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mmHg\uff09\u3001\u8fc7\u53bb12\u4e2a\u6708\u5185\u53d1\u751f\u663e\u8457\u5fc3\u8840\u7ba1\u635f\u4f24\u6216\u4e8b\u4ef6\u7684\u60a3\u8005\u6216\u60a3\u6709\u6d3b\u52a8\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u6216\u9700\u8981\u514d\u75ab\u6291\u5236\u7684\u75be\u75c5\u7684\u60a3\u8005\u3002\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08BICR\uff09\u6839\u636eRECIST v1.1\u8bc4\u4f30\u7684\u4e3b\u8981\u6709\u6548\u6027\u7ed3\u5c40\u6307\u6807\u4e3aOS\u548cPFS\u3002BICR\u8bc4\u4f30\u7684\u6b21\u8981\u6709\u6548\u6027\u7ed3\u5c40\u6307\u6807\u4e3aORR\u3002<\/p>\n<p>\u60a3\u8005\u4ee51:1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d7\u4e50\u536b\u739b\uff0820 mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u548c\u53ef\u745e\u8fbe\uff08200 mg\uff0c\u9759\u8109\u7ed9\u836f\uff0c\u6bcf\u4e09\u5468\u4e00\u6b21\uff09\u8054\u5408\u7528\u836f\u6216\u7814\u7a76\u8005\u9009\u62e9\u7684\u6cbb\u7597\uff0c\u5305\u62ec\u591a\u67d4\u6bd4\u661f\uff0860 mg\/m<sup>2<\/sup>\uff0c\u6bcf\u4e09\u5468\u4e00\u6b21\uff09\u6216\u7d2b\u6749\u9187\uff0880 mg\/m<sup>2<\/sup>\uff0c\u6bcf\u5468\u4e00\u6b21\uff0c\u7ed9\u836f3\u5468\/\u505c\u836f1\u5468\uff09\u3002\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u7528\u836f\u6301\u7eed\u81f3\u5b9e\u4f53\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\uff08RECIST v1.1\uff09\u5b9a\u4e49\u7684\u75be\u75c5\u8fdb\u5c55\uff08\u7ecfBICR\u786e\u8ba4\uff09\u3001\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u6216\u53ef\u745e\u8fbe\u7528\u836f\u6301\u7eed\u6700\u957f24\u4e2a\u6708\u3002\u5982\u679c\u6cbb\u7597\u7814\u7a76\u8005\u8ba4\u4e3a\u60a3\u8005\u53ef\u83b7\u5f97\u4e34\u5e8a\u83b7\u76ca\u4e14\u6cbb\u7597\u53ef\u8010\u53d7\uff0c\u5219\u5141\u8bb8\u5728RECIST\u5b9a\u4e49\u7684\u75be\u75c5\u8fdb\u5c55\u540e\u8fdb\u884c\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u7528\u836f\u3002\u5728411\u4f8b\u63a5\u53d7\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u7528\u836f\u7684\u60a3\u8005\u4e2d\uff0c\u5171\u6709121\u4f8b\uff0829%\uff09\u5728RECIST\u5b9a\u4e49\u7684\u75be\u75c5\u8fdb\u5c55\u540e\u7ee7\u7eed\u63a5\u53d7\u4e86\u7814\u7a76\u6cbb\u7597\u3002\u8fdb\u5c55\u540e\u6cbb\u7597\u7684\u4e2d\u4f4d\u6301\u7eed\u65f6\u95f4\u4e3a2.8\u4e2a\u6708\u3002\u6bcf8\u5468\u8fdb\u884c\u4e00\u6b21\u80bf\u7624\u72b6\u6001\u8bc4\u4f30\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u5b50\u5bab\u5185\u819c\u764c<\/strong><strong><sup>1,2,3,4,5<\/sup><\/strong><\/p>\n<p>\u5b50\u5bab\u5185\u819c\u764c\u53d1\u751f\u4e8e\u5b50\u5bab\u5185\u5c42\uff08\u5373\u5b50\u5bab\u5185\u819c\uff09\uff0c\u662f\u6700\u5e38\u89c1\u7684\u5b50\u5bab\u764c\u75c7\u7c7b\u578b\u3002\u636e\u4f30\u8ba1\uff0c2020\u5e74\u5168\u7403\u65b0\u53d1\u75c5\u4f8b\u8d85\u8fc741.7\u4e07\u4f8b\uff0c\u8d85\u8fc79.7\u4e07\u4f8b\u6b7b\u4e8e\u5b50\u5bab\u4f53\u764c\uff08\u4e0a\u8ff0\u4f