\u65e5\u672c\u4e1c\u4eac\u548c\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u5e02\uff0c2021\u5e7411\u670812\u65e5-\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u548c\u6e24\u5065\u516c\u53f8\uff08Nasdaq\uff1aBIIB\uff0c\u603b\u90e8\uff1a\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u5e02\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1aMichel Vounatsos\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u6e24\u5065\u201d\uff09\u5ba3\u5e03\uff0c\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u5f15\u8d77\u7684\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\uff08MCI\uff09\u548c\u8f7b\u5ea6AD\uff08\u7edf\u79f0\u4e3a\u65e9\u671fAD\uff09\u60a3\u8005\u4e2d\uff0c\u901a\u8fc7\u591a\u4e2a\u7edf\u8ba1\u6a21\u578b\uff0c\u8bc4\u4ef7Lecanemab\u6709\u6548\u6027\u7ed3\u679c\u4e00\u81f4\u6027\u7684\u654f\u611f\u6027\u5206\u6790\u7ed3\u679c\u3002\u536b\u6750\u57282021\u5e7411\u67089\u65e5\u81f312\u65e5\u5728\u9a6c\u8428\u8bf8\u585e\u5dde\u6ce2\u58eb\u987f\u4e3e\u884c\u76842021\u5e74\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e34\u5e8a\u8bd5\u9a8c\uff08CTAD\uff09\u4f1a\u8bae\u4e0a\u5ba3\u5e03\u4e86\u6b64\u7814\u7a76\u6210\u679c\u3002<\/p>\n
2021\u5e749\u6708\uff0c\u536b\u6750\u901a\u8fc7\u52a0\u901f\u6279\u51c6\u901a\u9053\u5411\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6eda\u52a8\u63d0\u4ea4Lecanemab\uff08\u4e00\u79cd\u8bd5\u9a8c\u6027\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u03b2\u539f\u7ea4\u7ef4\u6297\u4f53\uff09\u7684\u751f\u7269\u5236\u54c1\u8bb8\u53ef\u7533\u8bf7\uff08BLA\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u65e9\u671fAD\u3002<\/p>\n
\u7814\u7a76201\u662f\u4e00\u9879\u5728856\u4f8b\u65e9\u671fAD\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001IIb\u671f\u8bd5\u9a8c\uff0c\u8be5\u8bd5\u9a8c\u8bc4\u4ef7\u4e86\u5173\u952e\u6709\u6548\u6027\u8bc4\u4f30\uff0c\u5305\u62ec\u4e3b\u8981\u7ec8\u70b912\u4e2a\u6708\u65f6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7efc\u5408\u8bc4\u5206\uff08ADCOMS\uff09\u548c\u9009\u5b9a\u5173\u952e\u6b21\u8981\u7ec8\u70b918\u4e2a\u6708\u65f6\u4e34\u5e8a\u75f4\u5446\u8bc4\u5b9a\u91cf\u8868-\u603b\u5206\uff08CDR-SB\uff09\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8bc4\u4f30\u91cf\u8868-\u8ba4\u77e5\u5206\u91cf\u8868\uff08ADAS-Cog14\uff09\u7684\u4e34\u5e8a\u53d8\u5316\u30024\u4e2a\u7edf\u8ba1\u6a21\u578b\uff08\u91cd\u590d\u6d4b\u91cf\u7684\u6df7\u5408\u6a21\u578b\u3001\u75be\u75c5\u8fdb\u5c55\u6a21\u578b\u3001\u81ea\u7136\u4e09\u6b21\u6837\u6761\u6a21\u578b\u548c\u4e8c\u6b21\u6df7\u5408\u6a21\u578b\uff09\u76846\u6b21\u654f\u611f\u6027\u5206\u6790\u663e\u793a\uff0c18\u4e2a\u6708\u65f6ADCOMS\u3001CDR-SB\u548cADAS-Cog14\u7684Lecanemab\u6cbb\u7597\u6548\u679c\u4e00\u81f4\u3002<\/p>\n
