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1.1\uff09\u6bd2\u6027\u6216\u75be\u75c5\u8fdb\u5c55\u4e0d\u53ef\u63a5\u53d7\u3002\u5982\u679c\u60a3\u8005\u4e34\u5e8a\u7a33\u5b9a\uff0c\u4e14\u7814\u7a76\u8005\u8ba4\u4e3a\u60a3\u8005\u53ef\u83b7\u5f97\u4e34\u5e8a\u83b7\u76ca\uff0c\u5219\u5141\u8bb8\u5728RECIST\u5b9a\u4e49\u7684\u75be\u75c5\u8fdb\u5c55\u540e\u8fdb\u884c\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u7528\u836f\u3002\u53ef\u745e\u8fbe\u6700\u957f\u6301\u7eed24\u4e2a\u6708\uff1b\u7136\u800c\uff0c\u4e50\u536b\u739b\u53ef\u6301\u7eed\u8d85\u8fc724\u4e2a\u6708\u3002\u5728\u57fa\u7ebf\u65f6\u8fdb\u884c\u80bf\u7624\u72b6\u6001\u8bc4\u4f30\uff0c\u7136\u540e\u6bcf8\u5468\u8bc4\u4f30\u4e00\u6b21\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u80be\u7ec6\u80de\u764c\uff08<\/strong><strong>RCC<\/strong><strong>\uff09<\/strong><strong><sup>1,2,3,4,5,6<\/sup><\/strong><\/p>\n<p>\u636e\u4f30\u8ba1\uff0c2020\u5e74\u5168\u7403\u65b0\u8bca\u65ad\u80be\u764c\u75c5\u4f8b\u8d85\u8fc743.1\u4e07\u4f8b\uff0c\u8be5\u75be\u75c5\u6b7b\u4ea1\u4eba\u6570\u8d85\u8fc717.9\u4e07\u4f8b\u3002\u5728\u65e5\u672c\uff0c2020\u5e74\u65b0\u8bca\u65ad\u75c5\u4f8b\u8d85\u8fc72.5\u4e07\u4f8b\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u8d85\u8fc78,000\u4f8b\u3002\u636e\u4f30\u8ba1\uff0c2020\u5e74\u6b27\u6d32\u65b0\u8bca\u65ad\u80be\u764c\u75c5\u4f8b\u8d85\u8fc713.8\u4e07\u4f8b\uff0c\u8be5\u75be\u75c5\u6b7b\u4ea1\u4eba\u6570\u8d85\u8fc75.4\u4e07\u4f8b\u3002\u80be\u7ec6\u80de\u764c\u662f\u8fc4\u4eca\u4e3a\u6b62\u6700\u5e38\u89c1\u7684\u80be\u764c\u7c7b\u578b\uff1b\u6bcf10\u4f8b\u80be\u764c\u786e\u8bca\u75c5\u4f8b\u4e2d\u7ea6\u67099\u4f8b\u4e3a\u80be\u7ec6\u80de\u764c\u3002\u80be\u7ec6\u80de\u764c\u5728\u7537\u6027\u4e2d\u8f83\u5e38\u89c1\uff0c\u5176\u53d1\u751f\u7387\u7ea6\u4e3a\u5973\u6027\u7684\u4e24\u500d\u3002\u5927\u591a\u6570\u80be\u7ec6\u80de\u764c\u75c5\u4f8b\u662f\u5728\u5176\u4ed6\u8179\u90e8\u75be\u75c5\u7684\u5f71\u50cf\u5b66\u68c0\u67e5\u4e2d\u5076\u7136\u53d1\u73b0\u7684\u3002\u5728\u8bca\u65ad\u65f6\uff0c\u7ea630%\u7684RCC\u60a3\u8005\u60a3\u6709\u8f6c\u79fb\u6027\u75be\u75c5\u3002\u751f\u5b58\u7387\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u51b3\u4e8e\u8bca\u65ad\u65f6\u7684\u5206\u671f\uff0c\u786e\u8bca\u8f6c\u79fb\u6027\u75be\u75c5\u7684\u60a3\u8005\u7684\u4e94\u5e74\u751f\u5b58\u7387\u4e3a13%\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u4e50\u536b\u739b<\/strong><strong><sup>\u00ae<\/sup><\/strong><strong>\uff08\u4ed1\u4f10\u66ff\u5c3c\uff09\uff1b\u4ee5<\/strong><strong>10 mg<\/strong><strong>\u548c<\/strong><strong>4 