30\u8ba1\u503c\u5305\u62ec\u5b50\u5bab\u5185\u819c\u764c\u548c\u5b50\u5bab\u8089\u7624\uff1b\u5176\u4e2d\u8d85\u8fc790%\u7684\u5b50\u5bab\u4f53\u764c\u53d1\u751f\u5728\u5b50\u5bab\u5185\u819c\uff0c\u56e0\u6b64\u5b50\u5bab\u5185\u819c\u764c\u75c5\u4f8b\u548c\u6b7b\u4ea1\u75c5\u4f8b\u7684\u5b9e\u9645\u6570\u91cf\u7565\u4f4e\u4e8e\u8be5\u4f30\u8ba1\u503c\uff09\u3002\u5728\u65e5\u672c\uff0c2020\u5e74\u65b0\u53d1\u5b50\u5bab\u4f53\u764c\u75c5\u4f8b\u8d85\u8fc71.7\u4e07\u4f8b\uff0c\u8be5\u75be\u75c5\u6b7b\u4ea1\u4eba\u6570\u8d85\u8fc73,000\u4f8b\u3002\u636e\u4f30\u8ba1\uff0c2020\u5e74\u6b27\u6d32\u65b0\u53d1\u5b50\u5bab\u4f53\u764c\u75c5\u4f8b\u8d85\u8fc713\u4e07\u4f8b\uff0c\u6b7b\u4ea1\u4eba\u6570\u8d85\u8fc72.9\u4e07\u4f8b\u3002\u4f30\u8ba1\u8f6c\u79fb\u6027\u5b50\u5bab\u5185\u819c\u764c\uff08IV\u671f\uff09\u7684\u4e94\u5e74\u76f8\u5bf9\u751f\u5b58\u7387\u7ea6\u4e3a17%\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u4e50\u536b\u739b<\/strong><strong><sup>\u00ae<\/sup><\/strong><strong>\uff08\u4ed1\u4f10\u66ff\u5c3c\uff09\u80f6\u56ca<\/strong><\/p>\n<p>\u4e50\u536b\u739b\u662f\u7531\u536b\u6750\u7814\u53d1\u7684\u4e00\u79cd\u53e3\u670d\u591a\u6fc0\u9176\u6291\u5236\u5242\uff0c\u53ef\u6291\u5236\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u53d7\u4f53VEGFR1\uff08FLT1\uff09\u3001VEGFR2\uff08KDR\uff09\u548cVEGFR3\uff08FLT4\uff09\u7684\u6fc0\u9176\u6d3b\u6027\u3002\u9664\u6b63\u5e38\u7ec6\u80de\u529f\u80fd\u5916\uff0c\u4e50\u536b\u739b\u8fd8\u53ef\u6291\u5236\u4e0e\u81f4\u75c5\u6027\u8840\u7ba1\u751f\u6210\u3001\u80bf\u7624\u751f\u957f\u548c\u764c\u75c7\u8fdb\u5c55\u76f8\u5173\u7684\u5176\u4ed6\u6fc0\u9176\uff0c\u5305\u62ec\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGF\uff09\u53d7\u4f53FGFR1-4\u3001\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u03b1\uff08PDGFR\u03b1\uff09\u3001KIT\u548cRET\u3002\u5728\u540c\u7cfb\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u4e0e\u4efb\u4e00\u836f\u7269\u5355\u72ec\u7528\u836f\u76f8\u6bd4\uff0c\u4e50\u536b\u739b\u548c\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\u8054\u5408\u7528\u836f\u53ef\u51cf\u5c11\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff0c\u589e\u52a0\u6d3b\u5316\u7684\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff0c\u5e76\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u4e50\u536b\u739b\u5df2\u5728\u8d85\u8fc775\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u65e5\u672c\u3001\u4e2d\u56fd\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u7684\u90e8\u5206\u56fd\u5bb6\uff09\u83b7\u6279\u7528\u4e8e\u7532\u72b6\u817a\u764c\u7684\u5355\u836f\u6cbb\u7597\uff0c\u5e76\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u5c40\u90e8\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u3001\u8fdb\u5c55\u6027\u3001\u653e\u5c04\u6027\u7898\u96be\u6cbb\u6027\u5206\u5316\u578b\u7532\u72b6\u817a\u764c\u7684\u5355\u836f\u6cbb\u7597\u3002\u6b64\u5916\uff