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13\u4efd\u62a5\u544a\u5c55\u793aBAN2401\u548cElenbecestat\u7684II\u671f\u7814\u7a76\u7ed3\u679c<\/em><\/p>\n

\u6309\u71677\u670810\u65e5\u53d1\u5e03\u7684\u6d88\u606f\uff0c\u536b\u6750\u53e3\u5934\u62a5\u544a201\u7814\u7a76\uff08ClinicalTrials.gov\u00a0\u6807\u8bc6\u53f7\uff1aNCT01767311\uff09\u4e2d\u5173\u4e8eBAN2401\u5e94\u7528\u4e8e\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08\u7531\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5f15\u8d77\u7684\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u6216\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6027\u75f4\u5446\uff09\u6cbb\u7597\u7684\u6700\u65b0\u6982\u8981\u3002\u536b\u6750\u548c\u6e24\u5065\uff08Biogen\uff09\u66fe\u57287\u67086\u65e5\u5ba3\u5e03\uff0c201\u7814\u7a76\u572818\u4e2a\u6708\u5173\u952e\u9884\u5b9a\u4e49\u7ec8\u70b9\u7684\u6548\u679c\u8bc4\u4f30\u4e2d\uff0c\u5ef6\u7f13\u75c5\u60c5\u53d1\u5c55\uff08\u7528\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7efc\u5408\u8bc4\u5206\u8bc4\u4f30\uff09\u4e2d\u3001\u51cf\u5c11\u5927\u8111\u4e2d\u6dc0\u7c89\u6837\u86cb\u767d\u79ef\u7d2f\uff08\u7528\u6dc0\u7c89\u6837\u86cb\u767d-\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u9020\u5f71\u672f\uff0c\u5373\u6dc0\u7c89\u6837\u86cb\u767d-PET\u6765\u8bc4\u4f30\uff09\u65b9\u9762\u5177\u6709\u663e\u8457\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u8be5\u7814\u7a76\u662f\u9996\u4e2aIIb\u671f\u7814\u7a76\u6570\u636e\u4e2d\u6210\u529f\u663e\u793a\u51fa\u5176\u5728\u4e34\u5e8a\u529f\u80fd\u4e0a\u548c\u5927\u8111\u4e2d\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u79ef\u7d2f\u65b9\u9762\u7684\u75be\u75c5\u4fee\u9970\u4f5c\u7528\u3002\u7814\u7a76\u4e2d\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a\u8f93\u6db2\u53cd\u5e94\u548c\u6dc0\u7c89\u6837\u86cb\u767d\u76f8\u5173\u5f71\u50cf\u5f02\u5e38\uff08ARIA\uff09\u3002<\/p>\n

\u540c\u6837\uff0c\u536b\u6750\u7528\u6d77\u62a5\u5c55\u793a\u4e86\u6709\u5173Elenbecestat\u6700\u65b0\u7814\u7a76\u7684\u6458\u8981\uff0c\u9610\u8ff0202\u7814\u7a76\uff08ClinicalTrials.gov\u00a0\u6807\u8bc6\u53f7NCT02322021\uff09\u4e2dElenbecestat\u6cbb\u7597\u7531\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5f15\u8d77\u7684\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u548c\u8f7b\u3001\u4e2d\u5ea6\u8001\u5e74\u75f4\u5446\u75c7\u7684\u7ed3\u679c\u30022018\u5e746\u67086\u65e5\uff0c\u536b\u6750\u5ba3\u5e03\uff0c\u6839\u636e202\u7814\u7a7618\u4e2a\u6708\u7684\u9633\u6027\u7814\u7a76\u7ed3\u679c\uff0cElenbecestat\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff08\u4e3b\u8981\u7ec8\u70b9\uff09\u90fd\u5728\u53ef\u63a5\u53d7\u8303\u56f4\u3002\u6b64\u5916\uff0c\u7528\u6dc0\u7c89\u6837\u86cb\u767d-PET\u00a0\u6d4b\u5b9a\u5176\u5bf9\u5927\u8111\u4e2dA\u03b2\u00a0\u6c34\u5e73\u7684\u5f71\u54cd\uff08\u63a2\u7d22\u6027\u7ec8\u70b9\uff09\uff0c\u7ed3\u679c\u5177\u6709\u663e\u8457\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u53e6\u5916\uff0c\u7814\u7a76\u8fd8\u663e\u793a\u8be5\u836f\u53ef\u5ef6\u7f13\u4e00\u4e9b\u529f\u80fd\u6027\u4e34\u5e8a\u91cf\u8868\u6570\u636e\u4e0b\u964d\uff0c\u4e14\u53ef\u80fd\u5177\u6709\u4e34\u5e8a\u91cd\u8981\u5dee\u5f02\uff0c\u5c3d\u7ba1\u6ca1\u6709\u663e\u8457\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u89c2\u5bdf\u5230\u7684\u516d\u79cd\u6700\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u4e3a\u63a5\u89e6\u6027\u76ae\u708e\u3001\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3001\u5934\u75db\u3001\u8179\u6cfb\u3001\u8dcc\u5012\u548c\u76ae\u708e\u3002\u76ee\u524d\uff0c\u6b63\u5728\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u4e2d\u8fdb\u884c\u4e24\u9879Elenbecestat\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff08MISSION AD1\/2\uff09\u3002<\/p>\n

