{"id":3553,"date":"2017-06-05T00:00:00","date_gmt":"2017-06-05T03:16:26","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=3553"},"modified":"2021-04-08T11:25:12","modified_gmt":"2021-04-08T03:25:12","slug":"%e5%8d%ab%e6%9d%90%e5%9c%a8%e7%ac%ac53%e5%b1%8a%e7%be%8e%e5%9b%bd%e4%b8%b4%e5%ba%8a%e8%82%bf%e7%98%a4%e5%ad%a6%e4%bc%9a%ef%bc%88asco%ef%bc%89%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%8f%91%e5%b8%83%e6%8a%97","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2017\/06\/05\/%e5%8d%ab%e6%9d%90%e5%9c%a8%e7%ac%ac53%e5%b1%8a%e7%be%8e%e5%9b%bd%e4%b8%b4%e5%ba%8a%e8%82%bf%e7%98%a4%e5%ad%a6%e4%bc%9a%ef%bc%88asco%ef%bc%89%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%8f%91%e5%b8%83%e6%8a%97\/","title":{"rendered":"\u536b\u6750\u5728\u7b2c53\u5c4a\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u53d1\u5e03\u6297\u764c\u836f\u7269LENVIMA\u00ae\uff08\u4e50\u4f10\u66ff\u5c3c\uff09\u8054\u5408ANTI-PD-1\u6297\u4f53\u5e15\u59c6\u5355\u6297\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u764c\u7684\u7b2cIb\/II\u671f\u7814\u7a76\u7ed3\u679c"},"content":{"rendered":"

\u5bf923\u4f4d\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u5728\u8be5\u7814\u7a76\u7684IB\/ II\u671f\u7684\u7597\u6548\u5206\u6790\u7ed3\u679c\u8fdb\u884c\u4e86\u62a5\u9053\u3002\u8fd9\u4e9b\u60a3\u8005\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u4e2a\u5316\u7597\u65b9\u6848\u3002\u5728\u63a5\u53d7\u4e50\u4f10\u66ff\u5c3c\u548c\u5e15\u59c6\u5355\u6297\u8054\u5408\u6cbb\u7597\u540e\uff0c\u5206\u6790\u7ed3\u679c\u8868\u660e\uff0c\u5176\u4e3b\u8981\u7ec8\u70b9\uff0c\u7ecf\u72ec\u7acb\u5f71\u50cf\u5b66\u8bc4\u4f30\uff08IRR\uff09\u7684\u5ba2\u89c2\u53cd\u5e94\u7387\u4e3a52.2%\uff0895%\u7f6e\u4fe1\u533a\u95f4[CI] = 30.6\u201373.2\uff09\uff0c\u7ecf\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u5ba2\u89c2\u53cd\u5e94\u7387\u4e3a47.8%\uff0895%\u7f6e\u4fe1\u533a\u95f4[CI] = 26.8\u201369.4\uff09\u3002<\/p>\n

\u6b21\u8981\u7ec8\u70b9\u4e2d\u7ecf\u72ec\u7acb\u5f71\u50cf\u5b66\u8bc4\u4f30\uff08IRR\uff09\u7684\u4e34\u5e8a\u83b7\u76ca\u7387**\u4e3a65.2%\uff0895% CI\uff1a42.7 – 83.6\uff09\uff0c\u7ecf\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u4e34\u5e8a\u83b7\u76ca\u7387\u4e3a73.9%\uff0895% CI\uff1a51.6 – 89.8\uff09\u3002\u7ecf\u72ec\u7acb\u653e\u5c04\u6027\u8bc4\u4f30\uff08IRR\uff09\u7684\u75be\u75c5\u63a7\u5236\u7387***\u4e3a91.3%\uff0895% CI\uff1a72.0 – 98.9\uff09\uff0c\u7ecf\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u75be\u75c5\u63a7\u5236\u7387\u4e3a95.7%\uff0895% CI\uff1a78.1 – 99.9\uff09\u3002\u7ecf\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a9.7\u4e2a\u6708\uff0895% CI\uff1a4.2 – NE\uff09\uff0c\u672a\u5f97\u5230\u7ecf\u72ec\u7acb\u5f71\u50cf\u5b66\u8bc4\u4f30\uff08IRR\uff09\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u7684\u6570\u636e\u3002\u672c\u5206\u6790\u8282\u70b9\u4ea6\u672a\u5f97\u5230\u4e2d\u4f4d\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u7684\u6570\u636e\u3002<\/p>\n