mg<\/strong><strong>\u80f6\u56ca\u7684\u5f62\u5f0f\u63d0\u4f9b<\/strong><\/p>\n<p>\u4e50\u536b\u739b\u662f\u7531\u536b\u6750\u7814\u53d1\u7684\u4e00\u79cd\u53e3\u670d\u591a\u6fc0\u9176\u6291\u5236\u5242\uff0c\u53ef\u6291\u5236\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u53d7\u4f53VEGFR1\uff08FLT1\uff09\u3001VEGFR2\uff08KDR\uff09\u548cVEGFR3\uff08FLT4\uff09\u7684\u6fc0\u9176\u6d3b\u6027\u3002\u9664\u6b63\u5e38\u7ec6\u80de\u529f\u80fd\u5916\uff0c\u4e50\u536b\u739b\u8fd8\u53ef\u6291\u5236\u4e0e\u81f4\u75c5\u6027\u8840\u7ba1\u751f\u6210\u3001\u80bf\u7624\u751f\u957f\u548c\u764c\u75c7\u8fdb\u5c55\u76f8\u5173\u7684\u5176\u4ed6\u6fc0\u9176\uff0c\u5305\u62ec\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGF\uff09\u53d7\u4f53FGFR1-4\u3001\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u03b1\uff08PDGFR\u03b1\uff09\u3001KIT\u548cRET\u3002\u5728\u540c\u7cfb\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u4e0e\u4efb\u4e00\u836f\u7269\u5355\u72ec\u7528\u836f\u76f8\u6bd4\uff0c\u4ed1\u4f10\u66ff\u5c3c\u548c\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\u8054\u5408\u7528\u836f\u53ef\u51cf\u5c11\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff0c\u589e\u52a0\u6d3b\u5316\u7684\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff0c\u5e76\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u4e50\u536b\u739b\u5df2\u5728\u8d85\u8fc775\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u65e5\u672c\u3001\u4e2d\u56fd\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u7684\u90e8\u5206\u56fd\u5bb6\uff09\u83b7\u6279\u7528\u4e8e\u7532\u72b6\u817a\u764c\u7684\u5355\u836f\u6cbb\u7597\uff0c\u5e76\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u5c40\u90e8\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u3001\u8fdb\u5c55\u6027\u3001\u653e\u5c04\u6027\u7898\u96be\u6cbb\u6027\u5206\u5316\u578b\u7532\u72b6\u817a\u764c\u7684\u5355\u836f\u6cbb\u7597\u3002\u6b64\u5916\uff0c\u4e50\u536b\u739b\u5df2\u5728\u65e5\u672c\u3001\u6b27\u6d32\u3001\u4e2d\u56fd\u548c\u4e9a\u6d32\u7b4970\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u7684\u5355\u836f\u6cbb\u7597\uff0c\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u4e50\u536b\u739b\u8fd8\u5728\u65e5\u672c\u83b7\u6279\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u80f8\u817a\u764c\u7684\u5355\u836f\u6cbb\u7597\u3002\u572860\u591a\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u6b27\u6d32\u548c\u4e9a\uff09\u4e50\u536b\u739b\u548c\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u7528\u836f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7597\u540e\u7684\u80be\u7ec6\u80de\u764c\uff0c\u4ee5\u53ca\u5728\u7f8e\u56fd\u8be5\u8054\u5408\u7528\u836f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u6b21\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7597\u540e\u7684\u665a\u671f\u80be\u7ec6\u80de\u764c\u6210\u5e74\u60a3\u8005\u3002\u5728\u6b27\u6d32\uff0c\u4e50\u536b\u739b\u4ee5\u5546\u54c1\u540dKisplyx<sup>\u00ae<\/sup>\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u3002\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\uff0c\u4e50\u536b\u739b\u5df2\u83b7\u6279\u548c\u53ef\u745e\u8fbe\uff08\u901a\u7528\u540d\uff1a\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u8054\u5408\u7528\u836f\u7528\u4e8e\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u6210\u4eba\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