{"id":7465,"date":"2023-11-18T16:14:34","date_gmt":"2023-11-18T08:14:34","guid":{"rendered":"https:\/\/www.eisai.com.cn\/?p=7465"},"modified":"2023-11-23T16:55:46","modified_gmt":"2023-11-23T08:55:46","slug":"%e5%bc%95%e9%a2%86%e7%a7%91%e5%ad%a6%e6%b5%aa%e6%bd%ae%ef%bc%8c2023%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e9%ab%98%e5%b3%b0%e8%ae%ba%e5%9d%9b%e7%9b%9b%e5%a4%a7%e5%8f%ac%e5%bc%80","status":"publish","type":"post","link":"https:\/\/www.eisai.com.cn\/2023\/11\/18\/%e5%bc%95%e9%a2%86%e7%a7%91%e5%ad%a6%e6%b5%aa%e6%bd%ae%ef%bc%8c2023%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%85%e9%ab%98%e5%b3%b0%e8%ae%ba%e5%9d%9b%e7%9b%9b%e5%a4%a7%e5%8f%ac%e5%bc%80\/","title":{"rendered":"\u5f15\u9886\u79d1\u5b66\u6d6a\u6f6e\uff0c2023\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u9ad8\u5cf0\u8bba\u575b\u76db\u5927\u53ec\u5f00"},"content":{"rendered":"<p>\u5bfc\u8bed\uff1a\u75c5\u7406\u673a\u5236\u3001\u65b0\u836f\u7814\u53d1\u3001\u8bca\u7597\u7ba1\u7406\u5168\u65b9\u4f4d\u8986\u76d6\uff0c\u4e00\u8d77\u6765\u770b\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u9886\u57df\u6700\u65b0\u8fdb\u5c55\uff01<\/p>\n<p>&nbsp;<\/p>\n<p>2023\u5e7411\u670818\u65e5\uff0c\u7531\u4e2d\u56fd\u8111\u5065\u5eb7\u884c\u52a8\u4e13\u5bb6\u59d4\u5458\u4f1a\u6307\u5bfc\uff0c\u7cbe\u51c6\u533b\u5b66\u7814\u7a76\u4e0e\u4ea7\u4e1a\u53d1\u5c55\u8054\u76df\u53ca\u4e0a\u6d77\u533b\u5b66\u521b\u65b0\u53d1\u5c55\u57fa\u91d1\u4f1a\u4e3b\u529e\u3001\u536b\u6750\uff08\u4e2d\u56fd\uff09\u836f\u4e1a\u6709\u9650\u516c\u53f8\u5927\u529b\u652f\u6301\u76842023\u5e74\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u9ad8\u5cf0\u8bba\u575b\u4e8e\u5317\u4eac\u76db\u5927\u53ec\u5f00\uff0c\u56fd\u5185\u5916\u591a\u4f4d\u8ba4\u77e5\u969c\u788d\u9886\u57df\u7684\u4e13\u5bb6\u5b66\u8005\u9f50\u805a\u4e00\u5802\uff0c\u56f4\u7ed5\u8111\u5065\u5eb7\u3001\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u75c5\u7406\u673a\u5236\u53ca\u751f\u7269\u6807\u5fd7\u7269\u3001\u75be\u75c5\u4fee\u9970\u6cbb\u7597\uff08DMT\uff09\u836f\u7269\u6700\u65b0\u7814\u7a76\u6570\u636e\u3001\u60a3\u8005\u7ba1\u7406\u7b49\u70ed\u70b9\u8bdd\u9898\u5c55\u5f00\u4e86\u6df1\u5165\u63a2\u8ba8\uff0c\u5f00\u542fAD\u9886\u57df\u8de8\u65f6\u4ee3\u53d1\u5c55\u7684\u65b0\u683c\u5c40\u3002<\/p>\n<p>\u5728\u5f00\u573a\u81f4\u8f9e\u73af\u8282\uff0c\u5927\u4f1a\u4e3b\u5e2d\u4e0a\u6d77\u533b\u5b66\u521b\u65b0\u53d1\u5c55\u57fa\u91d1\u4f1a\u6267\u884c\u7406\u4e8b\u957f\u738b\u6ce2\u5973\u58eb\u3001\u9996\u90fd\u533b\u79d1\u5927\u5b66\u5ba3\u6b66\u533b\u9662\u8d3e\u5efa\u5e73\u6559\u6388\u3001\u798f\u5efa\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u534f\u548c\u533b\u9662\u9648\u6653\u6625\u6559\u6388\u81f4\u5f00\u573a\u8f9e\uff0c\u5747\u8868\u793a\u5f53\u524dAD\u9886\u57df\u5df2\u8fce\u6765\u4e86\u5386\u53f2\u6027\u7684\u98de\u8dc3\u4e0e\u7a81\u7834\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7466 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u72471-2.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u4e0a\u6d77\u533b\u5b66\u521b\u65b0\u53d1\u5c55\u57fa\u91d1\u4f1a\u6267\u884c\u7406\u4e8b\u957f\u738b\u6ce2\u5973\u58eb<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7467 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u72472.