{"id":6231,"date":"2022-09-12T11:44:25","date_gmt":"2022-09-12T03:44:25","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=6231"},"modified":"2022-10-28T11:59:11","modified_gmt":"2022-10-28T03:59:11","slug":"%e5%8d%ab%e6%9d%90%e5%9c%a82022%e5%b9%b4%e6%ac%a7%e6%b4%b2%e8%82%bf%e7%98%a4%e5%86%85%e7%a7%91%e5%ad%a6%e4%bc%9a%ef%bc%88esmo%ef%bc%89%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83halaven","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2022\/09\/12\/%e5%8d%ab%e6%9d%90%e5%9c%a82022%e5%b9%b4%e6%ac%a7%e6%b4%b2%e8%82%bf%e7%98%a4%e5%86%85%e7%a7%91%e5%ad%a6%e4%bc%9a%ef%bc%88esmo%ef%bc%89%e5%a4%a7%e4%bc%9a%e4%b8%8a%e5%85%ac%e5%b8%83halaven\/","title":{"rendered":"\u536b\u6750\u57282022\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u4e0a\u516c\u5e03HALAVEN\u00ae\uff08\u6d77\u4e50\u536b\u00ae\uff0c\u7532\u78fa\u9178\u827e\u7acb\u5e03\u6797\uff09\u7684\u4e8b\u540e\u5206\u6790\u7ed3\u679c"},"content":{"rendered":"

\u5206\u6790\u8bc4\u4ef7\u4e86\u827e\u7acb\u5e03\u6797\u5728\u4e09\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\u5bf9\u8f6c\u79fb\u6027<\/em>HER2<\/em>\u4f4e\u8868\u8fbe\u4e73\u817a\u764c\u7684\u7597\u6548<\/em><\/h3>\n

\u00a0<\/em><\/strong><\/p>\n

\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u201c\u536b\u6750\u201d\uff09\u516c\u5e03\u4e86\u4e09\u9879\u968f\u673a\u3001\u5173\u952e\u6027III\u671f\u7814\u7a76\uff08EMBRACE\u8bd5\u9a8c\/\u7814\u7a76305\u3001\u7814\u7a76301\u548c\u7814\u7a76304\uff09\u7684\u4e8b\u540e\u5206\u6790\u7ed3\u679c\uff0c\u8fd9\u4e09\u9879\u7814\u7a76\u65e8\u5728\u8bc4\u4ef7\u7532\u78fa\u9178\u827e\u7acb\u5e03\u6797\uff08HALAVEN\u00ae<\/sup>\uff0c\u4e2d\u6587\u540d\uff1a\u6d77\u4e50\u536b\u00ae<\/sup>\uff09\u4e0e\u5176\u5b83\u5316\u7597\uff08\u5206\u522b\u4e3a\u533b\u751f\u9009\u62e9\u7684\u5316\u7597\u836f\u7269[TPC]\u3001\u5361\u57f9\u4ed6\u6ee8\u548c\u957f\u6625\u745e\u6ee8\uff09\u76f8\u6bd4\u6cbb\u7597HER2\u4f4e\u8868\u8fbe\u6216\u65e0HER2\u8868\u8fbe\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC)\u60a3\u8005\u7684\u7597\u6548\u3002\u8fd9\u4e9b\u6570\u636e\u5df2\u4e8e2022\u5e749\u67089\u65e5\u81f313\u65e5\u5728\u6cd5\u56fd\u5df4\u9ece\u4e3e\u884c\u7684\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\uff08#ESMO22\uff0c\u7ebf\u4e0a\u7ebf\u4e0b\u7ed3\u5408)\u4e0a\u4ee5\u6d77\u62a5\u7684\u5f62\u5f0f\u5448\u73b0\uff08\u62a5\u544a\uff1a#259P\uff09\u3002<\/p>\n