0c\u4e50\u536b\u739b\u5df2\u5728\u65e5\u672c\u3001\u6b27\u6d32\u3001\u4e2d\u56fd\u548c\u4e9a\u6d32\u7b4970\u591a\u4e2a\u56fd\u5bb6\u83b7\u6279\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u7684\u5355\u836f\u6cbb\u7597\uff0c\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u4e50\u536b\u739b\u8fd8\u5728\u65e5\u672c\u83b7\u6279\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u80f8\u817a\u764c\u7684\u5355\u836f\u6cbb\u7597\u3002\u572860\u591a\u4e2a\u56fd\u5bb6\uff08\u5305\u62ec\u6b27\u6d32\u548c\u4e9a\uff09\u4e50\u536b\u739b\u548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mg<\/strong><\/p>\n<p>\u53ef\u745e\u8fbe\u662f\u4e00\u79cd\u6297\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53-1\uff08PD-1\uff09\u6cbb\u7597\u836f\u7269\uff0c\u5176\u901a\u8fc7\u63d0\u9ad8\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u5e2e\u52a9\u76d1\u6d4b\u548c\u6297\u51fb\u80bf\u7624\u7ec6\u80de\u7684\u80fd\u529b\u53d1\u6325\u4f5c\u7528\u3002\u53ef\u745e\u8fbe\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u963b\u65adPD-1\u4e0e\u5176\u914d\u4f53PD-L1\u548cPD-L2\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6fc0\u6d3b\u53ef\u80fd\u5f71\u54cd\u80bf\u7624\u7ec6\u80de\u548c\u5065\u5eb7\u7ec6\u80de\u7684T\u6dcb\u5df4\u7ec6\u80de\u3002<\/p>\n<p>MSD\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u884c\u4e1a\u5185\u89c4\u6a21\u6700\u5927\u7684\u514d\u75ab\u80bf\u7624\u5b66\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u3002\u76ee\u524d\u67091,600\u591a\u9879\u5728\u591a\u79cd\u764c\u75c7\u548c\u6cbb\u7597\u73af\u5883\u4e2d\u7814\u7a76\u53ef\u745e\u8fbe\u7684\u8bd5\u9a8c\u3002\u53ef\u745e\u8fbe\u4e34\u5e8a\u9879\u76ee\u65e8\u5728\u4e86\u89e3\u53ef\u745e\u8fbe\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u53ef\u80fd\u9884\u6d4b\u60a3\u8005\u4ece\u53ef\u745e\u8fbe\u6cbb\u7597\u4e2d\u83b7\u76ca\u53ef\u80fd\u6027\u7684\u56e0\u7d20\uff0c\u5305\u62ec\u63a2\u7d22\u51e0\u79cd\u4e0d\u540c\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u536b\u6750\u548c<\/strong><strong>MSD<\/strong><strong>\u7684\u6218\u7565\u5408\u4f5c<\/strong><\/p>\n<p>2018\u5e743\u6708\uff0c\u536b\u6750\u548cMSD\u901a\u8fc7\u4e00\u5bb6\u9644\u5c5e\u516c\u53f8\uff0c\u5c31\u4e50\u536b\u739b\u7684\u5168\u7403\u5171\u540c\u5f00\u53d1\u548c\u5171\u540c\u5546\u4e1a\u5316\u8fbe\u6210\u4e86\u6218\u7565\u5408\u4f5c\u3002\u6839\u636e\u534f\u8bae\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u8054\u5408\u5f00\u53d1\u3001\u751f\u4ea7\u4e50\u536b\u739b\u5e76\u5c06\u5176\u5546\u4e1a\u5316\u3002\u4e50\u536b\u739b\u65e2\u53ef\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\uff0c\u4e5f\u53ef\u4e0e\u53ef\u745e\u8fbe\uff08MSD\u7684\u6297PD-1\u6cbb\u7597\u836f\u7269\uff09\u8054\u5408\u7528\u836f\u3002<\/p>\n<p>\u9664\u4e86\u6b63\u5728\u8fdb\u884c\u7684\u8bc4\u4ef7\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u7528\u836f\u5728\u51e0\