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\u4e0a\u5e02\u7533\u8bf7\u4e3b\u8981\u662f\u57fa\u4e8elecanemab\u7528\u4e8e\u65e9\u671fAD\u60a3\u8005\u76842b\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08Study 201\uff09\u7684\u4e34\u5e8a\u3001\u751f\u7269\u6807\u5fd7\u7269\u548c\u5b89\u5168\u6027\u6570\u636e\u3002\u8be5\u8bd5\u9a8c\u7eb3\u5165\u4e86856\u540d\u56e0AD\u6216\u8f7b\u5ea6AD\u5bfc\u81f4\u8f7b\u5ea6\u8ba4\u77e5\u529f\u80fd\u969c\u788d\uff08MCI\uff09\u7684\u60a3\u8005\uff0c\u4ed6\u4eec\u786e\u8ba4\u5b58\u5728\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u7406\u3002\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u6700\u9ad8\u5242\u91cf\uff0810 mg\/kg\uff09\u7684lecanemab\u80fd\u591f\u663e\u8457\u964d\u4f4e\u60a3\u8005\u5927\u8111\u4e2d\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u6c34\u5e73\uff0c\u5728\u6cbb\u759718\u4e2a\u6708\u65f6\u4f7f\u8111\u6dc0\u7c89\u6837\u86cb\u767d\u51cf\u5c110.306 <\/span>SUVr\u5355\u4f4d\uff08\u57fa\u7ebf\u5e73\u5747\u503c\u4e3a1.37\uff09\u3002\u5e76\u4e14\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u5b89\u6170\u5242\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5728\u6269\u5c55\u8bd5\u9a8c\u9636\u6bb5\u8f6c\u4e3a\u63a5\u53d7lecanemab\u6cbb\u7597\u540e\uff0c\u6dc0\u7c89\u6837\u86cb\u767d\u6c34\u5e73\u4e5f\u663e\u793a\u51fa\u964d\u4f4e\u7684\u7ed3\u679c\u3002\u6b64\u5916\uff0c\u8bd5\u9a8c\u4e2dlecanemab\u5c55\u73b0\u51fa\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u6bcf\u4e24\u546810 mg\/kg\u65f6\u6dc0\u7c89\u6837\u86cb\u767d\u76f8\u5173\u6210\u50cf\u5f02\u5e38\u3001\u6c34\u80bf\u3001\u79ef\u6db2\u7684\u53d1\u751f\u7387\u4e3a9.9%\u3002<\/p>\n

Lecanemab\u7528\u4e8e\u65e9\u671fAD\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08Clarity AD\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u5e76\u4e8e2021\u5e743\u6708\u5b8c\u6210\u4e861795\u4f8b\u60a3\u8005\u7684\u5165\u7ec4\u3002\u7f8e\u56fdFDA\u540c\u610f\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6700\u7ec8\u7ed3\u679c\u53ef\u4ee5\u4f5c\u4e3a\u9a8c\u8bc1lecanemab\u4e34\u5e8a\u83b7\u76ca\u7684\u786e\u8bc1\u6027\u7814\u7a76\uff0c\u4ee5\u8fdb\u4e00\u6b65\u652f\u6301BLA\u3002<\/p>\n

