{"id":5785,"date":"2021-11-09T16:53:12","date_gmt":"2021-11-09T08:53:12","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=5785"},"modified":"2021-12-28T16:55:54","modified_gmt":"2021-12-28T08:55:54","slug":"dian-tu%e5%9c%a8%e4%bb%a5tau%e4%b8%ba%e9%9d%b6%e7%82%b9%e6%b2%bb%e7%96%97%e6%98%be%e6%80%a7%e9%81%97%e4%bc%a0%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e7%9a%84%e4%b8%b4%e5%ba%8a%e8%af%95","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2021\/11\/09\/dian-tu%e5%9c%a8%e4%bb%a5tau%e4%b8%ba%e9%9d%b6%e7%82%b9%e6%b2%bb%e7%96%97%e6%98%be%e6%80%a7%e9%81%97%e4%bc%a0%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e7%9a%84%e4%b8%b4%e5%ba%8a%e8%af%95\/","title":{"rendered":"DIAN-TU\u5728\u4ee5TAU\u4e3a\u9776\u70b9\u6cbb\u7597\u663e\u6027\u9057\u4f20\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u9009\u62e9LECANEMAB\u4f5c\u4e3a\u57fa\u7840\u6297\u6dc0\u7c89\u6837\u86cb\u767d\uff0c\u8bc4\u4f30\u63a2\u7d22\u6027\u6cbb\u7597\u6548\u679c"},"content":{"rendered":"

\u536b\u6750\u7684\u6297\u5fae\u7ba1\u7ed3\u5408\u533a (MTBR) tau \u6297\u4f53 E2814 \u5148\u524d\u88ab\u9009\u4e3a DIAN-TU TauNext Generation\uff08Tau NexGen\uff09\u8bd5\u9a8c\u6297 tau \u836f\u7269\u4e2d\u9996\u4e2a\u63a2\u7d22\u6027\u7597\u6cd5<\/em><\/h4>\n

 <\/p>\n

\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u201c\u536b\u6750\u201d\uff09\u5ba3\u5e03\uff0c\u7531\u5723\u8def\u6613\u65af\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u9886\u5bfc\u7684\u663e\u6027\u9057\u4f20\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c7\u7f51\u7edc\u8bd5\u9a8c\u7ec4\u7ec7\uff08DIAN-TU\uff09\u4e0e\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40 (FDA) \u548c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40 (EMA) \u8fbe\u6210\u534f\u8bae\uff0c\u4fee\u6539\u5305\u62ec\u57fa\u7840\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u836f\u7269\u4e34\u5e8a\u7814\u7a76 (Tau NexGen) \u8bbe\u8ba1\u3002Tau NexGen \u4e34\u5e8a\u7814\u7a76\u6700\u521d\u65e8\u5728\u4e13\u6ce8\u4e8etau\u9776\u70b9\u7684\u7597\u6cd5\u3002<\/p>\n

\u968f\u7740\u8d8a\u6765\u8d8a\u591a\u7684\u4e34\u5e8a\u7814\u7a76\u8bc1\u636e\u8868\u660e\uff0c\u9776\u5411\u6dc0\u7c89\u6837\u86cb\u767d\u53ef\u4ee5\u51cf\u5c11\u963f\u5c14\u8328\u6d77\u9ed8\u75c5 (AD) \u7684\u751f\u7269\u6807\u5fd7\u7269\uff0cTau NexGen \u4e34\u5e8a\u8bd5\u9a8c\u8d1f\u8d23\u4eba\u9009\u62e9\u536b\u6750\u7684\u63a2\u7d22\u6027\u6297\u6dc0\u7c89\u6837\u86cb\u767d \u03b2 (A\u03b2) \u539f\u7ea4\u7ef4\u6297\u4f53 lecanemab \u4f5c\u4e3a\u57fa\u7840\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u836f\u7269\u3002<\/p>\n