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u9996\u90fd\u533b\u79d1\u5927\u5b66\u5ba3\u6b66\u533b\u9662\u8d3e\u5efa\u5e73\u6559\u6388<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7468 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u72473-2.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u798f\u5efa\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u534f\u548c\u533b\u9662\u9648\u6653\u6625\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p>\u4f1a\u8bae\u4f0a\u59cb\uff0c\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u5929\u575b\u533b\u9662\u738b\u62e5\u519b\u6559\u6388\u9996\u5148\u4e3a\u6211\u4eec\u4ecb\u7ecd\u4e86\u8111\u5065\u5eb7\u7ba1\u7406\u4e2d\u5fc3\u7684\u6982\u5ff5\u3001\u73b0\u72b6\u4e0e\u5c55\u671b\u3002\u8111\u5065\u5eb7\u662f\u5b9e\u73b0\u53ef\u6301\u7eed\u53d1\u5c55\u76ee\u6807\u7684\u6838\u5fc3\uff0c\u5e76\u660e\u786e\u63d0\u51fa\u4e86\u8111\u5065\u5eb7\u5b9a\u4e49\u7684\u56db\u9879\u5185\u5bb9\uff0c\u5373\u8111\u7ed3\u6784\u6b63\u5e38\u3001\u8111\u529f\u80fd\u6b63\u5e38\u3001\u793e\u4f1a\u9002\u5e94\u826f\u597d\u3001\u65e0\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\uff0c\u5e76\u6307\u51fa\u8111\u5065\u5eb7\u7ba1\u7406\u4e2d\u5fc3\u5e94\u4ee5\u8fd9\u56db\u4e2a\u7ef4\u5ea6\u4e3a\u6838\u5fc3\u660e\u786e\u804c\u80fd\u5b9a\u4f4d\uff0c\u4ee5\u66f4\u597d\u5730\u63a8\u52a8\u6211\u56fd\u8111\u5065\u5eb7\u53d1\u5c55\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7471 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u72474-1.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u738b\u62e5\u519b\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\"><strong>\u7a81\u7834\u58c1\u5792\u3001\u5f00\u542f\u672a\u6765\uff0cAD\u8bca\u7597\u5f00\u542f\u65b0\u7bc7\u7ae0<\/strong><\/p>\n<p>\u968f\u7740AD\u81f4\u75c5\u673a\u5236\u7684\u660e\u6670\u4e0eDMT\u836f\u7269\u7684\u53d1\u5c55\uff0c\u8fd1\u5e74\u6765AD\u751f\u7269\u6807\u5fd7\u7269\u7684\u7814\u7a76\u5982\u706b\u5982\u837c\u3002\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u6c88\u7490\u6559\u6388\u5206\u4eab\u4e86AD\u751f\u7269\u6807\u5fd7\u7269\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u3002\u5728\u4eca\u5e74\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u534f\u4f1a\u56fd\u9645\u4f1a\u8bae\uff08AAIC\uff09\u5927\u4f1a\u4e0a\u53d1\u5e03\u4e86AD\u6700\u65b0\u8bca\u65ad\u6807\u51c6\uff0c\u5efa\u8bae\u901a\u8fc7\u6838\u5fc3\u751f\u7269\u6807\u5fd7\u7269\u5c06AD\u8fdb\u884c\u5206\u671f\u53ca\u8bca\u65adAD\uff0c\u7531\u6b64\u5728AD\u7684\u4e34\u5e8a\u5206\u671f\u4e2d\u589e\u52a0\u4e860\u9636\u6bb5\uff08stage 0\uff09\uff1b\u6b64\u5916\u8fd8\u4ecb\u7ecd\u4e86\u591a\u79cd\u8840\u6db2\u751f\u7269\u6807\u5fd7\u7269\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u5176\u5728\u8bca\u7597\u4e2d\u7684\u5e94\u7528\u4ef7\u503c\uff0c\u5e76\u5bf9A\u03b2\u548cTau-PET\u5728AD\u8bca\u65ad\u4e2d\u7684\u5408\u7406\u5e94\u7528\u7ed9\u51fa\u8bf8\u591a\u5efa\u8bae\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7472 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u72475.