{"id":6242,"date":"2022-09-12T13:40:36","date_gmt":"2022-09-12T05:40:36","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=6242"},"modified":"2022-10-28T13:50:43","modified_gmt":"2022-10-28T05:50:43","slug":"%e5%8d%ab%e6%9d%90%e5%92%8cmsd%e5%85%ac%e5%b8%83iii%e6%9c%9f%e8%af%95%e9%aa%8cleap-002%e7%9a%84%e7%bb%93%e6%9e%9c%ef%bc%8c%e8%af%a5%e8%af%95%e9%aa%8c%e8%af%84%e4%bb%b7%e4%ba%86%e4%b9%90%e5%8d%ab","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2022\/09\/12\/%e5%8d%ab%e6%9d%90%e5%92%8cmsd%e5%85%ac%e5%b8%83iii%e6%9c%9f%e8%af%95%e9%aa%8cleap-002%e7%9a%84%e7%bb%93%e6%9e%9c%ef%bc%8c%e8%af%a5%e8%af%95%e9%aa%8c%e8%af%84%e4%bb%b7%e4%ba%86%e4%b9%90%e5%8d%ab\/","title":{"rendered":"\u536b\u6750\u548cMSD\u516c\u5e03III\u671f\u8bd5\u9a8cLEAP-002\u7684\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u8bc4\u4ef7\u4e86\u4e50\u536b\u739b\u00ae\uff08\u4ed1\u4f10\u66ff\u5c3c\uff09\u548c\u53ef\u745e\u8fbe\u00ae\uff08\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u8054\u5408\u6cbb\u7597\u76f8\u8f83\u4e8e\u4e50\u536b\u739b\u5355\u836f\u6cbb\u7597\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027"},"content":{"rendered":"

\u7814\u7a76\u7ed3\u679c\u5c06\u57282022\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u7684\u4f18\u9009\u53e3\u5934\u62a5\u544a\u73af\u8282\u63ed\u6653<\/h3>\n

 <\/p>\n

\u4e1c\u4eac\u548c\u65b0\u6cfd\u897f\u5dde\u62c9\u5a01\u5e02\uff0c2022\u5e749\u670812\u65e5 \u2013 \u536b\u6750\uff08\u603b\u90e8\uff1a\u4e1c\u4eac\uff0c\u9996\u5e2d\u6267\u884c\u5b98\uff1a\u5185\u85e4\u6674\u592b\uff0c\u201c\u536b\u6750\u201d\uff09\u548cMSD\u5ba3\u5e03\u5176\u5c06\u9996\u6b21\u516c\u5e03III\u671f\u8bd5\u9a8c LEAP-002\u7684\u6700\u7ec8\u5206\u6790\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u65e8\u5728\u63a2\u8ba8\u536b\u6750\u7814\u53d1\u7684\u53e3\u670d\u591a\u9776\u70b9\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u4e50\u536b\u739b\u00ae<\/sup><\/strong>\u548cMSD\u7684\u6297 PD-1\u6cbb\u7597\u836f\u7269\u53ef\u745e\u8fbe\u00ae<\/sup><\/strong>\u8054\u5408\u6cbb\u7597\u76f8\u8f83\u4e8e\u4e50\u536b\u739b\u5355\u836f\u6cbb\u7597\u4f5c\u4e3a\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c (uHCC) \u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8be5\u7ed3\u679c\u4e8e9\u67089\u65e5\u81f313\u65e5\u5728\u6cd5\u56fd\u5df4\u9ece\u4e3e\u884c\u7684\u7ebf\u4e0a2022\u5e74\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a (ESMO) \u5927\u4f1a\u7684\u4f18\u9009\u53e3\u5934\u62a5\u544a\u73af\u8282\u63ed\u6653\uff08\u6458\u8981 #LBA34\uff09\u3002<\/p>\n

