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Neurology\u300b\u7684\u7f51\u7edc\u7248\u4e0a\u3002<\/p>\n<p><strong>\u7814\u7a76\u80cc\u666f\u548c\u76ee\u7684<\/strong><\/p>\n<p>\u6dc0\u7c89\u6837\u86cb\u767d\u7ea7\u8054\u5047\u8bf4\u662f\u5173\u4e8eAD\u75c5\u56e0\u7684\u4e3b\u8981\u7406\u8bba\uff0c\u8be5\u5047\u8bf4\u8ba4\u4e3a\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\uff08A\u03b2\uff09\u5728\u795e\u7ecf\u5143\u5916\u5f02\u5e38\u805a\u96c6\uff0c\u968f\u540e\u5f62\u6210tau\u795e\u7ecf\u539f\u7ea4\u7ef4\u7f20\u7ed3\uff0c\u5bf9\u795e\u7ecf\u5143\u9020\u6210\u635f\u4f24\uff0c\u5e76\u5bfc\u81f4\u75be\u75c5\u53d1\u4f5c\u3002\u539f\u7ea4\u7ef4\u5f62\u6001\u7684\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u6bd4\u7ea4\u7ef4\u548c\u6591\u5757\u5f62\u6001\u66f4\u5177\u795e\u7ecf\u6bd2\u6027\uff0c\u540e\u8005\u662f\u5f02\u5e38\u805a\u96c6A\u03b2\u7684\u6700\u540e\u9636\u6bb5\uff0c\u56e0\u6b64\u8ba4\u4e3aPF\u53ef\u80fd\u4f1a\u5bfc\u81f4\u795e\u7ecf\u9000\u884c\u6027\u53d8\uff08\u53c2\u8003\u6587\u732e\uff1aAmin L\u548cHarris 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1 \u6839\u636e\u4e34\u5e8a\u8bca\u65ad\u548c\u6dc0\u7c89\u6837\u86cb\u767d\u9633\u6027\/\u9634\u6027\u5206\u7c7b\u7684\u8111\u810a\u6db2\u4ed1\u5361\u5948\u5355\u6297\u76f8\u5173\u6dc0\u7c89\u6837\u86cb\u767d\u539f\u7ea4\u7ef4\uff08CSF Lec-PF\uff09\u6d53\u5ea6<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-8321 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2025\/01\/1.png\" alt=\"\" width=\"934\" height=\"524\" srcset=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2025\/01\/1.png 934w, https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2025\/01\/1-600x337.png 600w, https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2025\/01\/1-768x431.png 768w, https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2025\/01\/1-705x396.png 705w\" sizes=\"(max-width: 934px) 100vw, 934px\" \/><\/p>\n<p>\u56fe 1 \u8bf4\u660e<\/p>\n<p>\u65b9\u6846\u56fe\u4e2d\u7684\u65b9\u6846\u8868\u793a\u56db\u5206\u4f4d\u6570\u95f4\u8ddd\uff0c\u6c34\u5e73\u7ebf\u8868\u793a\u4e2d\u4f4d\u6570\u3002\u5404\u7ec4\u7f29\u5199\uff1a YNC\uff08\u5e74\u8f7b\u6b63\u5e38\u5bf9\u7167\u7ec4\u6dc0\u7c89\u6837\u86cb\u767d\u9634\u6027\uff09\u3001AMC\uff08\u5e74\u9f84\u5339\u914d\u5bf9\u7167\u7ec4\u6dc0\u7c89\u6837\u86cb\u767d\u9634\u6027\uff09\u3001CI-\uff08\u8ba4\u77e5\u529f\u80fd\u53d7\u635f\u7ec4\u6dc0\u7c89\u6837\u86cb\u767d\u9634\u6027\uff09\u3001CU+\uff08\u8ba4\u77e5\u529f\u80fd\u672a\u53d7\u635f\u7ec4\u6dc0\u7c89\u6837\u86cb\u767d\u9633\u6027\uff09\u3001MCI+\uff08\u8f7b\u5ea6\u8ba4\u77e5\u529f\u80fd\u53d7\u635f\u7ec4\u6dc0\u7c89\u6837\u86cb\u767d\u9633\u6027\uff09\u3001AD+\uff08AD \u75f4\u5446\u7ec4\u6dc0\u7c89\u6837\u86cb\u767d\u9633\u6027\uff09\u3001CSF\uff08\u8111\u810a\u6db2\uff09\u3002<\/p>\n<p>*p &lt; 0.05<\/p>\n<p>\u56fe 2 \u8111\u810a\u6db2\u6807\u8bb0\u7269\u4e0e\u8111\u810a\u6db2\u4ed1\u5361\u5948\u5355\u6297\u76f8\u5173\u6dc0\u7c89\u6837\u86cb\u767d\u539f\u7ea4\u7ef4\uff08CSF Lec-PF\uff09\u7684\u76f8\u5173\u6027<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-8320 