u5728\u7f8e\u56fd\u4e50\u536b\u739b\u5df2\u83b7\u6279\u548c\u53ef\u745e\u8fbe\uff08\u901a\u7528\u540d\uff1a\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u8054\u5408\u7528\u836f\u7528\u4e8e\u6cbb\u7597\u5728\u4efb\u4f55\u60c5\u51b5\u4e0b\u5728\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u3001\u4e0d\u9002\u5408\u6839\u6cbb\u6027\u624b\u672f\u6216\u653e\u7597\u7684\u975e\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\uff08MSI-H\uff09\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b\uff08dMMR\uff09\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\uff0c\u5728\u52a0\u62ff\u5927\u548c\u6fb3\u5927\u5229\u4e9a\u7b4910\u591a\u4e2a\u56fd\u5bb6\uff0c\u8be5\u8054\u5408\u7528\u836f\u5df2\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u7c7b\u4f3c\u9002\u5e94\u75c7\uff08\u5305\u62ec\u6709\u6761\u4ef6\u6279\u51c6\uff09\u3002\u5728\u4e00\u4e9b\u5730\u533a\uff0c\u8be5\u9002\u5e94\u75c7\u7684\u8fdb\u4e00\u6b65\u6279\u51c6\u53d6\u51b3\u4e8e\u5404\u9879\u786e\u8bc1\u6027\u8bd5\u9a8c\u4e2d\u4e34\u5e8a\u83b7\u76ca\u7684\u9a8c\u8bc1\u548c\u63cf\u8ff0\u3002\u5728\u6b27\u6d32\uff0c\u4e50\u536b\u739b\u5df2\u83b7\u6279\u548c\u53ef\u745e\u8fbe\uff08\u901a\u7528\u540d\uff1a\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u8054\u5408\u7528\u836f\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u542b\u94c2\u7c7b\u5316\u7597\u671f\u95f4\u6216\u6cbb\u7597\u540e\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u4e14\u4e0d\u9002\u5408\u6839\u6cbb\u6027\u624b\u672f\u6216\u653e\u7597\u7684\u665a\u671f\u6216\u590d\u53d1\u6027\u5b50\u5bab\u5185\u819c\u764c\u6210\u4eba\u60a3\u8005\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u53ef\u745e\u8fbe<\/strong><strong><sup>\u00ae<\/sup><\/strong><strong>\uff08\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u6ce8\u5c04\u6db2\uff0c<\/strong><strong>100 mg<\/strong><\/p>\n<p>\u53ef\u745e\u8fbe\u662f\u4e00\u79cd\u6297\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53-1\uff08PD-1\uff09\u6cbb\u7597\u836f\u7269\uff0c\u5176\u901a\u8fc7\u63d0\u9ad8\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u5e2e\u52a9\u76d1\u6d4b\u548c\u6297\u51fb\u80bf\u7624\u7ec6\u80de\u7684\u80fd\u529b\u53d1\u6325\u4f5c\u7528\u3002\u53ef\u745e\u8fbe\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u963b\u65adPD-1\u4e0e\u5176\u914d\u4f53PD-L1\u548cPD-L2\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6fc0\u6d3b\u53ef\u80fd\u5f71\u54cd\u80bf\u7624\u7ec6\u80de\u548c\u5065\u5eb7\u7ec6\u80de\u7684T\u6dcb\u5df4\u7ec6\u80de\u3002<\/p>\n<p>MSD\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u884c\u4e1a\u5185\u89c4\u6a21\u6700\u5927\u7684\u514d\u75ab\u80bf\u7624\u5b66\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u3002\u76ee\u524d\u67091,600\u591a\u9879\u5728\u591a\u79cd\u764c\u75c7\u548c\u6cbb\u7597\u73af\u5883\u4e2d\u7814\u7a76\u53ef\u745e\u8fbe\u7684\u8bd5\u9a8c\u3002\u53ef\u745e\u8fbe\u4e34\u5e8a\u9879\u76ee\u65e8\u5728\u4e86\u89e3\u53ef\u745e\u8fbe\