\u5728\u8bd5\u9a8c\u7684\u6700\u7ec8\u5206\u6790\u4e2d\uff0c\u76f8\u8f83\u4e8e\u63a5\u53d7\u4e50\u536b\u739b\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u5728\u4f5c\u4e3a\u7814\u7a76\u53cc\u91cd\u4e3b\u8981\u7ec8\u70b9\u4e4b\u4e00\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u65b9\u9762\u8868\u73b0\u51fa\u6539\u5584\u8d8b\u52bf\uff1b\u7136\u800c\uff0c\u6839\u636e\u9884\u5b9a\u7684\u7edf\u8ba1\u8ba1\u5212\uff0c\u8fd9\u4e00\u7ed3\u679c\u5e76\u4e0d\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08HR=0.84 [95% CI\uff1a0.71-1.00]\uff1bp=0.0227\uff09\u3002\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u6cbb\u7597\u7684\u4e2d\u4f4dOS\u4e3a21.2\u4e2a\u6708\uff0895% CI\uff1a19.0-23.6\uff09\uff0c\u800c\u4e50\u536b\u739b\u5355\u836f\u6cbb\u7597\u7684\u4e2d\u4f4dOS\u4e3a19.0\u4e2a\u6708\uff0895% CI\uff1a17.2-21.7\uff09\u3002\u6b64\u5916\uff0c\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u6cbb\u7597\u5728\u8bd5\u9a8c\u7684\u53e6\u4e00\u4e2a\u4e3b\u8981\u7ec8\u70b9\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u65b9\u9762\u4e5f\u8f83\u4e50\u536b\u739b\u5355\u836f\u6cbb\u7597\u8868\u73b0\u51fa\u6539\u5584\u8d8b\u52bf\uff1b\u4f46\u5728\u7b2c\u4e00\u6b21\u4e2d\u671f\u5206\u6790\u65f6\uff0c\u7ed3\u679c\u5e76\u672a\u8fbe\u5230\u9884\u5b9a\u7684\u7edf\u8ba1\u5b66\u610f\u4e49\u9608\u503c\uff08HR=0.87 [95% CI\uff1a0.73-1.02]\uff1bp=0.0466\uff09\u3002<\/p>\n

MSD\u7814\u7a76\u5b9e\u9a8c\u5ba4\u4e34\u5e8a\u7814\u7a76\u526f\u603b\u88c1Gregory Lubiniecki\u535a\u58eb\u8868\u793a\uff1a\u201cLEAP-002\u8bd5\u9a8c\u53cd\u6620\u4e86\u6211\u4eec\u7684\u7814\u7a76\u7b56\u7565\uff0c\u5373\u5728\u4e0d\u65ad\u6539\u8fdb\u6807\u51c6\u6cbb\u7597\u7684\u57fa\u7840\u4e0a\uff0c\u8fdb\u4e00\u6b65\u6539\u5584\u66f4\u591a\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u60a3\u8005\u7684\u7ed3\u5c40\u3002\u53ef\u745e\u8fbe\u548c\u4e50\u536b\u739b\u8054\u5408\u6cbb\u7597\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e3a21.2\u4e2a\u6708\uff0c\u8fd9\u4e3a\u8fdb\u4e00\u6b65\u7814\u7a76\u8be5\u6cbb\u7597\u7ec4\u5408\u7684\u6f5c\u529b\u63d0\u4f9b\u4e86\u5173\u952e\u4fe1\u606f\u3002\u201d<\/p>\n