HER2\u4f4e\u8868\u8fbe\u4e73\u817a\u764c\u4e9a\u578b\u662f\u4e00\u79cd\u65b0\u5b9a\u4e49\u7684\u764c\u75c7\u7c7b\u578b\uff0c\u5305\u62ec\u65e2\u5f80\u6839\u636e\u514d\u75ab\u7ec4\u5316\uff08IHC\uff09\u6d4b\u5b9a\u548c\u539f\u4f4d\u6742\u4ea4\uff08ISH\uff09\u6d4b\u5b9a\u7ed3\u679c\u8bc4\u4f30\u4e3aHER2\u9634\u6027\u7684\u80bf\u7624\u3002HER2\u4f4e\u8868\u8fbe\u80bf\u7624\u7684HER2\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\u8f83\u4f4e\uff0c\u4f46\u5e76\u4e0d\u8db3\u591f\u88ab\u8ba4\u4e3a\u662fHER2\u9633\u6027\u3002HER2\u4f4e\u8868\u8fbe\u5b9a\u4e49\u4e3aIHC\u8bc4\u5206\u4e3a1+\u62162\uff0c\u4e14ISH\u8bc4\u5206\u4e3a\u9634\u6027\u3002\u9884\u8ba12022\u5e74\u7f8e\u56fd\u7ea6\u670928.8\u4e07\u65b0\u589e\u5973\u6027\u4e73\u817a\u764c\u786e\u8bca\u75c5\u4f8b1<\/sup>\u3002\u636e\u4f30\u8ba1\uff0c\u7ea6\u670980-85%\u7684\u60a3\u8005\u4ee5\u524d\u88ab\u89c6\u4e3aHER2\u9634\u6027\u4e9a\u578b\u60a3\u8005\uff0c\u800c\u5176\u4e2d\u7ea660%\u7684\u60a3\u8005\u73b0\u5728\u5c06\u88ab\u89c6\u4e3aHER2\u4f4e\u8868\u8fbe\u4e9a\u578b\u60a3\u80052<\/sup>\u3002<\/p>\n

\u536b\u6750\u9996\u5e2d\u79d1\u5b66\u5b98\u517c\u9ad8\u7ea7\u526f\u603b\u88c1Takashi Owa\u535a\u58eb\u8868\u793a\uff1a\u201c\u5728\u8fd9\u9879\u4e8b\u540e\u5206\u6790\u4e2d\uff0cHER2\u4f4e\u8868\u8fbemBC\u60a3\u8005\u7684\u7ed3\u5c40\u4e0e\u4e09\u9879\u5173\u952e\u6027III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u4e00\u81f4\u3002\u968f\u7740\u80bf\u7624\u5b66\u754c\u5bf9mBC\u7684\u8ba4\u8bc6\u7684\u4e0d\u65ad\u6df1\u5165\uff0c\u7ee7\u7eed\u8bc4\u4ef7\u73b0\u6709\u7597\u6cd5\u5728\u65b0\u75be\u75c5\u80cc\u666f\u4e0b\u7684\u4f5c\u7528\uff0c\u4ee5\u6b64\u5e2e\u52a9\u533b\u7597\u4fdd\u5065\u4e13\u4e1a\u4eba\u5458\u5b8c\u5584\u77e5\u8bc6\u4f53\u7cfb\u4e5f\u53d8\u5f97\u8d8a\u6765\u8d8a\u91cd\u8981\u3002\u201d<\/p>\n