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u53ef\u80fd\u9884\u6d4b\u60a3\u8005\u4ece\u53ef\u745e\u8fbe\u6cbb\u7597\u4e2d\u83b7\u76ca\u53ef\u80fd\u6027\u7684\u56e0\u7d20\uff0c\u5305\u62ec\u63a2\u7d22\u51e0\u79cd\u4e0d\u540c\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u536b\u6750\u548c<\/strong><strong>MSD<\/strong><strong>\u7684\u6218\u7565\u5408\u4f5c<\/strong><\/p>\n<p>2018\u5e743\u6708\uff0c\u536b\u6750\u548cMSD\u901a\u8fc7\u4e00\u5bb6\u9644\u5c5e\u516c\u53f8\uff0c\u5c31\u4e50\u536b\u739b\u7684\u5168\u7403\u5171\u540c\u5f00\u53d1\u548c\u5171\u540c\u5546\u4e1a\u5316\u8fbe\u6210\u4e86\u6218\u7565\u5408\u4f5c\u3002\u6839\u636e\u534f\u8bae\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u8054\u5408\u5f00\u53d1\u3001\u751f\u4ea7\u4e50\u536b\u739b\u5e76\u5c06\u5176\u5546\u4e1a\u5316\u3002\u4e50\u536b\u739b\u65e2\u53ef\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\uff0c\u4e5f\u53ef\u4e0e\u53ef\u745e\u8fbe\uff08MSD\u7684\u6297PD-1\u6cbb\u7597\u836f\u7269\uff09\u8054\u5408\u7528\u836f\u3002<\/p>\n<p>\u9664\u4e86\u6b63\u5728\u8fdb\u884c\u7684\u8bc4\u4ef7\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u7528\u836f\u5728\u51e0\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\u7684\u4e34\u5e8a\u7814\u7a76\u5916\uff0c\u4e24\u5bb6\u516c\u53f8\u8fd8\u901a\u8fc7LEAP\uff08\u4ed1\u4f10\u66ff\u5c3c\u548c\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\uff09\u4e34\u5e8a\u9879\u76ee\u8054\u5408\u542f\u52a8\u4e86\u65b0\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u5e76\u6b63\u572820\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u4ef7\u8be5\u8054\u5408\u7528\u836f\u572810\u591a\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\u7684\u7597\u6548\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u536b\u6750\u4e13\u6ce8\u4e8e\u764c\u75c7\u6cbb\u7597<\/strong><\/p>\n<p>\u536b\u6750\u4e13\u6ce8\u4e8e\u6297\u764c\u836f\u7269\u7684\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u80bf\u7624\u5fae\u73af\u5883\uff08\u4ece\u73b0\u6709\u7684\u81ea\u4e3b\u7814\u53d1\u7684\u5316\u5408\u7269\u4e2d\u83b7\u5f97\u4e86\u5927\u91cf\u7684\u7ecf\u9a8c\u548c\u77e5\u8bc6\uff09\u4ee5\u53ca\u9a71\u52a8\u57fa\u56e0\u7a81\u53d8\u53ca\u5f02\u5e38\u526a\u63a5\u7684\u56e0\u7d20\uff08\u5229\u7528RNA\u526a\u5207\u5e73\u53f0\uff09\u7b49\u9886\u57df\uff08<em>Ricchi<\/em>\uff09\uff0c\u5728\u8fd9\u4e9b\u9886\u57df\uff0c\u8fd8\u6709\u5f88\u591a\u60a3\u8005\u7684\u9700\u6c42\u672a\u5f97\u5230\u771f\u6b63\u7684\u6ee1\u8db3\uff0c\u536b\u6750\u5e0c\u671b\u6210\u4e3a\u80bf\u7624\u5b66\u9886\u57df\u7684\u9886\u5bfc\u8005\u3002\u536b\u6750\u5e0c\u671b\u4ece\u8fd9\u4e9b<em>Ricchi<\/em>\u4e2d\u53d1\u73b0\u5177\u6709\u65b0\u9776\u70b9\u3001\u65b0\u4f5c\u7528\u673a\u5236\u5e76\u6709\u671b\u6cbb\u6108\u764c\u75c7\u7684\u521b\u65b0\u836f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u536b\u6750<\/strong><\/p>\n<p>\u536b\u6750\u662f\u4e00\u5bb6\u9886\u5148\u7684\u5168\u7403\u7814\u53d1\u5236\u836f\u516c\u53f8\uff0c\