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u6c88\u7490\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p>\u9996\u90fd\u533b\u79d1\u5927\u5b66\u5ba3\u6b66\u533b\u9662\u9b4f\u7fe0\u67cf\u6559\u6388\u89e3\u8bfb\u4e86\u6700\u65b0DMT\u836f\u7269\u76f8\u8f83\u4e8e\u4f20\u7edf\u836f\u7269\u7684\u65b0\u76ee\u6807\u548c\u65b0\u8981\u6c42\uff0c\u5982\u6e05\u9664\u75c5\u7406\u4ea7\u7269\u548c\u5ef6\u7f13\u75be\u75c5\u8fdb\u7a0b\uff0c\u800c\u4ed1\u5361\u5948\u5355\u6297\u7684\u7814\u7a76\u6570\u636e\u90fd\u5f88\u597d\u7684\u652f\u6301\u4e86DMT\u7684\u6cbb\u7597\u83b7\u76ca\u3002\u4ed1\u5361\u5948\u5355\u6297\u5177\u6709\u660e\u786e\u7684\u7597\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4ee3\u8868\u6297A\u03b2\u5355\u6297\u836f\u7269\u7a81\u7834\u91cd\u56f4\u3001\u5f00\u542fDMT\u65f6\u4ee3\u7684\u65b0\u7bc7\u7ae0\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7473 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u72476.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u9b4f\u7fe0\u67cf\u6559\u6388<\/p>\n<p>\u9b4f\u7fe0\u67cf\u6559\u6388\u4ecb\u7ecd\u9053\uff0c\u4ed1\u5361\u5948\u5355\u6297\u6301\u7eed\u6cbb\u7597\u53ef\u51cf\u7f13\u8ba4\u77e5\u548c\u529f\u80fd\u7684\u8870\u9000\u548c\u66f4\u597d\u7ef4\u6301\u529f\u80fd\uff0c\u7167\u6599\u8d1f\u62c5\u66f4\u5c11\uff0c\u5c24\u5176\u5728\u4f4eTau\u6c34\u5e73\u4e9a\u7ec4\uff08\u5373\u66f4\u65e9\u671f\u7684AD\u60a3\u8005\uff09\u4e2d\u53ef\u5ef6\u7f13\u4e34\u5e8a\u75f4\u5446\u8bc4\u5206\u603b\u548c\u91cf\u8868\uff08CDR-SB\uff09\u8870\u9000549%\uff0c\u63d0\u793a\u8d8a\u65e9\u6cbb\u7597\uff0c\u60a3\u8005\u83b7\u76ca\u8d8a\u591a\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u65e9\u671f\u542f\u52a8\u4ed1\u5361\u5948\u5355\u6297\u6cbb\u7597\uff0c\u8fd8\u53ef\u8ba976%\u7684\u66f4\u65e9\u671fAD\u60a3\u8005\u83b7\u5f97\u8ba4\u77e5\u548c\u529f\u80fd\u7ef4\u6301\uff0c60%\u60a3\u8005\u7684\u8ba4\u77e5\u548c\u529f\u80fd\u5f97\u5230\u6539\u5584<sup>[2]<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7474 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u72477.png\" alt=\"\" width=\"553\" height=\"226\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u65e9\u671f\u542f\u52a8\u4ed1\u5361\u5948\u5355\u6297\u6cbb\u7597\u8ba4\u77e5\u548c\u529f\u80fd\u7ef4\u6301\u3001\u6539\u5584<\/p>\n<p>&nbsp;<\/p>\n<p>\u5728AD\u8bca\u65ad\u53ca\u6cbb\u7597\u9886\u57df\u90fd\u53d6\u5f97\u7a81\u7834\u7684\u5f53\u4e0b\uff0cAD\u4e34\u5e8a\u8bca\u7597\u5b9e\u8df5\u4e5f\u63d0\u4e0a\u4e86\u8bae\u4e8b\u65e5\u7a0b\u3002\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66Lawrence Honig\u6559\u6388\u4e3a\u6211\u4eec\u8fdb\u884c\u4e86\u4e3b\u9898\u4e3a\u201cHealthcare System Readiness for New Treatments for Alzheimer Disease\u201d\u7684\u6388\u8bfe\uff0cLawrence\u6559\u6388\u6307\u51fa\uff0cAD\u6e90\u6027MCl\u53ca\u8f7b\u5ea6AD\u7b49\u65e9\u671fAD\u60a3\u8005\u3001\u8111\u810a\u6db2\u6216PET\uff08\u751a\u81f3\u8840\u6d46\uff09\u68c0\u67e5\u7ed3\u679c\u786e\u8ba4\u6709\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u60a3\u8005\u4eba\u7fa4\u5e94\u5c3d\u65e9\u63a5\u53d7DMT\u6cbb\u7597\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7475 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u72478.