\u4e3b\u8981\u7ec8\u70b9\u662f\u5bf912\u4e2a\u6708\u4e34\u5e8a\u53d8\u5316\u7684ADCOMS\u8fdb\u884c\u8d1d\u53f6\u65af\u5206\u6790\uff0c\u76ee\u7684\u662f\u786e\u5b9a\u6700\u6709\u6548\u5242\u91cf\uff08ED90\u5242\u91cf\uff09\u3002\u4e3b\u8981\u5206\u6790\u4e3a\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u4f7f\u4e34\u5e8a\u8870\u9000\u51cf\u7f1325%\u4ee5\u4e0a\u7684\u53ef\u80fd\u6027\u663e\u8457\u66f4\u5927\uff1a\u76ee\u6807\u662f\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u4f7f\u4e34\u5e8a\u8870\u9000\u51cf\u7f13\u226525%\u7684\u53ef\u80fd\u6027\u4e3a80%\u3002\u7814\u7a76\u8fbe\u5230\u4e86\u786e\u5b9a\u8fbe\u5230\u226590%\u6700\u4f73\u6cbb\u7597\u6548\u679c\u7684\u6700\u5c0f\u5242\u91cf\uff0810 mg\/kg\uff0c\u6bcf\u4e24\u5468\u4e00\u6b21\uff09\u7684\u76ee\u7684\uff0c\u5373ED90\u5242\u91cf\u300212\u4e2a\u6708\u65f6\uff0cED90\u5242\u91cf\u4f7f\u4e34\u5e8a\u8870\u9000\u51cf\u7f1325%\u7684\u53ef\u80fd\u6027\u4e3a64%\uff0c\u663e\u8457\u4f18\u4e8e\u5b89\u6170\u5242\u300212\u4e2a\u6708\u65f6\uff0cED90\u5242\u91cf\u4f18\u4e8e\u5b89\u6170\u5242\u7684\u53ef\u80fd\u6027\u4e3a98%\u3002\u5728\u6240\u6709\u5206\u6790\u4e2d\uff0c\u572818\u4e2a\u6708\u65f6\u89c2\u5bdf\u5230ADCOMS\uff0829%-37%\uff09\u3001CDR-SB\uff0826.5%-35%\uff09\u548cADAS-Cog\uff0847%-56%\uff09\u7684\u6cbb\u7597\u6548\u679c\u4e00\u81f4\uff0c\u57286\u4e2a\u6708\u65f6\u89c2\u5bdf\u5230\u6700\u9ad8\u5242\u91cf\uff0810 mg\/kg\uff0c\u6bcf\u4e24\u5468\u4e00\u6b21\uff09\u4e0e\u5b89\u6170\u5242\u5b58\u5728\u5dee\u5f02\u3002<\/p>\n
\u201c\u5728\u7814\u7a76201\u4e2d\uff0c\u591a\u4e2a\u4e34\u5e8a\u548c\u751f\u7269\u6807\u5fd7\u7269\u7ec8\u70b9\u5747\u8868\u660e\uff0cLecanemab\u53ef\u7a33\u5065\u6e05\u9664\u8111\u6dc0\u7c89\u6837\u86cb\u767d\u5e76\u51cf\u7f13\u4e34\u5e8a\u8870\u9000\u3002\u8be5\u654f\u611f\u6027\u5206\u6790\u8868\u660e\uff0c\u5728\u5404\u7edf\u8ba1\u6a21\u578b\u4e2d\uff0cLecanemab\u7684\u4e34\u5e8a\u6709\u6548\u6027\u7ed3\u679c\u4e00\u81f4\u4e14\u53ef\u9760\uff0c\u8fd9\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e86\u6211\u4eec\u5bf9\u8be5\u7814\u7a76\u6cbb\u7597\u4e34\u5e8a\u6f5c\u529b\u7684\u4fe1\u5fc3\u3002 \u201d\u536b\u6750\u526f\u603b\u88c1\u517c\u795e\u7ecf\u75c5\u4e1a\u52a1\u7ec4\u526f\u9996\u5e2d\u4e34\u5e8a\u5b98Michael Irizarry\u535a\u58eb\u8868\u793a\uff1a\u201c\u901a\u8fc7\u6211\u4eec\u7684\u7efc\u5408\u7814\u7a76\u9879\u76ee\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u6df1\u5165\u4e86\u89e3\u8fd9\u79cd\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u03b2\u539f\u7ea4\u7ef4\u6297\u4f53\u5982\u4f55\u5728\u65e9\u671f\u548c\u4e34\u5e8a\u524dAD\u6cbb\u7597\u4e2d\u53d1\u6325\u4f5c\u7528\u30022021\u5e743\u6708\uff0c\u536b\u6750\u5728\u6211\u4eec\u7684\u786e\u8bc1\u6027III\u671fClarity