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\uff0c\u5728\u5168\u7403\u7ea6\u670910,000\u540d\u5458\u5de5\u3002\u536b\u6750\u5c06\u4f01\u4e1a\u4f7f\u547d\u5b9a\u4e49\u4e3a\u201c\u5c06\u60a3\u8005\u53ca\u5176\u5bb6\u5c5e\u7684\u5229\u76ca\u653e\u5728\u9996\u4f4d\uff0c\u4e3a\u63d0\u5347\u5176\u798f\u7949\u505a\u51fa\u8d21\u732e\u201d\uff0c\u516c\u53f8\u5c06\u8fd9\u79cd\u4f7f\u547d\u79f0\u4e3a<em>\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\uff08<\/em><em>hhc<\/em><em>\uff09<\/em>\u7406\u5ff5\u3002\u536b\u6750\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u5b66\u548c\u795e\u7ecf\u75c5\u5b66\u7b49\u533b\u7597\u9700\u6c42\u9ad8\u5ea6\u672a\u5f97\u5230\u6ee1\u8db3\u7684\u6cbb\u7597\u9886\u57df\u63d0\u4f9b\u521b\u65b0\u4ea7\u54c1\uff0c\u52aa\u529b\u5b9e\u73b0\u516c\u53f8\u7684<em>hhc<\/em>\u7406\u5ff5\u3002\u672c\u7740<em>hhc<\/em>\u7684\u7cbe\u795e\uff0c\u536b\u6750\u4f1a\u8fdb\u4e00\u6b65\u5c65\u884c\u8fd9\u4e00\u627f\u8bfa\uff0c\u8fd0\u7528\u516c\u53f8\u62e5\u6709\u7684\u79d1\u5b66\u4e13\u4e1a\u77e5\u8bc6\u3001\u4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Inc.\uff09\u6216<u>www.eisai.eu<\/u>\uff08\u6b27\u6d32\u3001\u4e2d\u4e1c\u3001\u975e\u6d32\u3001\u4fc4\u7f57\u65af\u3001\u6fb3\u5927\u5229\u4e9a\u548c\u65b0\u897f\u5170\u603b\u90e8\uff1aEisai Europe Ltd.\uff09\uff0c\u5e76\u901a\u8fc7Twitter\uff08<u>\u7f8e\u56fd<\/u>\u548c<u>\u5168\u7403<\/u>\uff09\u548cLinkedIn\uff08<u>\u7f8e\u56fd<\/u>\u548c<u>EMEA<\/u>\uff09\u4e0e\u6211\u53f8\u8054\u7cfb\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>MSD<\/strong><strong>\u4e13\u6ce8\u4e8e\u764c\u75c7\u6cbb\u7597<\/strong><\/p>\n<p>MSD\u7684\u76ee\u6807\u662f\u5c06\u7a81\u7834\u6027\u79d1\u5b66\u8f6c\u5316\u4e3a\u521b\u65b0\u578b\u80bf\u7624\u836f\u7269\uff0c\u4ee5\u5e2e\u52a9\u5168\u7403\u764c\u75c7\u60a3\u8005\u3002\u5728MSD\uff0c\u4e3a\u764c\u75c7\u60a3\u8005\u5e26\u6765\u65b0\u5e0c\u671b\u7684\u6f5c\u529b\u63a8\u52a8\u4e86\u516c\u53f8\u7684\u76ee\u6807\uff0c\u652f\u6301\u764c\u75c7\u836f\u7269\u7684\u53ef\u53ca\u6027\u662f\u516c\u53f8\u7684\u627f\u8bfa\u3002\u4f5c\u4e3a\u5173\u6ce8\u764c\u75c7\u6cbb\u7597\u7684\u4e00\u90e8\u5206\uff0cMSD\u81f4\u529b\u4e8e\u63a2\u7d22\u514d\u75ab\u80bf\u7624\u5b66\u7684\u6f5c\u529b\uff0c\u8fd9\u662f\u8be5\u884c\u4e1a\u4e2d\u6700\u5927\u7684\u5f00\u53d1\u9879\u76ee\u4e4b\u4e00\uff0c\u6db5\u76d630\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u3002\u516c\u53f8\u8fd8\u5c06\u7ee7\u7eed\u901a\u8fc7\u6218\u7565\u6027\u6536\u8d2d\u6765\u52a0\u5f3a\u516c\u53f8\u7684\u4ea7\u54c1\u7ec4\u5408\uff0c\u5e76\u4f18\u5148\u5f00\u53d1\u5177\u6709\u6f5c\u529b\u7684\u51e0\u79cd\u6709\u671b\u6539\u5584\u665a\u671f\u764c\u75c7\u6cbb\u7597\u7684\u80bf\u7624\u5019\u9009\u836f\u7269\u3002\u6709\u5173\u516c\u53f8\u80bf\u7624\u5b66\u4e34\u5e8a\u8bd5\u9a8c\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<u>www.merck.com\/clinicaltrials<\/u>\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e<\/strong><strong>MSD<\/strong><\/p>\n<p>\u5728130\u591a\u5