 <\/p>\n

\u4e8b\u540e\u5206\u6790\u6570\u636e<\/strong><\/p>\n

\u4e8b\u540e\u5206\u6790\u5305\u62ec\u4e09\u9879\u8bd5\u9a8c\u7684\u6570\u636e\uff0c\u5373\u827e\u7acb\u5e03\u6797\u76f8\u8f83\u4e8eTPC\uff08NCT00388726\uff0cEMBRACE\u8bd5\u9a8c\/\u7814\u7a76305\uff09\u3001\u5361\u57f9\u4ed6\u6ee8\uff08NCT00337103\uff0c\u7814\u7a76301\uff09\u4ee5\u53ca\u957f\u6625\u745e\u6ee8\uff08NCT02225470\uff0c\u7814\u7a76304\uff09\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u5316\u7597\uff08\u5305\u62ec\u84bd\u73af\u548c\u7d2b\u6749\u70f7\u7c7b\u836f\u7269\uff09\u6cbb\u7597\uff08\u7814\u7a76301\u22642\u7ebf\uff1b\u7814\u7a76304\u548c\u548cEMBRACE\u8bd5\u9a8c\/\u7814\u7a76305\u4e3a2-5\u7ebf\uff09\u7684\u5c40\u90e8\u590d\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002EMBRACE\u8bd5\u9a8c\/\u7814\u7a76305\u3001\u7814\u7a76301\u548c\u7814\u7a76304\u5171\u5165\u7ec41589\u540d\u7b26\u5408\u6761\u4ef6\u7684\u60a3\u8005\uff0c\u6240\u6709\u7814\u7a76\u4e2d\u5404\u6cbb\u7597\u7ec4\u4e4b\u95f4\u7684\u57fa\u7ebf\u7279\u5f81\u57fa\u672c\u5747\u8861\u3002\u5bf9\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3001\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fdb\u884c\u4e86\u5206\u6790\u3002PFS\u548cORR\u7531\u72ec\u7acb\u5f71\u50cf\u5b66\u5ba1\u67e5\u59d4\u5458\u4f1a\u6839\u636e\u5b9e\u4f53\u7624\u7597\u6548\u8bc4\u4ef7\u6807\u51c6\uff08RECIST\uff09\uff081.0\u7248\uff1aEMBRACE\u8bd5\u9a8c\/\u7814\u7a76305\u548c\u7814\u7a76301\uff1b1.1\u7248\uff1a\u7814\u7a76304\uff09\u8fdb\u884c\u6d4b\u91cf\u3002ORR\u5219\u5728\u53ef\u8bc4\u4ef7\u60a3\u8005\uff08EMBRACE\u8bd5\u9a8c\/\u7814\u7a76305\uff09\u548c\u610f\u5411\u6cbb\u7597\u4eba\u7fa4\uff08\u7814\u7a76301\u548c\u7814\u7a76304\uff09\u4e2d\u8fdb\u884c\u6d4b\u91cf\u3002<\/p>\n

\u5728\u4e8b\u540e\u5206\u6790\u4e2d\uff0cHER2\u4f4e\u8868\u8fbe\u6216HER2\u9634\u6027\u60a3\u8005\u7684OS\u3001PFS\u548cORR\u603b\u4f53\u4e0a\u4e0eEMBRACE\u8bd5\u9a8c\/\u7814\u7a76305\u3001\u7814\u7a76301\u548c\u7814\u7a76304\u4e2d\u827e\u7acb\u5e03\u6797\u6cbb\u7597\u7ec4\u7684\u7ed3\u679c\u76f8\u4f3c3,4,5<\/sup>\u3002\u8fd9\u4e09\u9879\u7814\u7a76\u4e2dHER2\u4f4e\u8868\u8fbe\u548cHER2\u9634\u6027\u60a3\u8005\u7684\u7597\u6548\u7ed3\u679c\u603b\u7ed3\u89c1\u4e0b\u8868\uff1a<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nHER2\u4f4e\u8868\u8fbe<\/td>\nHER2\u9634\u6027<\/td>\n<\/tr>\n
EMBRACE\/<\/strong>\u7814\u7a76<\/strong>305<\/strong><\/td>\n<\/tr>\n
<\/td>\n\u827e\u7acb\u5e03\u6797<\/p>\n

(n=121)<\/td>\n

TPC<\/p>\n

(n=57)<\/td>\n

\u827e\u7acb\u5e03\u6797<\/p>\n

(n=222)<\/td>\n

TPC<\/p>\n

(n=117)<\/td>\n<\/tr>\n

\u4e2d\u4f4dOS\uff0c\u6708(95% CI)<\/td>\n12.8 (9.1-15.7)<\/td>\n11.0 (7.7-NE)<\/td>\n13.8 (12.0-14.9)<\/td>\n10.2 (8.4-14.6)<\/td>\n<\/tr>\n
HR (95% CI)<\/td>\n0.8 (0.5-1.3)<\/td>\n0.8 (0.6-1.1)<\/td>\n<\/tr>\n
\u4e2d\u4f4dPFS\uff0c\u6708(95% CI)<\/td>\n3.7 (3.1-4.1)<\/td>\n2.1 (1.9-3.7)<\/td>\n3.7 (3.1-4.9)<\/td>\n2.2 (1.9-3.3)<\/td>\n<\/tr>\n
HR (95% CI)<\/td>\n0.7 (0.4-1.0)<\/td>\n0.7 (0.6-<1.0)<\/td>\n<\/tr>\n
<\/td>\n\u827e\u7acb\u5e03\u6797<\/p>\n