\u53e6\u5916\uff0c\u6e24\u5065\uff08Biogen\uff09\u6b63\u5728\u8fdb\u884c\u9488\u5bf9Aducanumab\u957f\u671f\u7528\u836f\u7684Ib\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5728\u672c\u6b21\u53d1\u5e03\u4e2d\u8fdb\u884c\u4e86\u76f8\u5173\u53e3\u5934\u62a5\u544a\u548c\u6d77\u62a5\u5c55\u793a\u3002\u76ee\u524d\u536b\u6750\u548c\u6e24\u5065\uff08Biogen\uff09\u6b63\u5728\u9488\u5bf9Aducanumab\u8fdb\u884c\u4e24\u4e2aIII\u671f\u4e34\u5e8a\u7814\u7a76\uff08ENGAGE\/EMERGE\uff09\u3002<\/p>\n

\u6b64\u5916\uff0c\u6b64\u6b21\u53d1\u5e03\u8fd8\u4ecb\u7ecd\u4e86\u65b0\u578b\u78f7\u9178\u4e8c\u916f\u9176-9\u6291\u5236\u5242\uff0c\u5305\u62ec\u4e00\u4e2aI\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u7684\u53e3\u5934\u62a5\u544a\uff0c\u53ca\u4e00\u4e9b\u975e\u4e34\u5e8a\u6027\u7814\u7a76\u7ed3\u679c\u7684\u6d77\u62a5\u5c55\u793a\u3002E2027\u7531\u536b\u6750\u72ec\u5bb6\u7814\u53d1\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884cII\u3001III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u4f5c\u4e3a\u8def\u6613\u4f53\u75f4\u5446\u7684\u6f5c\u5728\u6cbb\u7597\u3002<\/p>\n

\u7761\u7720-\u89c9\u9192\u8282\u5f8b\u8c03\u8282\u5236\u5242Lemborexant\u5728\u4e0d\u89c4\u5f8b\u7761\u7720-\u89c9\u9192\u8282\u5f8b\u969c\u788d\u60a3\u8005\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u4e00\u9879II\u671f\u4e34\u5e8a\u7814\u7a76\uff08202\u7814\u7a76\uff09\u7684\u57fa\u7ebf\u6570\u636e\u4e5f\u5728AAIC 2018\u4e0a\u53d1\u5e03\u3002Lemborexant\u7531\u536b\u6750\u53d1\u73b0\uff0c\u81ea2015\u5e748\u6708\u8d77\u7531\u536b\u6750\u548c\u666e\u675c\u5236\u836f\u6709\u9650\u516c\u53f8\uff08Purdue Pharma L.P.\uff0c\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u5eb7\u6d85\u72c4\u683c\u5dde\uff0c\u4ee5\u4e0b\u7b80\u79f0\u4e3a”\u666e\u675c”\uff09\u5171\u540c\u5f00\u53d1\u3002<\/p>\n