Tau NexGen \u7814\u7a76\u7684\u76ee\u7684\u662f\u8bc4\u4f30\u63a2\u7d22\u6027\u7597\u6cd5\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u81f4\u75c5\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u751f\u7269\u6807\u5fd7\u7269\u548c\u8ba4\u77e5\u529f\u6548\u3002\u8be5\u7814\u7a76\u5c06\u8bc4\u4f30\u7814\u7a76\u836f\u7269\u6cbb\u7597\u662f\u5426\u4f1a\u51cf\u7f13\u8ba4\u77e5\u969c\u788d\u7684\u8fdb\u5c55\u901f\u5ea6\u5e76\u6539\u5584\u4e0e\u75be\u75c5\u76f8\u5173\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n

\u5df2\u77e5\u60a3\u6709\u663e\u6027\u9057\u4f20\u963f\u5c14\u8328\u6d77\u9ed8\u75c5 (DIAD) \u57fa\u56e0\u7a81\u53d8\u7684\u4eba\u4f1a\u60a3\u4e0aAD\u5e76\u4e14\u53ef\u80fd\u4f1a\u5728\u4e0e\u53d7\u5f71\u54cd\u7684\u7236\u6bcd\u76f8\u540c\u7684\u5e74\u9f84\u51fa\u73b0\u75c7\u72b6\uff0c\u901a\u5e38\u662f50\u591a\u5c81\u300140\u591a\u5c81\u751a\u81f330\u591a\u5c81\u30022021\u5e743\u6708\uff0cDIAN-TU \u9009\u62e9\u4e86\u6297\u5fae\u7ba1\u7ed3\u5408\u533a (MTBR) tau \u6297\u4f53 E2814\uff0c\u8be5\u6297\u4f53\u662f\u536b\u6750\u4e0e\u4f26\u6566\u5927\u5b66\u5b66\u9662\u5408\u4f5c\u7814\u7a76\u6210\u679c\uff0c\u4f5c\u4e3a DIAN-TU tau \u7814\u7a76\u7684\u6297 tau \u836f\u7269\u4e2d\u7684\u7b2c\u4e00\u4e2a\u7814\u7a76\u836f\u7269\u3002<\/p>\n

\u5728\u4fee\u8ba2\u540e\u7684 Tau NexGen \u7814\u7a76\u4e2d\uff0c\u6709\u75c7\u72b6\u7684\u53d7\u8bd5\u8005\u5c06\u63a5\u53d7 lecanemab \u6cbb\u7597\u516d\u4e2a\u6708\uff0c\u7136\u540e\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u6297 tau \u836f\u7269\u6216\u5b89\u6170\u5242\u3002\u7531\u4e8e\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u5728AD\u4e2d\u7684 tau \u7f20\u7ed3\u4e4b\u524d\u79ef\u7d2f\uff0c\u56e0\u6b64\u8fd9\u9879\u7814\u7a76\u8bbe\u8ba1\u4f7f\u7814\u7a76\u4eba\u5458\u80fd\u591f\u8bc4\u4f30\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u53bb\u9664\u662f\u5426\u4e3a\u6297 tau \u836f\u7269\u6700\u6709\u6548\u5730\u53d1\u6325\u4f5c\u7528\u626b\u6e05\u4e86\u9053\u8def\u3002\u5728\u5f00\u59cb\u7ed9\u4e88 lecanemab \u4e4b\u524d\uff0c\u51fa\u73b0\u75c7\u72b6\u7684\u53d7\u8bd5\u8005\u5c06\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u6297 tau \u836f\u7269\u6216\u5b89\u6170\u5242\u4e00\u5e74\u3002<\/p>\n