AD\u4e34\u5e8a\u7814\u7a76\u4e2d\u5b8c\u6210\u4e861,795\u4f8b\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u5165\u7ec4\u3002III\u671f\u4e34\u5e8a\u7814\u7a76\uff08AHEAD 3-45\uff09\u76ee\u524d\u6b63\u5728\u63a2\u7d22Lecanemab\u5728\u4e34\u5e8a\u524dAD\u4e2a\u4f53\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u201d<\/p>\n
\u672c\u65b0\u95fb\u7a3f\u8ba8\u8bba\u4e86\u5f00\u53d1\u7684\u836f\u7269\u7684\u8bd5\u9a8c\u6027\u7528\u9014\uff0c\u5e76\u4e0d\u65e8\u5728\u4f20\u8fbe\u5173\u4e8e\u6709\u6548\u6027\u6216\u5b89\u5168\u6027\u7684\u7ed3\u8bba\u3002\u65e0\u6cd5\u4fdd\u8bc1\u6b64\u7c7b\u8bd5\u9a8c\u6027\u836f\u7269\u5c06\u6210\u529f\u5b8c\u6210\u4e34\u5e8a\u5f00\u53d1\u6216\u83b7\u5f97\u536b\u751f\u4e3b\u7ba1\u90e8\u95e8\u6279\u51c6\u3002<\/p>\n
<\/p>\n
[\u7f16\u8005\u6ce8]<\/strong><\/p>\n 1.<\/strong>\u5173\u4e8e<\/strong>Lecanemab<\/strong>\uff08<\/strong>BAN2401<\/strong>\uff09<\/strong><\/p>\n Lecanemab\u662f\u4e00\u79cd\u62df\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u7684\u8bd5\u9a8c\u6027\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u662f\u536b\u6750\u548cBioArctic\u7684\u5408\u4f5c\u7814\u53d1\u7ed3\u679c\u3002Lecanemab\u53ef\u9009\u62e9\u6027\u7ed3\u5408\u4e2d\u548c\u5e76\u6d88\u9664\u53ef\u6eb6\u6027\u3001\u6bd2\u6027\u03b2\uff08A\u03b2\uff09\u6dc0\u7c89\u6837\u86cb\u767d\u805a\u96c6\u4f53\uff08\u539f\u7ea4\u7ef4\uff09\uff0c\u8fd9\u4e9b\u805a\u96c6\u4f53\u88ab\u8ba4\u4e3a\u52a0\u901f\u4e86AD\u7684\u795e\u7ecf\u7cfb\u7edf\u53d8\u6027\u8fdb\u7a0b\u3002\u56e0\u6b64\uff0cLecanemab\u53ef\u80fd\u5bf9\u75be\u75c5\u75c5\u7406\u673a\u5236\u4ea7\u751f\u5f71\u54cd\uff0c\u5e76\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u3002\u5c31\u6cbb\u759718\u4e2a\u6708\u65f6\u9884\u5148\u6307\u5b9a\u7684\u5206\u6790\u7ed3\u679c\u800c\u8a00\uff0c\u7814\u7a76201\u8868\u660e\uff0c\u65e9\u671fAD\u53d7\u8bd5\u8005\u7684\u8111A\u03b2\u84c4\u79ef\u51cf\u5c11\uff08P<0.0001\uff09\uff0cADCOMS*\u6d4b\u5f97\u7684\u75be\u75c5\u8fdb\u5c55\u51cf\u7f13\uff08P<0.05\uff09\u3002\u8be5\u7814\u7a76\u5728\u6cbb\u759712\u4e2a\u6708\u65f6\u672a\u8fbe\u5230\u4e3b\u8981\u7ed3\u5c40\u6307\u6807**\u3002\u5728\u6838\u5fc3\u9636\u6bb5\u548c\u6cbb\u7597\u95f4\u9694\u671f\uff08\u5e73\u574724\u4e2a\u6708\uff09\u540e\u542f\u52a8\u7814\u7a76201\u7684\u5f00\u653e\u671f\u5ef6\u7eed\u8bd5\u9a8c\uff0c\u4ee5\u8bc4\u4ef7\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u8be5\u9636\u6bb5\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n \u6839\u636e2007\u5e7412\u6708\u4e0eBioArctic\u7b7e\u8ba2\u7684\u534f\u8bae\uff0c\u536b\u6750\u83b7\u5f97\u4e86Lecanemab\u7528\u4e8e\u6cbb\u7597AD\u7684\u5168\u7403\u7814\u7a76\u3001\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u4e0a\u5e02\u6743\u5229\u30022014\u5e743\u6708\uff0c\u536b\u6750\u548c\u6e24\u5065\u7b7e\u8ba2\u4e86Lecanemab\u7684\u8054\u5408\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u534f\u8bae\uff0c\u53cc\u65b9\u4e8e2017\u5e7410\u6708\u4fee\u8ba2\u4e86\u8be5\u534f\u8bae\u3002\u76ee\u524d\uff0c\u6839\u636eII\u671f\u4e34\u5e8a\u7814\u7a76\uff08\u7814\u7a76201\uff09\u7684\u7ed3\u679c\uff0c\u6b63\u5728\u8fdb\u884c\u75c7\u72b6\u6027\u65e9\u671fAD\u7684Lecanemab\u5173\u952e\u6027III\u671f\u4e34\u5e8a\u7814\u7a76\uff08Clarity-AD\uff092020\u5e747\u6708\uff0c\u9488\u5bf9\u4e34\u5e8a\u524dAD\u4e2a\u4f53\uff08\u8fd9\u4e9b\u60a3\u8005\u4e34\u5e8a\u8868\u73b0\u6b63\u5e38\uff0c\u4f46\u5927\u8111\u4e2d\u6dc0\u7c89\u6837\u86cb\u767d\u6c34\u5e73\u4e3a\u4e2d\u7b49\u6216\u504f\u9ad8\uff09\u542f\u52a8\u4e86III\u671f\u4e34\u5e8a\u7814\u7a76\uff08AHEAD 3-45\uff09\u3002\u4ee5\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u5206\u90e8\u56fd\u7acb\u8001\u9f84\u5316\u7814\u7a76\u6240\u8d44\u52a9\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e34\u5e8a\u8bd5\u9a8c\u8054\u76df\uff08\u8be5\u8054\u76df\u4e3a\u7f8e\u56fd\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u76f8\u5173\u75f4\u5446\u75c7\u7684\u5b66\u672f\u4e34\u5e8a\u8bd5\u9a8c\u63d0\u4f9b\u57fa\u7840\u8bbe\u65bd\uff09\u548c\u536b\u6750\u4e0e\u6e24\u5065\u4e4b\u95f4\u7684\u516c\u79c1\u5408\u4f5c\u6a21\u5f0f\u8fdb\u884cAHEAD 3-45\u7814\u7a76\u3002<\/p>\n *\u7531\u536b\u6750\u5f00\u53d1\u7684ADCOMS\uff08AD\u7efc\u5408\u8bc4\u5206\uff09\u7ed3\u5408\u4e86ADAS-Cog\uff08\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8bc4\u4f30\u91cf\u8868-\u8ba4\u77e5\u5206\u91cf\u8868\uff09\u3001CDR\uff08\u4e34\u5e8a\u75f4\u5446\u8bc4\u5b9a\u91cf\u8868\uff09\u548cMMSE\uff08\u7b80\u6613\u7cbe\u795e\u72b6\u6001\u68c0\u67e5\u8868\uff09\u91cf\u8868\u7684\u9879\u76ee\uff0c\u4ee5\u4fbf\u7075\u654f\u5730\u68c0\u6d4b\u65e9\u671fAD\u75c7\u72b6\u7684\u4e34\u5e8a\u529f\u80fd\u53d8\u5316\u548c\u8bb0\u5fc6\u53d8\u5316\u3002<\/p>\n **\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cADCOMS\u6d4b\u5f97\u7684\u6cbb\u759712\u4e2a\u6708\u65f6\u81ea\u57fa\u7ebf\u7684\u4e34\u5e8a\u8870\u9000\u51cf\u7f13\u226525%\u7684\u4f30\u8ba1\u6982\u7387\u226580%\u3002<\/p>\n <\/p>\n 2.<\/strong>\u536b\u6750\u4e0e\u6e24\u5065\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u65b9\u9762\u7684\u5408\u4f5c<\/strong><\/p>\n \u536b\u6750\u548c\u6e24\u5065\u5728AD\u6cbb\u7597\u836f\u7269\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u65b9\u9762\u8fdb\u884c\u4e86\u5408\u4f5c\u3002\u536b\u6750\u662fLecanemab\u8054\u5408\u5f00\u53d1\u7684\u7275\u5934\u4eba\u3002<\/p>\n <\/p>\n 3.