\u57fa\u4e8e30\u591a\u5e74\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\/\u75f4\u5446\u9886\u57df\u7684\u836f\u7269\u7814\u53d1\u7ecf\u9a8c\uff0c\u536b\u6750\u529b\u6c42\u901a\u8fc7\u5168\u76d8\u7684\u65b9\u6cd5\u6765\u7814\u53d1\u75f4\u5446\u836f\u7269\u4ee5\u9884\u9632\u548c\u6cbb\u6108\u75f4\u5446\u3002\u536b\u6750\u5c06\u5c3d\u5feb\u7814\u53d1\u521b\u65b0\u578b\u836f\u7269\uff0c\u4ee5\u6ee1\u8db3\u60a3\u8005\u53ca\u5176\u5bb6\u5c5e\u7684\u5404\u79cd\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u836f\u9700\u6c42\uff0c\u5e76\u63d0\u5347\u4ed6\u4eec\u7684\u798f\u7949\u3002<\/p>\n

<\/p>\n

\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u534f\u4f1a\u56fd\u9645\u4f1a\u8bae\uff08AAIC\uff092018\u62a5\u544a\u5185\u5bb9\uff1a<\/p>\n

$\"\"$ <\/p>\n

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[\u7f16\u8005\u6309]<\/strong><\/b><\/p>\n

1\u3001\u5173\u4e8e\u00a0BAN2401<\/strong><\/b><\/span><\/p>\n

BAN2401\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u7531\u536b\u6750\u548cBioArctic\u6218\u7565\u8054\u76df\u5171\u540c\u7814\u53d1\u3002BAN2401\u901a\u8fc7\u9009\u62e9\u6027\u7ed3\u5408\u6765\u4e2d\u548c\u53ca\u6d88\u9664\u53ef\u6eb6\u6027\u3001\u6bd2\u6027A\u03b2\u805a\u5408\u7269\u2014\u2014\u8fd9\u4e9b\u7269\u8d28\u88ab\u8ba4\u4e3a\u80fd\u591f\u4fc3\u8fdb\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u795e\u7ecf\u9000\u884c\u6027\u8fdb\u7a0b\u3002\u56e0\u6b64\uff0cBAN2401\u53ef\u80fd\u5bf9\u8be5\u75c5\u7684\u75c5\u7406\u5177\u6709\u6f5c\u5728\u5f71\u54cd\u5e76\u53ef\u51cf\u7f13\u8be5\u75be\u75c5\u7684\u8fdb\u5c55\u3002\u6839\u636e\u536b\u6750\u548cBioArctic\u4e8e2007\u5e7412\u6708\u8fbe\u6210\u7684\u534f\u8bae\uff0c\u536b\u6750\u83b7\u5f97\u6388\u6743\u5728\u5168\u7403\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u836f\u7269BAN2401\u3002<\/p>\n

2\u3001\u5173\u4e8eElenbecestat\uff08\u901a\u7528\u540d\uff0c\u7814\u53d1\u4ee3\u7801\uff1aE2609\uff09<\/strong><\/b>
\nElenbecestat\u662f\u4e00\u79cd\u53e3\u670dBACE\uff08\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u88c2\u89e3\u9176\uff09\u6291\u5236\u5242\uff0c\u7531\u536b\u6750\u53d1\u73b0\u53ef\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff0c\u76ee\u524d\u5904\u4e8eIII\u671f\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u3002\u901a\u8fc7\u6291\u5236BACE\u8fd9\u4e00\u4ea7\u751fA\u03b2\u80bd\u7684\u5173\u952e\u9176\uff0cElenbecestat\u53ef\u51cf\u5c11A\u03b2\u7684\u4ea7\u751f\uff0c\u4ece\u800c\u51cf\u5c11\u7531\u4e8e\u6bd2\u6027\u5be1\u805a\u7269\u548c\u539f\u7ea4\u7ef4\u5728\u5927\u8111\u4e2d\u805a\u96c6\u800c\u5bfc\u81f4\u7684\u6dc0\u7c89\u6837\u6591\u5757\u7684\u5f62\u6210\u3002\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e24\u4e2a\u5173\u4e8eElenbecestat\u7528\u4e8e\u6cbb\u7597\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u5168\u7403III\u671f\u4e34\u5e8a\u7814\u7a76\uff08MISSION AD1\/2\uff09\u3002\u6b64\u5904\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5305\u62ec\u7531\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5f15\u8d77\u7684\u8f7b\u5ea6\u8ba4\u77e5\u635f\u5bb3\uff08MCI\uff09\/\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u524d\u9a71\u671f\uff09\u53ca\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u65e9\u671f\u9636\u6bb5\u3002\u6b64\u5916\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u4e3aElenbecestat\u7684\u7814\u53d1\u5f00\u901a\u4e86\u5feb\u901f\u901a\u9053\u3002FDA\u53ea\u5bf9\u5176\u8ba4\u4e3a\u5177\u6709\u6cbb\u7597\u4e25\u91cd\u75be\u75c5\u5e76\u89e3\u51b3\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u6f5c\u529b\u7684\u836f\u7269\u5f00\u653e\u4fc3\u8fdb\u7814\u53d1\u548c\u52a0\u901f\u8bc4\u5ba1\u7684\u901a\u9053\u3002<\/p>\n

