{"id":5678,"date":"2021-10-18T14:14:16","date_gmt":"2021-10-18T06:14:16","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=5678"},"modified":"2021-11-03T14:59:55","modified_gmt":"2021-11-03T06:59:55","slug":"%e5%8d%ab%e6%9d%90%e5%92%8cmsd%e8%8e%b7%e5%be%97%e6%ac%a7%e7%9b%9fchmp%e5%af%b9%e4%b9%90%e5%8d%ab%e7%8e%9b%ef%bc%88%e4%bb%91%e4%bc%90%e6%9b%bf%e5%b0%bc%ef%bc%89%e8%81%94%e5%90%88%e5%8f%af","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2021\/10\/18\/%e5%8d%ab%e6%9d%90%e5%92%8cmsd%e8%8e%b7%e5%be%97%e6%ac%a7%e7%9b%9fchmp%e5%af%b9%e4%b9%90%e5%8d%ab%e7%8e%9b%ef%bc%88%e4%bb%91%e4%bc%90%e6%9b%bf%e5%b0%bc%ef%bc%89%e8%81%94%e5%90%88%e5%8f%af\/","title":{"rendered":"\u536b\u6750\u548cMSD\u83b7\u5f97\u6b27\u76dfCHMP\u5bf9\u4e50\u536b\u739b\u00ae\uff08\u4ed1\u4f10\u66ff\u5c3c\uff09\u8054\u5408\u53ef\u745e\u8fbe\u00ae\uff08\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u6cbb\u7597\u4e24\u79cd\u4e0d\u540c\u7c7b\u578b\u764c\u75c7\u7684\u80af\u5b9a\u610f\u89c1"},"content":{"rendered":"<h3 style=\"text-align: center\"><strong><em>\u57fa\u4e8e<\/em><\/strong><strong><em>CLEAR\/KEYNOTE-581<\/em><\/strong><strong><em>\u8bd5\u9a8c\u4e2d\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08<\/em><\/strong><strong><em>PFS<\/em><\/strong><strong><em>\uff09\u3001\u603b\u751f\u5b58\u671f\uff08<\/em><\/strong><strong><em>OS<\/em><\/strong><strong><em>\uff09\u548c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08<\/em><\/strong><strong><em>ORR<\/em><\/strong><strong><em>\uff09\u76f8\u8f83\u4e8e\u8212\u5c3c\u66ff\u5c3c\u53d6\u5f97\u7684\u663e\u8457\u6548\u679c\uff0c\u5bf9\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\u7ed9\u4e88\u80af\u5b9a\u610f\u89c1<\/em><\/strong><\/h3>\n<h3 style=\"text-align: center\"><strong><em>\u57fa\u4e8e\u7814\u7a76<\/em><\/strong><strong><em>309\/KEYNOTE-775<\/em><\/strong><strong><em>\u8bd5\u9a8c\u4e2d\uff0c<\/em><\/strong><strong><em>OS<\/em><\/strong><strong><em>\u548c<\/em><\/strong><strong><em>PFS<\/em><\/strong><strong><em>\u76f8\u8f83\u4e8e\u5316\u7597\u53d6\u5f97\u7684\u663e\u8457\u6548\u679c\uff0c\u5bf9\u6cbb\u7597\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u7ed9\u4e88\u80af\u5b9a\u610f\u89c1<\/em><\/strong><\/h3>\n<p>&nbsp;<\/p>\n<p>\u4e1c\u4eac\u548c\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u51ef\u5c3c\u5c14\u6c83\u601d\uff0c2021\u5e7410\u670818\u65e5 &#8211; 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[95%\u7f6e\u4fe1\u533a\u95f4\uff0c0.32-0.49]\uff1bp&lt;0.0001\uff09\uff0c\u4e2d\u4f4dPFS\u4e3a23.9\u4e2a\u6708\uff0c\u800c\u8212\u5c3c\u66ff\u5c3c\u7ec4\u4e3a9.2\u4e2a\u6708\u3002\u6b64\u5916\uff0c\u63a5\u53d7\u4e50\u536b\u739b\u8054\u5408\u53ef\u745e\u8fbe\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u7ecf\u786e\u8ba4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a71%\uff0895%\u7f6e\u4fe1\u533a\u95f4\uff1a66-76\uff09\uff08n=252\uff09\uff0c\u800c\u8212\u5c3c\u66ff\u5c3c\u7ec4\u4e3a36%\uff0895%\u7f6e\u4fe1\u533a\u95f4\uff1a31-41\uff09\uff08n=129\uff09\u3002<\/p>\n<p>\u5728309\/KEYNOTE-775\u4e2d\uff0c\u4e50\u536b\u739b\u8054\u5408\u53ef\u745e\u8fbe\u5728\u8be5\u7814\u7a76\u7684\u4e24\u4e2a\u7597\u6548\u7ed3\u679c\u6307\u6807\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u6539\u5584\uff1a\u5728OS\u65b9\u9762\uff0c\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8638%\uff08HR=0.62 [95%\u7f6e\u4fe1\u533a\u95f4\uff0c0.51-0.75]\uff1bp&lt;0.0001 ) 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[95%\u7f6e\u4fe1\u533a\u95f4\uff0c0.47-0.66]\uff1bp&lt;0.0001\uff09\uff0c\u4e2d\u4f4dPFS\u4e3a7.2\u4e2a\u6708\uff0c\u800c\u5316\u7597\u7ec4\u4e3a3.8\u4e2a\u6708\uff08\u7814\u7a76\u8005\u9009\u62e9\u591a\u67d4\u6bd4\u661f\u6216\u7d2b\u6749\u9187\uff09\u3002<\/p>\n<p>\u201c\u53ef\u745e\u8fbe\u8054\u5408\u4e50\u536b\u739b\u5728\u665a\u671f\u80be\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u4e2d\u663e\u793a\u51fa\u6709\u5229\u4e8e\u60a3\u8005\u751f\u5b58\uff0c\u5e76\u4e3a\u8fd9\u4e9b\u60a3\u8005\u63d0\u4f9b\u4e86\u4e00\u79cd\u91cd\u8981\u7684\u6f5c\u5728\u65b0\u6cbb\u7597\u9009\u62e9\u3002\u6b64\u5916\uff0c\u53ef\u745e\u8fbe\u8054\u5408\u4e50\u536b\u739b\u662f\u9996\u4e2a\u663e\u793a\u51fa\u6709\u5229\u4e8e\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u751f\u5b58\u7684\u6297PD-1\u548c\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u6291\u5236\u5242\u7ec4\u5408\uff0c\u4e14\u65e0\u9700\u8003\u8651\u9519\u914d\u4fee\u590d\u72b6\u6001\u3002\u201dMSD\u7814\u7a76\u5b9e\u9a8c\u5ba4\u4e34\u5e8a\u7814\u7a76\u526f\u603b\u88c1Gregory 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