e74\u7684\u65f6\u95f4\u91cc\uff0cMSD\u4e00\u76f4\u81f4\u529b\u4e8e\u4e3a\u751f\u547d\u7684\u5ef6\u7eed\u800c\u53d1\u660e\u836f\u7269\uff0c\u4e3a\u4e16\u754c\u4e0a\u8bb8\u591a\u6700\u5177\u6311\u6218\u6027\u7684\u75be\u75c5\u63d0\u4f9b\u836f\u7269\u548c\u75ab\u82d7\uff0c\u4ee5\u5b9e\u73b0\u516c\u53f8\u62ef\u6551\u751f\u547d\u548c\u6539\u5584\u751f\u6d3b\u7684\u4f7f\u547d\u3002\u516c\u53f8\u901a\u8fc7\u5f71\u54cd\u6df1\u8fdc\u7684\u653f\u7b56\u3001\u9879\u76ee\u548c\u4f19\u4f34\u5173\u7cfb\u589e\u52a0\u60a3\u8005\u548c\u4eba\u7fa4\u83b7\u5f97\u533b\u7597\u4fdd\u5065\u7684\u673a\u4f1a\uff0c\u4ee5\u6b64\u8868\u660e\u516c\u53f8\u5bf9\u60a3\u8005\u548c\u4eba\u7fa4\u5065\u5eb7\u7684\u627f\u8bfa\u3002\u5982\u4eca\uff0cMSD\u5728\u9884\u9632\u548c\u6cbb\u7597\u5a01\u80c1\u4eba\u7c7b\u548c\u52a8\u7269\u7684\u75be\u75c5\uff08\u5305\u62ec\u764c\u75c7\u3001HIV\u548c\u57c3\u535a\u62c9\u75c5\u6bd2\u7b49\u611f\u67d3\u6027\u75be\u75c5\u4ee5\u53ca\u65b0\u51fa\u73b0\u7684\u52a8\u7269\u75be\u75c5\uff09\u7684\u7814\u7a76\u9886\u57df\uff0c\u4e00\u76f4\u4fdd\u6301\u8d70\u5728\u524d\u6cbf\uff0c\u81f4\u529b\u4e8e\u6210\u4e3a\u5168\u7403\u9886\u5148\u7684\u7814\u53d1\u5bc6\u96c6\u578b\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee<u>www.merck.com<\/u>\uff0c\u5e76\u901a\u8fc7<u>Twitter<\/u>\u3001<u>Facebook<\/u>\u3001<u>Instagram<\/u>\u3001<u>YouTube<\/u>\u548c<u>LinkedIn<\/u>\u4e0e\u6211\u53f8\u8054\u7cfb\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>MSD<\/strong><strong>\u7684\u524d\u77bb\u6027\u58f0\u660e<\/strong><\/p>\n<p>MSD\u7684\u65b0\u95fb\u7a3f\u4e2d\u5305\u542b\u201c\u524d\u77bb\u6027\u58f0\u660e\u201d\uff0c\u8fd9\u4e9b\u58f0\u660e\u662f\u6839\u636e1995\u5e74\u7f8e\u56fd\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u4e2d\u7684\u5b89\u5168\u6e2f\u89c4\u5b9a\u4f5c\u51fa\u7684\u3002\u8fd9\u4e9b\u524d\u77bb\u6027\u58f0\u660e\u57fa\u4e8e\u516c\u53f8\u7ba1\u7406\u5c42\u76ee\u524d\u7684\u4fe1\u5ff5\u548c\u671f\u671b\uff0c\u5e76\u53d7\u5236\u4e8e\u53ef\u80fd\u51fa\u73b0\u7684\u91cd\u5927\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u56e0\u7d20\u3002\u5bf9\u4e8e\u7ba1\u7ebf\u4ea7\u54c1\uff0c\u65e0\u6cd5\u4fdd\u8bc1\u4ea7\u54c1\u5c06\u83b7\u5f97\u5fc5\u8981\u7684\u76d1\u7ba1\u6279\u51c6\u6216\u8bc1\u660e\u5176\u4f1a\u53d6\u5f97\u5546\u4e1a\u5316\u6210\u529f\u3002\u5982\u679c\u57fa\u7840\u5047\u8bbe\u88ab\u8bc1\u660e\u4e0d\u51c6\u786e\u6216\u5b58\u5728\u98ce\u9669\u6216\u4e0d\u786e\u5b9a\u6027\uff0c\u5219\u5b9e\u9645\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0e\u524d\u77bb\u6027\u58f0\u660e\u6240\u5217\u7ed3\u679c\u5b58\u5728\u91cd\u5927\u5dee\u5f02\u3002<\/p>\n<p>\u98ce\u9669\u548c\u4e0d\u786e\u5b9a\u6027\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u4e00\u822c\u884c\u4e1a\u72b6\u51b5\u548c\u7ade\u4e89\uff1b\u4e00\u822c\u7ecf\u6d4e\u56e0\u7d20\uff0c\u5305\u62ec\u5229\u7387\u548c\u8d27\u5e01\u6c47\u7387\u6ce2\u52a8\uff1b\u5168\u7403\u7206\u53d1\u7684\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u75be