3\u3001\u5173\u4e8e\u00a0Aducanumab\uff08BIIB037\uff09<\/strong><\/b>
\nAducanuma\u662f\u4e00\u79cd\u5c1a\u5728\u7814\u7a76\u9636\u6bb5\u7684\u3001\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u5316\u5408\u836f\u54c1\uff0c\u662f\u901a\u8fc7\u53cd\u5411\u8f6c\u5316\u533b\u5b66\uff08RTM\uff09\u8fd9\u4e00\u795e\u7ecf\u514d\u75ab\u6280\u672f\u5e73\u53f0\u83b7\u5f97\uff0c\u4ece\u65e0\u8ba4\u77e5\u969c\u788d\u5065\u5eb7\u8001\u5e74\u53d7\u8bd5\u8005\u548c\u5177\u6709\u5f02\u5e38\u7f13\u6162\u8ba4\u77e5\u8870\u9000\u7684\u969c\u788d\u6027\u8001\u5e74\u53d7\u8bd5\u8005\u7684\u53bb\u8bc6\u522b\u5316B\u7ec6\u80de\u6587\u5e93\u4e2d\u53d1\u73b0\u7684\u4e00\u79cd\u4eba\u6e90\u91cd\u7ec4\u5355\u514b\u9686\u6297\u4f53\uff08mAb\uff09\u3002\u5728\u6309\u7167\u6e24\u5065\uff08Biogen\uff09\u548cNeurimmune\u516c\u53f8\u7b7e\u8ba2\u7684\u300a\u795e\u7ecf\u514d\u75ab\u5408\u4f5c\u5f00\u53d1\u548c\u8bb8\u53ef\u534f\u8bae\u300b\uff0c\u6e24\u5065\uff08Biogen\uff09\u4eceNeurimmune\u516c\u53f8\u53d6\u5f97\u4e86Aducanumab\u7684\u7814\u53d1\u548c\u8425\u9500\u6388\u6743\u3002Aducanumab\u00a0\u9776\u5411\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u805a\u96c6\u5f62\u5f0f\uff0c\u5305\u62ec\u53ef\u6eb6\u6027\u4f4e\u805a\u7269\u548c\u4e0d\u6eb6\u6027\u7ea4\u7ef4\u3002\u8fd9\u4e24\u79cd\u7269\u8d28\u53ef\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u5927\u8111\u4e2d\u5f62\u6210\u6dc0\u7c89\u6837\u6591\u5757\u3002\u6839\u636e\u4e34\u5e8a\u524d\u548c1b\u671f\u6570\u636e\uff0c\u7528Aducanumab\u8fdb\u884c\u6cbb\u7597\u53ef\u51cf\u5c11\u6dc0\u7c89\u6837\u6591\u5757\u7684\u6c34\u5e73\u3002
\n2016\u5e748\u6708\uff0cAducanumab\u88ab\u7eb3\u5165\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u7684\u201cPRIME\u201d\u9879\u76ee\u30022016\u5e749\u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5c06Aducanumab\u7eb3\u5165\u5176\u5feb\u901f\u5ba1\u8bc4\u9879\u76ee\u30022017\u5e744\u6708\uff0cAducanumab\u88ab\u7eb3\u5165\u65e5\u672c\u536b\u751f\u3001\u52b3\u5de5\u4e0e\u798f\u5229\u90e8\u7684\u201cSakigake\u201d\u6307\u5b9a\u7cfb\u7edf\u3002
\n2017\u5e7410\u6708\uff0c\u6e24\u5065\uff08Biogen\uff09\u548c\u536b\u6750\u8fbe\u6210\u5168\u7403\u5408\u4f5c\u534f\u8bae\uff0c\u5171\u540c\u7814\u53d1\u548c\u9500\u552eAducanumab\u3002<\/p>\n