<\/strong>\u536b\u6750\u4e0e<\/strong>BioArctic<\/strong>\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u65b9\u9762\u7684\u5408\u4f5c<\/strong><\/p>\n \u81ea2005\u5e74\u4ee5\u6765\uff0cBioArctic\u4e0e\u536b\u6750\u5c31AD\u6cbb\u7597\u836f\u7269\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8fdb\u884c\u4e86\u957f\u671f\u5408\u4f5c\u30022007\u5e7412\u6708\u7b7e\u7f72\u4e86Lecanemab\u6297\u4f53\u7684\u5546\u4e1a\u5316\u534f\u8bae\uff0c2015\u5e745\u6708\u7b7e\u7f72\u4e86AD\u6297\u4f53Lecanemab\u5907\u4efd\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u534f\u8bae\u3002\u536b\u6750\u8d1f\u8d23AD\u4ea7\u54c1\u7684\u4e34\u5e8a\u5f00\u53d1\u3001\u4e0a\u5e02\u7533\u8bf7\u548c\u5546\u4e1a\u5316\u3002BioArctic\u4e0d\u627f\u62c5\u7528\u4e8eAD\u7684lecanemab\u7684\u5f00\u53d1\u6210\u672c\u3002<\/p>\n <\/p>\n 4.<\/strong>\u5173\u4e8e\u536b\u6750\u682a\u5f0f\u4f1a\u793e<\/strong><\/p>\n \u536b\u6750\u682a\u5f0f\u4f1a\u793e\u662f\u4e00\u5bb6\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u7684\u9886\u5148\u5168\u7403\u5236\u836f\u516c\u53f8\u3002\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u7684\u4f01\u4e1a\u7406\u5ff5\u57fa\u4e8e\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\uff08<\/em>hhc<\/em>\uff09<\/em>\u7406\u5ff5\uff0c\u5373\u5c06\u60a3\u8005\u53ca\u5bb6\u5c5e\u7684\u5229\u76ca\u653e\u5728\u9996\u4f4d\uff0c\u4e3a\u63d0\u5347\u5176\u798f\u7949\u505a\u51fa\u8d21\u732e\u3002\u516c\u53f8\u51ed\u501f\u7814\u53d1\u673a\u6784\u3001\u751f\u4ea7\u57fa\u5730\u548c\u8425\u9500\u5b50\u516c\u53f8\u7684\u5168\u7403\u7f51\u7edc\uff0c\u81f4\u529b\u4e8e\u901a\u8fc7\u9488\u5bf9\u533b\u7597\u9700\u6c42\u672a\u5f97\u5230\u5145\u5206\u6ee1\u8db3\u7684\u9776\u75c5\u7076\u63d0\u4f9b\u521b\u65b0\u4ea7\u54c1\uff0c\u5c24\u5176\u4fa7\u91cd\u4e8e\u795e\u7ecf\u5b66\u548c\u80bf\u7624\u5b66\u6218\u7565\u9886\u57df\uff0c\u5b9e\u73b0\u516c\u53f8\u7684hhc<\/em>\u7406\u5ff5\u3002<\/p>\n \u536b\u6750\u8ba1\u5212\u5229\u7528\u4ece\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6cbb\u7597\u836f\u7269\u7814\u53d1\u548c\u4e0a\u5e02\u4e2d\u83b7\u5f97\u7684\u7ecf\u9a8c\uff0c\u5efa\u7acb\u201c\u536b\u6750\u75f4\u5446\u5e73\u53f0\u201d\u3002\u536b\u6750\u8ba1\u5212\u901a\u8fc7\u8be5\u5e73\u53f0\u6784\u5efa\u201c\u75f4\u5446\u751f\u6001\u7cfb\u7edf\u201d\uff0c\u4e0e\u533b\u7597\u673a\u6784\u3001\u8bca\u65ad\u5f00\u53d1\u516c\u53f8\u3001\u7814\u7a76\u7ec4\u7ec7\u548c\u751f\u7269\u98ce\u9669\u6295\u8d44\u516c\u53f8\u7b49\u5408\u4f5c\u4f19\u4f34\u4ee5\u53ca\u79c1\u4eba\u4fdd\u9669\u673a\u6784\u3001\u91d1\u878d\u4e1a\u3001\u5065\u8eab\u4ff1\u4e50\u90e8\u3001\u6c7d\u8f66\u5236\u9020\u5546\u3001\u96f6\u552e\u5546\u548c\u62a4\u7406\u673a\u6784\u7b49\u5408\u4f5c\u4f19\u4f34\u5408\u4f5c\uff0c\u4e3a\u75f4\u5446\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u5e26\u6765\u65b0\u7684\u798f\u7949\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u7684\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eehttps:\/\/www.eisai.com<\/u>\u3002<\/p>\n <\/p>\n 5.