(n=112)<\/td>\n

TPC<\/p>\n

(n=49)<\/td>\n

\u827e\u7acb\u5e03\u6797<\/p>\n

(n=202)<\/td>\n

TPC<\/p>\n

(n=99)<\/td>\n<\/tr>\n

ORR, % (95% CI)<\/td>\n18.8 (12.0-27.2)<\/td>\n6.1 (1.3-16.9)<\/td>\n10.4 (6.6-15.5)<\/td>\n4.0 (1.1-10.0)<\/td>\n<\/tr>\n
\u7814\u7a76<\/strong> 301<\/strong><\/td>\n<\/tr>\n
<\/td>\n\u827e\u7acb\u5e03\u6797<\/p>\n

(n=114)<\/td>\n

\u5361\u57f9\u4ed6\u6ee8<\/p>\n

(n=135)<\/td>\n

\u827e\u7acb\u5e03\u6797<\/p>\n

(n=248)<\/td>\n

\u5361\u57f9\u4ed6\u6ee8<\/p>\n

(n=237)<\/td>\n<\/tr>\n

\u4e2d\u4f4dOS\uff0c\u6708(95% CI)<\/td>\n15.7 (13.1-18.1)<\/td>\n13.5 (10.3-15.9)<\/td>\n15.9 (14.6-18.6)<\/td>\n13.5 (11.8-15.5)<\/td>\n<\/tr>\n
HR (95% CI)<\/td>\n0.9 (0.7-1.2)<\/td>\n0.8 (0.6-<1.0)<\/td>\n<\/tr>\n
\u4e2d\u4f4dPFS\uff0c\u6708(95% CI)<\/td>\n4.1 (2.8-5.4)<\/td>\n3.6 (2.7-4.2)<\/td>\n4.0 (3.0-4.3)<\/td>\n4.0 (3.0-4.9)<\/td>\n<\/tr>\n
HR (95% CI)<\/td>\n1.0 (0.7-1.4)<\/td>\n1.1 (0.9-1.3)<\/td>\n<\/tr>\n
ORR, % (95% CI)<\/td>\n8.8 (4.3-15.5)<\/td>\n10.4 (5.8-16.8)<\/td>\n10.1 (6.6-14.5)<\/td>\n8.9 (5.6-13.2)<\/td>\n<\/tr>\n
\u7814\u7a76<\/strong> 304<\/strong><\/td>\n<\/tr>\n
<\/td>\n\u827e\u7acb\u5e03\u6797<\/p>\n

(n=69)<\/td>\n

\u957f\u6625\u745e\u6ee8<\/p>\n

(n=67)<\/td>\n

\u827e\u7acb\u5e03\u6797<\/p>\n

(n=102)<\/td>\n

\u957f\u6625\u745e\u6ee8<\/p>\n

(n=100)<\/td>\n<\/tr>\n

\u4e2d\u4f4dOS\uff0c\u6708(95% CI)<\/td>\n13.2 (11.4-21.1)<\/td>\n11.0 (9.9-16.9)<\/td>\n13.5 (9.3-17.6)<\/td>\n14.3 (10.6-NE)<\/td>\n<\/tr>\n
HR (95% CI)<\/td>\n0.9 (0.5-1.4)<\/td>\n1.1 (0.8-1.7)<\/td>\n<\/tr>\n
\u4e2d\u4f4dPFS\uff0c\u6708(95% CI)<\/td>\n4.1 (2.8-4.2)<\/td>\n3.2 (2.7-4.2)<\/td>\n2.8 (2.7-4.1)<\/td>\n2.7 (1.4-2.8)<\/td>\n<\/tr>\n
HR (95% CI)<\/td>\n0.9 (0.6-1.3)<\/td>\n0.7 (0.5-0.9)<\/td>\n<\/tr>\n
ORR, % (95% CI)<\/td>\n34.8 (23.7-47.2)<\/td>\n22.4 (13.1-34.2)<\/td>\n24.5 (16.5-34.0)<\/td>\n18.0 (11.0-26.9)<\/td>\n<\/tr>\n
*CI\uff1a\u7f6e\u4fe1\u533a\u95f4\uff0cHR\uff1a\u98ce\u9669\u6bd4\uff0cNE\uff1a\u4e0d\u53ef\u8bc4\u4ef7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Media Inquiries:<\/span><\/strong><\/p>\n

Public Relations Department,<\/p>\n

Eisai Co., Ltd.<\/p>\n

+81-(0)3-3817-5120<\/p>\n","protected":false},"excerpt":{"rendered":"

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