4\u3001\u5173\u4e8e\u536b\u6750\u548c\u6e24\u5065\uff08Biogen\uff09\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u8054\u5408\u5f00\u53d1\u534f\u8bae<\/strong><\/b>
\n\u536b\u6750\u548c\u6e24\u5065\uff08Biogen\uff09\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6cbb\u7597\u836f\u7269\u7814\u53d1\u548c\u5546\u4e1a\u5316\u65b9\u9762\u8fdb\u884c\u7740\u5e7f\u6cdb\u7684\u5408\u4f5c\u3002\u536b\u6750\u5728BACE\u6291\u5236\u5242\u00a0Elenbecestat\u548c\u6297- A\u03b2\u539f\u7ea4\u7ef4\u6297\u4f53BAN2401\u7684\u8054\u5408\u7814\u53d1\u65b9\u9762\u5904\u4e8e\u4e3b\u5bfc\u5730\u4f4d\uff0c\u6e24\u5065\uff08Biogen\uff09\u5219\u5728\u7531\u8be5\u516c\u53f8\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u63a8\u51fa\u7684\u6297- A\u03b2\u6297\u4f53Aducanumab\u7684\u8054\u5408\u7814\u53d1\u65b9\u9762\u5904\u4e8e\u4e3b\u5bfc\u5730\u4f4d\u3002\u4e24\u5bb6\u516c\u53f8\u8ba1\u5212\u5728\u5168\u7403\u83b7\u5f97\u8fd9\u4e09\u79cd\u836f\u7269\u7684\u4e0a\u5e02\u8bb8\u53ef\u3002\u5982\u679c\u8fd9\u4e00\u7533\u8bf7\u83b7\u5f97\u6279\u51c6\uff0c\u8fd9\u4e24\u5bb6\u516c\u53f8\u5c06\u4f1a\u5728\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u65e5\u672c\u7b49\u4e3b\u8981\u5e02\u573a\u4e0a\u5171\u540c\u63a8\u5e7f\u4ee5\u4e0a\u4ea7\u54c1\u3002<\/p>\n

5\u3001\u5173\u4e8eE2027<\/strong><\/b>
\nE2027\u662f\u7531\u536b\u6750\u53d1\u73b0\u7684\u4e00\u79cd\u9009\u62e9\u6027\u78f7\u9178\u4e8c\u916f\u9176\uff08PDE\uff099\u00a0\u6291\u5236\u5242\u3002\u6291\u5236PDE9\u53ef\u964d\u4f4e\u7ec6\u80de\u95f4\u4fe1\u53f7\u4f20\u9012\u7684\u5173\u952e\u7269\u8d28\u2014\u2014\u73af\u78f7\u9e1f\u82f7\u7684\u964d\u89e3\u3002E2027\u00a0\u5e2e\u52a9\u7ef4\u6301\u5927\u8111\u5185\u7684\u73af\u78f7\u9e1f\u82f7\u6d53\u5ea6\uff0c\u5e76\u6709\u53ef\u80fd\u6210\u4e3a\u6cbb\u7597\u8def\u6613\u4f53\u75f4\u5446\u7684\u65b0\u65b9\u6848\u3002<\/p>\n

