\u5408\u8bc4\u5206\uff09\u7531\u536b\u6750\u5f00\u53d1\uff0c\u7ed3\u5408\u4e86ADAS-Cog\uff08\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8bc4\u4f30\u91cf\u8868\u00a0&#8211;\u00a0\u8ba4\u77e5\u5206\u91cf\u8868\uff09\u3001CDR-SB\uff08\u4e34\u5e8a\u75f4\u5446\u7efc\u5408\u6c47\u603b\u8bc4\u5b9a\u91cf\u8868\uff09\u548cMMSE\uff08\u7b80\u6613\u667a\u529b\u72b6\u6001\u68c0\u67e5\u91cf\u8868\uff09\u4e2d\u7684\u9879\u76ee\uff0c\u80fd\u591f\u7075\u654f\u5730\u68c0\u6d4b\u51fa\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u75c7\u72b6\u7684\u4e34\u5e8a\u529f\u80fd\u53d8\u5316\u548c\u8bb0\u5fc6\u53d8\u5316\u3002\u672c\u7814\u7a76201\u5229\u7528ADCOMS\u4f5c\u4e3a\u8bc4\u4f30\u4e34\u5e8a\u75c7\u72b6\u7684\u4e3b\u8981\u7ec8\u70b9\u3002<\/p>\n<p style=\"font-weight: 400;\">\n<p style=\"font-weight: 400;\"><b><strong style=\"font-style: inherit;\">4\u3001\u6dc0\u7c89\u6837\u86cb\u767dPET\u6210\u50cf<\/strong><\/b><\/p>\n<p style=\"font-weight: 400;\">\u6dc0\u7c89\u6837\u86cb\u767dPET\uff08\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff09\u6210\u50cf\u662f\u4e00\u79cd\u8bca\u65ad\u65b9\u6cd5\uff0c\u80fd\u591f\u663e\u793a\u8111\u4e2d\u5b58\u5728\u7684\u6dc0\u7c89\u6837\u6591\u5757\uff0c\u5e76\u901a\u8fc7\u7ed9\u4e88\u5fae\u91cf\u53ef\u7279\u5f02\u6027\u7ed3\u5408\u6dc0\u7c89\u6837\u6591\u5757\u5e76\u7528\u6b63\u7535\u5b50\u8fdb\u884c\u6807\u8bb0\u7684PET\u793a\u8e2a\u5242\u5b9a\u91cf\u8bc4\u4f30\u8111\u5185\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u7684\u5206\u5e03\u548c\u805a\u96c6\u60c5\u51b5\u3002\u6dc0\u7c89\u6837\u86cb\u767dPET\u6210\u50cf\u80fd\u591f\u8bc4\u4f30\u75c5\u7406\u6539\u53d8\u5e76\u8f85\u52a9\u8bca\u65ad\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08\u5305\u62ecMCI\uff09\u60a3\u8005\uff0c\u5e76\u6839\u636e\u6dc0\u7c89\u6837\u86cb\u767d\u5047\u8bbe\u4f30\u8ba1\u75be\u75c5\u4fee\u9970\u6cbb\u7597\u836f\u7269\u5242\u7684\u4e34\u5e8a\u7597\u6548\u3002SUVr\uff08\u6807\u51c6\u6444\u53d6\u503c\u6bd4\uff09\u7528\u4e8e\u8ba1\u7b97\u8111\u5185\u611f\u5174\u8da3\u533a\u57df\u4e0e\u8111\u533a\u57df\uff08\u53c2\u8003\u533a\u57df\uff09\u7684PET\u793a\u8e2a\u5242\u7d2f\u79ef\u5f3a\u5ea6\u7684\u6bd4\u7387\uff0c\u540e\u8005\u53ef\u663e\u793aPET\u793a\u8e2a\u5242\u4f4e\u800c\u7a33\u5b9a\u7684\u7d2f\u79ef\u60c5\u51b5\u3002\u8fd9\u4e9bSUVr\u503c\u53ef\u7528\u4e8e\u5b9a\u91cf\u6bd4\u8f83\u548c\u8bc4\u4f30\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u79ef\u805a\u3002\u5f53\u6574\u5408\u548c\u8bc4\u4f30\u7531\u4e0d\u540c\u793a\u8e2a\u5242\u6d4b\u91cf\u7684A\u03b2\u7d2f\u79ef\u53d8\u5316\u7684\u751f\u7269\u6807\u5fd7\u7269\u65f6\uff0c\u5219\u9700\u8981\u8865\u507fPET\u793a\u8e2a\u5242\u4e4b\u95f4\u6d4b\u91cf\u503c\u7684\u5dee\u5f02\u3002\u8fd9\u4fc3\u4f7fGAIIN