<\/strong>\u5173\u4e8e\u536b\u6750\u7f8e\u56fd<\/strong><\/p>\n \u5728\u536b\u6750\u516c\u53f8\uff0c\u5173\u5fc3\u4eba\u7c7b\u5065\u5eb7\uff08<\/em>hhc<\/em>\uff09<\/em>\u662f\u6211\u4eec\u7684\u76ee\u6807\u3002\u6211\u4eec\u5c06\u60a3\u8005\u53ca\u5bb6\u5c5e\u7684\u5229\u76ca\u653e\u5728\u9996\u4f4d\uff0c\u4e3a\u63d0\u5347\u5176\u798f\u7949\u505a\u51fa\u8d21\u732e\u3002\u4f5c\u4e3a\u603b\u90e8\u4f4d\u4e8e\u4e1c\u4eac\u7684\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u7684\u7f8e\u56fd\u5b50\u516c\u53f8\uff0c\u6211\u4eec\u70ed\u7231\u60a3\u8005\u62a4\u7406\uff0c\u8fd9\u9a71\u4f7f\u6211\u4eec\u52aa\u529b\u53d1\u73b0\u548c\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\u4ee5\u5e2e\u52a9\u89e3\u51b3\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u536b\u6750\u662f\u4e00\u5bb6\u5168\u9762\u6574\u5408\u7684\u5236\u836f\u4f01\u4e1a\uff0c\u4e1a\u52a1\u6d89\u53ca\u80bf\u7624\u5b66\u548c\u795e\u7ecf\u75c5\u5b66\uff08\u75f4\u5446\u76f8\u5173\u75be\u75c5\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff09\u8fd9\u4e24\u5927\u5168\u7403\u4e1a\u52a1\u677f\u5757\u3002\u6211\u4eec\u7684\u7f8e\u56fd\u603b\u90e8\u3001\u5546\u4e1a\u548c\u4e34\u5e8a\u5f00\u53d1\u7ec4\u7ec7\u4f4d\u4e8e\u65b0\u6cfd\u897f\u5dde\uff1b\u63a2\u7d22\u5b9e\u9a8c\u5ba4\u4f4d\u4e8e\u9a6c\u8428\u8bf8\u585e\u5dde\u548c\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5dde\uff1b\u5168\u7403\u9700\u6c42\u94fe\u7ec4\u7ec7\u4f4d\u4e8e\u9a6c\u91cc\u5170\u5dde\u548c\u5317\u5361\u7f57\u6765\u7eb3\u5dde\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u5173\u4e8e\u536b\u6750\u516c\u53f8\u7684\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.eisai.com\/US<\/u> \uff0c\u5e76\u5173\u6ce8\u6211\u4eec\u7684Twitter<\/u>\u548cLinkedIn<\/u>\u8d26\u53f7\u3002<\/p>\n <\/p>\n 6.<\/strong>\u5173\u4e8e\u6e24\u5065<\/strong><\/p>\n \u4f5c\u4e3a\u795e\u7ecf\u79d1\u5b66\u7684\u5148\u950b\uff0c\u6e24\u5065\u4e3a\u5168\u7403\u7f79\u60a3\u4e25\u91cd\u795e\u7ecf\u75be\u75c5\u7684\u60a3\u8005\u63a2\u5bfb\u3001\u7814\u53d1\u548c\u63d0\u4f9b\u521b\u65b0\u7597\u6cd5\u3002\u6e24\u5065\u662fCharles Weissmann\u3001Heinz Schaller\u3001Sir Kenneth Murray\u4e0e\u8bfa\u8d1d\u5c14\u5956\u83b7\u5f97\u8005Walter Gilbert\u548cPhillip