{"id":5850,"date":"2022-01-06T16:04:54","date_gmt":"2022-01-06T08:04:54","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=5850"},"modified":"2022-02-18T16:07:17","modified_gmt":"2022-02-18T08:07:17","slug":"%e5%8d%ab%e6%9d%90%e4%b8%8eroivant%e7%ad%be%e7%bd%b2%e8%af%95%e9%aa%8c%e6%80%a7%e6%8a%97%e7%99%8c%e8%8d%afh3b-8800%ef%bc%88%e4%b8%80%e7%a7%8d%e5%89%aa%e6%8e%a5%e8%b0%83%e8%8a%82%e5%89%82%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2022\/01\/06\/%e5%8d%ab%e6%9d%90%e4%b8%8eroivant%e7%ad%be%e7%bd%b2%e8%af%95%e9%aa%8c%e6%80%a7%e6%8a%97%e7%99%8c%e8%8d%afh3b-8800%ef%bc%88%e4%b8%80%e7%a7%8d%e5%89%aa%e6%8e%a5%e8%b0%83%e8%8a%82%e5%89%82%ef%bc%89\/","title":{"rendered":"\u536b\u6750\u4e0eROIVANT\u7b7e\u7f72\u8bd5\u9a8c\u6027\u6297\u764c\u836fH3B-8800\uff08\u4e00\u79cd\u526a\u63a5\u8c03\u8282\u5242\uff09\u7684\u72ec\u5bb6\u8bb8\u53ef\u534f\u8bae"},"content":{"rendered":"<p style=\"text-align: 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left\">\u536b\u6750\u682a\u5f0f\u4f1a\u793e<\/p>\n<p style=\"text-align: left\">\u516c\u5171\u5173\u7cfb\u90e8<\/p>\n<p style=\"text-align: left\">+81-(0)3-3817-5120<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left\"><strong>[<\/strong><strong>\u7f16\u8005\u6ce8<\/strong><strong>]<\/strong><\/p>\n<p style=\"text-align: left\"><strong>1.<\/strong><strong>\u5173\u4e8e<\/strong><strong>H3 Biomedicine, Inc. <\/strong><\/p>\n<p style=\"text-align: left\">H3 Biomedicine, Inc.\u662f\u4e00\u5bb6\u603b\u90e8\u4f4d\u4e8e\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5229\u7528\u5176\u96c6\u6210\u6570\u636e\u79d1\u5b66\u3001\u4eba\u7c7b\u751f\u7269\u5b66\u548c\u7cbe\u51c6\u5316\u5b66\u53d1\u73b0\u5f15\u64ce\uff0c\u53d1\u73b0\u548c\u5f00\u53d1\u7cbe\u51c6\u80bf\u7624\u6cbb\u7597\u65b9\u6cd5\uff0c\u81f4\u529b\u4e8e\u6539\u5584\u60a3\u8005\u751f\u6d3b\u3002\u8be5\u516c\u53f8\u6210\u7acb\u4e8e2010\u5e7412\u6708\uff0c\u662f\u536b\u6750\u7f8e\u56fd\u5236\u836f\u516c\u53f8Eisai Inc.\u7684\u5b50\u516c\u53f8\u3002H3 Biomedicine\u4e0e\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u5408\u4f5c\uff0c\u4e13\u6ce8\u4e8e\u5176\u7ba1\u7ebf\u4ea7\u54c1\u7684\u6301\u7eed\u957f\u671f\u4ea4\u4ed8\uff0c\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u8d1f\u8d23\u63d0\u4f9b\u5fc5\u8981\u7684\u7814\u7a76\u8d44\u91d1\u4ee5\u53ca\u5168\u7403\u5316\u5236\u836f\u516c\u53f8\u7684\u529f\u80fd\u548c\u8d44\u6e90\u3002<\/p>\n<p style=\"text-align: left\">\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.h3biomedicine.com\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left\"><strong>2.<\/strong><strong>\u5173\u4e8e<\/strong><strong>Roivant<\/strong><\/p>\n<p style=\"text-align: left\">Roivant\u7684\u4f7f\u547d\u662f\u901a\u8fc7\u4e70\u8fdb\u56e0\u5404\u79cd\u56e0\u7d20\u88ab\u675f\u4e4b\u9ad8\u9601\u4f46\u4ecd\u5177\u6709\u5f00\u53d1\u6f5c\u529b\u7684\u5019\u9009\u836f\u7269\uff0c\u5e76\u8fdb\u884c\u52a0\u901f\u5f00\u53d1\uff0c\u6539\u5584\u5411\u60a3\u8005\u63d0\u4f9b\u7684\u533b\u7597\u4fdd\u5065\u4ea7\u54c1\u3002Roivant\u901a\u8fc7\u521b\u9020\u6027\u5730\u6784\u5efa\u6280\u672f\u548c\u5f00\u53d1\u4eba\u624d\uff0c\u5229\u7528Roivant\u5e73\u53f0\u63a8\u51faVants\u2014\u2014\u591a\u5bb6\u7075\u6d3b\u4e14\u4e13\u6ce8\u7684\u751f\u7269\u5236\u836f\u548c\u533b\u7597\u6280\u672f\u516c\u53f8\uff0c\u4ece\u800c\u66f4\u5feb\u5730\u5f00\u53d1\u65b0\u578b\u836f\u7269\u3002<\/p>\n<p style=\"text-align: left\">\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.roivant.com\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left\">1 Yoshida, et al. (2011). Frequent pathway mutations of splicing machinery in myelodysplasia. <em>Nature <\/em>478(7367): 64-69. doi: 10.1038\/nature10496.<\/p>\n<p style=\"text-align: left\">2 Seiler, et al. (2018). Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types. <em>Cell Reports <\/em>23(1): 282-296.e4. doi: 10.1016\/j.celrep.2018.01.088.<\/p>\n<p style=\"text-align: left\">3 Seiler, et al. (2018). H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers. <em>Nature Medicine <\/em>24(4): 497-504. doi: 10.1038\/nm.4493.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u4e0b\u6587\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u536b\u6750\u5df2\u4e0eRoivant Sciences Ltd.\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aROIV\uff0c\u603b\u90e8\uff1a\u82f1\u56fd\u4f26\u6566\uff0c\u4e0b\u6587\u7b80\u79f0\u201cRoivant\u201d\uff09\u7684\u4e00\u5bb6\u5b50\u516c\u53f8\u7b7e\u8ba2\u8bb8\u53ef\u534f\u8bae\uff0c\u72ec\u5bb6\u6388\u4e88Roivant\u8bd5\u9a8c\u6027\u6297\u764c\u836fH3B-8800\u7684\u5168\u7403\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u6743\u3002H3B-8800\uff08Roivant\u5f00\u53d1\u4ee3\u7801\uff1aRVT-2001\uff09\u662f\u4e00\u79cd\u526a\u63a5\u8c03\u8282\u5242\u5316\u5408\u7269\uff0c\u7531\u536b\u6750\u7684\u7f8e\u56fd\u7814\u53d1\u5b50\u516c\u53f8H3 Biomedicine Inc.\u53d1\u73b0\uff0c\u76ee\u524d\u6b63\u5728\u4f5c\u4e3a\u8bd5\u9a8c\u6027\u6297\u764c\u836f\u8fdb\u884c\u5f00\u53d1\u3002<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-5850","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/5850"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=5850"}],"version-history":[{"count":4,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/5850\/revisions"}],"predecessor-version":[{"id":5852,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/5850\/revisions\/5852"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=5850"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=5850"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=5850"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}