Centiloid\u9879\u76ee\u5f00\u53d1\u51fa\u4e86\u767e\u5206\u5236\u91cf\u8868\uff08\u79f0\u4e3a\u201cCentiloid\u201d\uff09\uff0c\u201c\u9ad8\u786e\u5b9a\u6027\u201d\u6dc0\u7c89\u6837\u86cb\u767d\u9634\u6027\u53d7\u8bd5\u8005\u7684\u5e73\u5747\u503c\u4e3a\u96f6\uff0c\u800c\u201c\u5178\u578b\u201d\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u60a3\u8005\u7684\u5e73\u5747\u503c\u4e3a100\uff08Klunk et al., 2015\uff09\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u8be5Centiloid\u91cf\u8868\u7528\u4e8e\u6807\u51c6\u5316SUVr\u6d4b\u91cf\u503c\u4ee5\u8bc4\u4f30\u6dc0\u7c89\u6837\u86cb\u767d\u8d1f\u8377\u7684\u51cf\u5c11\u3002<\/p>\n<p style=\"font-weight: 400;\">\n<p><b><strong style=\"font-style: inherit;\">5\u3001\u536b\u6750\u548c\u6e24\u5065<strong>\uff08Biogen\uff09\u5173\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u8054\u5408\u5f00\u53d1\u534f\u8bae<\/strong><\/strong><\/b><\/p>\n<p>\u536b\u6750\u548c\u6e24\u5065\uff08Biogen\uff09\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6cbb\u7597\u7684\u8054\u5408\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u65b9\u9762\u8fdb\u884c\u4e86\u5927\u91cf\u5408\u4f5c\u3002\u536b\u6750\u662f\u8054\u5408\u5f00\u53d1Elenbecestat\uff08\u4e00\u79cdBACE\u6291\u5236\u5242\uff09\u548cBAN2401\uff08\u4e00\u79cd\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u03b2\uff08A\u03b2\uff09\u539f\u7ea4\u7ef4\u6297\u4f53\uff09\u7684\u4e3b\u5bfc\u8005\uff0c\u800c\u6e24\u5065\uff08Biogen\uff09\u662f\u8054\u5408\u5f00\u53d1Aducanumab\uff08\u6e24\u5065\uff08Biogen\uff09\u7528\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u8bd5\u9a8c\u7528\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u03b2\uff08A\u03b2\uff09\u6297\u4f53\uff09\u7684\u4e3b\u5bfc\u8005\uff0c\u4e24\u5bb6\u516c\u53f8\u8ba1\u5212\u5bfb\u6c42\u8fd9\u4e09\u79cd\u5316\u5408\u7269\u5728\u5168\u7403\u8303\u56f4\u5185\u7684\u4e0a\u5e02\u8bb8\u53ef\u3002\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u53cc\u65b9\u516c\u53f8\u8fd8\u5c06\u5728\u4e3b\u8981\u5e02\u573a\uff08\u5982\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u65e5\u672c\uff09\u5171\u540c\u63a8\u5e7f\u4ea7\u54c1\u3002\u5bf9\u4e8eBAN2401\u548cElenbecestat\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u5e73\u5747\u5206\u644a\u603b\u4f53\u6210\u672c\uff0c\u5305\u62ec\u7814\u53d1\u8d39\u7528\u3002\u536b\u6750\u5c06\u5728\u83b7\u5f97\u4e0a\u5e02\u8bb8\u53ef\u540e\u63a5\u53d7Elenbecestat\u548cBAN2401\u7684\u6240\u6709\u9500\u552e\u9884\u8ba2\u5e76\u8fdb\u884c\u53d1\u5e03\uff0c\u5e76\u4e14\u4e24\u5bb6\u516c\u53f8\u5c06\u5747\u4eab\u5229\u6da6\u3002<\/p>\n<p><strong>6<\/strong><strong>\u3001\u5173\u4e8e\u536b\u6750\u682