\u536b\u6750\u9996\u5e2d\u6267\u884c\u5b98Haruo Naito<\/span>\u5148\u751f\u8868\u793a\uff1a\u201c\u968f\u7740\u5168\u7403\u7fa4\u4f53\u7684\u589e\u957f\u548c\u8001\u9f84\u5316\uff0cAD\u60a3\u8005\u7684\u6570\u91cf\u5448\u4e0a\u5347\u8d8b\u52bf\u3002AD\u4e0d\u4ec5\u7ed9\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u5e26\u6765\u5de8\u5927\u8d1f\u62c5\uff0c\u4e5f\u7ed9\u793e\u4f1a\u5e26\u6765\u5de8\u5927\u8d1f\u62c5\u3002\u6211\u4eec\u8ba4\u8bc6\u5230\u5229\u76ca\u76f8\u5173\u8005\u5bf9\u8fdb\u4e00\u6b65\u63a8\u8fdb\u8be5\u75be\u75c5\u6cbb\u7597\u7cfb\u7edf\u7684\u5f3a\u70c8\u548c\u8feb\u5207\u671f\u671b\u3002\u591a\u5e74\u6765\uff0c\u536b\u6750\u4e00\u76f4\u52aa\u529b\u4e86\u89e3AD\u60a3\u8005\u7684\u7126\u8651\u60c5\u7eea\uff0c\u5e76\u4e00\u76f4\u5728\u8fdb\u884c\u65b0\u578b\u7597\u6cd5\u7684\u7814\u53d1\u3002Lecanemab\u7684BLA\u6eda\u52a8\u63d0\u4ea4\u6807\u5fd7\u7740AD\u6cbb\u7597\u7cfb\u7edf\u8fdb\u6b65\u7684\u65b0\u91cc\u7a0b\u7891\u3002\u4f5c\u4e3a\u6211\u4eec\u4eba\u7c7b\u533b\u7597\u4fdd\u5065\u4f7f\u547d\u7684\u4e00\u90e8\u5206\uff0c\u6211\u4eec\u81f4\u529b\u4e8e\u5c3d\u65e9\u4e3aAD\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u5e26\u6765\u65b0\u836f\u3002\u201d<\/p>\n

Lecanemab\uff08BAN2401\uff09\u662f\u4e00\u79cd\u62df\u7528\u4e8e\u6cbb\u7597AD\u7684\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u662f\u536b\u6750\u548cBioArctic\u5408\u4f5c\u7814\u53d1\u7684\u6210\u679c\u3002Lecanemab\u53ef\u9009\u62e9\u6027\u7ed3\u5408\u4e2d\u548c\u5e76\u6d88\u9664\u53ef\u6eb6\u6027\u3001\u6bd2\u6027\u6dc0\u7c89\u6837\u86cb\u767d-\u03b2\uff08A\u03b2\uff09\u805a\u96c6\u4f53\uff08\u539f\u7ea4\u7ef4\uff09\uff0c\u8fd9\u4e9b\u805a\u96c6\u4f53\u88ab\u8ba4\u4e3a\u52a0\u901fAD\u7684\u795e\u7ecf\u7cfb\u7edf\u53d8\u6027\u8fdb\u7a0b\u3002\u56e0\u6b64\uff0clecanemab\u53ef\u80fd\u5bf9\u75be\u75c5\u75c5\u7406\u5b66\u4ea7\u751f\u5f71\u54cd\u5e76\u51cf\u7f13\u75be\u75c5\u7684\u8fdb\u5c55\u3002<\/p>\n

 <\/p>\n

\u00b7 2007\u5e7412\u6708\u536b\u6750\u4e0eBioArctic\u7b7e\u8ba2\u7684\u534f\u8bae\uff0c\u83b7\u5f97\u4e86lecanemab\u7528\u4e8e\u6cbb\u7597AD\u7684\u5168\u7403\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u4e0a\u5e02\u6743\u5229\uff1b<\/p>\n

\u00b7 2014\u5e743\u6708\uff0c\u536b\u6750\u548c\u6e24\u5065\uff08Biogen\uff09\u7b7e\u8ba2\u4e86lecanemab\u7684\u8054\u5408\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u534f\u8bae\uff0c\u53cc\u65b9\u4e8e2017\u5e7410\u6708\u4fee\u8ba2\u4e86\u8be5\u534f\u8bae\u3002\u76ee\u524d\uff0c\u6839\u636e2\u671f\u4e34\u5e8a\u7814\u7a76\uff08\u7814\u7a76201\uff09\u7684\u7ed3\u679c\uff0c\u6b63\u5728\u8fdb\u884c\u75c7\u72b6\u6027\u65e9\u671fAD\u7684lecanemab\u5173\u952e\u60273\u671f\u4e34\u5e8a\u7814\u7a76\uff08Clarity-AD\uff09\uff1b<\/p>\n

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