6\u3001\u5173\u4e8eLemborexant\uff08\u901a\u7528\u540d\uff0c\u7814\u53d1\u4ee3\u7801\uff1a\u00a0E2006\uff09<\/strong><\/b>
\nLemborexant\u662f\u4e00\u79cd\u53cc\u98df\u6b32\u7d20\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u7531\u536b\u6750\u5185\u90e8\u53d1\u73b0\u5e76\u7814\u53d1\u3002\u8fd9\u4e00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u901a\u8fc7\u7ade\u4e89\u6027\u5730\u7ed3\u5408\u4e24\u79cd\u4e9a\u578b\u7684\u98df\u6b32\u7d20\u53d7\u4f53\uff08\u98df\u6b32\u7d20\u53d7\u4f531\u548c\u98df\u6b32\u7d20\u53d7\u4f532\uff09\u6765\u6291\u5236\u98df\u6b32\u7d20\u795e\u7ecf\u4f20\u9012\u3002\u60a3\u6709\u7761\u7720\u969c\u788d\u7684\u4eba\u7fa4\u4f53\u5185\u8c03\u8282\u7761\u7720\u548c\u89c9\u9192\u7684\u98df\u6b32\u7d20\u7cfb\u7edf\u65e0\u6cd5\u6b63\u5e38\u8fd0\u8f6c\u3002\u5728\u6b63\u5e38\u7761\u7720\u671f\u95f4\uff0c\u98df\u6b32\u7d20\u7cfb\u7edf\u7684\u6d3b\u8dc3\u5ea6\u88ab\u6291\u5236\uff0c\u6709\u53ef\u80fd\u4f1a\u81ea\u89c9\u963b\u6b62\u4e0d\u6b63\u5e38\u89c9\u9192\uff0c\u5e76\u901a\u8fc7\u5e72\u6270\u98df\u6b32\u7d20\u795e\u7ecf\u4f20\u9012\u6765\u4fc3\u8fdb\u7761\u7720\u5f00\u59cb\u548c\u7ef4\u6301\u7761\u7720\u8fc7\u7a0b\u3002\u56e0\u6b64\uff0c\u536b\u6750\u548c\u666e\u6e21\u4e00\u76f4\u5728\u7814\u53d1Lemborexant\u6765\u6cbb\u7597\u591a\u79cd\u7761\u7720\u969c\u788d\u3002
\n\u6b64\u5916\uff0c\u4e00\u9879\u5173\u4e8eLemborexant\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u4e0d\u89c4\u5219\u7684\u7761\u7720-\u89c9\u9192\u8282\u5f8b\u7d0a\u4e71\uff08ISWRD\uff09\u548c\u8f7b\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u75f4\u5446\u60a3\u8005\u4e2d\u8fdb\u884c\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

7\u670819\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0”\u536b\u6750”\uff09\u5ba3\u5e03\uff0c\u4e8e\u672c\u5e74\u5ea6\u5728\u829d\u52a0\u54e5\u4e3e\u884c\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u534f\u4f1a\u56fd\u9645\u4f1a\u8bae\uff08AAIC\uff09\uff08\u4f1a\u8bae\u65f6\u95f4\uff1a7\u670822\u65e5\u81f326\u65e5\uff09\u4e0a\u53d1\u5e0313\u4efd\u62a5\u544a\u3002\u62a5\u544a\u5185\u5bb9\u6d89\u53ca\u6297-\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\uff08A\u03b2\uff09\u539f\u7ea4\u7ef4\u6297\u4f53BAN2401\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff08201\u7814\u7a76\uff09\u7ed3\u679c\u3001\u53e3\u670d\u00a0BACE\uff08\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u88c2\u89e3\u9176\uff09\u6291\u5236\u5242Elenbecestat\uff08\u7814\u53d1\u4ee3\u7801\uff1aE2609\uff09\u7684II\u671f\u4e34\u5e8a\u7814\u7a76\uff08202\u7814\u7a76\uff09\u7ed3\u679c\u4ee5\u53ca\u516c\u53f8\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\/\u75f4\u5446\u75c7\u836f\u54c1\u7814\u53d1\u9886\u57df\u7684\u6700\u65b0\u6570\u636e\uff1a\u5305\u62ec\u6297-A\u03b2\u6297\u4f53\u00a0Aducanumab\u3002BAN2401\u3001Elenbecestat\u548cAducanumab\u7531\u536b\u6750\u548c\u6e24\u5065\uff08Biogen\uff09\uff08\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u5e02\uff09\u5171\u540c\u7814\u53d1\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-3412","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3412"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=3412"}],"version-history":[{"count":3,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3412\/revisions"}],"predecessor-version":[{"id":3417,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3412\/revisions\/3417"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=3412"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=3412"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=3412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}