\u901a\u8fc7\u9519\u5f00\u836f\u7269\u8fd9\u79cd\u65b9\u5f0f\uff0c\u5728\u4e00\u8d77\u8bc4\u4f30\u4e24\u79cd\u836f\u7269\u7684\u6548\u679c\u4e4b\u524d\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u80fd\u591f\u5355\u72ec\u8bc4\u4f30\u6297 tau \u836f\u7269\u7684\u6548\u679c\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u6709\u75c7\u72b6\u53d7\u8bd5\u8005\u5927\u8111\u4e2d tau \u86cb\u767d\u79ef\u7d2f\u7684\u51cf\u7f13\uff0c\u5982 PET \u8111\u90e8\u626b\u63cf\u6240\u793a\u3002\u4f5c\u4e3a\u6b21\u8981\u7ec8\u70b9\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u8bc4\u4f30\u63a2\u7d22\u6027\u7597\u6cd5\u662f\u5426\u5f71\u54cd\u6709\u75c7\u72b6\u524d\u53d7\u8bd5\u8005\u8111\u810a\u6db2\u4e2d\u7279\u5b9a\u7c7b\u578b\u7684 tau \u86cb\u767d\u2014\u2014\u78f7\u9178\u5316 tau 217 \u7684\u6c34\u5e73\u3002\u5982\u679c\u8fd9\u4e9b\u4e3b\u8981\u548c\u6b21\u8981\u7ec8\u70b9\u5728\u7814\u7a76\u5f00\u59cb\u4e24\u5e74\u540e\u7684\u5206\u6790\u4e2d\u4e3a\u9633\u6027\uff0c\u5219\u7814\u7a76\u5c06\u518d\u5ef6\u957f\u4e24\u5e74\uff0c\u4ee5\u8bc4\u4f30\u8be5\u836f\u7269\u662f\u5426\u51cf\u7f13\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u5e76\u5bf9 tau \u75c5\u7406\u5b66\u4ea7\u751f\u8fdb\u4e00\u6b65\u5f71\u54cd\u3002<\/p>\n

\u201c\u968f\u7740\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\u53bb\u9664\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u5bf9\u6dc0\u7c89\u6837\u86cb\u767d\u548c tau \u86cb\u767d\u5177\u6709\u751f\u7269\u5b66\u4e0a\u7684\u6709\u76ca\u5f71\u54cd\uff0c\u6211\u4eec\u76f8\u4fe1\u540c\u65f6\u9488\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u75c5\u7406\u2014\u2014\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u548c tau \u7f20\u7ed3\u2014\u2014\u53ef\u4ee5\u63d0\u4f9b\u6700\u9ad8\u7684\u6210\u529f\u673a\u4f1a\uff0c\u201d \u534e\u76db\u987f\u5927\u5b66\u9996\u5e2d\u7814\u7a76\u5458\u3001DIAN-TU \u4e3b\u4efb\u3001Charles F. \u548c Joanne Knight \u795e\u7ecf\u75c5\u5b66\u6770\u51fa\u6559\u6388\u3001\u533b\u5b66\u535a\u58eb Randall J.Bateman\u8868\u793a\u3002<\/p>\n

\u536b\u6750\u7684\u6297 MTBR tau \u6297\u4f53 E2814 \u88ab\u9009\u4e3a\u5f00\u521b\u6027\u663e\u6027\u9057\u4f20\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u7f51\u7edc\u8bd5\u9a8c\u5355\u5143 Tau NexGen \u7684\u6297 tau \u836f\u7269\u4e2d\u7684\u7b2c\u4e00\u4e2a\u63a2\u7d22\u6027\u7597\u6cd5\uff0c\u8be5\u8bd5\u9a8c\u6700\u521d\u65e8\u5728\u9488\u5bf9 tau \u86cb\u767d\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u53bb\u9664\u6dc0\u7c89\u6837\u6591\u5757\u53ef\u4ee5\u51cf\u7f13\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\uff0c\u8fd9\u4e3a\u6f5c\u5728\u5730\u5bf9\u6297\u8fd9\u79cd\u707e\u96be\u6027\u75be\u75c5\u521b\u9020\u4e86\u65b0\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