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\u7684\u4e34\u5e8a\u7814\u7a76\u5916\uff0c\u4e24\u5bb6\u516c\u53f8\u8fd8\u901a\u8fc7LEAP\uff08\u4ed1\u4f10\u66ff\u5c3c\u548c\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u7528\u836f\uff09\u4e34\u5e8a\u9879\u76ee\u8054\u5408\u542f\u52a8\u4e86\u65b0\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u5e76\u6b63\u572820\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc4\u4ef7\u8be5\u8054\u5408\u7528\u836f\u572810\u591a\u79cd\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\u7684\u7597\u6548\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u536b\u6750\u4e13\u6ce8\u4e8e\u764c\u75c7\u6cbb\u7597<\/strong><\/p>\n<p>\u536b\u6750\u4e13\u6ce8\u4e8e\u6297\u764c\u836f\u7269\u7684\u7814\u53d1\uff0c\u81f4\u529b\u4e8e\u80bf\u7624\u5fae\u73af\u5883\uff08\u4ece\u73b0\u6709\u7684\u81ea\u4e3b\u7814\u53d1\u7684\u5316\u5408\u7269\u4e2d\u83b7\u5f97\u4e86\u5927\u91cf\u7684\u7ecf\u9a8c\u548c\u77e5\u8bc6\uff09\u4ee5\u53ca\u9a71\u52a8\u57fa\u56e0\u7a81\u53d8\u53ca\u5f02\u5e38\u526a\u63a5\u7684\u56e0\u7d20\uff08\u5229\u7528RNA\u526a\u5207\u5e73\u53f0\uff09\u7b49\u9886\u57df\uff08<em>Ricchi<\/em>\uff09\uff0c\u5728\u8fd9\u4e9b\u9886\u57df\uff0c\u8fd8\u6709\u5f88\u591a\u60a3\u8005\u7684\u9700\u6c42\u672a\u5f97\u5230\u771f\u6b63\u7684\u6ee1\u8db3\uff0c\u536b\u6750\u5e0c\u671b\u6210\u4e3a\u80bf\u7624\u5b66\u9886\u57df\u7684\u9886\u5bfc\u8005\u3002\u536b\u6750\u5e0c\u671b\u4ece\u8fd9\u4e9b<em>Ricchi<\/em>\u4e2d\u53d1\u73b0\u5177\u6709\u65b0\u9776\u70b9\u3001\u65b0\u4f5c\u7528\u673a\u5236\u5e76\u6709\u671b\u6cbb\u6108\u764c\u75c7\u7684\u521b\u65b0\u836f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u5173\u4e8e\u536b\u6750<\/strong><\/p>\n<p>\u536b\u6750\u662f\u4e00\u5bb6\u9886\u5148\u7684\u5168\u7403\u7814\u53d1\u5236\u836f\u516c\u53f8\uff0c\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\uff0c\u5728\u5168\u7403\u7ea6\u670910,000\u540d\u5458\u5de5\u3002\u536b\u6750\u5c06\u4f01\u4e1a\u4f7f\u547d\u5b9a\u4e49\u4e3a\u201c\u5c06\u60a3\u8005\u53ca\u5176\u5bb6\u5c5e\u7684\u5229\u76ca\u653e\u5728\u9996\u4f4d\uff0c\u4e3a\u63d0\u5347\u5176\u798f\u7949\u505a\u51fa\u8d21\u732e\u201d\uff0c\u516c\u53f8\u5c06\u8fd9\u79cd\u4f7f\u547d\u79f0\u4e3a<em>\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\uff08<\/em><em>hhc<\/em><em>\uff09<\/em>\u7406\u5ff5\u3002\u536b\u6750\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u5b66\u548c\u795e\u7ecf\u75c5\u5b66\u7b49\u533b\u7597\u9700\u6c42\u9ad8\u5ea6\u672a\u5f97\u5230\u6ee1\u8db3\u7684\u6cbb\u7597\u9886\u57df\u63d0\u4f9b\u521b\u65b0\u4ea7\u54c1\uff0c\u52aa\u529b\u5b9e\u73b0\u516c\u53f8\u7684<em>hhc<\/em>\u7406\u5ff5\u3002\u672c\u7740<em>hhc<\/em>\u7684\u7cbe\u795e\uff0c\u536b\u6750\u4f1a\u8fdb\u4e00\u6b65\u5c65\u884c\u8fd9\u4e00\u627f\u8bfa\uff0c\u8fd0\u7528\u516c\u53f8\u62e5\u6709\u7684\u79d1\u5b66\u4e13\u4e1a\u77e5\u8bc6\u3001\u4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