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe Lawrence Honig\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p>\u5728\u4e0a\u5348\u4f1a\u8bae\u7684\u6700\u540e\uff0c\u89e3\u653e\u519b\u603b\u533b\u9662\u89e3\u6052\u9769\u6559\u6388\u4e3b\u6301\u4e86\u8ba8\u8bba\u73af\u8282\uff0c\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u7f57\u672c\u71d5\u6559\u6388\u3001\u9752\u5c9b\u5e02\u5e02\u7acb\u533b\u9662\u8c2d\u5170\u6559\u6388\u4e0eLawrence Honig\u6559\u6388\u5c31\u5f53\u524d\u7684DMT\u836f\u7269\u662f\u5426\u80fd\u591f\u771f\u6b63\u4e3aAD\u60a3\u8005\u5e26\u6765\u83b7\u76ca\u3001DMT\u836f\u7269\u5982\u4f55\u624d\u80fd\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u53d1\u6325\u6700\u5927\u4ef7\u503c\u4ee5\u53ca\u8111\u5065\u5eb7\u4e2d\u5fc3\u7684\u5efa\u8bbe\u5c55\u5f00\u4e86\u7cbe\u5f69\u8ba8\u8bba\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7476 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u72479.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u5927\u5496\u6c99\u53d1\u79c0<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\"><strong>\u8ffd\u6839\u6eaf\u6e90\uff0c\u660e\u786e\u75c5\u7406\u673a\u5236\uff0c\u63a8\u52a8AD\u8bca\u7597\u53d1\u5c55<\/strong><\/p>\n<p>\u5f53\u5929\u4e0b\u5348\u4f1a\u8bae\u5f00\u59cb\u65f6\uff0c\u5927\u4f1a\u4e3b\u5e2d\u5317\u4eac\u5927\u5b66\u7b2c\u516d\u533b\u9662\u4e8e\u6b23\u6559\u6388\u3001\u5c71\u4e1c\u7b2c\u4e00\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7701\u7acb\u533b\u9662\u675c\u6021\u5cf0\u6559\u6388\u81f4\u8f9e\u9053\uff0c\u5ff5\u5ff5\u4e0d\u5fd8\uff0c\u5fc5\u6709\u56de\u54cd\uff0c\u7ecf\u8fc7\u4e8c\u5341\u591a\u5e74\u6765\u7684\u4e0d\u61c8\u52aa\u529b\uff0cAD\u8bca\u7597\u9886\u57df\u7ec8\u4e8e\u7ffb\u5f00\u4e86\u5168\u65b0\u7bc7\u7ae0\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7477 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u724710.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u4e8e\u6b23\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7478 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u724711.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u675c\u6021\u5cf0\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p>\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u9644\u5c5e\u7b2c\u516d\u4eba\u6c11\u533b\u9662\u90ed\u8d77\u6d69\u6559\u6388\u4ecb\u7ecd\u4e86\u8fd1\u671fAD\u6700\u65b0\u7684\u75c5\u7406\u673a\u5236\u53d1\u73b0\u3002\u591a\u79cdAD\u81f4\u75c5\u673a\u7406\u7684\u5047\u8bf4\u6709\u4e86\u65b0\u7684\u6269\u5145\u548c\u53d1\u73b0\uff0c\u5373A\u03b2\u5be1\u805a\u4f53\u53ef\u4f5c\u4e3a\u201c\u79cd\u5b50\u201d\u52a0\u901fA\u03b2\u6c89\u79ef\uff0c\u540c\u65f6\u53ef\u4e0eTau\u86cb\u767d\u534f\u8c03\u4f5c\u7528<sup>[4,5]<\/sup>\u3002\u4ed1\u5361\u5948\u5355\u6297\u901a\u8fc7\u8bf1\u5bfc\u5c0f\u80f6\u8d28\u7ec6\u80de\u6e05\u9664\u6700\u5177\u6bd2\u6027\u7684A\u03b2\u5be1\u805a\u4f53\u548c\u539f\u7ea4\u7ef4\uff0c\u5e76\u9884\u9632\u6591\u5757\u751f\u6210\uff0c\u540c\u65f6\u51cf\u5c11\u4e0b\u6e38Tau\u75c5\u7406\u8fdb\u5c55\uff0c\u4ee5\u6b64\u6709\u6548\u5ef6\u7f13AD\u8fdb\u5c55\uff0c\u9a8c\u8bc1\u4e86\u4ee5\u201cA\u03b2\u7ea7\u8054\u5b66\u8bf4\u201d\u4e3a\u7406\u8bba\u57fa\u7840\u7684\u6cbb\u7597\u7b56\u7565<sup>[6,7]<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7479 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u724712.