\u201c\u536b\u6750\u5f88\u81ea\u8c6a\uff0c\u6211\u4eec\u7684\u63a2\u7d22\u6027\u6297\u6dc0\u7c89\u6837\u86cb\u767d \u03b2 \u539f\u7ea4\u7ef4\u6297\u4f53 lecanemab \u5df2\u88ab\u9009\u4e3a\u8be5\u7814\u7a76\u9886\u57df\u7684\u57fa\u7840\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u836f\u7269\u3002\u201d\u536b\u6750\u795e\u7ecf\u75c5\u5b66\u4e1a\u52a1\u9996\u5e2d\u4e34\u5e8a\u5b98\u3001FAAN \u533b\u5b66\u535a\u58eb Lynn Kramer\u8868\u793a\u3002\u201c\u5728\u6211\u4eec\u7684 2b \u671f\u7814\u7a76\u4e2d\uff0clecanemab 10 mg\/kg\u6bcf\u4e24\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u65e0\u9700\u6ef4\u5b9a\uff0c\u8bc1\u660e\u4ece\u7ed9\u836f\u65e9\u671f\u9636\u6bb5\u5c31\u53ef\u4ee5\u6709\u6548\u6e05\u9664\u8111\u6dc0\u7c89\u6837\u6591\u5757\uff0c\u5e76\u51cf\u7f13\u4e86\u65e9\u671f AD \u60a3\u8005\u7684\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u3002\u4ee4\u4eba\u9f13\u821e\u7684\u662f\uff0c\u540c\u6837\u5242\u91cf\u7684\u6cbb\u7597\u4e0b\u6dc0\u7c89\u6837\u86cb\u767d\u76f8\u5173\u6210\u50cf\u5f02\u5e38\u2014\u2014\u6c34\u80bf\/\u6e17\u6db2\u7684\u53d1\u751f\u7387\u4e3a 9.9%\uff0c\u6709\u75c7\u72b6\u7684\u4e0d\u5230 2%\u3002\u201d<\/p>\n

\u536b\u6750\u5c06\u795e\u7ecf\u75c5\u5b66\u5b9a\u4f4d\u4e3a\u5173\u952e\u7684\u6cbb\u7597\u9886\u57df\uff0c\u5c06\u7ee7\u7eed\u5728\u57fa\u4e8e\u5c16\u7aef\u795e\u7ecf\u5b66\u7814\u7a76\u7684\u65b0\u578b\u836f\u7269\u5f00\u53d1\u65b9\u9762\u8fdb\u884c\u521b\u65b0\uff0c\u5bfb\u6c42\u8fdb\u4e00\u6b65\u5e2e\u52a9\u6539\u5584\u60a3\u6709\u9ad8\u5ea6\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u75be\u75c5\uff08\u4f8b\u5982\u5305\u62ec AD \u5728\u5185\u7684\u75f4\u5446\uff09\u800c\u53d7\u5f71\u54cd\u7684\u4e2a\u4eba\u53ca\u5176\u5bb6\u4eba\u7684\u798f\u5229\u3002\u6211\u4eec\u7684\u613f\u666f\u5f88\u660e\u786e\uff1a\u4e00\u4e2a\u6ca1\u6709\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u4e16\u754c\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u536b\u6750\u7684\u6297\u5fae\u7ba1\u7ed3\u5408\u533a (MTBR) tau \u6297\u4f53 E2814 \u5148\u524d\u88ab\u9009\u4e3a DIAN-TU TauNext Generation\uff08Tau NexGen\uff09\u8bd5\u9a8c\u6297 tau \u836f\u7269\u4e2d\u9996\u4e2a\u63a2\u7d22\u6027\u7597\u6cd5<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-5785","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/5785"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=5785"}],"version-history":[{"count":2,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/5785\/revisions"}],"predecessor-version":[{"id":5900,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/5785\/revisions\/5900"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=5785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=5785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=5785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}