\u536b\u6750\u80bf\u7624\u4e1a\u52a1\u4e34\u5e8a\u7814\u7a76\u9ad8\u7ea7\u526f\u603b\u88c1Corina Dutcus\u535a\u58eb\u8868\u793a\uff1a\u201c\u867d\u7136\u7ed3\u679c\u4e0d\u662f\u6211\u4eec\u6240\u5e0c\u671b\u7684\uff0c\u4f46\u91cd\u8981\u7684\u662f\u6211\u4eec\u8981\u770b\u5230\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u4e50\u536b\u739b\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e3a19.0\u4e2a\u6708\u3002\u76ee\u524d\uff0c\u4e50\u536b\u739b\u5355\u836f\u6cbb\u7597\u5df2\u5728\u5168\u7403\u591a\u4e2a\u5730\u533a\uff08\u5305\u62ec\u7f8e\u56fd\u3001\u6b27\u76df\uff08EU\uff09\u3001\u65e5\u672c\u548c\u4e2d\u56fd\uff09\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\uff0cLEAP-002\u8bd5\u9a8c\u7684\u7ed3\u679c\u4e0d\u4ec5\u6709\u52a9\u4e8e\u52a0\u6df1\u6211\u4eec\u5bf9\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u6cbb\u7597\u7684\u7406\u89e3\uff0c\u4ece\u800c\u63a8\u52a8\u8fd9\u4e00\u6cbb\u7597\u65b9\u6848\u5728\u6574\u4e2a\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u4e2d\u7684\u5e94\u7528\uff0c\u8fd8\u53ef\u4e3a\u533b\u751f\u63d0\u4f9b\u66f4\u591a\u5173\u4e8e\u4e50\u536b\u739b\u5355\u836f\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\u7684\u4fe1\u606f\u3002\u201d<\/p>\n

\u4e50\u536b\u739b\u5355\u836f\u6cbb\u7597\u5df2\u5728\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u4e2d\u56fd\u83b7\u6279\u7528\u4e8euHCC\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u6b64\u5916\uff0c\u8fd8\u5728\u65e5\u672c\u83b7\u6279\u7528\u4e8e\u6cbb\u7597uHCC\u60a3\u8005\u3002\u4e50\u536b\u739b\u83b7\u6279\u662f\u57fa\u4e8eIII\u671f\u8bd5\u9a8cREFLECT\u7684\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u8bc4\u4ef7\u4e86\u4e50\u536b\u739b\u76f8\u8f83\u4e8e\u7d22\u62c9\u975e\u5c3c\u7528\u4e8euHCC\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n

\u4e50\u536b\u739b\uff08\u6b27\u76df\u5730\u533a\u5546\u54c1\u540d\u4e3aKISPLYX\u00ae\uff0c\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c [RCC]\uff09\u548c\u53ef\u745e\u8fbe\u8054\u5408\u6cbb\u7597\u5728\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u65e5\u672c\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u7279\u5b9a\u7c7b\u578b\u7684\u665a\u671f\u5b50\u5bab\u5185\u819c\u764c\u548c\u665a\u671fRCC\u60a3\u8005\u3002\u536b\u6750\u548cMSD\u6b63\u5728\u901a\u8fc7LEAP\uff08Lenvatinib And Pembrolizumab\uff09\u4e34\u5e8a\u9879\u76ee\u5728\u8d85\u8fc715\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\u7814\u7a76\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u6cbb\u7597\u7528\u4e8e\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u5b50\u5bab\u5185\u819c\u764c\u3001HCC\u3001\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001RCC\u3001\u5934\u9888\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u80c3\u764c\u548c\u98df\u9053\u764c\u3002<\/p>\n

 <\/p>\n

LEAP-002<\/strong>\u7814\u7a76\u8bbe\u8ba1\u548c\u6700\u7ec8\u5206\u6790\u7ed3\u679c\uff08\u6458\u8981<\/strong>#LBA34<\/strong>\uff09<\/strong><\/p>\n