aligncenter\" src=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2025\/01\/2.png\" alt=\"\" width=\"967\" height=\"569\" srcset=\"https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2025\/01\/2.png 967w, https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2025\/01\/2-600x353.png 600w, https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2025\/01\/2-768x452.png 768w, https:\/\/www.eisai.com.cn\/wordpress\/wp-content\/uploads\/2025\/01\/2-705x415.png 705w\" sizes=\"(max-width: 967px) 100vw, 967px\" \/><\/p>\n<p>\u56fe2\u8bf4\u660e<\/p>\n<p>\u9ed1\u7ebf\u548c\u7ea2\u7ebf\u5206\u522b\u8868\u793a\u6574\u4e2a\u53d7\u8bd5\u8005\u7ec4\u548c\u6dc0\u7c89\u6837\u86cb\u767d\u9633\u6027\u53d7\u8bd5\u8005\u7ec4CSF Lec-PF\u4e0e\u5404\u8111\u810a\u6db2\u6807\u8bb0\u7269\u4e4b\u95f4\u65af\u76ae\u5c14\u66fc\u76f8\u5173\u7cfb\u6570\u768495%\u7f6e\u4fe1\u533a\u95f4 (CI)\u3002\u9ed1\u70b9\u548c\u7ea2\u70b9\u8868\u793a\u65af\u76ae\u5c14\u66fc\u76f8\u5173\u7cfb\u6570\u7684\u4e2d\u503c\u3002\u9ed1\u7ebf\u548c\u7ea2\u7ebf\u4e4b\u95f4\u7684\u5de8\u5927\u5dee\u5f02\u53cd\u6620\u4e86A\u03b2 \u9633\u6027\u6216\u9634\u6027\u72b6\u6001\u7684\u663e\u8457\u5f71\u54cd\u3002<\/p>\n<p>\u5728\u8fd9\u9879\u5206\u6790\u4e2d\uff0c\u6240\u6709\u53d7\u8bd5\u8005\uff08\u9ed1\u7ebf\uff09\u7684CSF Lec-PF\u4e0e\u6240\u6709\u6d4b\u5b9a\u7684\u751f\u7269\u6807\u5fd7\u7269\uff08\u5373A\u03b242\u3001A\u03b242\/40\u6bd4\u503c\u3001p-tau 181\u3001p-tau 217\u3001\u603b-tau\u548c\u795e\u7ecf\u9897\u7c92\u86cb\u767d\uff09\u4e4b\u95f4\u7684\u76f8\u5173\u7cfb\u6570\u5747\u4e3a0.2\u6216\u66f4\u9ad8\uff0c\u8868\u660e CSF Lec-PF \u4e0e\u8fd9\u4e9b\u751f\u7269\u6807\u5fd7\u7269\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u76f8\u5173\u6027\u3002\u5728\u6dc0\u7c89\u6837\u86cb\u767d\u9633\u6027\u7ec4\uff08\u7ea2\u7ebf\uff09\u4e2d\uff0cCSF Lec-PF\u4e0eCSF total-tau\u7684Spearman\u76f8\u5173\u7cfb\u6570\u5206\u522b\u4e3a0.634\uff08CI\uff1a0.409-0.786\uff09\uff0cCSF Lec-PF\u4e0eCSF neurogranin\u7684Spearman\u76f8\u5173\u7cfb\u6570\u5206\u522b\u4e3a0.434\uff08CI\uff1a0.260-0.581\uff09\uff0c\u8868\u660eCSF Lec-PF\u4e0e\u8fd9\u4e24\u79cd\u751f\u7269\u6807\u5fd7\u7269\u4e4b\u95f4\u5b58\u5728\u5f88\u5f3a\u7684\u76f8\u5173\u6027\u3002\u53e6\u4e00\u65b9\u9762\uff0cCSF Lec-PF\u4e0e\u8111A\u03b2\u7d2f\u79ef\u751f\u7269\u6807\u5fd7\u7269CSF A\u03b242\u548cCSF A\u03b242\/40\u6bd4\u503c\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u90fd\u76f8\u5bf9\u8f83\u4f4e\u3002\u8fd9\u8868\u660e\uff0cCSF Lec-PF\u7684\u542b\u91cf\u4e0e\u795e\u7ecf\u9000\u884c\u6027\u53d8\u7684\u5173\u7cfb\u6bd4\u5927\u8111\u4e2dA\u03b2\u7684\u79ef\u7d2f\u66f4\u4e3a\u5bc6\u5207\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u6587\u7ae0\u53d1\u8868\u60c5\u51b5\uff1a<\/p>\n<p>\u671f\u520a\u540d\u79f0\uff1aAnnals of Neurology<\/p>\n<p>\u6587\u7ae0\u9898\u76ee: Lecanemab-associated amyloid-\u03b2 protofibril in cerebrospinal fluid correlates with<\/p>\n<p>biomarkers of neurodegeneration in Alzheimer\u2019s disease (Cerebrospinal fluid (CSF) lecanemab-associated amyloid protofibril concentrations correlate well with neurodegenerative biomarkers in AD)<\/p>\n<p>\u4f5c\u8005: Moeko Noguchi-Shinohara, Kazuyoshi Shuta, Hidetomo Murakami, Yukiko Mori, Junji Komatsu, Chizuru Kobayashi, Steven Hersch, Kanta Horie, Kenjiro Ono<\/p>\n<p>\u53d1\u8868\u65e5\u671f\uff1aJanuary 6, 2025 (US Eastern Standard Time).