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u90ed\u8d77\u6d69\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p>\u56db\u5ddd\u5927\u5b66\u534e\u897f\u533b\u9662\u9648\u82b9\u6559\u6388\u6307\u51fa\uff0cA\u03b2\u5728\u4f53\u5185\u4ee5\u591a\u79cd\u5f62\u5f0f\u5b58\u5728\uff0c\u5f53A\u03b2\u805a\u96c6\u6c89\u79ef\u5927\u4e8e\u6e05\u9664\u65f6\u4f1a\u9020\u6210\u6c89\u79ef\u8fc7\u8f7d\uff0c\u4ece\u800c\u8bf1\u53d1AD<sup>[8]<\/sup>\u3002A\u03b2\u5f02\u5e38\u805a\u96c6\u548c\u7a81\u89e6\u529f\u80fd\u5931\u8c03\u53d1\u751f\u5728Tau\u75c5\u7406\u4f20\u64ad\u3001\u5927\u8111\u7ed3\u6784\u6539\u53d8\uff08\u795e\u7ecf\u5143\u4e22\u5931\uff09\u3001\u51fa\u73b0\u4e34\u5e8a\u8868\u73b0\u6216\u75c7\u72b6\u7b49\u9636\u6bb5\u4e4b\u524d\uff0c\u5176\u6c89\u79ef\u4e0eAD\u7684\u8fdb\u5c55\u98ce\u9669\u5177\u6709\u76f8\u5173\u6027\uff0c\u56e0\u6b64A\u03b2\u6210\u4e3a\u76ee\u524dAD\u836f\u7269\u7814\u53d1\u7ba1\u7ebf\u4e2d\u7684\u70ed\u70b9\u4f5c\u7528\u9776\u4f4d<sup>[9]<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7480 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u724713.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u9648\u82b9\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p>\u5357\u5f00\u5927\u5b66\u9644\u5c5e\u5929\u6d25\u5e02\u73af\u6e56\u533b\u9662\u7eaa\u52c7\u6559\u6388\u4ee5\u201cAD\uff1a\u4ece\u4e34\u5e8a\u5230\u75c5\u7406\u8bca\u65ad\u201d\u5206\u4eab\u4e86\u5982\u4f55\u7cbe\u51c6\u65e9\u671fAD\u60a3\u8005\uff0c\u75c5\u7406\u7ed3\u679c\u662f\u8bca\u65adAD\u7684\u91d1\u6807\u51c6\uff0c\u4f46\u5982\u4f55\u4ee5\u66f4\u5c0f\u7684\u521b\u4f24\u5b9e\u73b0AD\u60a3\u8005\u7684\u65e9\u671f\u8bca\u65ad\uff1f\u5728\u672c\u6b21\u62a5\u544a\u4e2d\uff0c\u7eaa\u52c7\u6559\u6388\u6307\u51fa\u4e86\u7ed3\u6784\u5f71\u50cf\u5b66\u3001\u5206\u5b50\u5f71\u50cf\u5b66\u3001\u8840\u6db2\u6807\u5fd7\u7269\u5728AD\u8bca\u65ad\u4e2d\u7684\u4e0d\u540c\u4f5c\u7528\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7481 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u724714.jpg\" alt=\"\" width=\"415\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u7eaa\u52c7\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p>\u63a5\u4e0b\u6765\u89e3\u653e\u519b\u603b\u533b\u9662\u8d3e\u5efa\u519b\u6559\u6388\u8be6\u7ec6\u9610\u8ff0\u4e86\u201cA\u03b2\u5206\u5b50\u5f71\u50cf\u6280\u672f\u201d\u5728\u4e2d\u56fd\u7684\u5e94\u7528\u73b0\u72b6\uff0c\u63d0\u51faA\u03b2-PET\u5f71\u50cf\u5b66\u9002\u7528\u4e8e\u6301\u7eed\u6216\u8fdb\u5c55\u6027\u7684\u4e0d\u53ef\u89e3\u91ca\u7684MCI\u60a3\u8005\u3001\u53ef\u80fd\u4e3aAD\u4f46\u4e34\u5e8a\u75c7\u72b6\u6216\u75c5\u7a0b\u8fdb\u5c55\u4e0d\u5178\u578b\u7684\u60a3\u8005\u3001\u8fdb\u5c55\u6027\u75f4\u5446\u60a3\u8005\u5e76\u4e14\u53d1\u75c5\u5e74\u9f84\u65e9\uff08&lt; 65\u5c81\uff09\uff0c\u6211\u56fd\u7684\u5f71\u50cf\u5b66\u4ea7\u4e1a\u5e94\u5c3d\u5feb\u8ddf\u8fdb\u5b66\u672f\u7814\u7a76\u7684\u811a\u6b65\u8d70\u5728\u56fd\u9645\u7684\u524d\u6cbf\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7482 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u724715.