a\u5f0f\u4f1a\u793e<\/strong><\/p>\n<p>\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u662f\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u7684\u5168\u7403\u9886\u5148\u7684\u533b\u836f\u7814\u53d1\u516c\u53f8\u3002\u6211\u4eec\u516c\u53f8\u7684\u4f7f\u547d\u662f\u201c\u6211\u4eec\u5c06\u60a3\u8005\u53ca\u5bb6\u5c5e\u7684\u5229\u76ca\u653e\u5728\u9996\u4f4d\uff0c\u4e3a\u63d0\u5347\u5176\u798f\u7949\u505a\u51fa\u8d21\u732e\u3002\u201d\uff0c\u6211\u4eec\u79f0\u4e4b\u4e3a\u201c\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\uff08<em>hhc<\/em>\uff09\u201d\u7406\u5ff5\u3002\u5168\u7403\u7ea6\u670910000\u540d\u5458\u5de5\u5206\u522b\u5de5\u4f5c\u5728\u7814\u53d1\u4e2d\u5fc3\u3001\u751f\u4ea7\u57fa\u5730\u53ca\u9500\u552e\u5b50\u516c\u53f8\u3002\u6211\u4eec\u81f4\u529b\u4e8e\u901a\u8fc7\u63d0\u4f9b\u521b\u65b0\u4ea7\u54c1\u4ee5\u89e3\u51b3\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u6765\u5b9e\u73b0\u6211\u4eec\u7684<em>hhc<\/em>\u7406\u5ff5\uff0c\u7279\u522b\u5173\u6ce8\u795e\u7ecf\u79d1\u5b66\u548c\u80bf\u7624\u5b66\u4e24\u5927\u6218\u7565\u9886\u57df\u3002<\/p>\n<p>\u901a\u8fc7\u7814\u53d1\u548c\u9500\u552e\u5b89\u7406\u7533\uff08\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u53ca\u8def\u6613\u4f53\u75f4\u5446\u7684\u836f\u7269\uff09\u7684\u7ecf\u9a8c\uff0c\uff0c\u536b\u6750\u5df2\u5efa\u7acb\u4e86\u6db5\u76d6\u6bcf\u4e2a\u793e\u533a\u7684\u60a3\u8005\uff0c\u5e76\u534f\u8c03\u5404\u4e2a\u5229\u76ca\u76f8\u5173\u8005\uff08\u5305\u62ec\uff1a\u653f\u5e9c\u3001\u533b\u7597\u4e13\u4e1a\u4eba\u58eb\u53ca\u7167\u62a4\u8005\uff09\u7684\u793e\u4f1a\u73af\u5883\uff0c\u4e14\u5728\u5168\u7403\u4e3e\u529e\u4e86\u8d85\u4e00\u4e07\u6b21\u6709\u5173\u75f4\u5446\u8ba4\u77e5\u7684\u6d3b\u52a8\u3002\u4f5c\u4e3a\u5728\u75f4\u5446\u6cbb\u7597\u9886\u57df\u7684\u5148\u9a71\uff0c\u536b\u6750\u4e0d\u4ec5\u7814\u53d1\u4e0b\u4e00\u4ee3\u6cbb\u7597\u836f\u7269\uff0c\u540c\u65f6\u4e5f\u7814\u53d1\u8bca\u65ad\u65b9\u6cd5\u5e76\u63d0\u4f9b\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n<p style=\"font-weight: 400;\">\u5173\u4e8e\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.eisai.com\/\"><u>www.eisai.com<\/u><\/a>\u3002<\/p>\n<p style=\"font-weight: 400;\">\n<p style=\"font-weight: 400;\"><strong>7<\/strong><strong>\u3001<\/strong><strong>\u5173\u4e8e\u6e24\u5065\uff08Biogen\uff09<\/strong><\/p>\n<p style=\"font-weight: 400;\">\u5728\u6e24\u5065\uff08Biogen\uff09\uff0c\u6211\u4eec\u7684\u4f7f\u547d\u6e05\u6670\u660e\u786e\uff1a\u6211\u4eec\u662f\u795e\u7ecf\u79d1\u5b66\u9886\u57df\u7684\u5148\u950b\u3002\u6e24\u5065\uff08Biogen\uff09\u4e3a\u5168\u7403\u7f79\u60a3\u4e25\u91cd\u795e\u7ecf\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4eba\u7fa4\u63a2\u5bfb\u3001\u7814\u53d1\u548c\u63d0\u4f9b\u521b\u65b0\u7597\u6cd5\u3002\u6e24\u5065\uff08Biogen\uff09\u662fCharles