<\/p>\n<p>DOI: 10.1002\/ANA.27175<\/p>\n<p>&nbsp;<\/p>\n<p>\u4fe1\u606f\u8054\u7edc\uff1a<\/p>\n<p>\u25a0 Regarding research content<\/p>\n<p>Kanazawa University<\/p>\n<p>Professor Kenjiro Ono<\/p>\n<p>TEL: +81-(0)76-265-2292<\/p>\n<p>Email: onoken@med.kanazawa-u.ac.jp<\/p>\n<p>Associate Professor Moeko Shinohara<\/p>\n<p>TEL: +81-(0)76-265-2292<\/p>\n<p>Email: m-nohara@med.kanazawa-u.ac.jp<\/p>\n<p>Eisai Co., Ltd.<\/p>\n<p>Kanta Horie<\/p>\n<p>E-mail: kanta_horie@eisai.com<\/p>\n<p>\u25a0 Public Relations Officer<\/p>\n<p>General Affairs Section, General Affairs Division, Medical, Pharmaceutical and Health Sciences<\/p>\n<p>Administration Department, Kanazawa University<\/p>\n<p>Rina Yamada<\/p>\n<p>TEL: +81-(0)76-265-2109<\/p>\n<p>E-mail: t-isomu@adm.kanazawa-u.ac.jp<\/p>\n<p>Eisai Co., Ltd. PR Department<\/p>\n<p>TEL: +81-(0)3-3817-5120<\/p>\n<p style=\"text-align: right;\">\u7f16\u53f7\uff1aECN2025-0002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7531\u91d1\u6cfd\u5927\u5b66\u7684\u533b\u5b66\u3001\u5236\u836f\u548c\u5065\u5eb7\u79d1\u5b66\u7814\u7a76\u6240Kenjiro Ono\uff08\u5c0f\u91ce\u8d24\u4e8c\u90ce\uff09\u6559\u6388\u9886\u5bfc\u7684\u7814\u7a76\u5c0f\u7ec4\u4e0e\u536b\u6750\u682a\u5f0f\u4f1a\u793e\u5408\u4f5c\uff0c\u5229\u7528\u65b0\u5f00\u53d1\u7684\u4ed1\u5361\u5948\u5355\u6297\u76f8\u5173\u6dc0\u7c89\u6837\u86cb\u767d-\u03b2\u539f\u7ea4\u7ef4\uff08Lec-PF\uff09\u6d4b\u91cf\u7cfb\u7edf\u8bc1\u660e\uff0c\u4e0e\u975e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u4ece\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5230\u8f7b\u5ea6\u548c\u91cd\u5ea6\u75f4\u5446\u7684\u5404\u4e2a\u9636\u6bb5\u8111\u810a\u6db2\u4e2d\u7684Lec-PF\u6d53\u5ea6\u90fd\u6709\u6240\u5347\u9ad8\u3002\u6b64\u5916\uff0c\u8fd9\u9879\u7814\u7a76\u8fd8\u53d1\u73b0\uff0c\u8111\u810a\u6db2\u4e2d Lec-PF\u7684\u6d53\u5ea6\u4e0e\u53cd\u6620\u795e\u7ecf\u53d8\u6027\u7684\u751f\u7269\u6807\u5fd7\u7269\u6709\u660e\u663e\u7684\u76f8\u5173\u6027\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-8318","post","type-post","status-publish","format-standard","hentry","category-news-zh"],"_links":{"self":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/8318"}],"collection":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/comments?post=8318"}],"version-history":[{"count":4,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/8318\/revisions"}],"predecessor-version":[{"id":8330,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/posts\/8318\/revisions\/8330"}],"wp:attachment":[{"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/media?parent=8318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/categories?post=8318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.eisai.com.cn\/wp-json\/wp\/v2\/tags?post=8318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}