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u8d3e\u5efa\u519b\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p>\u6df1\u5733\u6e7e\u5b9e\u9a8c\u5ba4\u90ed\u817e\u98de\u535a\u58eb\u53ca\u5e7f\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u8111\u79d1\u533b\u9662\u949f\u7b11\u6885\u6559\u6388\u5206\u522b\u9488\u5bf9AD\u4f53\u6db2\u751f\u7269\u6807\u5fd7\u7269\u7684\u5e38\u7528\u68c0\u6d4b\u65b9\u6cd5\uff0c\u5373\u5355\u5206\u5b50\u6280\u672f\u548c\u5316\u5b66\u53d1\u5149\/\u7535\u5316\u5b66\u53d1\u5149\u6280\u672f\u7684\u5e94\u7528\u8fdb\u884c\u4e86\u5206\u4eab\uff0c\u6307\u51fa\u8840\u6d46\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\u5177\u6709\u5fae\u521b\u6027\u548c\u4fbf\u5229\u6027\uff0c\u4fbf\u4e8e\u4e34\u5e8a\u4f7f\u7528\uff0c\u5728AD\u65e9\u671f\u8bca\u65ad\u4e2d\u5177\u6709\u5de8\u5927\u5e94\u7528\u6f5c\u529b\uff0c\u5982p-Tau217\u662fAD\u8bca\u65ad\u975e\u5e38\u6709\u524d\u666f\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u80fd\u591f\u5c3d\u65e9\u68c0\u6d4b\u5230AD\u7684\u75c5\u7406\u53d8\u5316<sup>[10]<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7483 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u724716.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u90ed\u817e\u98de\u535a\u58eb<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7484 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u724717.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u949f\u7b11\u6885\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p>\u4f53\u6db2\u751f\u7269\u6807\u5fd7\u7269\u548c\u5f71\u50cf\u5b66\u751f\u7269\u6807\u5fd7\u7269\u53ef\u5e94\u7528\u4e8eAD\u7684\u65e9\u671f\u8bca\u65ad\u3001\u7cbe\u51c6\u9009\u62e9\u53ef\u4eceDMT\u836f\u7269\u4e2d\u83b7\u76ca\u7684AD\u60a3\u8005\u4ee5\u53ca\u76d1\u6d4b\u6cbb\u7597\u53cd\u5e94\u7b49\u5173\u952e\u8fc7\u7a0b\uff0c\u5f53\u524d\u4e0d\u4ec5\u751f\u7269\u6807\u5fd7\u7269\u7684\u79cd\u7c7b\u53ca\u6548\u80fd\u6b63\u5728\u589e\u52a0\uff0c\u5176\u68c0\u6d4b\u65b9\u6cd5\u4e5f\u6709\u4e86\u66f4\u65b0\u3002\u5728\u7ed3\u675f\u8fd9\u4e00\u73af\u8282\u7684\u8bb2\u8bfe\u540e\uff0c\u5728\u675c\u6021\u5cf0\u6559\u6388\u7684\u4e3b\u6301\u4e0b\uff0c\u91cd\u5e86\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u5415\u6d0b\u6559\u6388\u3001\u5317\u4eac\u534f\u548c\u533b\u9662\u6bdb\u6668\u6656\u6559\u6388\u3001\u5409\u6797\u5927\u5b66\u7b2c\u4e00\u533b\u9662\u5b59\u8389\u6559\u6388\u3001\u89e3\u653e\u519b\u603b\u533b\u9662\u5f20\u9526\u660e\u6559\u6388\u5c31\u4f17\u591a\u751f\u7269\u6807\u5fd7\u7269\u7684\u4e34\u5e8a\u5b9e\u8df5\u5e94\u7528\u5c55\u5f00\u4e86\u6df1\u5165\u8ba8\u8bba\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7485 