\u75c5\uff08COVID-19\uff09\u7684\u5f71\u54cd\uff1b\u7f8e\u56fd\u548c\u56fd\u9645\u5236\u836f\u884c\u4e1a\u76d1\u7ba1\u548c\u533b\u7597\u4fdd\u5065\u7acb\u6cd5\u7684\u5f71\u54cd\uff1b\u63a7\u5236\u533b\u7597\u4fdd\u5065\u6210\u672c\u7684\u5168\u7403\u8d8b\u52bf\uff1b\u6280\u672f\u8fdb\u6b65\uff0c\u7ade\u4e89\u8005\u83b7\u5f97\u7684\u65b0\u4ea7\u54c1\u548c\u4e13\u5229\uff1b\u65b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<\/sup>\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff0c\u300a\u80be\u764c\u7b80\u62a5\u300b\uff0cCancer Today\uff0c2020\u5e74\u3002<br \/>\n<u>https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/29-Kidney-fact-sheet.pdf<\/u>.<\/p>\n<p><sup>2 <\/sup>\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff0c\u300a\u65e5\u672c\u7b80\u62a5\u300b\uff0cCancer Today\uff0c2020\u5e74\u3002<br \/>\n<u>https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/392-japan-fact-sheets.pdf<\/u>.<\/p>\n<p><sup>3 <\/sup>\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\uff0c\u300a\u6709\u5173\u80be\u764c\u7684\u5173\u952e\u7edf\u8ba1\u6570\u636e\u300b\u3002<br \/>\n<u>https:\/\/www.cancer.org\/cancer\/kidney-cancer\/about\/key-statistics.html<\/u>.<\/p>\n<p><sup>4 <\/sup>\u897f\u96c5\u56fe\u764c\u75c7\u6cbb\u7597\u8054\u76df\uff0c\u300a\u80be\u764c\u7b80\u62a5\u300b\u3002<br \/>\n<u>https:\/\/www.seattlecca.org\/diseases\/kidney-cancer\/facts<\/u>.<\/p>\n<p><sup>5 <\/sup>Richard E.et al.\u80be\u7ec6\u80de\u764c\uff1a\u8bca\u65ad\u548c\u6cbb\u7597\uff0c <em>American Family Physician.<\/em>2019\u5e742\u67081\u65e5\uff1b99(3):179-184\u3002<br \/>\n<u>https:\/\/www.aafp.org\/afp\/2019\/0201\/afp20190201p179.pdf<\/u>.<\/p>\n<p><sup>6 <\/sup>Cancer. Net\uff0c\u300a2021\u5e74\u7edf\u8ba1\u6570\u636e\u300b\uff0c\u80be\u764c\u3002<br \/>\n<u>https:\/\/www.cancer.net\/cancer-types\/kidney-cancer\/statistics<\/u>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6279\u51c6\u57fa\u4e8eCLEAR\/KEYNOTE-581\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u8bc1\u660e\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u7528\u836f\u53ef\u663e\u8457\u964d\u4f4e\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u8fbe61%\uff0c\u4e14\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u7ea62\u5e74\uff0c\u800c\u8212\u5c3c\u66ff\u5c3c\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a9\u4e2a\u6708<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-5858","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/5858"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=5858"}],"version-history":[{"count":3,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/5858\/revisions"}],"predecessor-version":[{"id":5866,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/5858\/revisions\/5866"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=5858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=5858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=5858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}