Weissmann\uff0cHeinz Schaller\uff0cKenneth Murray\u4e0e\u8bfa\u8d1d\u5c14\u5956\u83b7\u5f97\u8005Walter Gilbert\u548cPhillip Sharp\u643a\u624b\u57281978\u5e74\u6210\u7acb\u7684\u5168\u7403\u9996\u6279\u751f\u7269\u6280\u672f\u516c\u53f8\u4e4b\u4e00\uff0c\u4eca\u5929\u6e24\u5065\uff08Biogen\uff09\u62e5\u6709\u6cbb\u7597\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u9886\u5148\u836f\u7269\u7ec4\u5408;\u00a0\u63a8\u51fa\u7b2c\u4e00\u4e2a\u4e5f\u662f\u552f\u4e00\u4e00\u4e2a\u6279\u51c6\u7528\u4e8e\u810a\u9ad3\u6027\u808c\u840e\u7f29\u7684\u6cbb\u7597\u836f\u7269\uff1b\u5e76\u4e13\u6ce8\u4e8e\u63a8\u8fdb\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u548c\u75f4\u5446\u3001\u795e\u7ecf\u514d\u75ab\u5b66\u3001\u8fd0\u52a8\u969c\u788d\u3001\u795e\u7ecf\u808c\u8089\u75be\u75c5\u3001\u75bc\u75db\u3001\u773c\u79d1\u3001\u795e\u7ecf\u7cbe\u795e\u75c5\u5b66\u548c\u6025\u6027\u795e\u7ecf\u75c5\u5b66\u9886\u57df\u7684\u79d1\u5b66\u7814\u7a76\u9879\u76ee\u3002\u6e24\u5065\uff08Biogen\uff09\u8fd8\u751f\u4ea7\u548c\u63a8\u5e7f\u5148\u8fdb\u751f\u7269\u5236\u5242\u7684\u751f\u7269\u4eff\u5236\u836f\u3002\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<a href=\"http:\/\/www.biogen.com\/\">www.biogen.com<\/a>\u3002<\/p>\n<p style=\"font-weight: 400;\">\n<p><strong>8<\/strong><strong>\u3001\u5173\u4e8eBioArctic AB<\/strong><\/p>\n<p>BioArctic AB\uff08publ\uff09\u662f\u4e00\u5bb6\u745e\u5178\u7684\u7814\u53d1\u578b\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u75be\u75c5\u4fee\u9970\u6cbb\u7597\u548c\u53ef\u9760\u7684\u751f\u7269\u6807\u5fd7\u7269\u53ca\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u8bca\u65ad\uff0c\u5982\uff1a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\u3002\u516c\u53f8\u4e5f\u5728\u7814\u53d1\u5b8c\u5168\u6027\u810a\u9ad3\u635f\u4f24\u7684\u6f5c\u5728\u7597\u6cd5\u3002BioArctic\u5173\u6ce8\u9ad8\u5ea6\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u9886\u57df\u7684\u521b\u65b0\u6cbb\u7597\u3002\u57fa\u4e8e\u745e\u5178\u4e4c\u666e\u8428\u62c9\u5927\u5b66\u7684\u521b\u65b0\u7814\u7a76\uff0c\u516c\u53f8\u521b\u7acb\u4e8e2003\u5e74\u3002\u4e0e\u5404\u5927\u5b66\u4ee5\u53ca\u6211\u4eec\u5168\u7403\u91cd\u8981\u6218\u7565\u4f19\u4f34\uff08\u5305\u62ec\uff1a\u536b\u6750\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u9879\u76ee\u4ee5\u53ca\u827e\u4f2f\u7ef4\u7684\u5e15\u91d1\u68ee\u75c5\u9879\u76ee\uff09\u7684\u5408\u4f5c\u5bf9\u516c\u53f8\u81f3\u5173\u91cd\u8981\u3002\u9879\u76ee\u662f\u5bf9\u4e0e\u5168\u7403\u533b\u836f\u516c\u53f8\u5408\u4f5c\u7684\u5168\u8d44\u91d1\u9879\u76ee\u4ee5\u53ca\u5177\u6709\u663e\u8457\u5e02\u573a\u6f5c\u529b\u548c\u5bf9\u5916\u8bb8\u53ef\u6f5c\u529b\u7684\u521b\u65b0\u81ea\u7814\u9879\u76ee\u7684\u6574\u5408\u3002BioArctic\u7684B\u80a1\u5df2\u5728\u7eb3\u65af\u8fbe\u514b\u65af\u5fb7\u54e5\u5c14\u6469\u8bc1\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\u3002<\/p>\n<p