Anti-PD-1\u6297\u4f53\u4e00\u822c\u5bf9\u60a3\u6709\u9ad8\u9891\u7387\u7684\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09\u7684\u60a3\u8005\u66f4\u4e3a\u6709\u6548\uff0c\u8fd9\u79cd\u751f\u7269\u6807\u8bb0\u7269\u4f1a\u5bfc\u81f4DNA\u9519\u914d\u4fee\u590d\u529f\u80fd\u969c\u788d\uff0c\u800c\u5bf9\u5176\u4ed6\u75c5\u4eba\u5219\u4e0d\u90a3\u4e48\u6709\u6548\u3002\u7136\u800c\uff0c\u5728\u672c\u6b21\u7814\u7a76\u4e2d\uff0c\u65e0\u8bba\u75c5\u4eba\u7684\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09\u72b6\u6001\u5982\u4f55\uff0c\u8054\u5408\u6cbb\u7597\u90fd\u89c2\u5bdf\u5230\u80bf\u7624\u7f13\u89e3\uff0c\u5176\u80bf\u7624\u72b6\u6001\u6709\u6240\u597d\u8f6c\u3002<\/p>\n

\u8be5\u8054\u5408\u7597\u6cd5\u7684\u6700\u5e38\u89c1\u7684\u4e94\u79cd\u4e0d\u826f\u53cd\u5e94\u4e3a\uff1b\u9ad8\u8840\u538b\uff0c\u75b2\u52b3\uff0c\u5173\u8282\u75db\uff0c\u8179\u6cfb\uff0c\u6076\u5fc3\u3002<\/p>\n

\u5b50\u5bab\u5185\u819c\u764c\u662f\u5168\u7403\u5973\u6027\u4e2d\u7684\u7b2c\u516d\u5927\u5e38\u89c1\u6076\u6027\u80bf\u7624\uff0c2012\u5e74\u6709320000\u4f8b\u65b0\u786e\u8bca\u75c5\u4f8b\uff0c\u636e\u4f30\u8ba1\uff0c2017\u5e74\u5728\u7f8e\u56fd\u5927\u7ea6\u4f1a\u670960000\u540d\u5973\u6027\u88ab\u65b0\u8bca\u65ad\u4e3a\u5b50\u5bab\u5185\u819c\u764c\uff0c\u7ea610000\u540d\u5973\u6027\u6b7b\u4e8e\u8be5\u75c5\u3002\u56e0\u6b64\u5728\u8be5\u75be\u75c5\u9886\u57df\u4ecd\u5b58\u5728\u7740\u91cd\u8981\u800c\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u6709\u5fc5\u8981\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n

\u536b\u6750\u5c06\u80bf\u7624\u89c6\u4e3a\u516c\u53f8\u7684\u4e00\u4e2a\u5173\u952e\u6cbb\u7597\u9886\u57df\uff0c\u81f4\u529b\u4e8e\u7814\u53d1\u6709\u53ef\u80fd\u6cbb\u6108\u764c\u75c7\u7684\u9769\u547d\u6027\u65b0\u836f\u7269\u3002\u536b\u6750\u5c06\u7ee7\u7eed\u63a2\u7d22\u79d1\u5b66\u8bc1\u636e\uff0c\u4f7f\u4e50\u4f10\u66ff\u5c3c\u80fd\u591f\u5728\u672a\u6765\u6700\u5927\u9650\u5ea6\u5730\u6ee1\u8db3\u60a3\u8005\u591a\u6837\u5316\u7684\u9700\u6c42\uff0c\u5e76\u4e3a\u764c\u75c7\u60a3\u8005\u3001\u60a3\u8005\u5bb6\u5c5e\u53ca\u533b\u7597\u4ece\u4e1a\u8005\u5e26\u6765\u66f4\u591a\u798f\u7949\u3002<\/p>\n