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u724718.jpg\" alt=\"\" width=\"415\" height=\"276\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u5927\u5496\u6c99\u53d1\u79c0<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\"><strong>AD<\/strong><strong>\u53ef\u9632\u53ef\u63a7\uff0c\u5168\u7a0b\u79ef\u6781\u5e94\u5bf9\u53ef\u51cf\u8f7b\u75be\u75c5\u8d1f\u62c5<\/strong><\/p>\n<p>\u201c\u5168\u7403\u75f4\u5446\u60a3\u8005\u7684\u7167\u62a4\u73b0\u72b6\u582a\u5fe7\uff0c\u4e14\u7167\u62a4\u8005\u9762\u4e34\u7684\u538b\u529b\u4e5f\u4e0d\u5bb9\u5ffd\u89c6\u3002\u201d\u4e0a\u6d77\u5e02\u7cbe\u795e\u536b\u751f\u4e2d\u5fc3\u674e\u971e\u6559\u6388\u5728\u6388\u8bfe\u4e2d\u6307\u51fa\u3002\u674e\u971e\u6559\u6388\u5206\u4eab\u4e86SMARRT\u7814\u7a76\u548cFINGER\u7814\u7a76\u7684\u6700\u65b0\u7ed3\u679c\uff0c\u901a\u8fc7\u7cfb\u7edf\u6027\u3001\u591a\u9886\u57df\u7684\u4e2a\u6027\u5316\u5e72\u9884\u53ef\u663e\u8457\u6539\u5584\u53d7\u8bd5\u8005\u8ba4\u77e5\u5e76\u63d0\u9ad8\u751f\u6d3b\u8d28\u91cf\uff0c\u964d\u4f4eAD\u98ce\u9669\uff0c\u4e14\u5176\u5e72\u9884\u7ed3\u679c\u4f3c\u4e4e\u4e0d\u53d7\u9057\u4f20\u56e0\u7d20\u7684\u5f71\u54cd\uff1b\u5f3a\u70c8\u5efa\u8bae\u5728\u6574\u4e2a\u751f\u547d\u8fc7\u7a0b\u4e2d\uff0c\u5bf9\u751f\u6d3b\u65b9\u5f0f\u3001\u5408\u5e76\u75c7\u7b49\u91cd\u70b9\u56e0\u7d20\u5b9e\u65bd\u5e72\u9884<sup>[11]<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7486 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u724719.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u674e\u971e\u6559\u6388<\/p>\n<p>&nbsp;<\/p>\n<p>\u9488\u5bf9\u60a3\u8005\u7ba1\u7406\u8fd9\u4e00\u91cd\u8981\u8bae\u9898\uff0c\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u90b5\u9038\u592b\u533b\u9662\u9648\u709c\u6559\u6388\u3001\u5357\u4eac\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u8111\u79d1\u533b\u9662\u77f3\u9759\u840d\u6559\u6388\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662\u6c64\u835f\u51ac\u6559\u6388\u3001\u4e1c\u5357\u5927\u5b66\u9644\u5c5e\u4e2d\u5927\u533b\u9662\u8c22\u6625\u660e\u6559\u6388\u3001\u5e7f\u4e1c\u7701\u4eba\u6c11\u533b\u9662\u8d75\u6d01\u7693\u6559\u6388\u5c31\u65e9\u671fAD\u60a3\u8005\u7684\u5168\u7a0b\u7ba1\u7406\uff0c\u4ee5\u53ca\u5728\u4e34\u5e8a\u4e0a\u63a5\u53d7DMT\u836f\u7269\u6cbb\u7597\u7684AD\u60a3\u8005\u7684\u89c4\u8303\u7ba1\u7406\u8fdb\u884c\u4e86\u8ba8\u8bba\u3002\u5728\u7528\u836f\u524d\u8fdb\u884c\u5168\u9762\u8bc4\u4f30\u3001\u4e25\u683c\u7b5b\u67e5\u60a3\u8005\u662fAD\u7cbe\u51c6\u7528\u836f\u7684\u57fa\u77f3\uff0c\u53ef\u5bf9\u60a3\u8005\u5f00\u5c55\u66f4\u5177\u9488\u5bf9\u6027\u7684\u6cbb\u7597\uff0c\u7528\u836f\u540e\u501f\u52a9\u6570\u5b57\u5316\u5de5\u5177\u53ef\u5e2e\u52a9\u4e34\u5e8a\u533b\u751f\u76d1\u6d4b\u60a3\u8005\u4e0d\u826f\u53cd\u5e94\u3001\u8bc4\u4f30\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7487 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2023\/11\/\u56fe\u724720.jpg\" alt=\"\" width=\"414\" height=\"275\" \/><\/p>\n<p style=\"text-align: center\">\u56fe \u5927\u5496\u6c99\u53d1\u79c0<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\"><strong>\u5c0f\u7ed3<\/strong><\/p>\n<p>\u672c\u6b21\u5927\u4f1a\u7684\u5185\u5bb9\u78b0\u649e\u5728AD\u7684\u591a\u9886\u57df\u4e2d\u6b21\u7b2c\u5f00\u82b1\uff0c\u8bca\u65ad\u9886\u57df\u6709\u591a\u9879\u751f\u7269\u6807\u5fd7\u7269\u7814\u7a76\u7684\u8fdb\u5c55\uff0c\u6cbb\u7597\u9886\u57df\u6709\u4ed1\u5361\u5948\u5355\u6297\u7b49\u65b0\u836f\u91cd\u78c5\u4e0a\u5e02\uff0c\u75c5\u7406\u673a\u5236\u7684\u7814\u7a76\u5982\u706b\u5982\u837c\uff0c\u60a3\u8005\u7ba1\u7406\u4e0e\u7167\u62a4\u4e5f\u6ca1\u6709\u88ab\u6211\u4eec\u5ffd\u7565\uff0c\u591a\u65b9\u4e00\u540c\u52aa\u529b\u63a8\u8fdb\u201c\u8111\u5065\u5eb7\u884c\u52a8\u201d\uff0c\u624d\u80fd\u8ba9\u201c\u4eba\u4eba\u4eab\u6709\u8111\u5065\u5eb7\u201d\u7684\u76ee\u6807\u6700\u7ec8\u8fbe\u6210\uff01<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<p>[1] Cummings