LEAP-002\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u6d3b\u6027\u836f\u7269\u5bf9\u7167III\u671f\u8bd5\u9a8c\uff08ClinicalTrials.gov, NCT03713593\uff09\uff0c\u65e8\u5728\u8bc4\u4ef7\u4e50\u536b\u739b\u548c\u53ef\u745e\u8fbe\u8054\u5408\u6cbb\u7597\u76f8\u8f83\u4e8e\u4e50\u536b\u739b\u5355\u836f\u6cbb\u7597\u7528\u4e8euHCC\u6210\u4eba\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u60a3\u8005\u4ee51:1\u7684\u6bd4\u4f8b\u968f\u673a\u63a5\u53d7\u4e50\u536b\u739b\uff08\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7ed9\u836f12mg [\u7b5b\u9009\u65f6\u4f53\u91cd\u226560kg\u7684\u60a3\u8005]\u62168mg [\u7b5b\u9009\u65f6\u4f53\u91cd\uff1c60kg\u7684\u60a3\u8005]\uff09\u548c\u53ef\u745e\u8fbe\uff08\u6bcf\u4e09\u5468\u5468\u671f\u7684\u7b2c1\u65e5\u9759\u8109\u5185 [IV]\u7ed9\u836f200mg\uff09\u8054\u5408\u7ed9\u836f\uff1b\u6216\u4e50\u536b\u739b\uff08\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7ed9\u836f12mg [\u7b5b\u9009\u65f6\u4f53\u91cd\u226560kg\u7684\u60a3\u8005]\u62168mg [\u7b5b\u9009\u65f6\u4f53\u91cd\uff1c60kg\u7684\u60a3\u8005]\uff09\u548c\u751f\u7406\u76d0\u6c34\u5b89\u6170\u5242\uff08\u6bcf\u4e09\u5468\u5468\u671f\u7684\u7b2c1\u65e5\u9759\u8109\u5185\u7ed9\u836f\uff09\u3002\u4e50\u536b\u739b\u7ed9\u836f\u4e00\u76f4\u6301\u7eed\u5230\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u3002\u53ef\u745e\u8fbe\/\u5b89\u6170\u5242\u7684\u7ed9\u836f\u65f6\u95f4\u6700\u591a\u4e3a35\u4e2a\u5468\u671f\uff08\u7ea6\u4e24\u5e74\uff09\u3002<\/p>\n

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\u622a\u81f3\u6700\u7ec8\u5206\u6790\u7684\u6570\u636e\u622a\u6b62\u65e5\u671f\uff082022\u5e746\u670821\u65e5\uff09\uff0c\u5171\u6709794\u540d\u60a3\u8005\u5165\u7ec4\u5e76\u63a5\u53d7\u6cbb\u7597\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a32.1\u4e2a\u6708\uff08\u8303\u56f4\uff1a25.8-41.1\uff09\u3002\u5171\u53d1\u751f534\u4f8bOS\u4e8b\u4ef6\uff0c\u5176\u4e2d\u8054\u5408\u6cbb\u7597\u7ec436\u540d\u60a3\u8005\uff089.1%\uff09\u548c\u4e50\u536b\u739b\u5355\u836f\u6cbb\u7597\u7ec424\u540d\u60a3\u8005\uff086.1%\uff09\u4ecd\u5728\u63a5\u53d7\u7814\u7a76\u6cbb\u7597\u3002<\/p>\n

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 <\/p>\n

Eisai Co., Ltd.<\/p>\n

\n
\n

Public Relations:<\/span><\/strong><\/p>\n

+81-(0)3-3817-5120<\/p>\n

Investor Relations:<\/span><\/strong><\/p>\n

+81-(0) 70-8688-9685<\/p>\n<\/div>\n<\/div>\n

 <\/p>\n

Merck & Co., Inc., Kenilworth, N.J., U.S.A.<\/p>\n

\n
\n

Media Relations<\/span><\/strong><\/p>\n

Melissa Moody: +1-(215) 407-3536<\/p>\n

Nikki Sullivan: +1-(718) 644-0730<\/p>\n

Investor Relations<\/span><\/strong><\/p>\n

Peter Dannenbaum: +1- (908) 740-1037<\/p>\n

Damini Chokshi: +1-(908) 740- 1807<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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