style=\"font-weight: 400;\">\n<p><strong>\u6e24\u5065\uff08Biogen\uff09\u5b89\u5168\u6e2f\u58f0\u660e<\/strong><\/p>\n<p style=\"font-weight: 400;\">\u672c\u65b0\u95fb\u7a3f\u5305\u542b\u524d\u77bb\u6027\u9648\u8ff0\uff0c\u5305\u62ec\u6839\u636e1995\u5e74\u300a\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\u7684\u5b89\u5168\u6e2f\u6761\u6b3e\uff0c\u00a0BAN2401 II\u671f\u7814\u7a76\u7ed3\u679c\u7684\u9648\u8ff0\uff1bBAN2401\u6f5c\u5728\u7684\u4e34\u5e8a\u7597\u6548\uff1bBAN2401\u7684\u6f5c\u5728\u6548\u76ca\u3001\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u4ee5\u53ca\u6cbb\u7597\u5176\u4ed6\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff1bBAN2401\u4e34\u5e8a\u5f00\u53d1\u65b9\u6848\uff1b\u4e0e\u836f\u7269\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u76f8\u5173\u7684\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\uff1b\u5f53\u524d\u548c\u672a\u6765\u76d1\u7ba1\u6587\u4ef6\u7684\u65f6\u95f4\u548c\u72b6\u6001\uff1b\u6e24\u5065\uff08Biogen\uff09\u7684\u6218\u7565\u4e0e\u8ba1\u5212\uff1b\u9884\u671f\u6548\u76ca\u4ee5\u53ca\u6e24\u5065\uff08Biogen\uff09\u4e0e\u536b\u6750\u5408\u4f5c\u5b89\u6392\u7684\u53ef\u80fd\u6027\uff1b\u6e24\u5065\uff08Biogen\uff09\u7684\u5546\u4e1a\u7ecf\u8425\u6f5c\u529b\u548c\u6e20\u9053\u9879\u76ee\uff0c\u5305\u62ecBAN2401\u3001Elenbecestat\u548c\u00a0Aducanumab\u3002\u8fd9\u4e9b\u524d\u77bb\u6027\u9648\u8ff0\u53ef\u80fd\u4f34\u6709\u8bf8\u5982\uff1a\u201c\u76ee\u6807\u201d\u3001\u201c\u9884\u8ba1\u201d\u3001\u201c\u76f8\u4fe1\u201d\u3001\u201c\u53ef\u4ee5\u201d\u3001\u201c\u4f30\u8ba1\u201d\u3001\u201c\u9664\u5916\u201d\u3001\u201c\u9884\u6d4b\u201d\u3001\u201c\u6253\u7b97\u201d\u3001\u201c\u4e5f\u8bb8\u201d\u3001\u201c\u8ba1\u5212\u201d\u3001\u201c\u6f5c\u529b\u201d\u3001\u201c\u53ef\u80fd\u201d\u201c\u5c06\u4f1a\u201d\u7b49\u63aa\u8bcd\u4ee5\u53ca\u5176\u4ed6\u542b\u4e49\u7c7b\u4f3c\u7684\u63aa\u8bcd\u548c\u7528\u8bed\u3002\u836f\u7269\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u5177\u6709\u9ad8\u98ce\u9669\uff0c\u5e76\u4e14\u53ea\u6709\u5c11\u6570\u7814\u7a76\u548c\u5f00\u53d1\u8ba1\u5212\u80fd\u591f\u5b9e\u73b0\u4ea7\u54c1\u7684\u5546\u4e1a\u5316\u3002\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u53ef\u80fd\u65e0\u6cd5\u6307\u793a\u5b8c\u6574\u7ed3\u679c\u6216\u8005\u540e\u671f\u6216\u66f4\u5927\u89c4\u6a21\