J, Zhou Y, Lee G, et al. Alzheimer&#8217;s disease drug development pipeline: 2023. Alzheimers Dement (N Y). 2023 May 25;9(2):e12385.<\/p>\n<p>[2]Tahami Monfared AA, Ye W, Sardesai A, et a;. A Path to Improved Alzheimer&#8217;s Care: Simulating Long-Term Health Outcomes of Lecanemab in Early Alzheimer&#8217;s Disease from the CLARITY AD Trial. Neurol Ther. 2023 Jun;12(3):863-881.<\/p>\n<p>[3] Cummings J, Apostolova L, Rabinovici GD, et al. Lecanemab: Appropriate Use Recommendations. J Prev Alzheimers Dis.<\/p>\n<p>[4]Ou YN, Yang YX, Deng YT, et al. Identification of novel drug targets for Alzheimer&#8217;s disease by integrating genetics and proteomes from brain and blood. Mol Psychiatry. 2021 Oct;26(10):6065-6073.<\/p>\n<p>[5]Vadukul DM, Vrancx C, Burguet P, et al. An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-\u03b2. Sci Rep. 2021 Jun 2;11(1):11570.<\/p>\n<p>[6]Hardy J, Mummery C. An anti-amyloid therapy works for Alzheimer&#8217;s disease: why has it taken so long and what is next? Brain. 2023 Apr 19;146(4):1240-1242.<\/p>\n<p>[7]van Dyck CH, Swanson CJ, Aisen P, et al. Lecanemab in Early Alzheimer&#8217;s Disease. N Engl J Med. 2023 Jan 5;388(1):9-21.<\/p>\n<p>[8]Paroni G, Bisceglia P, Seripa D. Understanding the Amyloid Hypothesis in Alzheimer&#8217;s Disease. J Alzheimers Dis. 2019;68(2):493-510.<\/p>\n<p>[9]Cummings J, Zhou Y, Lee G, et al. Alzheimer&#8217;s disease drug development pipeline: 2023. Alzheimers Dement (N Y). 2023 May 25;9(2):e12385.<\/p>\n<p>[10]Palmqvist S, Janelidze S, Quiroz YT, et al. Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders. JAMA. 2020 Aug 25;324(8):772-781.<\/p>\n<p>[11]Sindi S, Solomon A, K\u00e5reholt I, et al. Telomere Length Change in a Multidomain Lifestyle Intervention to Prevent Cognitive Decline: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):491-498.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5bfc\u8bed\uff1a\u75c5\u7406\u673a\u5236\u3001\u65b0\u836f\u7814\u53d1\u3001\u8bca\u7597\u7ba1\u7406\u5168\u65b9\u4f4d\u8986\u76d6\uff0c\u4e00\u8d77\u6765\u770b\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u9886\u57df\u6700\u65b0\u8fdb\u5c55\uff01<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-7465","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/7465"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=7465"}],"version-history":[{"count":5,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/7465\/revisions"}],"predecessor-version":[{"id":7470,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/7465\/revisions\/7470"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=7465"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=7465"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=7465"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}