Sharp\u643a\u624b\u57281978\u5e74\u6210\u7acb\u7684\u5168\u7403\u9996\u6279\u751f\u7269\u79d1\u6280\u516c\u53f8\u4e4b\u4e00\u3002\u5982\u4eca\uff0c\u6e24\u5065\u62e5\u6709\u6cbb\u7597\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u9886\u5148\u836f\u7269\u7ec4\u5408\uff0c\u63a8\u51fa\u4e86\u9996\u4e2a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\u7684\u836f\u7269\uff0c\u5e76\u6b63\u5728\u63d0\u4f9b\u9996\u4e2a\u4e5f\u662f\u552f\u4e00\u83b7\u6279\u7528\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u660e\u786e\u75c5\u7406\u5b66\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u6e24\u5065\u8fd8\u5728\u8fdb\u884c\u751f\u7269\u4eff\u5236\u836f\u5546\u4e1a\u5316\uff0c\u5e76\u81f4\u529b\u4e8e\u63a8\u8fdb\u795e\u7ecf\u79d1\u5b66\u9886\u57df\u884c\u4e1a\u7684\u6700\u591a\u6837\u5316\u6e20\u9053\uff0c\u8fd9\u5c06\u6539\u53d8\u5177\u6709\u9ad8\u5ea6\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u7684\u82e5\u5e72\u9886\u57df\u60a3\u8005\u7684\u6807\u51c6\u6cbb\u7597\u3002<\/p>\n 2020\u5e74\uff0c\u6e24\u5065\u53d1\u8d77\u4e86\u4e00\u9879\u4e3a\u671f20\u5e74\u3001\u8017\u8d442.5\u4ebf\u7f8e\u5143\u7684\u5927\u80c6\u5021\u8bae\uff0c\u65e8\u5728\u89e3\u51b3\u6c14\u5019\u3001\u5065\u5eb7\u548c\u516c\u5e73\u7b49\u5bc6\u5207\u76f8\u5173\u7684\u95ee\u9898\u3002Healthy Climate, Healthy Lives\u2122\u65e8\u5728\u6d88\u9664\u516c\u53f8\u8fd0\u8425\u4e2d\u7684\u5316\u77f3\u71c3\u6599\uff0c\u5e76\u4e0e\u77e5\u540d\u673a\u6784\u5efa\u7acb\u5408\u4f5c\u5173\u7cfb\uff0c\u4ee5\u63a8\u8fdb\u79d1\u5b66\u8fdb\u6b65\u3001\u6539\u5584\u4eba\u7c7b\u5065\u5eb7\u7ed3\u679c\uff0c\u5e76\u4e3a\u533b\u7597\u6c34\u5e73\u4f4e\u4e0b\u7684\u793e\u533a\u63d0\u4f9b\u652f\u6301\u3002<\/p>\n \u8be5\u516c\u53f8\u7ecf\u5e38\u5728\u5176\u7f51\u7ad9www.biogen.com\u4e0a\u53d1\u5e03\u5bf9\u6295\u8d44\u8005\u800c\u8a00\u53ef\u80fd\u5f88\u91cd\u8981\u7684\u4fe1\u606f\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95eewww.biogen.com\uff0c\u5e76\u5728\u793e\u4ea4\u5a92\u4f53-Twitter<\/u>\u3001LinkedIn<\/u>\u3001Facebook<\/u>\u3001YouTube<\/u>\u4e0a\u5173\u6ce8\u6e24\u5065\u7684\u8d26\u53f7\u3002<\/p>\n <\/p>\n 7.<\/strong>\u6e24\u5065\u5b89\u5168\u6e2f<\/strong><\/p>\n \u672c\u65b0\u95fb\u7a3f\u4e2d\u5305\u542b\u524d\u77bb\u6027\u58f0\u660e\uff0c\u5305\u62ec\u6839\u636e1995\u5e74\u7f8e\u56fd\u300a\u79c1\u4eba\u8bc1\u5238\u8bc9\u8bbc\u6539\u9769\u6cd5\u6848\u300b\u4e2d\u7684\u5b89\u5168\u6e2f\u6761\u6b3e\u5c31Lecanemab\u7684\u6f5c\u5728\u4e34\u5e8a\u7597\u6548\uff1bLecanemab\u548cADUHELM\u7684\u6f5c\u5728\u83b7\u76ca\u3001\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff1b\u6f5c\u5728\u76d1\u7ba1\u8ba8\u8bba\u3001\u63d0\u4ea4\u548c\u6279\u51c6\u53ca\u5176\u65f6\u95f4\u5b89\u6392\uff1bClarity 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