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u4ea6\u65e0\u6cd5\u786e\u4fdd\u83b7\u5f97\u76d1\u7ba1\u90e8\u95e8\u7684\u6279\u51c6\u3002\u8bfb\u8005\u4e0d\u5e94\u8fc7\u5206\u4f9d\u8d56\u8fd9\u4e9b\u9648\u8ff0\u6216\u79d1\u5b66\u6570\u636e\u3002<\/p>\n<p>\u8fd9\u4e9b\u9648\u8ff0\u6d89\u53ca\u5404\u79cd\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u56e0\u7d20\uff0c\u6709\u53ef\u80fd\u5bfc\u81f4\u5b9e\u9645\u7ed3\u679c\u4e0e\u8fd9\u4e9b\u9648\u8ff0\u6240\u53cd\u6620\u7684\u5185\u5bb9\u6709\u5b9e\u8d28\u6027\u7684\u5dee\u8ddd\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u83b7\u5f97\u7684\u989d\u5916\u6570\u636e\u3001\u5206\u6790\u6216\u7ed3\u679c\u53ef\u80fd\u5f15\u8d77\u7684\u610f\u5916\u95ee\u9898\uff1b\u76d1\u7ba1\u673a\u6784\u53ef\u80fd\u8981\u6c42\u63d0\u4f9b\u989d\u5916\u4fe1\u606f\u6216\u8fdb\u4e00\u6b65\u7814\u7a76\u6216\u8005\u76d1\u7ba1\u673a\u6784\u53ef\u80fd\u62d2\u7edd\u6279\u51c6\u6216\u63a8\u8fdf\u6279\u51c6\u6e24\u5065\uff08Biogen\uff09\u7684\u5019\u9009\u836f\u7269\uff08\u5305\u62ecBAN2401\u3001Elenbecestat\u548c\/\u6216Aducanumab\uff09\uff1b\u53d1\u751f\u4e0d\u826f\u5b89\u5168\u4e8b\u4ef6\uff1b\u610f\u5916\u8d39\u7528\u6216\u5ef6\u8bef\u7684\u98ce\u9669\uff1b\u5176\u4ed6\u610f\u5916\u969c\u788d\u7684\u98ce\u9669\uff1bBAN2401\u3001Elenbecestat\u548c\/\u6216Aducanumab\u7684\u5f00\u53d1\u548c\u6f5c\u5728\u5546\u4e1a\u5316\u80fd\u5426\u53d6\u5f97\u6210\u529f\u5b58\u5728\u4e0d\u786e\u5b9a\u6027\uff08\u8fd9\u53ef\u80fd\u53d7\u5230\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5176\u4e2d\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u989d\u5916\u6570\u636e\u6216\u5206\u6790\u5f15\u8d77\u7684\u610f\u5916\u95ee\u9898\u3001\u53d1\u751f\u4e0d\u826f\u5b89\u5168\u4e8b\u4ef6\u3001\u5728\u67d0\u4e9b\u53f8\u6cd5\u7ba1\u8f96\u533a\u672a\u83b7\u5f97\u76d1\u7ba1\u90e8\u95e8\u7684\u6279\u51c6\uff0c\u6e24\u5065\uff08Biogen\uff09\u7684\u6570\u636e\u3001\u77e5\u8bc6\u4ea7\u6743\u548c\u5176\u4ed6\u6240\u6709\u6743\u672a\u80fd\u5f97\u5230\u4fdd\u62a4\u548c\u6267\u884c\u4ee5\u53ca\u4e0e\u77e5\u8bc6\u4ea7\u6743\u7d22\u8d54\u548c\u5f02\u8bae\u76f8\u5173\u7684\u4e0d\u786e\u5b9a\u6027\uff09\uff1b\u5173\u4e8e\u6e24\u5065\uff08Biogen\uff09\u4e0e\u536b\u6750\u5408\u4f5c\u7814\u53d1\u7684\u9884\u671f\u6536\u76ca\u548c\u6f5c\u529b\u662f\u5426\u80fd\u591f\u5b9e\u73b0\u5177\u6709\u4e0d\u786e\u5b9a\u6027\uff1b\u4ea7\u54c1\u8d23\u4efb\u7d22\u8d54\uff1b\u4ee5\u53ca\u7b2c\u4e09\u65b9\u5408\u4f5c\u98ce\u9669\u3002\u4e0a\u8ff0\u5185\u5bb9\u5217\u51fa\u53ef\u80fd\u5bfc\u81f4\u5b9e\u9645\u7ed3\u679c\u4e0e\u6e24\u5065\uff08Biogen\uff09\u5728\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u4e2d\u6240\u8ff0\u9884\u671f\u4e0d\u4e00\u81f4\u7684\u8bb8\u591a\uff08\u4f46\u975e\u5168\u90e8\uff09\u56e0\u7d20\u3002\u6295\u8d44\u8005\u5e94\u5f53\u8003\u8651\u8fd9\u4e00\u8b66\u793a\u6027\u58f0\u660e\uff0c\u4ee5\u53ca\u6e24\u5065\uff08Biogen\uff09\u5728\u6700\u8fd1\u7684\u5e74\u5ea6\u62a5\u544a\u6216\u5b63\u5ea6\u62a5\u544a\u4ee5\u53ca\u6e24\u5065\uff08Biogen\uff09\u5411\u7f8e\u56fd\u8bc1\u5238\u4ea4\u6613\u59d4\u5458\u4f1a\u63d0\u4ea4\u7684\u5176\u4ed6\u62a5\u544a\u4e2d\u5217\u660e\u7684\u98ce\u9669\u56e0\u7d20\u3002\u8fd9\u4e9b\u9648\u8ff0\u7684\u4f9d\u636e\u662f\u6e24\u5065\uff08Biogen\uff09\u5f53\u524d\u7684\u4fe1\u5ff5\u548c\u671f\u671b\uff0c\u4ec5\u5728\u672c\u65b0\u95fb\u7a3f\u53d1\u5e03\u4e4b\u65e5\u4f5c\u51fa\u3002\u65e0\u8bba\u662f\u5426\u7531\u4e8e\u65b0\u4fe1\u606f\u3001\u672a\u6765\u5f00\u53d1\u6216\u5176\u4ed6\u4e8b\u7531\u5bfc\u81f4\u4efb\u4f55\u524d\u77bb\u6027\u9648\u8ff0\u53d1\u751f\u53d8\u66f4\uff0c\u6e24\u5065\uff08Biogen\uff09\u5747\u4e0d\u627f\u62c5\u5bf9\u5176\u8fdb\u884c\u516c\u5f00\u66f4\u65b0\u7684\u4e49\u52a1\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>7\u670825\u65e5\uff0c\u5728\u7f8e\u56fd\u4f0a\u5229\u8bfa\u4f0a\u5dde\u829d\u52a0\u54e5\u4e3e\u884c\u76842018\u5e74\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u534f\u4f1a\u56fd\u9645\u4f1a\u8bae\uff08AAIC\uff09\u4e0a\uff0c\u4f5c\u4e3a\u4f1a\u8baeDT-01&#8243;\u6cbb\u7597\u7684\u6700\u65b0\u8fdb\u5c55&#8221;\u7684\u4e00\u90e8\u5206\uff08\u6f14\u8bb2\u7f16\u53f7\uff1aDT-01-07\uff09\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u6e24\u5065\uff08Biogen\uff09\uff08\u7eb3\u65af\u8fbe\u514b\u4ee3\u7801: BIIB\uff09\uff08\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1aMichel Vounatsos\uff09\u5ba3\u5e03\u4e86BAN2401\uff08\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u03b2\uff08A\u03b2\uff09\u539f\u7ea4\u7ef4\u6297\u4f53\uff09\u5728856\u4f8b\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u4e2d\u7684II\u671f\u7814\u7a76\uff08201\u7814\u7a76\uff09\u7684\u8be6\u7ec6\u7ed3\u679c\u3002\u6b64\u6458\u8981\u5728AAIC\u4e0a\u88ab\u63a5\u53d7\u4e3a\u6700\u65b0\u7a81\u7834\u6027\u53e3\u5934\u62a5\u544a\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-3406","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3406"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=3406"}],"version-history":[{"count":2,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3406\/revisions"}],"predecessor-version":[{"id":3408,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3406\/revisions\/3408"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=3406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=3406"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=3406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}