*\u00a0\u00a0\u00a0\u00a0 Keytruda\u00ae\u662f\u9ed8\u6c99\u4e1c\u516c\u53f8\uff08Merck Sharp & Dohme Corp\uff09\u7684\u4e00\u4e2a\u6ce8\u518c\u5546\u6807\u3002\u9ed8\u6c99\u4e1c\u516c\u53f8\u662f\u4f4d\u4e8e\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u601d\u5821\u7684\u9ed8\u514b\u6709\u9650\u516c\u53f8\uff08Merck & Co.\uff0cInc\uff09\u7684\u4e00\u4e2a\u5b50\u516c\u53f8\u3002
\n**\u00a0\u00a0 \u4e34\u5e8a\u53d7\u76ca\u7387\uff1a\u5b8c\u5168\u7f13\u89e3+\u90e8\u5206\u7f13\u89e3+\u7ef4\u6301\u75be\u75c5\u7a33\u5b9a\u8fbe\u523023\u5468\u6216\u66f4\u957f\u65f6\u95f4\u7684\u60a3\u8005\u767e\u5206\u6bd4\u3002
\n*** \u75be\u75c5\u63a7\u5236\u7387\uff1a\u5b8c\u5168\u7f13\u89e3+\u90e8\u5206\u7f13\u89e3+\u7ef4\u6301\u75be\u75c5\u7a33\u5b9a\u8fbe\u52305\u5468\u6216\u66f4\u957f\u65f6\u95f4\u7684\u60a3\u8005\u767e\u5206\u6bd4\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

6\u67085\u65e5\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0”\u536b\u6750”\uff09\u5ba3\u5e03\uff0c\u5728\u7f8e\u56fd\u829d\u52a0\u54e5\u4e3e\u884c\u7684\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u7b2c53\u5c4a\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u5176\u81ea\u4e3b\u7814\u53d1\u7684\u591a\u6fc0\u9176\u6291\u5236\u5242\u00a0\u2014\u00a0\u7532\u78fa\u9178\u4e50\u4f10\u66ff\u5c3c\uff08lenvatinib mesylate\uff09\uff08\u5546\u54c1\u540d\uff1aLenvima\u00ae \/ Kisplyx\u00ae\uff0c”\u4e50\u4f10\u66ff\u5c3c”\uff09\u8054\u5408\u9ed8\u6c99\u4e1c\uff08MSD\uff0c\u4f4d\u4e8e\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u80af\u7eb3\u5c14\u6c83\u65af\u5821\uff0c\u5728\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u79f0\u4e3a\u9ed8\u514b\uff08Merck\uff09\uff09\u5f00\u53d1\u7684anti-PD-1\u6297\u4f53\u5e15\u59c6\u5355\u6297\uff08pembrolizumab\uff09\uff08\u5546\u54c1\u540d\uff1aKEYTRUDA\u00ae*\uff09\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u5b50\u5bab\u5185\u819c\u764c\u7684\u7b2cIb\/II\u671f\u7684\u521d\u6b65\u7814\u7a76\u7ed3\u679c\u3002\u4e24\u5bb6\u516c\u53f8\u6b63\u5728\u5408\u4f5c\u63a2\u7d22\u8fd9\u4e00\u8054\u5408\u7597\u6cd5\u3002\u5176\u6b63\u5728\u8fdb\u884c\u7684111\u7814\u7a76\u5c06\u8bc4\u4f30\u4e50\u4f10\u66ff\u5c3c\/\u5e15\u59c6\u5355\u6297\u8fd9\u5bf9\u836f\u7269\u7ec4\u5408\u5bf9\u76f8\u5173\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u4f5c\u7528\u3002<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-3553","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3553"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=3553"}],"version-history":[{"count":2,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3553\/revisions"}],"predecessor-version":[{"id":3555,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/3553\/revisions\/3555"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=3553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=3553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=3553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}